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Azziz R, Carmina E, Dewailly D, Diamanti-Kandarakis E, Escobar-Morreale HF, Futterweit W, Janssen OE, Legro RS, Norman RJ, Taylor AE, Witchel SF. Task Force on the Phenotype of the Polycystic Ovary Syndrome of The Androgen Excess and PCOS Society. The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report. <i>Fertil Steril<\/i> 2009; 91: 456\u2013488.","DOI":"10.1016\/j.fertnstert.2008.06.035"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2.  Maciel GA, Baracat EC, Benda JA, Markham SM, Hensinger K, Chang RJ, Erickson GF. Stockpiling of transitional and classic primary follicles in ovaries of women with polycystic ovary syndrome. <i>J Clin Endocrinol Metab<\/i> 2004; 89: 5321\u20135327.","DOI":"10.1210\/jc.2004-0643"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3.  Stubbs SA, Stark J, Dilworth SM, Franks S, Hardy K. 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Identification of several circulating microRNAs from a genome-wide circulating microRNA expression profile as potential biomarkers for impaired glucose metabolism in polycystic ovarian syndrome. <i>Endocrine<\/i> 2016; 53: 280\u2013290.","DOI":"10.1007\/s12020-016-0878-9"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7.  Xu L, Xiong F, Bai Y, Xiao J, Zhang Y, Chen J, Li Q. Circ_0043532 regulates miR-182\/SGK3 axis to promote granulosa cell progression in polycystic ovary syndrome. <i>Reprod Biol Endocrinol<\/i> 2021; 19: 167.","DOI":"10.1186\/s12958-021-00839-5"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8.  Naji M, Nekoonam S, Aleyasin A, Arefian E, Mahdian R, Azizi E, Shabani Nashtaei M, Amidi F. Expression of miR-15a, miR-145, and miR-182 in granulosa-lutein cells, follicular fluid, and serum of women with polycystic ovary syndrome (PCOS). <i>Arch Gynecol Obstet<\/i> 2018; 297: 221\u2013231.","DOI":"10.1007\/s00404-017-4570-y"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9.  Diao FY, Xu M, Hu Y, Li J, Xu Z, Lin M, Wang L, Zhou Y, Zhou Z, Liu J, Sha J. The molecular characteristics of polycystic ovary syndrome (PCOS) ovary defined by human ovary cDNA microarray. <i>J Mol Endocrinol<\/i> 2004; 33: 59\u201372.","DOI":"10.1677\/jme.0.0330059"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10.  Liu H, Gu Y, Wang H, Yin J, Zheng G, Zhang Z, Lu M, Wang C, He Z. Overexpression of PP2A inhibitor SET oncoprotein is associated with tumor progression and poor prognosis in human non-small cell lung cancer. <i>Oncotarget<\/i> 2015; 6: 14913\u201314925.","DOI":"10.18632\/oncotarget.3818"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11.  Farrell AS, Allen-Petersen B, Daniel CJ, Wang X, Wang Z, Rodriguez S, Impey S, Oddo J, Vitek MP, Lopez C, Christensen DJ, Sheppard B, Sears RC. Targeting inhibitors of the tumor suppressor PP2A for the treatment of pancreatic cancer. <i>Mol Cancer Res<\/i> 2014; 12: 924\u2013939.","DOI":"10.1158\/1541-7786.MCR-13-0542"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12.  Sobral LM, Sousa LO, Coletta RD, Cabral H, Greene LJ, Tajara EH, Gutkind JS, Curti C, Leopoldino AM. Stable SET knockdown in head and neck squamous cell carcinoma promotes cell invasion and the mesenchymal-like phenotype in vitro, as well as necrosis, cisplatin sensitivity and lymph node metastasis in xenograft tumor models. <i>Mol Cancer<\/i> 2014; 13: 32.","DOI":"10.1186\/1476-4598-13-32"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13.  Chakravarti D, Hong R. 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Bellissimo T, Tito C, Ganci F, Sacconi A, Masciarelli S, Di Martino G, Porta N, Cirenza M, Sorci M, De Angelis L, Rosa P, Calogero A, Fatica A, Petrozza V, Fontemaggi G, Blandino G, Fazi F. Argonaute 2 drives miR-145-5p-dependent gene expression program in breast cancer cells. <i>Cell Death Dis<\/i> 2019; 10: 17.","DOI":"10.1038\/s41419-018-1267-5"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20.  Cao H, Pan G, Tang S, Zhong N, Liu H, Zhou H, Peng Q, Zou Y. miR-145-5p regulates the proliferation, migration and invasion in cervical carcinoma by targeting KLF5. <i>OncoTargets Ther<\/i> 2020; 13: 2369\u20132376.","DOI":"10.2147\/OTT.S241366"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21.  Fan S, Chen P, Li S. miR-145-5p inhibits the proliferation, migration, and invasion of esophageal carcinoma cells by targeting ABRACL. <i>BioMed Res Int<\/i> 2021; 2021: 6692544.","DOI":"10.1155\/2021\/6692544"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22.  Hosokawa K, Muranski P, Feng X, Keyvanfar K, Townsley DM, Dumitriu B, Chen J, Kajigaya S, Taylor JG, Hourigan CS, Barrett AJ, Young NS. Identification of novel microRNA signatures linked to acquired aplastic anemia. <i>Haematologica<\/i> 2015; 100: 1534\u20131545.","DOI":"10.3324\/haematol.2015.126128"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23.  Xiong T, Du Y, Fu Z, Geng G. MicroRNA-145-5p promotes asthma pathogenesis by inhibiting kinesin family member 3A expression in mouse airway epithelial cells. <i>J Int Med Res<\/i> 2019; 47: 3307\u20133319.","DOI":"10.1177\/0300060518789819"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24.  Yan G, Zhang L, Fang T, Zhang Q, Wu S, Jiang Y, Sun H, Hu Y. MicroRNA-145 suppresses mouse granulosa cell proliferation by targeting activin receptor IB. <i>FEBS Lett<\/i> 2012; 586: 3263\u20133270.","DOI":"10.1016\/j.febslet.2012.06.048"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25.  Cai G, Ma X, Chen B, Huang Y, Liu S, Yang H, Zou W. MicroRNA-145 negatively regulates cell proliferation through targeting IRS1 in isolated ovarian granulosa cells from patients with polycystic ovary syndrome. <i>Reprod Sci<\/i> 2017; 24: 902\u2013910.","DOI":"10.1177\/1933719116673197"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26.  He K, Shi L, Jiang T, Li Q, Chen Y, Meng C. Association between SET expression and glioblastoma cell apoptosis and proliferation. <i>Oncol Lett<\/i> 2016; 12: 2435\u20132444.","DOI":"10.3892\/ol.2016.4951"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27.  Almeida LO, Garcia CB, Matos-Silva FA, Curti C, Leopoldino AM. Accumulated SET protein up-regulates and interacts with hnRNPK, increasing its binding to nucleic acids, the Bcl-xS repression, and cellular proliferation. <i>Biochem Biophys Res Commun<\/i> 2014; 445: 196\u2013202.","DOI":"10.1016\/j.bbrc.2014.01.175"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28.  Fukukawa C, Shima H, Tanuma N, Okada T, Kato N, Adachi Y, Kikuchi K. The oncoprotein I-2PP2A\/SET negatively regulates the MEK\/ERK pathway and cell proliferation. <i>Int J Oncol<\/i> 2005; 26: 751\u2013756.","DOI":"10.3892\/ijo.26.3.751"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29.  Du C, Waltzer WC, Wilusz JE, Spaliviero M, Darras F, Romanov V. Circular STAG2 RNA modulates bladder cancer progression via miR-145-5p\/TAGLN2 and is considered as a biomarker for recurrence. <i>Cancers (Basel)<\/i> 2024; 16: 16.","DOI":"10.3390\/cancers16050978"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30.  Zhang Z, Liu W, Huang T, Li J, Hu H, Xu X, Fan Z. CircCPA4 induces ASCT2 expression to promote tumor property of non-small cell lung cancer cells in a miR-145-5p-dependent manner. <i>Thorac Cancer<\/i> 2024; 15: 764\u2013777.","DOI":"10.1111\/1759-7714.15257"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31.  Chen Z, Wang Y, Wang K, Zhang Z, Han M, Li G, Zhang B, Yang Y, Loor JJ, Yang Z, Zhong F, Dai R, Wang M. CircRNA-02191 regulating unsaturated fatty acid synthesis by adsorbing miR-145 to enhance CD36 expression in bovine mammary gland. <i>Int J Biol Macromol<\/i> 2023; 244: 125306.","DOI":"10.1016\/j.ijbiomac.2023.125306"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32.  Song M, Xu P, Wang L, Liu J, Hou X. Hsa_circ_0001326 inhibited the proliferation, migration, and invasion of trophoblast cells via miR-145-5p\/TGFB2 axis. <i>Am J Reprod Immunol<\/i> 2023; 89: e13682.","DOI":"10.1111\/aji.13682"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33.  Pan Y, Huang Q, Peng X, Yu S, Liu N. Circ_0015756 promotes ovarian cancer progression via the miR-145-5p\/PSAT1 axis. <i>Reprod Biol<\/i> 2022; 22: 100702.","DOI":"10.1016\/j.repbio.2022.100702"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34.  Jia C, Wang S, Yin C, Liu L, Zhou L, Ma Y. Loss of hsa_circ_0118530 inhibits human granulosa-like tumor cell line KGN cell injury by sponging miR-136. <i>Gene<\/i> 2020; 744: 144591.","DOI":"10.1016\/j.gene.2020.144591"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35.  Deng L, Chen Q, Xie J, Wei W, Hui H. circPUM1 promotes polycystic ovary syndrome progression by sponging to miR-760. <i>Gene<\/i> 2020; 754: 144903.","DOI":"10.1016\/j.gene.2020.144903"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36.  Che Q, Liu M, Xu J, Liu Y, Cao X, Dong X, Liu S. Characterization of circular RNA expression profiles in cumulus cells from patients with polycystic ovary syndrome. <i>Fertil Steril<\/i> 2019; 111: 1243\u20131251.e1.","DOI":"10.1016\/j.fertnstert.2019.02.023"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37.  Zhou J, Peng X, Ru Y, Xu J. 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