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The                  evolution of pregnancy. <i>Early Hum Dev<\/i>               2014; 90:                  741\u2013745.","DOI":"10.1016\/j.earlhumdev.2014.08.013"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2.  Van Dyke                     JU,                        Brandley                     MC,                        Thompson                     MB. The                  evolution of viviparity: molecular and genomic data from squamate reptiles advance                  understanding of live birth in amniotes.                     <i>Reproduction<\/i>               2013; 147:                  R15\u2013R26.","DOI":"10.1530\/REP-13-0309"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3.  McGowen                     MR,                        Erez                     O,                        Romero                     R,                        Wildman                     DE. The                  evolution of embryo implantation. <i>Int J Dev                     Biol<\/i>               2014; 58:                  155\u2013161.","DOI":"10.1387\/ijdb.140020dw"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4.  Enders                     AC,                        Carter                     AM.                  Comparative placentation: some interesting modifications for                  histotrophic nutrition -- a review.                     <i>Placenta<\/i>               2006; 27 (Suppl A):                  S11\u2013S16.","DOI":"10.1016\/j.placenta.2005.10.013"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5.  Mika                     K,                        Whittington                     CM,                        McAllan                     BM,                        Lynch                     VJ.                  Gene expression phylogenies and ancestral transcriptome                  reconstruction resolves major transitions in the origins of                  pregnancy. <i>eLife<\/i>               2022; 11: e74297.","DOI":"10.7554\/eLife.74297"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6.  Carter                     AM,                        Enders                     AC.                  Comparative aspects of trophoblast development and                  placentation. <i>Reprod Biol Endocrinol<\/i>               2004; 2: 46.","DOI":"10.1186\/1477-7827-2-46"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7.  Wildman                     DE,                        Chen                     C,                        Erez                     O,                        Grossman                     LI,                        Goodman                     M,                        Romero                     R.                  Evolution of the mammalian placenta revealed by phylogenetic                  analysis. <i>Proc Natl Acad Sci USA<\/i>               2006; 103:                  3203\u20133208.","DOI":"10.1073\/pnas.0511344103"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8.  Carter                     AM.                  Genomics, the diversification of mammals, and the evolution of                  placentation. <i>Dev Biol<\/i>               2024; 516:                  167\u2013182.","DOI":"10.1016\/j.ydbio.2024.08.011"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9.  Roberts                     RM,                        Green                     JA,                        Schulz                     LC. The                  evolution of the placenta. <i>Reproduction<\/i>               2016; 152:                  R179\u2013R189.","DOI":"10.1530\/REP-16-0325"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10.  Carter                     AM.                  Recent advances in understanding evolution of the placenta:                  insights from transcriptomics. <i>F1000 Res<\/i>               2018; 7: 89.","DOI":"10.12688\/f1000research.13115.1"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11.  Lynch                     VJ,                        Leclerc                     RD,                        May                     G,                        Wagner                     GP.                  Transposon-mediated rewiring of gene regulatory networks                  contributed to the evolution of pregnancy in mammals.                     <i>Nat Genet<\/i>               2011; 43:                  1154\u20131159.","DOI":"10.1038\/ng.917"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12.  Mika                     K,                        Lynch                     VJ.                  Transposable elements continuously remodel the regulatory                  landscape, transcriptome, and function of decidual stromal cells.                     <i>Genome Biol Evol<\/i>               2022; 14: evac164.","DOI":"10.1093\/gbe\/evac164"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13.  Soares                     MJ,                        Varberg                     KM,                        Iqbal                     K.                  Hemochorial placentation: development, function, and                  adaptations. <i>Biol Reprod<\/i>               2018; 99:                  196\u2013211.","DOI":"10.1093\/biolre\/ioy049"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14.  Albrecht                     ED,                        Pepe                     GJ.                  Regulation of uterine spiral artery remodeling: a                  review. <i>Reprod Sci<\/i>               2020; 27:                  1932\u20131942.","DOI":"10.1007\/s43032-020-00212-8"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15.  Renaud                     SJ,                        Jeyarajah                     MJ. How                  trophoblasts fuse: an in-depth look into placental syncytiotrophoblast                  formation. <i>Cell Mol Life Sci<\/i>               2022; 79: 433.","DOI":"10.1007\/s00018-022-04475-z"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16.  Rai                     A,                        Cross                     JC.                  Development of the hemochorial maternal vascular spaces in the                  placenta through endothelial and vasculogenic mimicry.                     <i>Dev Biol<\/i>               2014; 387:                  131\u2013141.","DOI":"10.1016\/j.ydbio.2014.01.015"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17.  Cornelis                     G,                        Heidmann                     O,                        Degrelle                     SA,                        Vernochet                     C,                        Lavialle                     C,                        Letzelter                     C,                        Bernard-Stoecklin                     S,                        Hassanin                     A,                        Mulot                     B,                        Guillomot                     M,                        Hue                     I,                        Heidmann                     T,                        Dupressoir                     A.                  Captured retroviral envelope syncytin gene associated with the                  unique placental structure of higher ruminants.                     <i>Proc Natl Acad Sci USA<\/i>               2013; 110:                  E828\u2013E837.","DOI":"10.1073\/pnas.1215787110"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18.  Sugimoto                     J,                        Sugimoto                     M,                        Bernstein                     H,                        Jinno                     Y,                        Schust                     D. A                  novel human endogenous retroviral protein inhibits cell-cell                  fusion. <i>Sci Rep<\/i>               2013; 3: 1462.","DOI":"10.1038\/srep01462"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19.  Nakagawa                     S,                        Bai                     H,                        Sakurai                     T,                        Nakaya                     Y,                        Konno                     T,                        Miyazawa                     T,                        Gojobori                     T,                        Imakawa                     K.                  Dynamic evolution of endogenous retrovirus-derived genes expressed                  in bovine conceptuses during the period of placentation.                     <i>Genome Biol Evol<\/i>               2013; 5:               296\u2013306.","DOI":"10.1093\/gbe\/evt007"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20.  Nakaya                     Y,                        Koshi                     K,                        Nakagawa                     S,                        Hashizume                     K,                        Miyazawa                     T.                  Fematrin-1 is involved in fetomaternal cell-to-cell fusion in                  Bovinae placenta and has contributed to diversity of ruminant                  placentation. <i>J Virol<\/i>               2013; 87:                  10563\u201310572.","DOI":"10.1128\/JVI.01398-13"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21.  Peaston                     AE,                        Evsikov                     AV,                        Graber                     JH, de                        Vries                     WN,                        Holbrook                     AE,                        Solter                     D,                        Knowles                     BB.                  Retrotransposons regulate host genes in mouse oocytes and                  preimplantation embryos. <i>Dev Cell<\/i>               2004; 7:               597\u2013606.","DOI":"10.1016\/j.devcel.2004.09.004"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22.  Weiss                     RA. On                  the concept and elucidation of endogenous retroviruses.                     <i>Philos Trans R Soc Lond B Biol Sci<\/i>               2013; 368: 20120494.","DOI":"10.1098\/rstb.2012.0494"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23.  Grow                     EJ,                        Flynn                     RA,                        Chavez                     SL,                        Bayless                     NL,                        Wossidlo                     M,                        Wesche                     DJ,                        Martin                     L,                        Ware                     CB,                        Blish                     CA,                        Chang                     HY,                        Pera                     RA,                        Wysocka                     J.                  Intrinsic retroviral reactivation in human preimplantation embryos                  and pluripotent cells. <i>Nature<\/i>               2015; 522:                  221\u2013225.","DOI":"10.1038\/nature14308"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24.  Chuong                     EB,                        Elde                     NC,                        Feschotte                     C.                  Regulatory activities of transposable elements: from conflicts to                  benefits. <i>Nat Rev Genet<\/i>               2017; 18: 71\u201386.","DOI":"10.1038\/nrg.2016.139"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25.  Adelson                     DL,                        Raison                     JM,                        Edgar                     RC.                  Characterization and distribution of retrotransposons and simple                  sequence repeats in the bovine genome. <i>Proc Natl                     Acad Sci USA<\/i>               2009; 106:                  12855\u201312860.","DOI":"10.1073\/pnas.0901282106"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26.  Xiao                     R,                        Park                     K,                        Lee                     H,                        Kim                     J,                        Park                     C.                  Identification and classification of endogenous retroviruses in                  cattle. <i>J Virol<\/i>               2008; 82:                  582\u2013587.","DOI":"10.1128\/JVI.01451-07"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27.  Garcia-Etxebarria                     K,                        Jugo                     BM.                  Genome-wide detection and characterization of endogenous                  retroviruses in Bos taurus. <i>J Virol<\/i>               2010; 84:                  10852\u201310862.","DOI":"10.1128\/JVI.00106-10"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28.  Garcia-Etxebarria                     K,                        Jugo                     BM.                  Evolutionary history of bovine endogenous retroviruses in the                  Bovidae family. <i>BMC Evol Biol<\/i>               2013; 13: 256.","DOI":"10.1186\/1471-2148-13-256"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29.  Xiao                     R,                        Kim                     J,                        Choi                     H,                        Park                     K,                        Lee                     H,                        Park                     C.                  Characterization of the bovine endogenous retrovirus beta3                  genome. <i>Mol Cells<\/i>               2008; 25:                  142\u2013147.","DOI":"10.1016\/S1016-8478(23)17563-7"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30.  Xiao                     R,                        Park                     K, Oh                     Y,                        Kim                     J,                        Park                     C.                  Structural characterization of the genome of BERV gamma4, the most                  abundant endogenous retrovirus family in cattle.                     <i>Mol Cells<\/i>               2008; 26:                  404\u2013408.","DOI":"10.1016\/S1016-8478(23)14015-5"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31.  Torresi                     C,                        Casciari                     C,                        Giammarioli                     M,                        Feliziani                     F, De                        Mia                     GM.                  Characterization of a novel full-length bovine endogenous                  retrovirus, BERV-\u03b21. <i>Arch Virol<\/i>               2015; 160:                  3105\u20133114.","DOI":"10.1007\/s00705-015-2603-z"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32.  Saleh                     AA,                        Yang                     N,                        Rashad                     AMA,                        Hassanine                     NNAM,                        Moawad                     AS,                        Gao                     B,                        Song                     C.                  Evolution of endogenous retroviruses (ERVs) in the Bovinae                  subfamily. <i>Gene<\/i>               2025; 965: 149663.","DOI":"10.1016\/j.gene.2025.149663"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33.  Tang                     L,                        Swedlund                     B,                        Dupont                     S,                        Harland                     C, Costa                        Monteiro Moreira                     G,                        Durkin                     K,                        Artesi                     M,                        Mullaart                     E,                        Sartelet                     A,                        Karim                     L,                        Coppieters                     W,                        Georges                     M,                        Charlier                     C. GWAS                  reveals determinants of mobilization rate and dynamics of an active endogenous                  retrovirus of cattle. <i>Nat Commun<\/i>               2024; 15: 2154.","DOI":"10.1038\/s41467-024-46434-1"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34.  Hecht                     SJ,                        Stedman                     KE,                        Carlson                     JO,                        DeMartini                     JC.                  Distribution of endogenous type B and type D sheep retrovirus                  sequences in ungulates and other mammals. <i>Proc                     Natl Acad Sci USA<\/i>               1996; 93:                  3297\u20133302.","DOI":"10.1073\/pnas.93.8.3297"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35.  Morozov                     VA,                        Morozov                     AV,                        Lagaye                     S.                  Endogenous JSRV-like proviruses in domestic cattle: analysis of                  sequences and transcripts. <i>Virology<\/i>               2007; 367:               59\u201370.","DOI":"10.1016\/j.virol.2007.05.018"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36.  Nakaya                     Y,                        Miyazawa                     T.                  Dysfunction of bovine endogenous retrovirus K2 envelope                  glycoprotein is related to unsuccessful intracellular trafficking.                     <i>J Virol<\/i>               2014; 88:                  6896\u20136905.","DOI":"10.1128\/JVI.00288-14"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37.  Nakaya                     Y,                        Miyazawa                     T. The                  roles of syncytin-like proteins in ruminant placentation.                     <i>Viruses<\/i>               2015; 7:                  2928\u20132942.","DOI":"10.3390\/v7062753"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38.  Koshi                     K,                        Nakaya                     Y,                        Kizaki                     K,                        Ishiguro-Oonuma                     T,                        Miyazawa                     T,                        Spencer                     TE,                        Hashizume                     K.                  Induction of ovine trophoblast cell fusion by fematrin-1 in                  vitro. <i>Anim Sci J<\/i>               2016; 87:                  419\u2013422.","DOI":"10.1111\/asj.12439"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39.  McLean                     KJ,                        Crouse                     MS,                        Crosswhite                     MR,                        Black                     DN,                        Dahlen                     CR,                        Borowicz                     PP,                        Reynolds                     LP,                        Ward                     AK,                        Neville                     BW,                        Caton                     JS.                  Endogenous retroviral gene elements (<i>syncytin-Rum1<\/i>                  and <i>BERV-K1<\/i>), <i>interferon<\/i>-\u03c4, and                     <i>pregnancy associated glycoprotein-1<\/i> are differentially                  expressed in maternal and fetal tissues during the first 50 days of gestation in                  beef heifers. <i>Transl Anim Sci<\/i>               2017; 1:               239\u2013249.","DOI":"10.2527\/tas2017.0026"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40.  Galli                     J,                        Almi\u00f1ana                     C,                        Wiesendanger                     M,                        Schuler                     G,                        Kowalewski                     MP,                        Klisch                     K.                  Bovine placental extracellular vesicles carry the fusogenic                  syncytin BERV-K1. <i>Theriogenology<\/i>               2024; 223:               59\u201369.","DOI":"10.1016\/j.theriogenology.2024.04.012"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41.  Koshi                     K,                        Ushizawa                     K,                        Kizaki                     K,                        Takahashi                     T,                        Hashizume                     K.                  Expression of endogenous retrovirus-like transcripts in bovine                  trophoblastic cells. <i>Placenta<\/i>               2011; 32:                  493\u2013499.","DOI":"10.1016\/j.placenta.2011.04.002"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42.  Sakurai                     T,                        Nakagawa                     S,                        Bai                     H,                        Bai                     R,                        Kusama                     K,                        Ideta                     A,                        Aoyagi                     Y,                        Kaneko                     K,                        Iga                     K,                        Yasuda                     J,                        Miyazawa                     T,                        Imakawa                     K.                  Novel endogenous retrovirus-derived transcript expressed in the                  bovine placenta is regulated by WNT signaling.                     <i>Biochem J<\/i>               2017; 474:                  3499\u20133512.","DOI":"10.1042\/BCJ20170531"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43.  Kelly                     CJ,                        Chitko-McKown                     CG,                        Chuong                     EB.                  Ruminant-specific retrotransposons shape regulatory evolution of                  bovine immunity. <i>Genome Res<\/i>               2022; 32:                  1474\u20131486.","DOI":"10.1101\/gr.276241.121"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44.  Verneret                     M,                        Leroux                     C,                        Faraut                     T,                        Navratil                     V,                        Lerat                     E,                        Turpin                     J. A                  genome-wide study of ruminants uncovers two endogenous retrovirus families                  recently active in goats. <i>Mob DNA<\/i>               2025; 16: 4.","DOI":"10.1186\/s13100-024-00337-6"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45.  Davenport                     KM,                        Ortega                     MS,                        Liu                     H,                        O\u2019Neil                     EV,                        Kelleher                     AM,                        Warren                     WC,                        Spencer                     TE.                  Single-nuclei RNA sequencing (snRNA-seq) uncovers trophoblast cell                  types and lineages in the mature bovine placenta.                     <i>Proc Natl Acad Sci USA<\/i>               2023; 120: e2221526120.","DOI":"10.1073\/pnas.2221526120"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46.  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