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Arreguin-Arevalo JA, Nett TM. A nongenomic action of 17beta-estradiol as the mechanism underlying the acute suppression of secretion of luteinizing hormone. <i>Biol Reprod<\/i> 2005; 73: 115\u2013122.","DOI":"10.1095\/biolreprod.105.040329"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Iqbal J, Latchoumanin O, Clarke IJ. Rapid in vivo effects of estradiol-17beta in ovine pituitary gonadotropes are displayed by phosphorylation of extracellularly regulated kinase, serine\/threonine kinase, and 3,5-cyclic adenosine 5-monophosphate-responsive element-binding protein. <i>Endocrinology<\/i> 2007; 148: 5794\u20135802.","DOI":"10.1210\/en.2007-0986"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Rudolf FO, Kadokawa H. Expression of estradiol receptor, GPR30, in bovine anterior pituitary and effects of GPR30 agonist on GnRH-induced LH secretion. <i>Anim Reprod Sci<\/i> 2013; 139: 9\u201317.","DOI":"10.1016\/j.anireprosci.2013.04.003"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Rudolf FO, Kadokawa H. Effects of STX, a novel estrogen membrane receptor agonist, on GnRH-induced luteinizing hormone secretion from cultured bovine anterior pituitary cells. <i>J Vet Med Sci<\/i> 2014; 76: 1623\u20131625.","DOI":"10.1292\/jvms.14-0179"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Nakamura U, Rudolf FO, Pandey K, Kadokawa H. The non-steroidal mycoestrogen zeranol suppresses luteinizing hormone secretion from the anterior pituitary of cattle via the estradiol receptor GPR30 in a rapid, non-genomic manner. <i>Anim Reprod Sci<\/i> 2015; 156: 118\u2013127.","DOI":"10.1016\/j.anireprosci.2015.03.009"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Nakamura U, Kadokawa H. The nonsteroidal mycoestrogen zearalenone and its five metabolites suppress LH secretion from the bovine anterior pituitary cells via the estradiol receptor GPR30 in vitro. <i>Theriogenology<\/i> 2015; 84: 1342\u20131349.","DOI":"10.1016\/j.theriogenology.2015.07.014"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Watson CS, Jeng YJ, Kochukov MY. Nongenomic actions of estradiol compared with estrone and estriol in pituitary tumor cell signaling and proliferation. <i>FASEB J<\/i> 2008; 22: 3328\u20133336.","DOI":"10.1096\/fj.08-107672"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Selles J, Polini N, Alvarez C, Massheimer V. Novel action of estrone on vascular tissue: regulation of NOS and COX activity. <i>Steroids<\/i> 2005; 70: 251\u2013256.","DOI":"10.1016\/j.steroids.2004.10.012"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Forrest DW, Kaltenbach CC, Dunn TG. Estriol- and estradiol-17 beta-induced luteinizing hormone release in ovariectomized cows and ewes. <i>J Anim Sci<\/i> 1981; 52: 1106\u20131113.","DOI":"10.2527\/jas1981.5251106x"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Schoenemann HM, Humphrey WD, Crowder ME, Nett TM, Reeves JJ. Pituitary luteinizing hormone-releasing hormone receptors in ovariectomized cows after challenge with ovarian steroids. <i>Biol Reprod<\/i> 1985; 32: 574\u2013583.","DOI":"10.1095\/biolreprod32.3.574"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Endo N, Nagai K, Tanaka T, Kamomae H. Comparison between lactating and non-lactating dairy cows on follicular growth and corpus luteum development, and endocrine patterns of ovarian steroids and luteinizing hormone in the estrous cycles. <i>Anim Reprod Sci<\/i> 2012; 134: 112\u2013118.","DOI":"10.1016\/j.anireprosci.2012.08.018"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Spicer LJ, Echternkamp SE. Ovarian follicular growth, function and turnover in cattle: a review. <i>J Anim Sci<\/i> 1986; 62: 428\u2013451.","DOI":"10.2527\/jas1986.622428x"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Patel OV, Takenouchi N, Takahashi T, Hirako M, Sasaki N, Domeki I. Plasma oestrone and oestradiol concentrations throughout gestation in cattle: relationship to stage of gestation and fetal number. <i>Res Vet Sci<\/i> 1999; 66: 129\u2013133.","DOI":"10.1053\/rvsc.1998.0254"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Thomas MP, Potter BV. The structural biology of oestrogen metabolism. <i>J Steroid Biochem Mol Biol<\/i> 2013; 137: 27\u201349.","DOI":"10.1016\/j.jsbmb.2012.12.014"},{"key":"15","unstructured":"15. Wright JV, Schliesman B, Robinson L. 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Seasonal differences in the parameters of luteinizing hormone release to exogenous gonadotropin releasing hormone in prepubertal Holstein heifers in Sapporo. <i>J Reprod Dev<\/i> 2007; 53: 121\u2013125.","DOI":"10.1262\/jrd.18058"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Saumande J, Lopez-Sebastian A. Changes in the plasma concentrations of free and conjugated oestrogens in heifers after treatment to induce superovulation and the relationship with number of ovulations. <i>J Reprod Fertil<\/i> 1982; 66: 411\u2013416.","DOI":"10.1530\/jrf.0.0660411"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Thomas P, Dong J. Binding and activation of the seven-transmembrane estrogen receptor GPR30 by environmental estrogens: a potential novel mechanism of endocrine disruption. <i>J Steroid Biochem Mol Biol<\/i> 2006; 102: 175\u2013179.","DOI":"10.1016\/j.jsbmb.2006.09.017"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Jeng YJ, Watson CS. 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Iqbal J, Latchoumanin O, Sari IP, Lang RJ, Coleman HA, Parkington HC, Clarke IJ. Estradiol-17beta inhibits gonadotropin-releasing hormone-induced Ca2+ in gonadotropes to regulate negative feedback on luteinizing hormone release. <i>Endocrinology<\/i> 2009; 150: 4213\u20134220.","DOI":"10.1210\/en.2009-0092"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Terasawa E, Noel SD, Keen KL. Rapid action of oestrogen in luteinising hormone-releasing hormone neurones: the role of GPR30. <i>J Neuroendocrinol<\/i> 2009; 21: 316\u2013321.","DOI":"10.1111\/j.1365-2826.2009.01839.x"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Broselid S, Berg KA, Chavera TA, Kahn R, Clarke WP, Olde B, Leeb-Lundberg LM. 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