{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T09:51:04Z","timestamp":1756893064642,"version":"3.37.0"},"reference-count":34,"publisher":"Japanese Society of Animal Reproduction","issue":"1","funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K06443"],"award-info":[{"award-number":["20K06443"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K01937"],"award-info":[{"award-number":["24K01937"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Reprod. Dev.","Journal of Reproduction and Development"],"published-print":{"date-parts":[[2025]]},"DOI":"10.1262\/jrd.2024-089","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T22:13:26Z","timestamp":1734646406000},"page":"49-54","source":"Crossref","is-referenced-by-count":3,"title":["Chloroquine inhibits artificial oocyte activation induced by ethanol or Sr&lt;sup&gt;2+&lt;\/sup&gt; but not by sperm in mice"],"prefix":"10.1262","volume":"71","author":[{"given":"Tadashi","family":"YAMAZAKI","sequence":"first","affiliation":[{"name":"Department of Integrated Applied Life Science, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi, Yamanashi 400-8510, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md Wasim","family":"BARI","sequence":"additional","affiliation":[{"name":"Faculty of Life and Environmental Sciences, University of Yamanashi, Yamanashi 400-8510, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"KISHIGAMI","sequence":"additional","affiliation":[{"name":"Department of Integrated Applied Life Science, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi, Yamanashi 400-8510, Japan"},{"name":"Faculty of Life and Environmental Sciences, University of Yamanashi, Yamanashi 400-8510, Japan"},{"name":"Center for advanced Assisted Reproductive Technologies, University of Yamanashi, Yamanashi 400-8510, Japan"},{"name":"Advanced Biotechnology Center, University of Yamanashi, Yamanashi 400-8510, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"349","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1.  Cuthbertson KS, Cobbold PH. Phorbol ester and sperm activate mouse oocytes by inducing sustained oscillations in cell Ca<sup>2+<\/sup>. <i>Nature<\/i> 1985; 316: 541\u2013542.","DOI":"10.1038\/316541a0"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2.  Miyazaki S, Yuzaki M, Nakada K, Shirakawa H, Nakanishi S, Nakade S, Mikoshiba K. Block of Ca<sup>2+<\/sup> wave and Ca<sup>2+<\/sup> oscillation by antibody to the inositol 1,4,5-trisphosphate receptor in fertilized hamster eggs. <i>Science<\/i> 1992; 257: 251\u2013255.","DOI":"10.1126\/science.1321497"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3.  Miyazaki S, Shirakawa H, Nakada K, Honda Y. Essential role of the inositol 1,4,5-trisphosphate receptor\/Ca<sup>2+<\/sup> release channel in Ca<sup>2+<\/sup> waves and Ca<sup>2+<\/sup> oscillations at fertilization of mammalian eggs. <i>Dev Biol<\/i> 1993; 158: 62\u201378.","DOI":"10.1006\/dbio.1993.1168"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4.  Marcus GJ. Activation of cumulus-free mouse oocytes. <i>Mol Reprod Dev<\/i> 1990; 26: 159\u2013162.","DOI":"10.1002\/mrd.1080260210"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5.  Yang R, Ji CL, Zhang M, Zhang J, Yuan HJ, Luo MJ, Jiao GZ, Tan JH. Role of calcium-sensing receptor in regulating activation susceptibility of postovulatory aging mouse oocytes. <i>J Reprod Dev<\/i> 2023; 69: 185\u2013191.","DOI":"10.1262\/jrd.2023-026"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6.  Bos-Mikich A, Swann K, Whittingham DG. Calcium oscillations and protein synthesis inhibition synergistically activate mouse oocytes. <i>Mol Reprod Dev<\/i> 1995; 41: 84\u201390.","DOI":"10.1002\/mrd.1080410113"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7.  Kline D, Kline JT. Repetitive calcium transients and the role of calcium in exocytosis and cell cycle activation in the mouse egg. <i>Dev Biol<\/i> 1992; 149: 80\u201389.","DOI":"10.1016\/0012-1606(92)90265-I"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8.  Jellerette T, He CL, Wu H, Parys JB, Fissore RA. Down-regulation of the inositol 1,4,5-trisphosphate receptor in mouse eggs following fertilization or parthenogenetic activation. <i>Dev Biol<\/i> 2000; 223: 238\u2013250.","DOI":"10.1006\/dbio.2000.9675"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9.  Fawzy M, Emad M, Mahran A, Sabry M, Fetih AN, Abdelghafar H, Rasheed S. Artificial oocyte activation with SrCl<sub>2<\/sub> or calcimycin after ICSI improves clinical and embryological outcomes compared with ICSI alone: results of a randomized clinical trial. <i>Hum Reprod<\/i> 2018; 33: 1636\u20131644.","DOI":"10.1093\/humrep\/dey258"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10.  Wakayama T, Perry AC, Zuccotti M, Johnson KR, Yanagimachi R. Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei. <i>Nature<\/i> 1998; 394: 369\u2013374.","DOI":"10.1038\/28615"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11.  Torikai K, Shimizu K, Nagatomo H, Kasai M, Kato-Itoh M, Kamada Y, Shibasaki I, Jeon H, Kikuchi R, Wakayama S, Suchy F, Nakauchi H, Wakayama T, Mizutani E. Removal of sperm tail using trypsin and pre-activation of oocyte facilitates intracytoplasmic sperm injection in mice and rats. <i>J Reprod Dev<\/i> 2023; 69: 48\u201352.","DOI":"10.1262\/jrd.2022-065"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12.  Gu C, Cooper DM. Ca(<sup>2+<\/sup>), Sr(<sup>2+<\/sup>), and Ba(<sup>2+<\/sup>) identify distinct regulatory sites on adenylyl cyclase (AC) types VI and VIII and consolidate the apposition of capacitative cation entry channels and Ca(<sup>2+<\/sup>)-sensitive ACs. <i>J Biol Chem<\/i> 2000; 275: 6980\u20136986.","DOI":"10.1074\/jbc.275.10.6980"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13.  Zhang D, Pan L, Yang LH, He XK, Huang XY, Sun FZ. Strontium promotes calcium oscillations in mouse meiotic oocytes and early embryos through InsP3 receptors, and requires activation of phospholipase and the synergistic action of InsP3. <i>Hum Reprod<\/i> 2005; 20: 3053\u20133061.","DOI":"10.1093\/humrep\/dei215"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14.  Coatney GR. Pitfalls in a discovery: the chronicle of chloroquine. <i>Am J Trop Med Hyg<\/i> 1963; 12: 121\u2013128.","DOI":"10.4269\/ajtmh.1963.12.121"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15.  Mauthe M, Orhon I, Rocchi C, Zhou X, Luhr M, Hijlkema KJ, Coppes RP, Engedal N, Mari M, Reggiori F. Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion. <i>Autophagy<\/i> 2018; 14: 1435\u20131455.","DOI":"10.1080\/15548627.2018.1474314"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16.  Wu YF, Zhao P, Luo X, Xu JC, Xue L, Zhou Q, Xiong M, Shen J, Peng YB, Yu MF, Chen W, Ma L, Liu QH. Chloroquine inhibits Ca<sup>2+<\/sup> permeable ion channels-mediated Ca<sup>2+<\/sup> signaling in primary B lymphocytes. <i>Cell Biosci<\/i> 2017; 7: 28.","DOI":"10.1186\/s13578-017-0155-5"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17.  Spears LD, Tran AV, Qin CY, Hobbs SB, Burns CA, Royer NK, Zhang Z, Ralston L, Fisher JS. Chloroquine increases phosphorylation of AMPK and Akt in myotubes. <i>Heliyon<\/i> 2016; 2: e00083.","DOI":"10.1016\/j.heliyon.2016.e00083"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18.  Xu J, Zhang D, Ju S, Sun L, Zhang S, Wu C, Rui R, Dai J. Mitophagy is involved in the mitochondrial dysfunction of vitrified porcine oocytes. <i>Mol Reprod Dev<\/i> 2021; 88: 427\u2013436.","DOI":"10.1002\/mrd.23472"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19.  He H, Wang J, Mou X, Liu X, Li Q, Zhong M, Luo B, Yu Z, Zhang J, Xu T, Dou C, Wu D, Qing W, Wu L, Zhou K, Fan Z, Wang T, Hu T, Zhang X, Zhou J, Miao YL. Selective autophagic degradation of ACLY (ATP citrate lyase) maintains citrate homeostasis and promotes oocyte maturation. <i>Autophagy<\/i> 2023; 19: 163\u2013179.","DOI":"10.1080\/15548627.2022.2063005"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20.  Naito K, Toyoda Y, Yanagimachi R. Production of normal mice from oocytes fertilized and developed without zonae pellucidae. <i>Hum Reprod<\/i> 1992; 7: 281\u2013285.","DOI":"10.1093\/oxfordjournals.humrep.a137633"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21.  Hargreaves CA, Rogers S, Hills F, Rahman F, Howell RJ, Homa ST. Effects of co-trimoxazole, erythromycin, amoxycillin, tetracycline and chloroquine on sperm function <i>in vitro<\/i>. <i>Hum Reprod<\/i> 1998; 13: 1878\u20131886.","DOI":"10.1093\/humrep\/13.7.1878"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22.  Uribe P, Meri\u00f1o J, Matus CE, Schulz M, Zambrano F, Villegas JV, Conejeros I, Taubert A, Hermosilla C, S\u00e1nchez R. Autophagy is activated in human spermatozoa subjected to oxidative stress and its inhibition impairs sperm quality and promotes cell death. <i>Hum Reprod<\/i> 2022; 37: 680\u2013695.","DOI":"10.1093\/humrep\/deac021"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23.  Raji Y, Osonuga OA, Olaleye SB, Adedokun KI, Akinsomisoye OS, Mewoyeka OO. Comparative activities of chloroquine, mefloquine and sulphadoxine-pyrimethamine on in vivo and ex vivo male reproductive functions in mammalian models. <i>J Med Sci<\/i> 2006; 6: 410\u2013415.","DOI":"10.3923\/jms.2006.410.415"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24.  Xue J, Moyer A, Peng B, Wu J, Hannafon BN, Ding WQ. Chloroquine is a zinc ionophore. <i>PLoS One<\/i> 2014; 9: e109180.","DOI":"10.1371\/journal.pone.0109180"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25.  Lawrence Y, Ozil JP, Swann K. The effects of a Ca<sup>2+<\/sup> chelator and heavy-metal-ion chelators upon Ca<sup>2+<\/sup> oscillations and activation at fertilization in mouse eggs suggest a role for repetitive Ca<sup>2+<\/sup> increases. <i>Biochem J<\/i> 1998; 335: 335\u2013342.","DOI":"10.1042\/bj3350335"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26.  Suzuki T, Yoshida N, Suzuki E, Okuda E, Perry AC. Full-term mouse development by abolishing Zn<sup>2+<\/sup>-dependent metaphase II arrest without Ca<sup>2+<\/sup> release. <i>Development<\/i> 2010; 137: 2659\u20132669.","DOI":"10.1242\/dev.049791"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27.  Akizawa H, Lopes EM, Fissore RA. Zn<sup>2+<\/sup> is essential for Ca<sup>2+<\/sup> oscillations in mouse eggs. <i>eLife<\/i> 2023; 12: RP88082.","DOI":"10.7554\/eLife.88082"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28.  Scott CC, Wasnik V, Nunes-Hassler P, Demaurex N, Kruse K, Gruenberg J. Calcium storage in multivesicular endo-lysosome. <i>Phys Biol<\/i> 2023; 20: 066004.","DOI":"10.1088\/1478-3975\/acfe6a"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29.  Kang H, Choi SW, Kim JY, Oh SJ, Kim SJ, Lee MS. ER-to-lysosome Ca<sup>2+<\/sup> refilling followed by K<sup>+<\/sup> efflux-coupled store-operated Ca<sup>2+<\/sup> entry in inflammasome activation and metabolic inflammation. <i>eLife<\/i> 2024; 12: RP87561.","DOI":"10.7554\/eLife.87561.3"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30.  Fedele AO, Proud CG. Chloroquine and bafilomycin A mimic lysosomal storage disorders and impair mTORC1 signalling. <i>Biosci Rep<\/i> 2020; 40: BSR20200905.","DOI":"10.1042\/BSR20200905"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31.  Saunders CM, Larman MG, Parrington J, Cox LJ, Royse J, Blayney LM, Swann K, Lai FA. PLC zeta: a sperm-specific trigger of Ca(<sup>2+<\/sup>) oscillations in eggs and embryo development. <i>Development<\/i> 2002; 129: 3533\u20133544.","DOI":"10.1242\/dev.129.15.3533"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32.  Cox LJ, Larman MG, Saunders CM, Hashimoto K, Swann K, Lai FA. Sperm phospholipase Czeta from humans and cynomolgus monkeys triggers Ca<sup>2+<\/sup> oscillations, activation and development of mouse oocytes. <i>Reproduction<\/i> 2002; 124: 611\u2013623.","DOI":"10.1530\/rep.0.1240611"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33.  Che JF, Wu HX, Zeng SC, Wu YR, Dai J, Cheng DH, Gong F, Lu GX, Lin G, Dai C. Defects in phospholipase C zeta cause polyspermy and low fertilization after conventional IVF: not just ICSI failure. <i>Asian J Androl<\/i> 2024; 26: 175\u2013182.","DOI":"10.4103\/aja202355"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34.  Nakai M, Suzuki SI, Fuchimoto DI, Sembon S, Kikuchi K. Oocyte activation with phospholipase C\u03b6 mRNA induces repetitive intracellular Ca<sup>2+<\/sup> rises and improves the quality of pig embryos after intracytoplasmic sperm injection. <i>J Reprod Dev<\/i> 2024; 70: 229\u2013237.","DOI":"10.1262\/jrd.2023-105"}],"container-title":["Journal of Reproduction and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jrd\/71\/1\/71_2024-089\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T04:53:02Z","timestamp":1738990382000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jrd\/71\/1\/71_2024-089\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1262\/jrd.2024-089","relation":{},"ISSN":["0916-8818","1348-4400"],"issn-type":[{"type":"print","value":"0916-8818"},{"type":"electronic","value":"1348-4400"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"2024-089"}}