{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T13:04:31Z","timestamp":1792760671177,"version":"4.5.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentomaxillofacial Radiology"],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:sec><jats:title>Objectives:<\/jats:title><jats:p> Pseudarthrosis after mandibular reconstruction leads to chronic overload of the osteosynthesis and impedes dental rehabilitation. This study evaluates the impact of gap site on osseous union in mandible reconstruction using a new volumetric analysis method with repeated cone-beam computed tomography (CBCT). <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> The degree of bone regeneration was evaluated in 16 patients after mandible reconstruction with a fibula free flap and patient-specific reconstruction plates. Percentual bone volume and width changes in intersegmental gaps were retrospectively analyzed using a baseline CBCT in comparison to a follow-up CBCT. Patients\u2019 characteristics, plate-related complications, and gap sites (anterior\/posterior) were analyzed. Detailed assessments of both gap sites (buccal\/lingual\/superior\/inferior) were additionally performed. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Intersegmental gap width (p = 0.002) and site (p &lt; 0.001) significantly influence bone volume change over two consecutive CBCTs. An initial larger gap width resulted in a lower bone volume change. In addition, anterior gaps showed significantly less bone volume changes. Initial gap width was larger at posterior segmental gaps (2.97 vs 1.65\u2009mm, p = 0.017). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p> A methodology framework has been developed that allows to quantify pseuarthrosis in reconstructed mandibles using CBCT imaging. The study identifies the anterior segmental gap as a further risk factor for pseudarthrosis in reconstructions with CAD\/CAM reconstruction plates. Future research should evaluate whether this outcome is related to the biomechanics induced at this site. <\/jats:p><\/jats:sec>","DOI":"10.1259\/dmfr.20220131","type":"journal-article","created":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T09:09:20Z","timestamp":1656407360000},"source":"Crossref","is-referenced-by-count":23,"title":["Increased rate of pseudarthrosis in the anterior intersegmental gap after mandibular reconstruction with fibula free flaps: a volumetric analysis"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4221-4878","authenticated-orcid":false,"given":"Claudius","family":"Steffen","sequence":"first","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Department of Oral and Maxillofacial Surgery, Augustenburger Platz 1, Berlin, 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