{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T13:57:34Z","timestamp":1781013454785,"version":"3.54.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentomaxillofacial Radiology"],"published-print":{"date-parts":[[2021,10,1]]},"abstract":"<jats:sec><jats:title>Objectives:<\/jats:title><jats:p> Salivary duct carcinoma is an aggressive tumour commonly showing local invasion and\/or nerve palsy. However, their CT\/MRI findings, especially, regarding T2WI, and the diffusion-weighted-image (DWI), were not well known. In this study, we correlated the CT\/MRI appearance and the pathological findings containing the nerve invasion cases such as a facial nerve. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> We reviewed 14 cases of SDC (parotid = 11, submandibular = 2, minor salivary gland = 1) pathologically proven peripheral nerve involvement. Their CT findings of all patient including dynamic contrast-enhancement study\uff64MRI (n = 9) and DWI (n = 6) were also analyzed with histopathological correlation. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> On contrast-enhanced CT, the solid component was moderately enhanced. On MRI, T2WI central low signal core (n = 6) with peripheral high intensity rim (n = 5) was frequently observed except heterogeneous low and high (n = 1), diffuse low (n = 1), and high (n = 1) signal cases. The hyaline degenerative area located in the tumour core was poorly enhanced. Eleven tumours had an ill-defined margin, reflecting invasive tumour growth. On DWI, they showed high signal [the central low and peripherally high (n = 4), and diffuse (n = 1), heterogeneously high signal (n = 1)]. The mean ADC value was 1.148 ~ 0.961 x 10\u20133 mm<jats:sup>2<\/jats:sup>\/s. With pathological correlation, the central low signal area on T2WI reflected hyaline degeneration. The sites of gross nerve involvement were revealed as tubular or branching structures on CE-CT (n = 3), and MRI (n = 1). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p> (1) We frequently observed a central low signal area on T2WI\/DWI in SDC. With histopathological correlation, it corresponded to the central hyaline degeneration with the peripheral viable tumour. 2) The gross nerve involvement might be detected as a strongly enhancement structure. <\/jats:p><\/jats:sec>","DOI":"10.1259\/dmfr.20200603","type":"journal-article","created":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T19:55:04Z","timestamp":1618948504000},"page":"20200603","source":"Crossref","is-referenced-by-count":4,"title":["The radiologic (CT\/MRI)-pathological correlations of the salivary duct carcinoma (SDC) with hyaline degeneration and peripheral nerve invasion"],"prefix":"10.1093","volume":"50","author":[{"given":"Nobukata","family":"Kazawa","sequence":"first","affiliation":[{"name":"Department of Radiology, Nagoya City University Hospital, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Shibamoto","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nagoya City University 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