{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:03:54Z","timestamp":1787508234388,"version":"build-2736575974"},"reference-count":34,"publisher":"Cold Spring Harbor Laboratory","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["RNA"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:p>\n                    Distinct isoforms of spliceosomal RNAs may be involved in regulating pre-messenger RNA splicing in eukaryotic cells. During a large-scale effort to identify small noncoding RNAs in\n                    <jats:italic>Drosophila<\/jats:italic>\n                    , we isolated a U5 snRNA-like molecule containing a 5\u2032 segment identical to that of the canonical (major) U5 snRNA but with a variant Sm binding site and a distinct 3\u2032 hairpin sequence. Based on this finding, another six similar U5 snRNA-like sequences were identified within the\n                    <jats:italic>Drosophila<\/jats:italic>\n                    genome by sequence similarity to the invariant loop in the 5\u2032 half of U5. Interestingly, although all of these variants are expressed in vivo, each shows a distinct temporal expression profile during\n                    <jats:italic>Drosophila<\/jats:italic>\n                    development, and one is expressed primarily in fly heads. The presence of these U5 snRNA variants within RNP particles suggests their role in splicing and implies a possible connection to regulation of developmental and tissue-specific gene expression.\n                  <\/jats:p>","DOI":"10.1261\/rna.2141505","type":"journal-article","created":{"date-parts":[[2005,9,30]],"date-time":"2005-09-30T18:47:44Z","timestamp":1128106064000},"page":"1473-1477","source":"Crossref","is-referenced-by-count":30,"title":["Identification and analysis of U5 snRNA variants in\n                    <i>Drosophila<\/i>"],"prefix":"10.1261","volume":"11","author":[{"given":"LI","family":"CHEN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DENNIS J.","family":"LULLO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ENBO","family":"MA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SUSAN E.","family":"CELNIKER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DONALD C.","family":"RIO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JENNIFER A.","family":"DOUDNA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[2005,9,30]]},"reference":[{"key":"2021112105401293000_11.10.1473.1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5461.2185"},{"key":"2021112105401293000_11.10.1473.2","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S0300-9084(02)01402-5","volume":"84","year":"2002","journal-title":"Biochimie"},{"key":"2021112105401293000_11.10.1473.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00128-8"},{"key":"2021112105401293000_11.10.1473.4","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/11.23.8359"},{"key":"2021112105401293000_11.10.1473.5","doi-asserted-by":"publisher","DOI":"10.1038\/79598"},{"key":"2021112105401293000_11.10.1473.6","doi-asserted-by":"crossref","first-page":"5181","DOI":"10.1002\/j.1460-2075.1993.tb06213.x","volume":"12","year":"1993","journal-title":"EMBO J."},{"key":"2021112105401293000_11.10.1473.7","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.18.6659-6667.2000"},{"key":"2021112105401293000_11.10.1473.8","first-page":"2180","volume":"14","year":"1994","journal-title":"Mol. 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Annotation of the Drosophila melanogaster euchromatic genome: A systematic review. 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