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The scheme is exemplified by G\u00b7U and U\u00b7G wobble pairs, and their predicable local effects on helical twist angle are validated by MD simulations. New insights into a possible rationale for contextual occurrence of G\u00b7U and other non-WC pairs, as well as the influence of a G\u00b7U pair on other non-Watson-Crick pair neighborhood and RNA-protein interactions are obtained from analysis of crystal structure data. A few instances of RNA-protein interactions along the major groove are documented in addition to the well-recognized interaction of the G\u00b7U pair along the minor groove. The nonisostericity-mediated influence of wobble pairs for facilitating helical packing through long-range interactions in ribosomal RNAs is also reviewed.<\/jats:p>","DOI":"10.1261\/rna.036905.112","type":"journal-article","created":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T14:26:24Z","timestamp":1373984784000},"page":"1038-1053","source":"Crossref","is-referenced-by-count":42,"title":["An innate twist between Crick\u2019s wobble and Watson-Crick base pairs"],"prefix":"10.1261","volume":"19","author":[{"given":"Prakash","family":"Ananth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunaseelan","family":"Goldsmith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narayanarao","family":"Yathindra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[2013,7,16]]},"reference":[{"key":"2023052412101450000_19.8.1038.1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/23.3.341"},{"key":"2023052412101450000_19.8.1038.2","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1080\/07391102.1998.10508281","article-title":"Hydration of RNA base pairs","volume":"16","year":"1998","journal-title":"J Biomol Struct Dyn"},{"key":"2023052412101450000_19.8.1038.3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.23.12851"},{"key":"2023052412101450000_19.8.1038.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(92)81649-1"},{"key":"2023052412101450000_19.8.1038.5","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.1.235"},{"key":"2023052412101450000_19.8.1038.6","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1997.1118"},{"key":"2023052412101450000_19.8.1038.7","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1997.0936"},{"key":"2023052412101450000_19.8.1038.8","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1999.2906"},{"key":"2023052412101450000_19.8.1038.9","unstructured":"Case DA , Darden TA , Cheatham TE III , Simmerling CL , Wang J , Duke RE , Luo R , Walker RC , Zhang W , Merz KM , 2010. 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