{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:04:55Z","timestamp":1790777095602,"version":"4.1.0"},"reference-count":43,"publisher":"Japanese Society of Animal Reproduction","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Reproduction and Development","J. Reprod. Dev."],"published-print":{"date-parts":[[2016]]},"DOI":"10.1262\/jrd.2015-113","type":"journal-article","created":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T22:23:01Z","timestamp":1453933381000},"page":"167-176","source":"Crossref","is-referenced-by-count":11,"title":["Triploid human embryonic stem cells derived from tripronuclear zygotes displayed pluripotency and trophoblast differentiation ability similar to the diploid human embryonic stem cells"],"prefix":"10.1262","volume":"62","author":[{"given":"Ruttachuk","family":"RUNGSIWIWUT","sequence":"first","affiliation":[{"name":"Reproductive Medicine Unit, Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranee","family":"NUMCHAISRIKA","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Unit, Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vichuda","family":"AHNONKITPANIT","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Unit, Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pramuan","family":"VIRUTAMASEN","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Unit, Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamthorn","family":"PRUKSANANONDA","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Unit, Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"349","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM. Embryonic stem cell lines derived from human blastocysts. <i>Science<\/i> 1998; 282: 1145\u20131147.","DOI":"10.1126\/science.282.5391.1145"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Reubinoff BE, Pera MF, Fong CY, Trounson A, Bongso A. Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. <i>Nat Biotechnol<\/i> 2000; 18: 399\u2013404.","DOI":"10.1038\/74447"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Suss-Toby E, Gerecht-Nir S, Amit M, Manor D, Itskovitz-Eldor J. Derivation of a diploid human embryonic stem cell line from a mononuclear zygote. <i>Hum Reprod<\/i> 2004; 19: 670\u2013675.","DOI":"10.1093\/humrep\/deh135"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Lavon N, Narwani K, Golan-Lev T, Buehler N, Hill D, Benvenisty N. Derivation of euploid human embryonic stem cells from aneuploid embryos. <i>Stem Cells<\/i> 2008; 26: 1874\u20131882.","DOI":"10.1634\/stemcells.2008-0156"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Huan Q, Gao X, Wang Y, Shen Y, Ma W, Chen ZJ. Comparative evaluation of human embryonic stem cell lines derived from zygotes with normal and abnormal pronuclei. <i>Dev Dyn<\/i> 2010; 239: 425\u2013438.","DOI":"10.1002\/dvdy.22175"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Chen X, Luo Y, Fan Y, Yue L, Wu X, Chen Y, Sun X. Triploid and diploid embryonic stem cell lines derived from tripronuclear human zygotes. <i>J Assist Reprod Genet<\/i> 2012; 29: 713\u2013721.","DOI":"10.1007\/s10815-012-9764-4"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Mateizel I, De Temmerman N, Ullmann U, Cauffman G, Sermon K, Van de Velde H, De Rycke M, Degreef E, Devroey P, Liebaers I, Van Steirteghem A. Derivation of human embryonic stem cell lines from embryos obtained after IVF and after PGD for monogenic disorders. <i>Hum Reprod<\/i> 2006; 21: 503\u2013511.","DOI":"10.1093\/humrep\/dei345"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Bradley CK, Scott HA, Chami O, Peura TT, Dumevska B, Schmidt U, Stojanov T. Derivation of Huntington\u2019s disease-affected human embryonic stem cell lines. <i>Stem Cells Dev<\/i> 2011; 20: 495\u2013502.","DOI":"10.1089\/scd.2010.0120"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Stefanova VT, Grifo JA, Hansis C. Derivation of novel genetically diverse human embryonic stem cell lines. <i>Stem Cells Dev<\/i> 2012; 21: 1559\u20131570.","DOI":"10.1089\/scd.2011.0642"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Biancotti JC, Narwani K, Mandefro B, Golan-Lev T, Buehler N, Hill D, Svendsen CN, Benvenisty N. The in vitro survival of human monosomies and trisomies as embryonic stem cells. <i>Stem Cell Res (Amst)<\/i> 2012; 9: 218\u2013224.","DOI":"10.1016\/j.scr.2012.07.002"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Str\u00f6m S, Rodriguez-Wallberg K, Holm F, Bergstr\u00f6m R, Eklund L, Str\u00f6mberg AM, Hovatta O. No relationship between embryo morphology and successful derivation of human embryonic stem cell lines. <i>PLoS ONE<\/i> 2010; 5: e15329.","DOI":"10.1371\/journal.pone.0015329"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Matt DW, Ingram AR, Graff DP, Edelstein MC. Normal birth after single-embryo transfer in a patient with excessive polypronuclear zygote formation following in vitro fertilization and intracytoplasmic sperm injection. <i>Fertil Steril<\/i> 2004; 82: 1662\u20131665.","DOI":"10.1016\/j.fertnstert.2004.04.069"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Barak Y, Kogosowski A, Goldman S, Soffer Y, Gonen Y, Tesarik J. Pregnancy and birth after transfer of embryos that developed from single-nucleated zygotes obtained by injection of round spermatids into oocytes. <i>Fertil Steril<\/i> 1998; 70: 67\u201370.","DOI":"10.1016\/S0015-0282(98)00106-X"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Baharvand H, Ashtiani SK, Taee A, Massumi M, Valojerdi MR, Yazdi PE, Moradi SZ, Farrokhi A. Generation of new human embryonic stem cell lines with diploid and triploid karyotypes. <i>Dev Growth Differ<\/i> 2006; 48: 117\u2013128.","DOI":"10.1111\/j.1440-169X.2006.00851.x"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Sun X, Long X, Yin Y, Jiang Y, Chen X, Liu W, Zhang W, Du H, Li S, Zheng Y, Kong S, Pang Q, Shi Y, Huang Y, Huang S, Liao B, Xiao G, Wang W. Similar biological characteristics of human embryonic stem cell lines with normal and abnormal karyotypes. <i>Hum Reprod<\/i> 2008; 23: 2185\u20132193.","DOI":"10.1093\/humrep\/den137"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Noggle S, Fung HL, Gore A, Martinez H, Satriani KC, Prosser R, Oum K, Paull D, Druckenmiller S, Freeby M, Greenberg E, Zhang K, Goland R, Sauer MV, Leibel RL, Egli D. Human oocytes reprogram somatic cells to a pluripotent state. <i>Nature<\/i> 2011; 478: 70\u201375.","DOI":"10.1038\/nature10397"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Liu W, Sun X. Skewed X chromosome inactivation in diploid and triploid female human embryonic stem cells. <i>Hum Reprod<\/i> 2009; 24: 1834\u20131843.","DOI":"10.1093\/humrep\/dep126"},{"key":"18","unstructured":"18. Pruksananonda K, Rungsiwiwut R, Numchaisrika P, Ahnonkitpanich V, Virutamasen P. Development of human embryonic stem cell derivation. <i>J Med Assoc Thai<\/i> 2009; 92: 443\u2013450."},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Pruksananonda K, Rungsiwiwut R, Numchaisrika P, Ahnonkitpanit V, Isarasena N, Virutamasen P. Eighteen-year cryopreservation does not negatively affect the pluripotency of human embryos: evidence from embryonic stem cell derivation. <i>Biores Open Access<\/i> 2012; 1: 166\u2013173.","DOI":"10.1089\/biores.2012.0242"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. <i>Cell<\/i> 2007; 131: 861\u2013872.","DOI":"10.1016\/j.cell.2007.11.019"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Marchand M, Horcajadas JA, Esteban FJ, McElroy SL, Fisher SJ, Giudice LC. Transcriptomic signature of trophoblast differentiation in a human embryonic stem cell model. <i>Biol Reprod<\/i> 2011; 84: 1258\u20131271.","DOI":"10.1095\/biolreprod.110.086413"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Dvash T, Lavon N, Fan G. Variations of X chromosome inactivation occur in early passages of female human embryonic stem cells. <i>PLoS ONE<\/i> 2010; 5: e11330.","DOI":"10.1371\/journal.pone.0011330"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Pieters MH, Dumoulin JC, Ignoul-Vanvuchelen RC, Bras M, Evers JL, Geraedts JP. Triploidy after in vitro fertilization: cytogenetic analysis of human zygotes and embryos. <i>J Assist Reprod Genet<\/i> 1992; 9: 68\u201376.","DOI":"10.1007\/BF01204118"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Porter R, Han T, Tucker MJ, Graham J, Liebermann J, Sills ES. Estimation of second polar body retention rate after conventional insemination and intracytoplasmic sperm injection: in vitro observations from more than 5000 human oocytes. <i>J Assist Reprod Genet<\/i> 2003; 20: 371\u2013376.","DOI":"10.1023\/A:1025481011680"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Macas E, Imthurn B, Rosselli M, Keller PJ. The chromosomal complements of multipronuclear human zygotes resulting from intracytoplasmic sperm injection. <i>Hum Reprod<\/i> 1996; 11: 2496\u20132501.","DOI":"10.1093\/oxfordjournals.humrep.a019147"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Liao H, Zhang S, Cheng D, Ouyang Q, Lin G, Gu Y, Lu C, Gong F, Lu G. Cytogenetic analysis of human embryos and embryonic stem cells derived from monopronuclear zygotes. <i>J Assist Reprod Genet<\/i> 2009; 26: 583\u2013589.","DOI":"10.1007\/s10815-009-9355-1"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Kim HS, Oh SK, Park YB, Ahn HJ, Sung KC, Kang MJ, Lee LA, Suh CS, Kim SH, Kim DW, Moon SY. Methods for derivation of human embryonic stem cells. <i>Stem Cells<\/i> 2005; 23: 1228\u20131233.","DOI":"10.1634\/stemcells.2004-0296"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Biancotti JC, Narwani K, Buehler N, Mandefro B, Golan-Lev T, Yanuka O, Clark A, Hill D, Benvenisty N, Lavon N. Human embryonic stem cells as models for aneuploid chromosomal syndromes. <i>Stem Cells<\/i> 2010; 28: 1530\u20131540.","DOI":"10.1002\/stem.483"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Stojkovic P, Lako M, Stewart R, Przyborski S, Armstrong L, Evans J, Murdoch A, Strachan T, Stojkovic M. An autogeneic feeder cell system that efficiently supports growth of undifferentiated human embryonic stem cells. <i>Stem Cells<\/i> 2005; 23: 306\u2013314.","DOI":"10.1634\/stemcells.2004-0137"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Pyle AD, Lock LF, Donovan PJ. Neurotrophins mediate human embryonic stem cell survival. <i>Nat Biotechnol<\/i> 2006; 24: 344\u2013350.","DOI":"10.1038\/nbt1189"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Baker DE, Harrison NJ, Maltby E, Smith K, Moore HD, Shaw PJ, Heath PR, Holden H, Andrews PW. Adaptation to culture of human embryonic stem cells and oncogenesis in vivo. <i>Nat Biotechnol<\/i> 2007; 25: 207\u2013215.","DOI":"10.1038\/nbt1285"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Draper JS, Smith K, Gokhale P, Moore HD, Maltby E, Johnson J, Meisner L, Zwaka TP, Thomson JA, Andrews PW. Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells. <i>Nat Biotechnol<\/i> 2004; 22: 53\u201354.","DOI":"10.1038\/nbt922"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Seol HW, Oh SK, Park YB, Kim HS, Baek JA, Seo J, Kim EH, Ku SY, Kim SH, Choi YM, Moon SY. Separation and maintenance of normal cells from human embryonic stem cells with trisomy 12 mosaicism. <i>Chromosome Res<\/i> 2008; 16: 1075\u20131084.","DOI":"10.1007\/s10577-008-1258-y"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Mitalipova MM, Rao RR, Hoyer DM, Johnson JA, Meisner LF, Jones KL, Dalton S, Stice SL. Preserving the genetic integrity of human embryonic stem cells. <i>Nat Biotechnol<\/i> 2005; 23: 19\u201320.","DOI":"10.1038\/nbt0105-19"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Grandela C, Wolvetang E. hESC adaptation, selection and stability. <i>Stem Cell Rev<\/i> 2007; 3: 183\u2013191.","DOI":"10.1007\/s12015-007-0008-4"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Verlinsky Y, Zech NH, Strelchenko N, Kukharenko V, Shkumatov A, Zlatopolsky Z, Kuliev A. Correlation between preimplantation genetic diagnosis for chromosomal aneuploidies and the efficiency of establishing human ES cell lines. <i>Stem Cell Res (Amst)<\/i> 2009; 2: 78\u201382.","DOI":"10.1016\/j.scr.2008.07.002"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Taei A, Gourabi H, Seifinejad A, Totonchi M, Shahbazi E, Valojerdi MR, Eftekhari P, Karimian L, Baharvand H. Derivation of new human embryonic stem cell lines from preimplantation genetic screening and diagnosis-analyzed embryos. <i>In Vitro Cell Dev Biol Anim<\/i> 2010; 46: 395\u2013402.","DOI":"10.1007\/s11626-010-9293-3"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Xu RH, Chen X, Li DS, Li R, Addicks GC, Glennon C, Zwaka TP, Thomson JA. BMP4 initiates human embryonic stem cell differentiation to trophoblast. <i>Nat Biotechnol<\/i> 2002; 20: 1261\u20131264.","DOI":"10.1038\/nbt761"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Catalina P, Bueno C, Montes R, Nieto A, Ligero G, Sanchez L, Jara M, Rasillo A, Orfao A, Cigudosa J, Hovatta O, Greaves M, Menendez P. Genetic stability of human embryonic stem cells: A first-step toward the development of potential hESC-based systems for modeling childhood leukemia. <i>Leuk Res<\/i> 2009; 33: 980\u2013990.","DOI":"10.1016\/j.leukres.2008.08.028"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Hovatta O, Jaconi M, T\u00f6h\u00f6nen V, B\u00e9na F, Gimelli S, Bosman A, Holm F, Wyder S, Zdobnov EM, Irion O, Andrews PW, Antonarakis SE, Zucchelli M, Kere J, Feki A. A teratocarcinoma-like human embryonic stem cell (hESC) line and four hESC lines reveal potentially oncogenic genomic changes. <i>PLoS ONE<\/i> 2010; 5: e10263.","DOI":"10.1371\/journal.pone.0010263"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Oida S, Iimura T, Maruoka Y, Takeda K, Sasaki S. Cloning and sequence of bone morphogenetic protein 4 (BMP-4) from a human placental cDNA library. <i>DNA Seq<\/i> 1995; 5: 273\u2013275.","DOI":"10.3109\/10425179509030980"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Pera MF, Andrade J, Houssami S, Reubinoff B, Trounson A, Stanley EG, Ward-van Oostwaard D, Mummery C. Regulation of human embryonic stem cell differentiation by BMP-2 and its antagonist noggin. <i>J Cell Sci<\/i> 2004; 117: 1269\u20131280.","DOI":"10.1242\/jcs.00970"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Ezashi T, Telugu BPVL, Roberts RM. Model systems for studying trophoblast differentiation from human pluripotent stem cells. <i>Cell Tissue Res<\/i> 2012; 349: 809\u2013824.","DOI":"10.1007\/s00441-012-1371-2"}],"container-title":["Journal of Reproduction and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jrd\/62\/2\/62_2015-113\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T04:38:43Z","timestamp":1498279123000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jrd\/62\/2\/62_2015-113\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1262\/jrd.2015-113","relation":{},"ISSN":["0916-8818","1348-4400"],"issn-type":[{"value":"0916-8818","type":"print"},{"value":"1348-4400","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}