{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:57:50Z","timestamp":1773968270442,"version":"3.50.1"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"1129","license":[{"start":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T00:00:00Z","timestamp":1633564800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,1]]},"abstract":"<jats:p>T2-FLAIR mismatch sign has been advocated to be 100% specific for IDH-mutant 1p\/19q non-codeleted gliomas (diffuse astrocytomas). However, false positives have been reported in recent works. Loose application of the criteria may lead to erroneous classification, especially by non-trained neuroradiologists. In this pictorial essay, we aim to bring attention to the need for strict criteria for the application of T2-FLAIR mismatch sign and to discuss the potential pitfalls in the application of these criteria. For that, a series of adult brain tumour cases are presented to demonstrate how to apply this radiological sign in the clinical practice.<\/jats:p>","DOI":"10.1259\/bjr.20210825","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T17:36:10Z","timestamp":1633628170000},"source":"Crossref","is-referenced-by-count":22,"title":["T2-FLAIR mismatch sign: a roadmap of pearls and pitfalls"],"prefix":"10.1093","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0801-1153","authenticated-orcid":false,"given":"Catarina","family":"Pinto","sequence":"first","affiliation":[{"name":"Neuroradiology Department, Centro Hospitalar Universit\u00e1rio do Porto , Porto , Portugal"}]},{"given":"Carolina","family":"Noronha","sequence":"additional","affiliation":[{"name":"Neurosurgery Department, Centro Hospitalar Universit\u00e1rio do Porto , Porto , Portugal"}]},{"given":"Ricardo","family":"Taipa","sequence":"additional","affiliation":[{"name":"Neuropathology Unit, Department of Neurosciences, Centro Hospitalar Universit\u00e1rio do Porto , Porto , Portugal"}]},{"given":"Cristina","family":"Ramos","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, Centro Hospitalar Universit\u00e1rio do Porto , Porto , Portugal"}]}],"member":"286","published-online":{"date-parts":[[2021,10,7]]},"reference":[{"key":"2024050310484273800_b1","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","article-title":"The 2016 World Health organization classification of tumors of the central nervous system: a summary","volume":"131","author":"Louis","year":"2016","journal-title":"Acta Neuropathol"},{"key":"2024050310484273800_b2","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1056\/NEJMoa0808710","article-title":"Idh1 and IDH2 mutations in gliomas","volume":"360","author":"Yan","year":"2009","journal-title":"N Engl J 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