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Ichimura A, Hirasawa A, Poulain-Godefroy O, Bonnefond A, Hara T, Yengo L, Kimura I, Leloire A, Liu N, Iida K, Choquet H, Besnard P, Lecoeur C, Vivequin S, Ayukawa K, Takeuchi M, Ozawa K, Tauber M, Maffeis C, Morandi A, Buzzetti R, Elliott P, Pouta A, Jarvelin MR, K\u00f6rner A, Kiess W, Pigeyre M, Caiazzo R, Van Hul W, Van Gaal L, Horber F, Balkau B, L\u00e9vy-Marchal C, Rouskas K, Kouvatsi A, Hebebrand J, Hinney A, Scherag A, Pattou F, Meyre D, Koshimizu TA, Wolowczuk I, Tsujimoto G, Froguel P. Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. <i>Nature<\/i> 2012; 483: 350\u2013354.","DOI":"10.1038\/nature10798"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Hirasawa A, Tsumaya K, Awaji T, Katsuma S, Adachi T, Yamada M, Sugimoto Y, Miyazaki S, Tsujimoto G. Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. <i>Nat Med<\/i> 2005; 11: 90\u201394.","DOI":"10.1038\/nm1168"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Oh DY, Talukdar S, Bae EJ, Imamura T, Morinaga H, Fan W, Li P, Lu WJ, Watkins SM, Olefsky JM. GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. <i>Cell<\/i> 2010; 142: 687\u2013698.","DOI":"10.1016\/j.cell.2010.07.041"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Katsuma S, Hatae N, Yano T, Ruike Y, Kimura M, Hirasawa A, Tsujimoto G. Free fatty acids inhibit serum deprivation-induced apoptosis through GPR120 in a murine enteroendocrine cell line STC-1. <i>J Biol Chem<\/i> 2005; 280: 19507\u201319515.","DOI":"10.1074\/jbc.M412385200"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Matsumura S, Eguchi A, Mizushige T, Kitabayashi N, Tsuzuki S, Inoue K, Fushiki T. Colocalization of GPR120 with phospholipase-Cbeta2 and alpha-gustducin in the taste bud cells in mice. <i>Neurosci Lett<\/i> 2009; 450: 186\u2013190.","DOI":"10.1016\/j.neulet.2008.11.056"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Kim N, Lee JO, Lee HJ, Kim HI, Kim JK, Lee YW, Lee SK, Kim SJ, Park SH, Kim HS. Endogenous ligand for GPR120, docosahexaenoic acid, exerts benign metabolic effects on the skeletal muscles via AMP-activated protein kinase pathway. <i>J Biol Chem<\/i> 2015; 290: 20438\u201320447.","DOI":"10.1074\/jbc.M115.657379"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Zhao Y, Zha D, Wang L, Qiao L, Lu L, Mei L, Chen C, Qiu J. Phenotypic characterization of GPR120-expressing cells in the interstitial tissue of pancreas. <i>Tissue Cell<\/i> 2013; 45: 421\u2013427.","DOI":"10.1016\/j.tice.2013.07.005"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Ishii S, Hirane M, Kato S, Fukushima N, Tsujiuchi T. Opposite effects of GPR120 and GPR40 on cell motile activity induced by ethionine in liver epithelial cells. <i>Biochem Biophys Res Commun<\/i> 2015; 456: 135\u2013138.","DOI":"10.1016\/j.bbrc.2014.11.047"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Moriyama R, Deura C, Imoto S, Nose K, Fukushima N. Expression of the long-chain fatty acid receptor GPR120 in the gonadotropes of the mouse anterior pituitary gland. <i>Histochem Cell Biol<\/i> 2015; 143: 21\u201327.","DOI":"10.1007\/s00418-014-1257-3"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Nakamura S, Noda K, Miwa M, Minabe S, Hagiwara T, Hirasawa A, Matsuyama S, Moriyama R. Colocalization of GPR120 and anterior pituitary hormone-producing cells in female Japanese Black cattle. <i>J Reprod Dev<\/i> 2020; 66: 135\u2013141.","DOI":"10.1262\/jrd.2019-111"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Garrel G, Simon V, Denoyelle C, Cruciani-Guglielmacci C, Migrenne S, Counis R, Magnan C, Cohen-Tannoudji J. Unsaturated fatty acids stimulate LH secretion via novel PKCepsilon and -theta in gonadotrope cells and inhibit GnRH-induced LH release. <i>Endocrinology<\/i> 2011; 152: 3905\u20133916.","DOI":"10.1210\/en.2011-1167"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Moriyama R, Yamazaki T, Kato T, Kato Y. Long-chain unsaturated fatty acids reduce the transcriptional activity of the rat follicle-stimulating hormone \u03b2-subunit gene. <i>J Reprod Dev<\/i> 2016; 62: 195\u2013199.","DOI":"10.1262\/jrd.2015-138"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Deura C, Moriyama R. Short-term but not long-term high-fat diet induces an increase in gene expression of gonadotropic hormones and GPR120 in the male mouse pituitary gland. <i>J Reprod Dev<\/i> 2020; 66: 143\u2013148.","DOI":"10.1262\/jrd.2019-144"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Zucker I. Light-dark rhythms in rat eating and drinking behavior. <i>Physiol Behav<\/i> 1971; 6: 115\u2013126.","DOI":"10.1016\/0031-9384(71)90078-3"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Refinetti R, Menaker M. The circadian rhythm of body temperature. <i>Physiol Behav<\/i> 1992; 51: 613\u2013637.","DOI":"10.1016\/0031-9384(92)90188-8"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Reppert SM, Weaver DR. Coordination of circadian timing in mammals. <i>Nature<\/i> 2002; 418: 935\u2013941.","DOI":"10.1038\/nature00965"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Boden MJ, Kennaway DJ. Circadian rhythms and reproduction. <i>Reproduction<\/i> 2006; 132: 379\u2013392.","DOI":"10.1530\/rep.1.00614"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Yap CC, Wharfe MD, Mark PJ, Waddell BJ, Smith JT. Diurnal regulation of hypothalamic kisspeptin is disrupted during mouse pregnancy. <i>J Endocrinol<\/i> 2016; 229: 307\u2013318.","DOI":"10.1530\/JOE-16-0086"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Taya K, Igarashi M. Changes in FSH, LH and prolactin secretion during estrous cycle in rats. <i>Endocrinol Jpn<\/i> 1973; 20: 199\u2013205.","DOI":"10.1507\/endocrj1954.20.199"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Taya K, Igarashi M. Circadian rhythms in serum LH, FSH and prolactin levels in adult male rats. <i>Endocrinol Jpn<\/i> 1974; 21: 211\u2013215.","DOI":"10.1507\/endocrj1954.21.211"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Xie Y, Tang Q, Chen G, Xie M, Yu S, Zhao J, Chen L. New insights into the circadian rhythm and its related diseases. <i>Front Physiol<\/i> 2019; 10: 682.","DOI":"10.3389\/fphys.2019.00682"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Kumar Jha P, Challet E, Kalsbeek A. Circadian rhythms in glucose and lipid metabolism in nocturnal and diurnal mammals. <i>Mol Cell Endocrinol<\/i> 2015; 418: 74\u201388.","DOI":"10.1016\/j.mce.2015.01.024"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Delezie J, Dumont S, Dardente H, Oudart H, Gr\u00e9chez-Cassiau A, Klosen P, Teboul M, Delaunay F, P\u00e9vet P, Challet E. The nuclear receptor REV-ERB\u03b1 is required for the daily balance of carbohydrate and lipid metabolism. <i>FASEB J<\/i> 2012; 26: 3321\u20133335.","DOI":"10.1096\/fj.12-208751"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Wada E, Koyanagi S, Kusunose N, Akamine T, Masui H, Hashimoto H, Matsunaga N, Ohdo S. Modulation of peroxisome proliferator-activated receptor-\u03b1 activity by bile acids causes circadian changes in the intestinal expression of Octn1\/Slc22a4 in mice. <i>Mol Pharmacol<\/i> 2015; 87: 314\u2013322.","DOI":"10.1124\/mol.114.094979"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Robinson DS. The effect of changes in nutritional state on the lipolytic activity of rat adipose tissue. <i>J Lipid Res<\/i> 1960; 1: 332\u2013338.","DOI":"10.1016\/S0022-2275(20)39056-8"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Kishida K, Kuriyama H, Funahashi T, Shimomura I, Kihara S, Ouchi N, Nishida M, Nishizawa H, Matsuda M, Takahashi M, Hotta K, Nakamura T, Yamashita S, Tochino Y, Matsuzawa Y. Aquaporin adipose, a putative glycerol channel in adipocytes. <i>J Biol Chem<\/i> 2000; 275: 20896\u201320902.","DOI":"10.1074\/jbc.M001119200"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Fredrickson DS, Gordon RS Jr. Transport of fatty acids. <i>Physiol Rev<\/i> 1958; 38: 585\u2013630.","DOI":"10.1152\/physrev.1958.38.4.585"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Serg\u00e9 A, de Keijzer S, Van Hemert F, Hickman MR, Hereld D, Spaink HP, Schmidt T, Snaar-Jagalska BE. Quantification of GPCR internalization by single-molecule microscopy in living cells. <i>Integr Biol<\/i> 2011; 3: 675\u2013683.","DOI":"10.1039\/c0ib00121j"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Resuehr D, Wildemann U, Sikes H, Olcese J. E-box regulation of gonadotropin-releasing hormone (GnRH) receptor expression in immortalized gonadotrope cells. <i>Mol Cell Endocrinol<\/i> 2007; 278: 36\u201343.","DOI":"10.1016\/j.mce.2007.08.008"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Resuehr HE, Resuehr D, Olcese J. Induction of mPer1 expression by GnRH in pituitary gonadotrope cells involves EGR-1. <i>Mol Cell Endocrinol<\/i> 2009; 311: 120\u2013125.","DOI":"10.1016\/j.mce.2009.07.005"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Sharma S, Morinaga H, Hwang V, Fan W, Fernandez MO, Varki N, Olefsky JM, Webster NJ. Free fatty acids induce Lhb mRNA but suppress Fshb mRNA in pituitary L\u03b2T2 gonadotropes and diet-induced obesity reduces FSH levels in male mice and disrupts the proestrous LH\/FSH surge in female mice. <i>Endocrinology<\/i> 2013; 154: 2188\u20132199.","DOI":"10.1210\/en.2012-2218"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Liu Y, Chen LY, Sokolowska M, Eberlein M, Alsaaty S, Martinez-Anton A, Logun C, Qi HY, Shelhamer JH. The fish oil ingredient, docosahexaenoic acid, activates cytosolic phospholipase A<sub>2<\/sub> via GPR120 receptor to produce prostaglandin E<sub>2<\/sub> and plays an anti-inflammatory role in macrophages. <i>Immunology<\/i> 2014; 143: 81\u201395.","DOI":"10.1111\/imm.12296"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Milligan G, Alvarez-Curto E, Hudson BD, Prihandoko R, Tobin AB. FFA4\/GPR120: pharmacology and therapeutic opportunities. <i>Trends Pharmacol Sci<\/i> 2017; 38: 809\u2013821.","DOI":"10.1016\/j.tips.2017.06.006"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Sassone-Corsi P. The cyclic AMP pathway. <i>Cold Spring Harb Perspect Biol<\/i> 2012; 4: 4.","DOI":"10.1101\/cshperspect.a011148"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Winters SJ, Ghooray D, Fujii Y, Moore JP Jr, Nevitt JR, Kakar SS. Transcriptional regulation of follistatin expression by GnRH in mouse gonadotroph cell lines: evidence for a role for cAMP signaling. <i>Mol Cell Endocrinol<\/i> 2007; 271: 45\u201354.","DOI":"10.1016\/j.mce.2007.03.006"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Thompson IR, Ciccone NA, Xu S, Zaytseva S, Carroll RS, Kaiser UB. GnRH pulse frequency-dependent stimulation of FSH\u03b2 transcription is mediated via activation of PKA and CREB. <i>Mol Endocrinol<\/i> 2013; 27: 606\u2013618.","DOI":"10.1210\/me.2012-1281"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Thompson IR, Kaiser UB. 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