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Labernia J, L\u00f3pez-Gatius F, Santolaria P, Hanzen C, Laurent Y, Houtain JY. Influence of calving season on the interactions among reproductive disorders of dairy cows. <i>Anim Sci<\/i> 1998; 67: 387\u2013393.","DOI":"10.1017\/S1357729800032781"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Garc\u00eda-Ispierto I, L\u00f3pez-Gatius F, Bech-Sabat G, Santolaria P, Y\u00e1niz JL, Nogareda C, De Rensis F, L\u00f3pez-B\u00e9jar M. Climate factors affecting conception rate of high producing dairy cows in northeastern Spain. <i>Theriogenology<\/i> 2007; 67: 1379\u20131385.","DOI":"10.1016\/j.theriogenology.2007.02.009"},{"key":"19","unstructured":"19. Hanzen CH, Bascon F, Theron L, L\u00f3pez-Gatius F. Ovarian cysts in cattle. Part 1: Definitions, symptoms and diagnostic. <i>Ann M\u00e9d Vet<\/i> 2007; 151: 247\u2013256."},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. L\u00f3pez-Gatius F, Santolaria P, Y\u00e1niz J, Fenech M, L\u00f3pez-B\u00e9jar M. 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