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Boonkum W, Misztal I, Duangjinda M, Pattarajinda V, Tumwasorn S, Buaban S. Short communication: genetic effects of heat stress on days open for Thai Holstein crossbreds. <i>J Dairy Sci<\/i> 2011; 94: 1592\u20131596.","DOI":"10.3168\/jds.2010-3491"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Mellado M, Coronel F, Estrada A, R\u00edos FG. Lactation performance of holstein and holstein x gyr cattle under intensive condition in a subtropical environment. <i>Trop Subtropical Agroecosystems<\/i> 2011; 14: 927\u2013931.","DOI":"10.56369\/tsaes.964"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Boonkum W, Misztal I, Duangjinda M, Pattarajinda V, Tumwasorn S, Sanpote J. Genetic effects of heat stress on milk yield of Thai Holstein crossbreds. <i>J Dairy Sci<\/i> 2011; 94: 487\u2013492.","DOI":"10.3168\/jds.2010-3421"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Oakley AE, Clifton DK, Steiner RA. Kisspeptin signaling in the brain. <i>Endocr Rev<\/i> 2009; 30: 713\u2013743.","DOI":"10.1210\/er.2009-0005"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Okamura H, Yamamura T, Wakabayashi Y. Kisspeptin as a master player in the central control of reproduction in mammals: an overview of kisspeptin research in domestic animals. <i>Anim Sci J<\/i> 2013; 84: 369\u2013381.","DOI":"10.1111\/asj.12056"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Messager S, Chatzidaki EE, Ma D, Hendrick AG, Zahn D, Dixon J, Thresher RR, Malinge I, Lomet D, Carlton MB, Colledge WH, Caraty A, Aparicio SA. Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54. <i>Proc Natl Acad Sci USA<\/i> 2005; 102: 1761\u20131766.","DOI":"10.1073\/pnas.0409330102"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Smith JT. The role of kisspeptin and gonadotropin inhibitory hormone in the seasonal regulation of reproduction in sheep. <i>Domest Anim Endocrinol<\/i> 2012; 43: 75\u201384.","DOI":"10.1016\/j.domaniend.2011.11.003"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Goodman RL, Maltby MJ, Millar RP, Hileman SM, Nestor CC, Whited B, Tseng AS, Coolen LM, Lehman MN. Evidence that dopamine acts via kisspeptin to hold GnRH pulse frequency in check in anestrous ewes. <i>Endocrinology<\/i> 2012; 153: 5918\u20135927.","DOI":"10.1210\/en.2012-1611"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Hashizume T, Saito H, Sawada T, Yaegashi T, Ezzat AA, Sawai K, Yamashita T. Characteristics of stimulation of gonadotropin secretion by kisspeptin-10 in female goats. <i>Anim Reprod Sci<\/i> 2010; 118: 37\u201341.","DOI":"10.1016\/j.anireprosci.2009.05.017"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Tanaka T, Ohkura S, Wakabayashi Y, Okamura H. Effect of peripherally administered kisspeptin-10 on GnRH neurosecretion into the hypophyseal portal circulation in ovariectomized goat does. <i>Small Rumin Res<\/i> 2012; 105: 273\u2013276.","DOI":"10.1016\/j.smallrumres.2012.01.007"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Kadokawa H, Matsui M, Hayashi K, Matsunaga N, Kawashima C, Shimizu T, Kida K, Miyamoto A. Peripheral administration of kisspeptin-10 increases plasma concentrations of GH as well as LH in prepubertal Holstein heifers. <i>J Endocrinol<\/i> 2008; 196: 331\u2013334.","DOI":"10.1677\/JOE-07-0504"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Naniwa Y, Nakatsukasa K, Setsuda S, Oishi S, Fujii N, Matsuda F, Uenoyama Y, Tsukamura H, Maeda K, Ohkura S. Effects of full-length kisspeptin administration on follicular development in Japanese Black beef cows. <i>J Reprod Dev<\/i> 2013; 59: 588\u2013594.","DOI":"10.1262\/jrd.2013-064"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Ezzat Ahmed A, Saito H, Sawada T, Yaegashi T, Yamashita T, Hirata T, Sawai K, Hashizume T. Characteristics of the stimulatory effect of kisspeptin-10 on the secretion of luteinizing hormone, follicle-stimulating hormone and growth hormone in prepubertal male and female cattle. <i>J Reprod Dev<\/i> 2009; 55: 650\u2013654.","DOI":"10.1262\/jrd.20255"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Skrapits K, Borsay BA, Herczeg L, Ciofi P, Liposits Z, Hrabovszky E. Neuropeptide co-expression in hypothalamic kisspeptin neurons of laboratory animals and the human. <i>Front Neurosci<\/i> 2015; 9: 29.","DOI":"10.3389\/fnins.2015.00029"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. 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Neurokinin B stimulates GnRH release in the male monkey (<i>Macaca mulatta<\/i>) and is colocalized with kisspeptin in the arcuate nucleus. <i>Endocrinology<\/i> 2010; 151: 4494\u20134503.","DOI":"10.1210\/en.2010-0223"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Lehman MN, Coolen LM, Goodman RL. Minireview: kisspeptin\/neurokinin B\/dynorphin (KNDy) cells of the arcuate nucleus: a central node in the control of gonadotropin-releasing hormone secretion. <i>Endocrinology<\/i> 2010; 151: 3479\u20133489.","DOI":"10.1210\/en.2010-0022"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Ohkura S, Takase K, Matsuyama S, Mogi K, Ichimaru T, Wakabayashi Y, Uenoyama Y, Mori Y, Steiner RA, Tsukamura H, Maeda KI, Okamura H. Gonadotrophin-releasing hormone pulse generator activity in the hypothalamus of the goat. <i>J Neuroendocrinol<\/i> 2009; 21: 813\u2013821.","DOI":"10.1111\/j.1365-2826.2009.01909.x"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Yamamura T, Wakabayashi Y, Ohkura S, Navarro VM, Okamura H. Effects of intravenous administration of neurokinin receptor subtype-selective agonists on gonadotropin-releasing hormone pulse generator activity and luteinizing hormone secretion in goats. <i>J Reprod Dev<\/i> 2015; 61: 20\u201329.","DOI":"10.1262\/jrd.2014-109"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Mostari P, Ieda N, Deura C, Minabe S, Yamada S, Uenoyama Y, Maeda K, Tsukamura H. Dynorphin-kappa opioid receptor signaling partly mediates estrogen negative feedback effect on LH pulses in female rats. <i>J Reprod Dev<\/i> 2013; 59: 266\u2013272.","DOI":"10.1262\/jrd.2012-193"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Ruiz-Pino F, Garcia-Galiano D, Manfredi-Lozano M, Leon S, S\u00e1nchez-Garrido MA, Roa J, Pinilla L, Navarro VM, Tena-Sempere M. Effects and interactions of tachykinins and dynorphin on FSH and LH secretion in developing and adult rats. <i>Endocrinology<\/i> 2015; 156: 576\u2013588.","DOI":"10.1210\/en.2014-1026"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Nakahara T, Uenoyama Y, Iwase A, Oishi S, Nakamura S, Minabe S, Watanabe Y, Deura C, Noguchi T, Fujii N, Kikkawa F, Maeda K, Tsukamura H. Chronic peripheral administration of kappa-opioid receptor antagonist advances puberty onset associated with acceleration of pulsatile luteinizing hormone secretion in female rats. <i>J Reprod Dev<\/i> 2013; 59: 479\u2013484.","DOI":"10.1262\/jrd.2013-046"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Tanco VM, Whitlock BK, Jones MA, Wilborn RR, Brandebourg TD, Foradori CD. Distribution and regulation of gonadotropin-releasing hormone, kisspeptin, RF-amide related peptide-3, and dynorphin in the bovine hypothalamus. <i>Peer J<\/i> 2016; 4: e1833.","DOI":"10.7717\/peerj.1833"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Cardoso RC, Alves BR, Sharpton SM, Williams GL, Amstalden M. Nutritional programming of accelerated puberty in heifers: involvement of pro-opiomelanocortin neurones in the arcuate nucleus. <i>J Neuroendocrinol<\/i> 2015; 27: 647\u2013657.","DOI":"10.1111\/jne.12291"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Alves BR, Cardoso RC, Prezotto LD, Thorson JF, Bedenbaugh M, Sharpton SM, Caraty A, Keisler DH, Tedeschi LO, Williams GL, Amstalden M. Elevated body weight gain during the juvenile period alters neuropeptide Y-gonadotropin-releasing hormone circuitry in prepubertal heifers. <i>Biol Reprod<\/i> 2015; 92: 46.","DOI":"10.1095\/biolreprod.114.124636"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Smith JT, Clay CM, Caraty A, Clarke IJ. KiSS-1 messenger ribonucleic acid expression in the hypothalamus of the ewe is regulated by sex steroids and season. <i>Endocrinology<\/i> 2007; 148: 1150\u20131157.","DOI":"10.1210\/en.2006-1435"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Franceschini I, Lomet D, Cateau M, Delsol G, Tillet Y, Caraty A. Kisspeptin immunoreactive cells of the ovine preoptic area and arcuate nucleus co-express estrogen receptor alpha. <i>Neurosci Lett<\/i> 2006; 401: 225\u2013230.","DOI":"10.1016\/j.neulet.2006.03.039"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Matsuda F, Nakatsukasa K, Suetomi Y, Naniwa Y, Ito D, Inoue N, Wakabayashi Y, Okamura H, Maeda KI, Uenoyama Y, Tsukamura H, Ohkura S. The luteinising hormone surge-generating system is functional in male goats as in females: involvement of kisspeptin neurones in the medial preoptic area. <i>J Neuroendocrinol<\/i> 2015; 27: 57\u201365.","DOI":"10.1111\/jne.12235"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Rometo AM, Krajewski SJ, Voytko ML, Rance NE. Hypertrophy and increased kisspeptin gene expression in the hypothalamic infundibular nucleus of postmenopausal women and ovariectomized monkeys. <i>J Clin Endocrinol Metab<\/i> 2007; 92: 2744\u20132750.","DOI":"10.1210\/jc.2007-0553"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Watanabe Y, Uenoyama Y, Suzuki J, Takase K, Suetomi Y, Ohkura S, Inoue N, Maeda KI, Tsukamura H. Oestrogen-induced activation of preoptic kisspeptin neurones may be involved in the luteinising hormone surge in male and female Japanese monkeys. <i>J Neuroendocrinol<\/i> 2014; 26: 909\u2013917.","DOI":"10.1111\/jne.12227"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Brailoiu GC, Dun SL, Ohsawa M, Yin D, Yang J, Chang JK, Brailoiu E, Dun NJ. KiSS-1 expression and metastin-like immunoreactivity in the rat brain. <i>J Comp Neurol<\/i> 2005; 481: 314\u2013329.","DOI":"10.1002\/cne.20350"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Smith JT, Cunningham MJ, Rissman EF, Clifton DK, Steiner RA. Regulation of Kiss1 gene expression in the brain of the female mouse. <i>Endocrinology<\/i> 2005; 146: 3686\u20133692.","DOI":"10.1210\/en.2005-0488"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Tomikawa J, Homma T, Tajima S, Shibata T, Inamoto Y, Takase K, Inoue N, Ohkura S, Uenoyama Y, Maeda K, Tsukamura H. Molecular characterization and estrogen regulation of hypothalamic KISS1 gene in the pig. <i>Biol Reprod<\/i> 2010; 82: 313\u2013319.","DOI":"10.1095\/biolreprod.109.079863"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Adachi S, Yamada S, Takatsu Y, Matsui H, Kinoshita M, Takase K, Sugiura H, Ohtaki T, Matsumoto H, Uenoyama Y, Tsukamura H, Inoue K, Maeda K. Involvement of anteroventral periventricular metastin\/kisspeptin neurons in estrogen positive feedback action on luteinizing hormone release in female rats. <i>J Reprod Dev<\/i> 2007; 53: 367\u2013378.","DOI":"10.1262\/jrd.18146"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Smith JT, Li Q, Pereira A, Clarke IJ. Kisspeptin neurons in the ovine arcuate nucleus and preoptic area are involved in the preovulatory luteinizing hormone surge. <i>Endocrinology<\/i> 2009; 150: 5530\u20135538.","DOI":"10.1210\/en.2009-0712"},{"key":"39","unstructured":"39. Okamura H. Brain atlas of cattle (in Japanese). <i>In: A foundational research for elucidation and estimation of agriculturae, Forestry and Fisheries Research Council. <\/i>2002: 41\u201372."},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Jiao Y, Sun Z, Lee T, Fusco FR, Kimble TD, Meade CA, Cuthbertson S, Reiner A. A simple and sensitive antigen retrieval method for free-floating and slide-mounted tissue sections. <i>J Neurosci Methods<\/i> 1999; 93: 149\u2013162.","DOI":"10.1016\/S0165-0270(99)00142-9"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Ohkura S, Uenoyama Y, Yamada S, Homma T, Takase K, Inoue N, Maeda K, Tsukamura H. Physiological role of metastin\/kisspeptin in regulating gonadotropin-releasing hormone (GnRH) secretion in female rats. <i>Peptides<\/i> 2009; 30: 49\u201356.","DOI":"10.1016\/j.peptides.2008.08.004"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Goodman RL, Hileman SM, Nestor CC, Porter KL, Connors JM, Hardy SL, Millar RP, Cernea M, Coolen LM, Lehman MN. Kisspeptin, neurokinin B, and dynorphin act in the arcuate nucleus to control activity of the GnRH pulse generator in ewes. <i>Endocrinology<\/i> 2013; 154: 4259\u20134269.","DOI":"10.1210\/en.2013-1331"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Matsuyama S, Ohkura S, Mogi K, Wakabayashi Y, Mori Y, Tsukamura H, Maeda K, Ichikawa M, Okamura H. Morphological evidence for direct interaction between kisspeptin and gonadotropin-releasing hormone neurons at the median eminence of the male goat: an immunoelectron microscopic study. <i>Neuroendocrinology<\/i> 2011; 94: 323\u2013332.","DOI":"10.1159\/000331576"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Uenoyama Y, Inoue N, Pheng V, Homma T, Takase K, Yamada S, Ajiki K, Ichikawa M, Okamura H, Maeda KI, Tsukamura H. Ultrastructural evidence of kisspeptin-gonadotrophin-releasing hormone (GnRH) interaction in the median eminence of female rats: implication of axo-axonal regulation of GnRH release. <i>J Neuroendocrinol<\/i> 2011; 23: 863\u2013870.","DOI":"10.1111\/j.1365-2826.2011.02199.x"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45. Jafarzadeh Shirazi MR, Zamiri MJ, Salehi MS, Moradi S, Tamadon A, Namavar MR, Akhlaghi A, Tsutsui K, Caraty A. Differential expression of RFamide-related peptide, a mammalian gonadotrophin-inhibitory hormone orthologue, and kisspeptin in the hypothalamus of Abadeh ecotype does during breeding and anoestrous seasons. <i>J Neuroendocrinol<\/i> 2014; 26: 186\u2013194.","DOI":"10.1111\/jne.12137"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46. Gottsch ML, Navarro VM, Zhao Z, Glidewell-Kenney C, Weiss J, Jameson JL, Clifton DK, Levine JE, Steiner RA. Regulation of Kiss1 and dynorphin gene expression in the murine brain by classical and nonclassical estrogen receptor pathways. <i>J Neurosci<\/i> 2009; 29: 9390\u20139395.","DOI":"10.1523\/JNEUROSCI.0763-09.2009"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47. Reames PS, Hatler TB, Hayes SH, Ray DL, Silvia WJ. Differential regulation of estrous behavior and luteinizing hormone secretion by estradiol-17\u03b2 in ovariectomized dairy cows. <i>Theriogenology<\/i> 2011; 75: 233\u2013240.","DOI":"10.1016\/j.theriogenology.2010.08.009"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48. Wintermantel TM, Campbell RE, Porteous R, Bock D, Gr\u00f6ne HJ, Todman MG, Korach KS, Greiner E, P\u00e9rez CA, Sch\u00fctz G, Herbison AE. Definition of estrogen receptor pathway critical for estrogen positive feedback to gonadotropin-releasing hormone neurons and fertility. <i>Neuron<\/i> 2006; 52: 271\u2013280.","DOI":"10.1016\/j.neuron.2006.07.023"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49. Zhang C, Tonsfeldt KJ, Qiu J, Bosch MA, Kobayashi K, Steiner RA, Kelly MJ, R\u00f8nnekleiv OK. Molecular mechanisms that drive estradiol-dependent burst firing of Kiss1 neurons in the rostral periventricular preoptic area. <i>Am J Physiol Endocrinol Metab<\/i> 2013; 305: E1384\u2013E1397.","DOI":"10.1152\/ajpendo.00406.2013"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50. Desroziers E, Mikkelsen J, Simonneaux V, Keller M, Tillet Y, Caraty A, Franceschini I. 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