{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:44:43Z","timestamp":1787964283835,"version":"build-2784847793"},"reference-count":46,"publisher":"Japanese Society of Animal Reproduction","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Reprod. Dev.","Journal of Reproduction and Development"],"published-print":{"date-parts":[[2019]]},"DOI":"10.1262\/jrd.2018-121","type":"journal-article","created":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T22:43:43Z","timestamp":1549579423000},"page":"223-229","source":"Crossref","is-referenced-by-count":21,"title":["Improvement of fertility in repeat breeder dairy cattle by embryo transfer following artificial insemination: possibility of interferon tau replenishment effect"],"prefix":"10.1262","volume":"65","author":[{"given":"Hikari","family":"YAGINUMA","sequence":"first","affiliation":[{"name":"Animal Bio-Technology Center, Livestock Improvement Association of Japan Inc., Tokyo 135-0041, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsumi","family":"FUNESHIMA","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Tokyo University of Agriculture, Kanagawa 243-0034, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nao","family":"TANIKAWA","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Tokyo University of Agriculture, Kanagawa 243-0034, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoharu","family":"MIYAMURA","sequence":"additional","affiliation":[{"name":"Animal Bio-Technology Center, Livestock Improvement Association of Japan Inc., Tokyo 135-0041, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"TSUCHIYA","sequence":"additional","affiliation":[{"name":"Animal Bio-Technology Center, Livestock Improvement Association of Japan Inc., Tokyo 135-0041, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"NOGUCHI","sequence":"additional","affiliation":[{"name":"University Farm, Tokyo University of Agriculture, Shizuoka 418-0109, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisataka","family":"IWATA","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Tokyo University of Agriculture, Kanagawa 243-0034, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehito","family":"KUWAYAMA","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Tokyo University of Agriculture, Kanagawa 243-0034, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koumei","family":"SHIRASUNA","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Tokyo University of Agriculture, Kanagawa 243-0034, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seizo","family":"HAMANO","sequence":"additional","affiliation":[{"name":"Animal Bio-Technology Center, Livestock Improvement Association of Japan Inc., Tokyo 135-0041, Japan"},{"name":"Maebashi Institute of Animal Science, Livestock Improvement Association of Japan Inc., Gunma 371-0121, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"349","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1.  Dochi O, Takahashi K, Hirai T, Hayakawa H, Tanisawa M, Yamamoto Y, Koyama H. The use of embryo transfer to produce pregnancies in repeat-breeding dairy cattle. <i>Theriogenology<\/i> 2008; 69: 124\u2013128.","DOI":"10.1016\/j.theriogenology.2007.09.001"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2.  Yusuf M, Nakao T, Ranasinghe RB, Gautam G, Long ST, Yoshida C, Koike K, Hayashi A. Reproductive performance of repeat breeders in dairy herds. <i>Theriogenology<\/i> 2010; 73: 1220\u20131229.","DOI":"10.1016\/j.theriogenology.2010.01.016"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3.  Bulman DC, Lamming GE. Milk progesterone levels in relation to conception, repeat breeding and factors influencing acyclicity in dairy cows. <i>J Reprod Fertil<\/i> 1978; 54: 447\u2013458.","DOI":"10.1530\/jrf.0.0540447"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4.  Gustafsson H, Emanuelson U. Characterisation of the repeat breeding syndrome in Swedish dairy cattle. <i>Acta Vet Scand<\/i> 2002; 43: 115\u2013125.","DOI":"10.1186\/1751-0147-43-115"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5.  Garcia-Ispierto I, L\u00f3pez-Gatius F. Progesterone supplementation in the early luteal phase after artificial insemination improves conception rates in high-producing dairy cows. <i>Theriogenology<\/i> 2017; 90: 20\u201324.","DOI":"10.1016\/j.theriogenology.2016.11.006"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6.  Bartlett PC, Kirk JH, Mather EC. Repeated insemination in Michigan Holstein-Friesian cattle: Incidence, descriptive epidemiology and estimated economic impact. <i>Theriogenology<\/i> 1986; 26: 309\u2013322.","DOI":"10.1016\/0093-691X(86)90150-0"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7.  B\u00e5ge R, Gustafsson H, Larsson B, Forsberg M, Rodr\u00edguez-Mart\u00ednez H. Repeat breeding in dairy heifers: follicular dynamics and estrous cycle characteristics in relation to sexual hormone patterns. <i>Theriogenology<\/i> 2002; 57: 2257\u20132269.","DOI":"10.1016\/S0093-691X(02)00840-3"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8.  Canu S, Boland M, Lloyd GM, Newman M, Christie MF, May PJ, Christley RM, Smith RF, Dobson H. Predisposition to repeat breeding in UK cattle and success of artificial insemination alone or in combination with embryo transfer. <i>Vet Rec<\/i> 2010; 167: 44\u201351.","DOI":"10.1136\/vr.c3544"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9.  Katagiri S, Moriyoshi M. Alteration of the endometrial EGF profile as a potential mechanism connecting the alterations in the ovarian steroid hormone profile to embryonic loss in repeat breeders and high-producing cows. <i>J Reprod Dev<\/i> 2013; 59: 415\u2013420.","DOI":"10.1262\/jrd.2013-048"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10.  Sood P, Zachut M, Dekel I, Dube H, Jacoby S, Moallem U. Preovulatory follicle characteristics and oocyte competence in repeat breeder dairy cows. <i>J Dairy Sci<\/i> 2017; 100: 9372\u20139381.","DOI":"10.3168\/jds.2017-12973"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11.  Kurykin J, Waldmann A, Tiirats T, Kaart T, Jaakma U. Morphological quality of oocytes and blood plasma metabolites in repeat breeding and early lactation dairy cows. <i>Reprod Domest Anim<\/i> 2011; 46: 253\u2013260.","DOI":"10.1111\/j.1439-0531.2010.01652.x"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12.  Puglisi R, Cambuli C, Capoferri R, Giannino L, Lukaj A, Duchi R, Lazzari G, Galli C, Feligini M, Galli A, Bongioni G. Differential gene expression in cumulus oocyte complexes collected by ovum pick up from repeat breeder and normally fertile Holstein Friesian heifers. <i>Anim Reprod Sci<\/i> 2013; 141: 26\u201333.","DOI":"10.1016\/j.anireprosci.2013.07.003"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13.  Awasthi H, Saravia F, Rodr\u00edguez-Mart\u00ednez H, B\u00e5ge R. Do cytoplasmic lipid droplets accumulate in immature oocytes from over-conditioned repeat breeder dairy heifers? <i>Reprod Domest Anim<\/i> 2010; 45: e194\u2013e198.","DOI":"10.1111\/j.1439-0531.2009.01514.x"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14.  Kafi M, Azari M, Chashnigir O, Gharibzadeh S, Aghabozorgi Z, Asaadi A, Divar MR. Inherent inferior quality of follicular fluid in repeat breeder heifers as evidenced by low rates of in vitro production of bovine embryos. <i>Theriogenology<\/i> 2017; 102: 29\u201334.","DOI":"10.1016\/j.theriogenology.2017.07.011"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15.  Son DS, Choe CY, Cho SR, Choi SH, Kim HJ, Hur TY, Jung YG, Kang HG, Kim IH. A CIDR-based timed embryo transfer protocol increases the pregnancy rate of lactating repeat breeder dairy cows. <i>J Reprod Dev<\/i> 2007; 53: 1313\u20131318.","DOI":"10.1262\/jrd.19066"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16.  Rodrigues CA, Teixeira AA, Ferreira RM, Ayres H, Mancilha RF, Souza AH, Baruselli PS. Effect of fixed-time embryo transfer on reproductive efficiency in high-producing repeat-breeder Holstein cows. <i>Anim Reprod Sci<\/i> 2010; 118: 110\u2013117.","DOI":"10.1016\/j.anireprosci.2009.06.020"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17.  Kim UH, Suh GH, Hur TY, Kang SJ, Kang HG, Park SB, Kim HS, Kim IH. Comparison of two types of CIDR-based timed artificial insemination protocols for repeat breeder dairy cows. <i>J Reprod Dev<\/i> 2007; 53: 639\u2013645.","DOI":"10.1262\/jrd.18147"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18.  Imakawa K, Anthony RV, Kazemi M, Marotti KR, Polites HG, Roberts RM. Interferon-like sequence of ovine trophoblast protein secreted by embryonic trophectoderm. <i>Nature<\/i> 1987; 330: 377\u2013379.","DOI":"10.1038\/330377a0"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19.  Meyer MD, Hansen PJ, Thatcher WW, Drost M, Badinga L, Roberts RM, Li J, Ott TL, Bazer FW. Extension of corpus luteum lifespan and reduction of uterine secretion of prostaglandin F2 alpha of cows in response to recombinant interferon-tau. <i>J Dairy Sci<\/i> 1995; 78: 1921\u20131931.","DOI":"10.3168\/jds.S0022-0302(95)76817-5"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20.  Spencer TE, Burghardt RC, Johnson GA, Bazer FW. Conceptus signals for establishment and maintenance of pregnancy. <i>Anim Reprod Sci<\/i> 2004; 82\u221283: 537\u2013550.","DOI":"10.1016\/j.anireprosci.2004.04.014"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21.  Hamano S, Kuwayama M. In vitro fertilization and development of bovine oocytes recovered from the ovaries of individual donors: A comparison between the cutting and aspiration method. <i>Theriogenology<\/i> 1993; 39: 703\u2013712.","DOI":"10.1016\/0093-691X(93)90255-4"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22.  Yang L, Guo R, Yao X, Yan J, Bai Y, Zhang L. Expression of progesterone receptor and progesterone-induced blocking factor in the spleen during early pregnancy in ewews. <i>Livest Sci<\/i> 2018; 209: 14\u201319.","DOI":"10.1016\/j.livsci.2018.01.004"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23.  Takahashi T, Sakumoto R, Hayashi KG, Hosoe M, Shirai J, Hashizume K. Generation of recombinant bovine interferon tau in the human embryonic kidney cell line and its biological activity. <i>Anim Sci J<\/i> 2017; 88: 1498\u20131505.","DOI":"10.1111\/asj.12820"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24.  Toji N, Koshi K, Furusawa T, Takahashi T, Ishiguro-Oonuma T, Kizaki K, Hashizume K. A cell-based interferon-tau assay with an interferon-stimulated gene 15 promoter. <i>Biomed Res<\/i> 2018; 39: 13\u201320.","DOI":"10.2220\/biomedres.39.13"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25.  Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. <i>Methods<\/i> 2001; 25: 402\u2013408.","DOI":"10.1006\/meth.2001.1262"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26.  Sheikh AA, Hooda OK, Kalyan A, Kamboj A, Mohammed S, Alhussien M, Reddi S, Shimray PG, Rautela A, Pandita S, Kapila S, De S, Dang AK. Interferon-tau stimulated gene expression: A proxy to predict embryonic mortality in dairy cows. <i>Theriogenology<\/i> 2018; 120: 61\u201367.","DOI":"10.1016\/j.theriogenology.2018.07.028"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27.  Gifford CA, Racicot K, Clark DS, Austin KJ, Hansen TR, Lucy MC, Davies CJ, Ott TL. Regulation of interferon-stimulated genes in peripheral blood leukocytes in pregnant and bred, nonpregnant dairy cows. <i>J Dairy Sci<\/i> 2007; 90: 274\u2013280.","DOI":"10.3168\/jds.S0022-0302(07)72628-0"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28.  Hansen TR, Henkes LK, Ashley RL, Bott RC, Antoniazzi AQ, Han H. Endocrine actions of interferon-tau in ruminants. <i>Soc Reprod Fertil Suppl<\/i> 2010; 67: 325\u2013340.","DOI":"10.5661\/RDR-VII-325"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29.  Han H, Austin KJ, Rempel LA, Hansen TR. Low blood ISG15 mRNA and progesterone levels are predictive of non-pregnant dairy cows. <i>J Endocrinol<\/i> 2006; 191: 505\u2013512.","DOI":"10.1677\/joe.1.07015"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30.  Yang L, Wang XL, Wan PC, Zhang LY, Wu Y, Tang DW, Zeng SM. Up-regulation of expression of interferon-stimulated gene 15 in the bovine corpus luteum during early pregnancy. <i>J Dairy Sci<\/i> 2010; 93: 1000\u20131011.","DOI":"10.3168\/jds.2009-2529"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31.  Shirasuna K, Matsumoto H, Kobayashi E, Nitta A, Haneda S, Matsui M, Kawashima C, Kida K, Shimizu T, Miyamoto A. Upregulation of interferon-stimulated genes and interleukin-10 in peripheral blood immune cells during early pregnancy in dairy cows. <i>J Reprod Dev<\/i> 2012; 58: 84\u201390.","DOI":"10.1262\/jrd.11-094K"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32.  Hashiyada Y, Okada M, Imai K. Transition of the pregnancy rate of bisected bovine embryos after co-transfer with trophoblastic vesicles prepared from in vivo-cultured in vitro-fertilized embryos. <i>J Reprod Dev<\/i> 2005; 51: 749\u2013756.","DOI":"10.1262\/jrd.17032"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33.  Mori M, Kasa S, Hattori MA, Ueda S. Development of a single bovine embryo improved by co-culture with trophoblastic vesicles in vitamin-supplemented medium. <i>J Reprod Dev<\/i> 2012; 58: 717\u2013721.","DOI":"10.1262\/jrd.2012-085"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34.  Oliveira JF, Henkes LE, Ashley RL, Purcell SH, Smirnova NP, Veeramachaneni DN, Anthony RV, Hansen TR. Expression of interferon (IFN)-stimulated genes in extrauterine tissues during early pregnancy in sheep is the consequence of endocrine IFN-tau release from the uterine vein. <i>Endocrinology<\/i> 2008; 149: 1252\u20131259.","DOI":"10.1210\/en.2007-0863"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35.  Bott RC, Ashley RL, Henkes LE, Antoniazzi AQ, Bruemmer JE, Niswender GD, Bazer FW, Spencer TE, Smirnova NP, Anthony RV, Hansen TR. Uterine vein infusion of interferon tau (IFNT) extends luteal life span in ewes. <i>Biol Reprod<\/i> 2010; 82: 725\u2013735.","DOI":"10.1095\/biolreprod.109.079467"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36.  Yang L, Wang Y, Li S, Zhu M, He K, Yao X, Zhang L. Differential expression of interferon-gamma, IL-4 and IL-10 in peripheral blood mononuclear cells during early pregnancy of the bovine. <i>Reprod Biol<\/i> 2018; 18: 312\u2013315.","DOI":"10.1016\/j.repbio.2018.06.005"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37.  Rashid MB, Talukder AK, Kusama K, Haneda S, Takedomi T, Yoshino H, Moriyasu S, Matsui M, Shimada M, Imakawa K, Miyamoto A. Evidence that interferon-tau secreted from Day-7 embryo in vivo generates anti-inflammatory immune response in the bovine uterus. <i>Biochem Biophys Res Commun<\/i> 2018; 500: 879\u2013884.","DOI":"10.1016\/j.bbrc.2018.04.178"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38.  Takahashi M, Takahashi H, Hamano S, Watanabe S, Inumaru S, Geshi M, Okuda K, Yokomizo Y, Okano A. Possible role of interferon-tau on in vitro development of bovine embryos. <i>J Reprod Dev<\/i> 2003; 49: 297\u2013305.","DOI":"10.1262\/jrd.49.297"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39.  Brooks K, Spencer TE. Biological roles of interferon tau (IFNT) and type I IFN receptors in elongation of the ovine conceptus. <i>Biol Reprod<\/i> 2015; 92: 47.","DOI":"10.1095\/biolreprod.114.124156"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40.  Gustafsson H, Larsson K. Embryonic mortality in heifers after artificial insemination and embryo transfer: differences between virgin and repeat breeder heifers. <i>Res Vet Sci<\/i> 1985; 39: 271\u2013274.","DOI":"10.1016\/S0034-5288(18)31712-0"},{"key":"41","unstructured":"41.  Kimura K, Matsuyama S, Kojima T. Effect of transfer of cattle elongating embryo to a repeat breeder cow on pregnancy rate and incidence of a return to estrus. <i>Reprod Fertil Dev<\/i> 2010; 23: 145."},{"key":"42","doi-asserted-by":"crossref","unstructured":"42.  Hayashi KG, Hosoe M, Kizaki K, Fujii S, Kanahara H, Takahashi T, Sakumoto R. Differential gene expression profiling of endometrium during the mid-luteal phase of the estrous cycle between a repeat breeder (RB) and non-RB cows. <i>Reprod Biol Endocrinol<\/i> 2017; 15: 20.","DOI":"10.1186\/s12958-017-0237-6"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43.  Katagiri S, Moriyoshi M, Takahashi Y. Low incidence of an altered endometrial epidermal growth factor (EGF) profile in repeat breeder Holstein heifers and differential effect of parity on the EGF profile between fertile Holstein (dairy) and Japanese Black (beef) cattle. <i>J Reprod Dev<\/i> 2013; 59: 575\u2013579.","DOI":"10.1262\/jrd.2013-067"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44.  Lange-Consiglio A, Cazzaniga N, Garlappi R, Spelta C, Pollera C, Perrini C, Cremonesi F. Platelet concentrate in bovine reproduction: effects on in vitro embryo production and after intrauterine administration in repeat breeder cows. <i>Reprod Biol Endocrinol<\/i> 2015; 13: 65.","DOI":"10.1186\/s12958-015-0064-6"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45.  Miyake Y, Miyoshi K, Moriya H, Matsui M, Haneda S. Stduies on the accident rate in single and multiple births in dairy cows. <i>Jpn J Large Anim Clin<\/i> 2010; 1: 5\u20139.","DOI":"10.4190\/jjlac.1.5"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46.  Sreenan JM, Diskin MG. Effect of a unilateral or bilateral twin embryo distribution on twinning and embryo survival rate in the cow. <i>J Reprod Fertil<\/i> 1989; 87: 657\u2013664.","DOI":"10.1530\/jrf.0.0870657"}],"container-title":["Journal of Reproduction and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jrd\/65\/3\/65_2018-121\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,15]],"date-time":"2019-06-15T03:23:09Z","timestamp":1560568989000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jrd\/65\/3\/65_2018-121\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.1262\/jrd.2018-121","relation":{},"ISSN":["0916-8818","1348-4400"],"issn-type":[{"value":"0916-8818","type":"print"},{"value":"1348-4400","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}