{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T15:06:27Z","timestamp":1767452787922},"reference-count":37,"publisher":"Japanese Society of Animal Reproduction","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Reprod. Dev.","Journal of Reproduction and Development"],"published-print":{"date-parts":[[2013]]},"DOI":"10.1262\/jrd.2012-176","type":"journal-article","created":{"date-parts":[[2013,2,22]],"date-time":"2013-02-22T00:26:53Z","timestamp":1361492813000},"page":"273-281","source":"Crossref","is-referenced-by-count":3,"title":["Early Regression of Spermatogenesis in Boars of an Inbred Duroc Strain Caused by Incident Orchitis\/Epididymo-orchitis"],"prefix":"10.1262","volume":"59","author":[{"given":"Junko","family":"NOGUCHI","sequence":"first","affiliation":[{"name":"Division of Animal Sciences, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305-8602, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiko","family":"NAKAI","sequence":"additional","affiliation":[{"name":"Genetically Modified Organism Research Center, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305-8602, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"KIKUCHI","sequence":"additional","affiliation":[{"name":"Division of Animal Sciences, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305-8602, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"KANEKO","sequence":"additional","affiliation":[{"name":"Division of Animal Sciences, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305-8602, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriaki","family":"IMAEDA","sequence":"additional","affiliation":[{"name":"Gifu Prefectural Livestock Research Institute, Minokamo, Gifu 505-0037, Japan"},{"name":"Present: Faculty of Applied Biological Science, Gifu University, Gifu, Gifu 501-1193, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"349","reference":[{"key":"1","unstructured":"1. Sharpe RM. Regulation of spermatogenesis. In: Knobil E, Neil JD (eds.), The Physiology of Reproduction, 2<sup>nd<\/sup> eds. New York: Raven Press; 1994: 1363-1434."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. de Kretser DM, Loveland KL, Mainhardt A, Simorangkir D, Wreford N. Spermatogenesis. <i>Human Reprod<\/i> 1998; 13(Suppl 1): 1&ndash;8.","DOI":"10.1093\/humrep\/13.suppl_1.1"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2006.00438.x"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1992.tb05485.x"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1262\/jrd.10-138H"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Kaneko H, Noguchi J, Kikuchi K, Todoroki J, Hasegawa Y. Alterations in peripheral concentrations of inhibin A in cattle studied using a time-resolved immunofluorometric assay: relationship with estradiol and follicle-stimulating hormone in various reproductive conditions. <i>Biol Reprod<\/i> 2002; 67: 38&ndash;45.","DOI":"10.1095\/biolreprod67.1.38"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Carreau S, Genissel C, Bilinska B, Levallet J. Sources of oestrogen in the testis and reproductive tract of the male. <i>Int J Androl<\/i> 1999; 22: 211&ndash;223.","DOI":"10.1046\/j.1365-2605.1999.00172.x"},{"key":"8","unstructured":"8. Fraczek B, Kotula-Balak M, Wojtusiak A, Pierscinski A, Bilinska B. Cytochrome P450 aromatase in the testis of immature and mature pigs. <i>Reprod Biol<\/i> 2001; 1: 51&ndash;59."},{"key":"9","unstructured":"9. Mikuz G, Damjanov I. Inflammation of the testis, epididymis, peritesticular membranes, and scrotum. <i>Pathol Annul<\/i> 1982; 17: 101&ndash;128."},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Schuppe HC, Meinhardt A. Immune privilege and inflammation of the testis. In: Markert UR (ed.), Immunology of Gametes and Embryo Implantaion. Vol 88. Basel: Karger; 2005: 1&ndash;14.","DOI":"10.1159\/000087816"},{"key":"11","unstructured":"11. Hall LB Jr, Kluge JP, Evans LE, Hill HT. The effect of pseudorabies (Aujeszky&rsquo;s) virus infection on young mature boars and boar fertility. <i>Can J Comp Med<\/i> 1984; 48: 192&ndash;197."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Ramirez-Mendoza H, Hernandez-Jauregui P, Reyes-Leyva J, Zenteno E, Moreno-Lopez J, Kennedy S. Lesions in the reproductive tract of boars experimentally infected with porcine rubulavirus. <i>J Comp Pathol<\/i> 1997; 117: 237&ndash;252.","DOI":"10.1016\/S0021-9975(97)80018-7"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Prieto C, Suarez P, Bautista JM, Sanchez R, Rillo SM, Simarro I, Solana A, Castro JM. Semen changes in boars after experimental infection with porcine reproductive and respiratory syndrome (PRRS) virus. <i>Theriogenology<\/i> 1996; 45: 383&ndash;395.","DOI":"10.1016\/0093-691X(95)00375-I"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Sur JH, Doster AR, Christian JS, Galeota JA, Wills RW, Zimmerman JJ, Osorio FA. Porcine reproductive and respiratory syndrome virus replicates in testicular germ cells, alters spermatogenesis, and induces germ cell death by apoptosis. <i>J Virol<\/i> 1997; 71: 9170&ndash;9179.","DOI":"10.1128\/JVI.71.12.9170-9179.1997"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Omeke BCO, Igboeli G. Disruption of spermatogenesis in boars sub-clinically infected with <i>Trypanosoma brucei brucei<\/i>. <i>Anim Reprod Sci<\/i> 2000; 63: 197&ndash;204.","DOI":"10.1016\/S0378-4320(00)00172-X"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.65.2.208-231.2001"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Weidner W, Krause W, Ludwig M. Relevance of male accessory gland infection for subsequent fertility with special focus on prostatitis. <i>Hum Reprod Update<\/i> 1999; 5: 421&ndash;432.","DOI":"10.1093\/humupd\/5.5.421"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Schuppe HC, Meinhardt A, Allam JP, Bergmann M, Weidner W, Haidl G. Chronic orchitis: a neglected cause of male infertility? <i>Andrologia<\/i> 2008; 40: 84&ndash;91.","DOI":"10.1111\/j.1439-0272.2008.00837.x"},{"key":"19","unstructured":"19. Tung KSK, Alexander NJ. Monocytic orchitis and aspermatogenesis in normal and vasectomized rhesus macaques (<i>Macaca mulatta<\/i>). <i>Am J Pathol<\/i> 1980; 101: 17&ndash;29."},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Goldacre MJ, Wotton CJ, Seagroatt V, Yeates D. Immune-related disease before and after vasectomy: an epidemiological database study. <i>Hum Reprod<\/i> 2007; 22: 1273&ndash;1278.","DOI":"10.1093\/humrep\/dem010"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Dooher GB, Artzt K, Bennett D, Hurtenbach U. Observations on autoimmune orchitis in sterile mice carrying a recessive lethal mutation at the T\/t complex exhibiting spontaneous allergic orchitis. <i>J Reprod Fertil<\/i> 1981; 62: 505&ndash;511.","DOI":"10.1530\/jrf.0.0620505"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4800(76)90002-2"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Tung KSK, Teuscher LEC, Meng A, Blaustein JC, Kohno S, Howell R. The black mink (<i>Mustela Vison<\/i>) A natural model of immunologic male infertility. <i>J Exp Med<\/i> 1981; 154: 1016&ndash;1032.","DOI":"10.1084\/jem.154.4.1016"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Itoh M, Hiramine C, Hojo K. A new model of autoimmune orchitis induced by immunization with viable syngeneic testicular germ cells alone. I. Immunological and histological studies. <i>Clin Exp Immunol<\/i> 1991; 83: 137&ndash;142.","DOI":"10.1111\/j.1365-2249.1991.tb05603.x"},{"key":"25","unstructured":"25. Itoh M, De-Rooij D, Takeuchi Y. Mode of inflammatory cell infiltration in testes of mice injected with syngeneic testicular germ cells without adjuvant. <i>J Anat<\/i> 1995; 187: 671&ndash;679."},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Naito M, Itoh M. Patterns of infiltration of lymphocytes into the testis under normal and pathological conditions in mice. <i>Am J Reprod Immunol<\/i> 2008; 59: 55&ndash;61.","DOI":"10.1111\/j.1600-0897.2007.00556.x"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Abe M, Kurosawa M, Ishikawa O, Miyachi Y, Kido H. Mast cell tryptase stimulates both human dermal fibroblast proliferation and type I collagen production. <i>Clin Exp Allergy<\/i> 1998; 28: 1509&ndash;1517.","DOI":"10.1046\/j.1365-2222.1998.00360.x"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Temkin V, Kantor B, Weg V, Hartman ML, Levi-Schaffer F. Tryptase activates the mitogen-activated protein kinase\/activator protein-1 pathway in human peripheral blood eosinophils, causing cytokine production and release. <i>J Immunol<\/i> 2002; 169: 2662&ndash;2669.","DOI":"10.4049\/jimmunol.169.5.2662"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Meineke V, Frungieri MB, Jessberger B, Vogt H, Mayerhofer A. Human testicular mast cells contain tryptase: increased mast cell number and altered distribution in the testes of infertile men. <i>Fertil Steril<\/i> 2000; 74: 239&ndash;244.","DOI":"10.1016\/S0015-0282(00)00626-9"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Frungieri MB, Calandra RS, Lustig L, Meineke V, Kohn FM, Vogt H, Mayerhofer A. Number, distribution pattern, and identification of macrophages in the testes of infertile men. <i>Fertil Steril<\/i> 2002; 78: 298&ndash;306.","DOI":"10.1016\/S0015-0282(02)03206-5"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.2002.03029.x"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Hackett RA, Huang TW, Berger RE. Experimental <i>Escherichia coli<\/i> epididymitis in rabbits. <i>Urology<\/i> 1988; 32: 236&ndash;240.","DOI":"10.1016\/0090-4295(88)90391-3"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Lekili M, Tekgul S, Ergen A, Tasar C, Hascelik G. Acute experimental unilateral orchitis in the rabbit and its effect on fertility. <i>Int Urol Nephrol<\/i> 1992; 24: 291&ndash;297.","DOI":"10.1007\/BF02549538"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Greskovich F, Mathur S, Nyberg JR, Collins BS. Effect of early antibiotic treatment on the formation of sperm antibodies in experimentally induced epididymitis. <i>Arch Androl<\/i> 1993; 30: 183&ndash;191.","DOI":"10.3109\/01485019308987755"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. el-Demiry MI, Elton R, Hargreave TB, James K, Busuttil A, Chisholm GD. Immunocompetent cells in human testis in health and disease. <i>Fertil Steril<\/i> 1987; 48: 470&ndash;479.","DOI":"10.1016\/S0015-0282(16)59421-7"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Lenzi A, Gandini L, Lombardo F, Rago R, Paoli D, Dondero F. Antisperm antibody detection: 2. Clinical, biological, and statistical correlation between methods. <i>Am J Reprod Immunol<\/i> 1997; 38: 224&ndash;230.","DOI":"10.1111\/j.1600-0897.1997.tb00303.x"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Gubin DA, Dmochowski R, Kutteh WH. Multivariant analysis of men from infertile couples with and without antisperm antibodies. <i>Am J Reprod Immunol<\/i> 1998; 39: 157&ndash;160.","DOI":"10.1111\/j.1600-0897.1998.tb00348.x"}],"container-title":["Journal of Reproduction and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jrd\/59\/3\/59_2012-176\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T02:26:31Z","timestamp":1616725591000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jrd\/59\/3\/59_2012-176\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1262\/jrd.2012-176","relation":{},"ISSN":["0916-8818","1348-4400"],"issn-type":[{"value":"0916-8818","type":"print"},{"value":"1348-4400","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}