{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T20:32:32Z","timestamp":1775680352770,"version":"3.50.1"},"reference-count":61,"publisher":"Japanese Society of Animal Reproduction","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Reproduction and Development","J. Reprod. Dev."],"published-print":{"date-parts":[[2017]]},"DOI":"10.1262\/jrd.2017-050","type":"journal-article","created":{"date-parts":[[2017,8,30]],"date-time":"2017-08-30T22:09:27Z","timestamp":1504130967000},"page":"547-554","source":"Crossref","is-referenced-by-count":16,"title":["Intrauterine growth retardation promotes fetal intestinal autophagy in rats via the mechanistic target of rapamycin pathway"],"prefix":"10.1262","volume":"63","author":[{"given":"Chao","family":"WANG","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruiming","family":"ZHANG","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le","family":"ZHOU","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jintian","family":"HE","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"HUANG","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farman A","family":"SIYAL","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"ZHANG","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"ZHONG","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"WANG","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"349","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Wu G, Bazer FW, Wallace JM, Spencer TE. Board-invited review: intrauterine growth retardation: implications for the animal sciences. <i>J Anim Sci<\/i> 2006; 84: 2316\u20132337.","DOI":"10.2527\/jas.2006-156"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Roman A, Desai N, Rochelson B, Gupta M, Solanki M, Xue X, Chatterjee PK, Metz CN. Maternal magnesium supplementation reduces intrauterine growth restriction and suppresses inflammation in a rat model. <i>Am J Obstet Gynecol<\/i> 2013; 208: 383.e1\u2013383.e7.","DOI":"10.1016\/j.ajog.2013.03.001"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Dong L, Zhong X, Ahmad H, Li W, Wang Y, Zhang L, Wang T. Intrauterine Growth Restriction Impairs Small Intestinal Mucosal Immunity in Neonatal Piglets. <i>J Histochem Cytochem<\/i> 2014; 62: 510\u2013518.","DOI":"10.1369\/0022155414532655"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Desai M, Gayle D, Babu J, Ross MG. Programmed obesity in intrauterine growth-restricted newborns: modulation by newborn nutrition. <i>Am J Physiol Regul Integr Comp Physiol<\/i> 2005; 288: R91\u2013R96.","DOI":"10.1152\/ajpregu.00340.2004"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Hamilton BE, Hoyert DL, Martin JA, Strobino DM, Guyer B. Annual summary of vital statistics: 20102011. <i>Pediatrics<\/i> 2013; 131: 548\u2013558.","DOI":"10.1542\/peds.2012-3769"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Wu G, Bazer FW, Cudd TA, Meininger CJ, Spencer TE. Maternal nutrition and fetal development. <i>J Nutr<\/i> 2004; 134: 2169\u20132172.","DOI":"10.1093\/jn\/134.9.2169"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. McMillen IC, Robinson JS. Developmental origins of the metabolic syndrome: prediction, plasticity, and programming. <i>Physiol Rev<\/i> 2005; 85: 571\u2013633.","DOI":"10.1152\/physrev.00053.2003"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Furness JB, Kunze WA, Clerc N. Nutrient tasting and signaling mechanisms in the gut. II. The intestine as a sensory organ: neural, endocrine, and immune responses. <i>Am J Physiol<\/i> 1999; 277: G922\u2013G928.","DOI":"10.1152\/ajpgi.1999.277.5.G922"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Manogura AC, Turan O, Kush ML, Berg C, Bhide A, Turan S, Moyano D, Bower S, Nicolaides KH, Galan HL, M\u00fcller T, Thilaganathan B, Gembruch U, Harman CR, Baschat AA. Predictors of necrotizing enterocolitis in preterm growth-restricted neonates. <i>Am J Obstet Gynecol<\/i> 2008; 198: 638.e1\u2013638.e5.","DOI":"10.1016\/j.ajog.2007.11.048"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Wang T, Huo YJ, Shi F, Xu RJ, Hutz RJ. Effects of intrauterine growth retardation on development of the gastrointestinal tract in neonatal pigs. <i>Biol Neonate<\/i> 2005; 88: 66\u201372.","DOI":"10.1159\/000084645"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Wang Y, Zhang L, Zhou G, Liao Z, Ahmad H, Liu W, Wang T. Dietary L-arginine supplementation improves the intestinal development through increasing mucosal Akt and mammalian target of rapamycin signals in intra-uterine growth retarded piglets. <i>Br J Nutr<\/i> 2012; 108: 1371\u20131381.","DOI":"10.1017\/S0007114511006763"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. D\u2019Inca R, Che L, Thymann T, Sangild PT, Le Huerou-Luron I. Intrauterine growth restriction reduces intestinal structure and modifies the response to colostrum in preterm and term piglets. <i>Livest Sci<\/i> 2010; 133: 20\u201322.","DOI":"10.1016\/j.livsci.2010.06.015"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Reed JJ, Ward MA, Vonnahme KA, Neville TL, Julius SL, Borowicz PP, Taylor JB, Redmer DA, Grazul-Bilska AT, Reynolds LP, Caton JS. Effects of selenium supply and dietary restriction on maternal and fetal body weight, visceral organ mass and cellularity estimates, and jejunal vascularity in pregnant ewe lambs. <i>J Anim Sci<\/i> 2007; 85: 2721\u20132733.","DOI":"10.2527\/jas.2006-785"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Wang W, Degroote J, Van Ginneken C, Van Poucke M, Vergauwen H, Dam TM, Vanrompay D, Peelman LJ, De Smet S, Michiels J. Intrauterine growth restriction in neonatal piglets affects small intestinal mucosal permeability and mRNA expression of redox-sensitive genes. <i>FASEB J<\/i> 2016; 30: 863\u2013873.","DOI":"10.1096\/fj.15-274779"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Wang J, Chen L, Li D, Yin Y, Wang X, Li P, Dangott LJ, Hu W, Wu G. Intrauterine growth restriction affects the proteomes of the small intestine, liver, and skeletal muscle in newborn pigs. <i>J Nutr<\/i> 2008; 138: 60\u201366.","DOI":"10.1093\/jn\/138.1.60"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Che L, Thymann T, Bering SB, LE Hu\u00ebrou-Luron I, Dinca R, Zhang K, Sangild PT. IUGR does not predispose to necrotizing enterocolitis or compromise postnatal intestinal adaptation in preterm pigs. <i>Pediatr Res<\/i> 2010; 67: 54\u201359.","DOI":"10.1203\/PDR.0b013e3181c1b15e"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Bell AW, Bauman DE. Adaptations of glucose metabolism during pregnancy and lactation. <i>J Mammary Gland Biol Neoplasia<\/i> 1997; 2: 265\u2013278.","DOI":"10.1023\/A:1026336505343"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Hellstr\u00f6m A, Ley D, Hansen-Pupp I, Hallberg B, L\u00f6fqvist C, van Marter L, van Weissenbruch M, Ramenghi LA, Beardsall K, Dunger D, H\u00e5rd AL, Smith LE. Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development. <i>Acta Paediatr<\/i> 2016; 105: 576\u2013586.","DOI":"10.1111\/apa.13350"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Sferruzzi-Perri AN, Sandovici I, Constancia M, Fowden AL. Placental phenotype and the insulin-like growth factors: resource allocation to fetal growth. <i>J Physiol<\/i> 2017; 595: 5057\u20135093. .","DOI":"10.1113\/JP273330"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Fleming SE, Zambell KL, Fitch MD. Glucose and glutamine provide similar proportions of energy to mucosal cells of rat small intestine. <i>Am J Physiol<\/i> 1997; 273: G968\u2013G978.","DOI":"10.1152\/ajpgi.1997.273.4.G968"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Funston RN, Larson DM, Vonnahme KA. Effects of maternal nutrition on conceptus growth and offspring performance: implications for beef cattle production. <i>J Anim Sci<\/i> 2010; 88(Suppl): E205\u2013E215.","DOI":"10.2527\/jas.2009-2351"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Roos S, Jansson N, Palmberg I, S\u00e4lj\u00f6 K, Powell TL, Jansson T. Mammalian target of rapamycin in the human placenta regulates leucine transport and is down-regulated in restricted fetal growth. <i>J Physiol<\/i> 2007; 582: 449\u2013459.","DOI":"10.1113\/jphysiol.2007.129676"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Jung CH, Ro S-H, Cao J, Otto NM, Kim D-H. mTOR regulation of autophagy. <i>FEBS Lett<\/i> 2010; 584: 1287\u20131295.","DOI":"10.1016\/j.febslet.2010.01.017"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Kumsta C, Hansen M. Hormetic heat shock and HSF-1 overexpression improve C. elegans survival and proteostasis by inducing autophagy. <i>Autophagy<\/i> 2017; 13: 1076\u20131077.","DOI":"10.1080\/15548627.2017.1299313"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Navarro-Yepes J, Burns M, Anandhan A, Khalimonchuk O, del Razo LM, Quintanilla-Vega B, Pappa A, Panayiotidis MI, Franco R. Oxidative stress, redox signaling, and autophagy: cell death versus survival. <i>Antioxid Redox Signal<\/i> 2014; 21: 66\u201385.","DOI":"10.1089\/ars.2014.5837"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Xia S, Lv J, Gao Q, Li L, Chen N, Wei X, Xiao J, Chen J, Tao J, Sun M, Mao C, Zhang L, Xu Z. Prenatal exposure to hypoxia induced Beclin 1 signaling-mediated renal autophagy and altered renal development in rat fetuses. <i>Reprod Sci<\/i> 2015; 22: 156\u2013164.","DOI":"10.1177\/1933719114536474"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Anderson GD, Ahokas RA, Lipshitz J, Dilts PV Jr. Effect of maternal dietary restriction during pregnancy on maternal weight gain and fetal birth weight in the rat. <i>J Nutr<\/i> 1980; 110: 883\u2013890.","DOI":"10.1093\/jn\/110.5.883"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-\u0394 \u0394 C(T)) Method. <i>Methods<\/i> 2001; 25: 402\u2013408.","DOI":"10.1006\/meth.2001.1262"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Xu W, Bai K, He J, Su W, Dong L, Zhang L, Wang T. Leucine improves growth performance of intrauterine growth retardation piglets by modifying gene and protein expression related to protein synthesis. <i>Nutrition<\/i> 2016; 32: 114\u2013121.","DOI":"10.1016\/j.nut.2015.07.003"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Haim Y, Bl\u00fcher M, Slutsky N, Goldstein N, Kl\u00f6ting N, Harman-Boehm I, Kirshtein B, Ginsberg D, Gericke M, Guiu Jurado E, Kovsan J, Tarnovscki T, Kachko L, Bashan N, Gepner Y, Shai I, Rudich A. Elevated autophagy gene expression in adipose tissue of obese humans: A potential non-cell-cycle-dependent function of E2F1. <i>Autophagy<\/i> 2015; 11: 2074\u20132088.","DOI":"10.1080\/15548627.2015.1094597"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Vogl DT, Stadtmauer EA, Tan KS, Heitjan DF, Davis LE, Pontiggia L, Rangwala R, Piao S, Chang YC, Scott EC, Paul TM, Nichols CW, Porter DL, Kaplan J, Mallon G, Bradner JE, Amaravadi RK. Combined autophagy and proteasome inhibition: a phase 1 trial of hydroxychloroquine and bortezomib in patients with relapsed\/refractory myeloma. <i>Autophagy<\/i> 2014; 10: 1380\u20131390.","DOI":"10.4161\/auto.29264"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Rangwala R, Chang YC, Hu J, Algazy KM, Evans TL, Fecher LA, Schuchter LM, Torigian DA, Panosian JT, Troxel AB, Tan KS, Heitjan DF, DeMichele AM, Vaughn DJ, Redlinger M, Alavi A, Kaiser J, Pontiggia L, Davis LE, ODwyer PJ, Amaravadi RK. Combined MTOR and autophagy inhibition: phase I trial of hydroxychloroquine and temsirolimus in patients with advanced solid tumors and melanoma. <i>Autophagy<\/i> 2014; 10: 1391\u20131402.","DOI":"10.4161\/auto.29119"},{"key":"33","unstructured":"33. Zabielski R, Godlewski MM, Guilloteau P. Control of development of gastrointestinal system in neonates. <i>J Physiol Pharmacol<\/i> 2008; 59(Suppl 1): 35\u201354."},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Wesolowski SR, Hay WW Jr. Role of placental insufficiency and intrauterine growth restriction on the activation of fetal hepatic glucose production. <i>Mol Cell Endocrinol<\/i> 2016; 435: 61\u201368.","DOI":"10.1016\/j.mce.2015.12.016"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Gupta M, Solanki MH, Chatterjee PK, Xue X, Roman A, Desai N, Rochelson B, Metz CN. Maternal magnesium deficiency in mice leads to maternal metabolic dysfunction and altered lipid metabolism with fetal growth restriction. <i>Mol Med<\/i> 2014; 20: 332\u2013340.","DOI":"10.2119\/molmed.2014.00137"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Roman A, Gupta M, Carreon C, Nanda N, Xue XY, Williamson A, Rochelson B, Metz C. Maternal magnesium supplementation reduces placental infarction and apoptosis in a rat model of intrauterine growth restriction. <i>Am J Obstet Gynecol<\/i> 2015; 212: S370.","DOI":"10.1016\/j.ajog.2014.10.967"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Desai M, Crowther NJ, Lucas A, Hales CN. Organ-selective growth in the offspring of protein-restricted mothers. <i>Br J Nutr<\/i> 1996; 76: 591\u2013603.","DOI":"10.1079\/BJN19960065"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Wu G, Pond WG, Ott T, Bazer FW. Maternal dietary protein deficiency decreases amino acid concentrations in fetal plasma and allantoic fluid of pigs. <i>J Nutr<\/i> 1998; 128: 894\u2013902.","DOI":"10.1093\/jn\/128.5.894"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Desai M, Gayle D, Babu J, Ross MG. The timing of nutrient restriction during rat pregnancy\/lactation alters metabolic syndrome phenotype. <i>Am J Obstet Gynecol<\/i> 2007; 196: 555.e1\u2013555.e7.","DOI":"10.1016\/j.ajog.2006.11.036"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Meyer AM, Reed JJ, Vonnahme KA, Soto-Navarro SA, Reynolds LP, Ford SP, Hess BW, Caton JS. Effects of stage of gestation and nutrient restriction during early to mid-gestation on maternal and fetal visceral organ mass and indices of jejunal growth and vascularity in beef cows. <i>J Anim Sci<\/i> 2010; 88: 2410\u20132424.","DOI":"10.2527\/jas.2009-2220"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Hay WW Jr. Recent observations on the regulation of fetal metabolism by glucose. <i>J Physiol<\/i> 2006; 572: 17\u201324.","DOI":"10.1113\/jphysiol.2006.105072"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Mahajan SD, Singh S, Shah P, Gupta N, Kochupillai N. Effect of maternal malnutrition and anemia on the endocrine regulation of fetal growth. <i>Endocr Res<\/i> 2004; 30: 189\u2013203.","DOI":"10.1081\/ERC-200027380"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Tyrala EE, Chen X, Boden G. Glucose metabolism in the infant weighing less than 1100 grams. <i>J Pediatr<\/i> 1994; 125: 283\u2013287.","DOI":"10.1016\/S0022-3476(94)70212-8"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Chacko SK, Ordonez J, Sauer PJJ, Sunehag AL. Gluconeogenesis is not regulated by either glucose or insulin in extremely low birth weight infants receiving total parenteral nutrition. <i>J Pediatr<\/i> 2011; 158: 891\u2013896.","DOI":"10.1016\/j.jpeds.2010.12.040"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45. Edison RJ, Berg K, Remaley A, Kelley R, Rotimi C, Stevenson RE, Muenke M. Adverse birth outcome among mothers with low serum cholesterol. <i>Pediatrics<\/i> 2007; 120: 723\u2013733.","DOI":"10.1542\/peds.2006-1939"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46. Shanklin DR, Cooke RJ. Effects of intrauterine growth on intestinal length in the human fetus. <i>Biol Neonate<\/i> 1993; 64: 76\u201381.","DOI":"10.1159\/000243974"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47. Baserga M, Bertolotto C, Maclennan NK, Hsu JL, Pham T, Laksana GS, Lane RH. Uteroplacental insufficiency decreases small intestine growth and alters apoptotic homeostasis in term intrauterine growth retarded rats. <i>Early Hum Dev<\/i> 2004; 79: 93\u2013105.","DOI":"10.1016\/j.earlhumdev.2004.04.015"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48. DInca R, Kloareg M, Gras-Le Guen C, Le Hu\u00ebrou-Luron I. Intrauterine growth restriction modifies the developmental pattern of intestinal structure, transcriptomic profile, and bacterial colonization in neonatal pigs. <i>J Nutr<\/i> 2010; 140: 925\u2013931.","DOI":"10.3945\/jn.109.116822"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49. Ashkenazi A, Fairbrother WJ, Leverson JD, Souers AJ. From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors. <i>Nat Rev Drug Discov<\/i> 2017; 16: 273\u2013284.","DOI":"10.1038\/nrd.2016.253"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50. Chen M, Guerrero AD, Huang L, Shabier Z, Pan M, Tan TH, Wang J. Caspase-9-induced mitochondrial disruption through cleavage of anti-apoptotic BCL-2 family members. <i>J Biol Chem<\/i> 2007; 282: 33888\u201333895.","DOI":"10.1074\/jbc.M702969200"},{"key":"51","doi-asserted-by":"crossref","unstructured":"52. Ghavami S, Yeganeh B, Stelmack GL, Kashani HH, Sharma P, Cunnington R, Rattan S, Bathe K, Klonisch T, Dixon IMC, Freed DH, Halayko AJ. Apoptosis, autophagy and ER stress in mevalonate cascade inhibition-induced cell death of human atrial fibroblasts. <i>Cell Death Dis<\/i> 2012; 3: e330.","DOI":"10.1038\/cddis.2012.61"},{"key":"52","doi-asserted-by":"crossref","unstructured":"53. Maiuri MC, Zalckvar E, Kimchi A, Kroemer G. Self-eating and self-killing: crosstalk between autophagy and apoptosis. <i>Nat Rev Mol Cell Biol<\/i> 2007; 8: 741\u2013752.","DOI":"10.1038\/nrm2239"},{"key":"53","doi-asserted-by":"crossref","unstructured":"54. Wu HJ, Pu JL, Krafft PR, Zhang JM, Chen S. The molecular mechanisms between autophagy and apoptosis: potential role in central nervous system disorders. <i>Cell Mol Neurobiol<\/i> 2015; 35: 85\u201399.","DOI":"10.1007\/s10571-014-0116-z"},{"key":"54","doi-asserted-by":"crossref","unstructured":"55. Tsuyuki S, Takabayashi M, Kawazu M, Kudo K, Watanabe A, Nagata Y, Kusama Y, Yoshida K. Detection of WIPI1 mRNA as an indicator of autophagosome formation. <i>Autophagy<\/i> 2014; 10: 497\u2013513.","DOI":"10.4161\/auto.27419"},{"key":"55","doi-asserted-by":"crossref","unstructured":"56. Mizushima N, Yoshimori T, Levine B. Methods in mammalian autophagy research. <i>Cell<\/i> 2010; 140: 313\u2013326.","DOI":"10.1016\/j.cell.2010.01.028"},{"key":"56","doi-asserted-by":"crossref","unstructured":"57. Bj\u00f8rk\u00f8y G, Lamark T, Brech A, Outzen H, Perander M, Overvatn A, Stenmark H, Johansen T. p62\/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. <i>J Cell Biol<\/i> 2005; 171: 603\u2013614.","DOI":"10.1083\/jcb.200507002"},{"key":"57","doi-asserted-by":"crossref","unstructured":"58. Tucci M, Stucci S, Savonarola A, Resta L, Cives M, Rossi R, Silvestris F. An imbalance between Beclin-1 and p62 expression promotes the proliferation of myeloma cells through autophagy regulation. <i>Exp Hematol<\/i> 2014; 42: 897\u2013908.e1.","DOI":"10.1016\/j.exphem.2014.06.005"},{"key":"58","doi-asserted-by":"crossref","unstructured":"59. Onodera J, Ohsumi Y. Autophagy is required for maintenance of amino acid levels and protein synthesis under nitrogen starvation. <i>J Biol Chem<\/i> 2005; 280: 31582\u201331586.","DOI":"10.1074\/jbc.M506736200"},{"key":"59","doi-asserted-by":"crossref","unstructured":"60. Russell RC, Tian Y, Yuan H, Park HW, Chang YY, Kim J, Kim H, Neufeld TP, Dillin A, Guan KL. ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase. <i>Nat Cell Biol<\/i> 2013; 15: 741\u2013750.","DOI":"10.1038\/ncb2757"},{"key":"60","doi-asserted-by":"crossref","unstructured":"61. Kim J, Kundu M, Viollet B, Guan K-L. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. <i>Nat Cell Biol<\/i> 2011; 13: 132\u2013141.","DOI":"10.1038\/ncb2152"},{"key":"61","doi-asserted-by":"crossref","unstructured":"62. Roos S, Lagerl\u00f6f O, Wennergren M, Powell TL, Jansson T. Regulation of amino acid transporters by glucose and growth factors in cultured primary human trophoblast cells is mediated by mTOR signaling. <i>Am J Physiol Cell Physiol<\/i> 2009; 297: C723\u2013C731.","DOI":"10.1152\/ajpcell.00191.2009"}],"container-title":["Journal of Reproduction and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jrd\/63\/6\/63_2017-050\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T23:36:50Z","timestamp":1570059410000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jrd\/63\/6\/63_2017-050\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":61,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1262\/jrd.2017-050","relation":{},"ISSN":["0916-8818","1348-4400"],"issn-type":[{"value":"0916-8818","type":"print"},{"value":"1348-4400","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}