{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:27:05Z","timestamp":1790728025117,"version":"4.1.0"},"reference-count":41,"publisher":"Japanese Society of Animal Reproduction","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Reprod. Dev.","Journal of Reproduction and Development"],"published-print":{"date-parts":[[2021]]},"DOI":"10.1262\/jrd.2021-087","type":"journal-article","created":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T22:09:04Z","timestamp":1634162944000},"page":"386-391","source":"Crossref","is-referenced-by-count":11,"title":["Steroidal but not embryonic regulation of mucin 1 expression in bovine endometrium"],"prefix":"10.1262","volume":"67","author":[{"given":"Kaiyu","family":"KUBOTA","sequence":"first","affiliation":[{"name":"Institute of Livestock and Grassland Science, National Agriculture and Food Research Organization (NARO), Tochigi 329-2793, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"MIWA","sequence":"additional","affiliation":[{"name":"Institute of Livestock and Grassland Science, National Agriculture and Food Research Organization (NARO), Tochigi 329-2793, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken-Go","family":"HAYASHI","sequence":"additional","affiliation":[{"name":"Institute of Livestock and Grassland Science, National Agriculture and Food Research Organization (NARO), Ibaraki 305-0901, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misa","family":"HOSOE","sequence":"additional","affiliation":[{"name":"Institute of Livestock and Grassland Science, National Agriculture and Food Research Organization (NARO), Ibaraki 305-0901, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miki","family":"SAKATANI","sequence":"additional","affiliation":[{"name":"Institute of Livestock and Grassland Science, National Agriculture and Food Research Organization (NARO), Tochigi 329-2793, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"349","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1.  De Vries A. Economic value of pregnancy in dairy cattle. <i>J Dairy Sci<\/i> 2006; 89: 3876\u20133885.","DOI":"10.3168\/jds.S0022-0302(06)72430-4"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2.  Wiltbank MC, Baez GM, Garcia-Guerra A, Toledo MZ, Monteiro PL, Melo LF, Ochoa JC, Santos JE, Sartori R. Pivotal periods for pregnancy loss during the first trimester of gestation in lactating dairy cows. <i>Theriogenology<\/i> 2016; 86: 239\u2013253.","DOI":"10.1016\/j.theriogenology.2016.04.037"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3.  BonDurant RH. Selected diseases and conditions associated with bovine conceptus loss in the first trimester. <i>Theriogenology<\/i> 2007; 68: 461\u2013473.","DOI":"10.1016\/j.theriogenology.2007.04.022"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4.  L\u00f3pez-Gatius F, Garc\u00eda-Ispierto I. Ultrasound and endocrine findings that help to assess the risk of late embryo\/early foetal loss by non-infectious cause in dairy cattle. <i>Reprod Domest Anim<\/i> 2010; 45(Suppl 3): 15\u201324.","DOI":"10.1111\/j.1439-0531.2010.01620.x"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5.  Ledoux D, Ponsart C, Grimard B, Gatien J, Deloche MC, Fritz S, Lefebvre R, Humblot P. Sire effect on early and late embryonic death in French Holstein cattle. <i>Animal<\/i> 2015; 9: 766\u2013774.","DOI":"10.1017\/S1751731114003140"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6.  Reese ST, Franco GA, Poole RK, Hood R, Fernadez Montero L, Oliveira Filho RV, Cooke RF, Pohler KG. Pregnancy loss in beef cattle: A meta-analysis. <i>Anim Reprod Sci<\/i> 2020; 212: 106251.","DOI":"10.1016\/j.anireprosci.2019.106251"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7.  Diskin MG, Morris DG. Embryonic and early foetal losses in cattle and other ruminants. <i>Reprod Domest Anim<\/i> 2008; 43(Suppl 2): 260\u2013267.","DOI":"10.1111\/j.1439-0531.2008.01171.x"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8.  Bazer FW, Spencer TE, Johnson GA, Burghardt RC, Wu G. Comparative aspects of implantation. <i>Reproduction<\/i> 2009; 138: 195\u2013209.","DOI":"10.1530\/REP-09-0158"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9.  Spencer TE, Forde N, Lonergan P. The role of progesterone and conceptus-derived factors in uterine biology during early pregnancy in ruminants. <i>J Dairy Sci<\/i> 2016; 99: 5941\u20135950.","DOI":"10.3168\/jds.2015-10070"},{"key":"10","unstructured":"10.  Bazer FW, Thatcher WW, Hansen PJ, Mirando MA, Ott TL, Plante C. Physiological mechanisms of pregnancy recognition in ruminants. <i>J Reprod Fertil Suppl<\/i> 1991; 43: 39\u201347."},{"key":"11","doi-asserted-by":"crossref","unstructured":"11.  Burghardt RC, Johnson GA, Jaeger LA, Ka H, Garlow JE, Spencer TE, Bazer FW. Integrins and extracellular matrix proteins at the maternal-fetal interface in domestic animals. <i>Cells Tissues Organs<\/i> 2002; 172: 202\u2013217.","DOI":"10.1159\/000066969"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12.  Forde N, Bazer FW, Spencer TE, Lonergan P. \u2018Conceptualizing\u2019 the endometrium: Identification of conceptus-derived proteins during early pregnancy in cattle. <i>Biol Reprod<\/i> 2015; 92: 156.","DOI":"10.1095\/biolreprod.115.129296"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13.  Spencer TE, Sandra O, Wolf E. Genes involved in conceptus-endometrial interactions in ruminants: insights from reductionism and thoughts on holistic approaches. <i>Reproduction<\/i> 2008; 135: 165\u2013179.","DOI":"10.1530\/REP-07-0327"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14.  Gendler SJ, Spicer AP. Epithelial mucin genes. <i>Annu Rev Physiol<\/i> 1995; 57: 607\u2013634.","DOI":"10.1146\/annurev.ph.57.030195.003135"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15.  Brayman M, Thathiah A, Carson DD. MUC1: a multifunctional cell surface component of reproductive tissue epithelia. <i>Reprod Biol Endocrinol<\/i> 2004; 2: 4.","DOI":"10.1186\/1477-7827-2-4"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16.  Hey NA, Li TC, Devine PL, Graham RA, Saravelos H, Aplin JD. MUC1 in secretory phase endometrium: expression in precisely dated biopsies and flushings from normal and recurrent miscarriage patients. <i>Hum Reprod<\/i> 1995; 10: 2655\u20132662.","DOI":"10.1093\/oxfordjournals.humrep.a135762"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17.  Hild-Petito S, Fazleabas AT, Julian J, Carson DD. Mucin (Muc-1) expression is differentially regulated in uterine luminal and glandular epithelia of the baboon (Papio anubis). <i>Biol Reprod<\/i> 1996; 54: 939\u2013947.","DOI":"10.1095\/biolreprod54.5.939"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18.  Bowen JA, Bazer FW, Burghardt RC. Spatial and temporal analyses of integrin and Muc-1 expression in porcine uterine epithelium and trophectoderm in vivo. <i>Biol Reprod<\/i> 1996; 55: 1098\u20131106.","DOI":"10.1095\/biolreprod55.5.1098"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19.  Johnson GA, Bazer FW, Jaeger LA, Ka H, Garlow JE, Pfarrer C, Spencer TE, Burghardt RC. Muc-1, integrin, and osteopontin expression during the implantation cascade in sheep. <i>Biol Reprod<\/i> 2001; 65: 820\u2013828.","DOI":"10.1095\/biolreprod65.3.820"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20.  Braga VM, Gendler SJ. Modulation of Muc-1 mucin expression in the mouse uterus during the estrus cycle, early pregnancy and placentation. <i>J Cell Sci<\/i> 1993; 105: 397\u2013405.","DOI":"10.1242\/jcs.105.2.397"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21.  Hoffman LH, Olson GE, Carson DD, Chilton BS. Progesterone and implanting blastocysts regulate Muc1 expression in rabbit uterine epithelium. <i>Endocrinology<\/i> 1998; 139: 266\u2013271.","DOI":"10.1210\/endo.139.1.5750"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22.  Aplin JD. MUC-1 glycosylation in endometrium: possible roles of the apical glycocalyx at implantation. <i>Hum Reprod<\/i> 1999; 14(Suppl 2): 17\u201325.","DOI":"10.1093\/humrep\/14.suppl_2.17"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23.  DeSouza MM, Surveyor GA, Price RE, Julian J, Kardon R, Zhou X, Gendler S, Hilkens J, Carson DD. MUC1\/episialin: a critical barrier in the female reproductive tract. <i>J Reprod Immunol<\/i> 1999; 45: 127\u2013158.","DOI":"10.1016\/S0165-0378(99)00046-7"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24.  Chervenak JL, Illsley NP. Episialin acts as an antiadhesive factor in an in vitro model of human endometrial-blastocyst attachment. <i>Biol Reprod<\/i> 2000; 63: 294\u2013300.","DOI":"10.1095\/biolreprod63.1.294"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25.  Hayashi KG, Hosoe M, Fujii S, Kanahara H, Sakumoto R. Temporal expression and localization of vascular endothelial growth factor family members in the bovine uterus during peri-implantation period. <i>Theriogenology<\/i> 2019; 133: 56\u201364.","DOI":"10.1016\/j.theriogenology.2019.04.021"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26.  Cardoso B, Oliveira ML, Pugliesi G, Batista E, Binelli M. Cytobrush: A tool for sequential evaluation of gene expression in bovine endometrium. <i>Reprod Domest Anim<\/i> 2017; 52: 1153\u20131157.","DOI":"10.1111\/rda.13037"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27.  VanDemark NL, Salisbury GW. The relation of the post-partum breeding interval to reproductive efficiency in the dairy cow. <i>J Anim Sci<\/i> 1950; 9: 307\u2013313.","DOI":"10.2527\/jas1950.93307x"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28.  Goff AK, Smith LC. Effect of steroid treatment of endometrial cells on blastocyst development during co-culture. <i>Theriogenology<\/i> 1998; 49: 1021\u20131030.","DOI":"10.1016\/S0093-691X(98)00050-8"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29.  Hwangbo Y, Lee MR, Cheong HT, Yang BK, Park CK. Effects of Progesterone and 17\u03b2-estradiol under presence or absence of FBS on plasminogen activators activity in porcine uterine epithelial cells. <i>Dev Reprod<\/i> 2018; 22: 309\u2013318.","DOI":"10.12717\/DR.2018.22.4.309"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30.  Mori M, Hayashi T, Isozaki Y, Takenouchi N, Sakatani M. Heat shock decreases the embryonic quality of frozen-thawed bovine blastocysts produced in vitro. <i>J Reprod Dev<\/i> 2015; 61: 423\u2013429.","DOI":"10.1262\/jrd.2015-003"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31.  Fields SD, Hansen PJ, Ealy AD. Fibroblast growth factor requirements for in vitro development of bovine embryos. <i>Theriogenology<\/i> 2011; 75: 1466\u20131475.","DOI":"10.1016\/j.theriogenology.2010.12.007"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32.  Meseguer M, Aplin JD, Caballero-Campo P, O\u2019Connor JE, Mart\u00edn JC, Remoh\u00ed J, Pellicer A, Sim\u00f3n C. Human endometrial mucin MUC1 is up-regulated by progesterone and down-regulated in vitro by the human blastocyst. <i>Biol Reprod<\/i> 2001; 64: 590\u2013601.","DOI":"10.1095\/biolreprod64.2.590"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33.  Bowen JA, Bazer FW, Burghardt RC. Spatial and temporal analyses of integrin and Muc-1 expression in porcine uterine epithelium and trophectoderm in vitro. <i>Biol Reprod<\/i> 1997; 56: 409\u2013415.","DOI":"10.1095\/biolreprod56.2.409"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34.  Xiao CW, Goff AK. Hormonal regulation of oestrogen and progesterone receptors in cultured bovine endometrial cells. <i>J Reprod Fertil<\/i> 1999; 115: 101\u2013109.","DOI":"10.1530\/jrf.0.1150101"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35.  Tibbetts TA, Mendoza-Meneses M, O\u2019Malley BW, Conneely OM. Mutual and intercompartmental regulation of estrogen receptor and progesterone receptor expression in the mouse uterus. <i>Biol Reprod<\/i> 1998; 59: 1143\u20131152.","DOI":"10.1095\/biolreprod59.5.1143"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36.  Tibbetts TA, Conneely OM, O\u2019Malley BW. Progesterone via its receptor antagonizes the pro-inflammatory activity of estrogen in the mouse uterus. <i>Biol Reprod<\/i> 1999; 60: 1158\u20131165.","DOI":"10.1095\/biolreprod60.5.1158"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37.  Oyelese Y, Smulian JC. Placenta previa, placenta accreta, and vasa previa. <i>Obstet Gynecol<\/i> 2006; 107: 927\u2013941.","DOI":"10.1097\/01.AOG.0000207559.15715.98"},{"key":"38","unstructured":"38.  Guillomot M. Cellular interactions during implantation in domestic ruminants. <i>J Reprod Fertil Suppl<\/i> 1995; 49: 39\u201351."},{"key":"39","doi-asserted-by":"crossref","unstructured":"39.  Spicer AP, Rowse GJ, Lidner TK, Gendler SJ. Delayed mammary tumor progression in Muc-1 null mice. <i>J Biol Chem<\/i> 1995; 270: 30093\u201330101.","DOI":"10.1074\/jbc.270.50.30093"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40.  Croy BA, Ashkar AA, Foster RA, DiSanto JP, Magram J, Carson D, Gendler SJ, Grusby MJ, Wagner N, Muller W, Guimond MJ. Histological studies of gene-ablated mice support important functional roles for natural killer cells in the uterus during pregnancy. <i>J Reprod Immunol<\/i> 1997; 35: 111\u2013133.","DOI":"10.1016\/S0165-0378(97)00054-5"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41.  Kasimanickam R, Kasimanickam V, Grende K. Endometrial expression of various genes (ISGs, PPARs, RXRs and MUC1) on day 16 post-ovulation in repeat breeder cows, with or without subclinical endometritis. <i>Theriogenology<\/i> 2020; 142: 251\u2013259.","DOI":"10.1016\/j.theriogenology.2019.10.036"}],"container-title":["Journal of Reproduction and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jrd\/67\/6\/67_2021-087\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T03:46:04Z","timestamp":1639799164000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jrd\/67\/6\/67_2021-087\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.1262\/jrd.2021-087","relation":{},"ISSN":["0916-8818","1348-4400"],"issn-type":[{"value":"0916-8818","type":"print"},{"value":"1348-4400","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]},"article-number":"2021-087"}}