{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T03:52:29Z","timestamp":1781927549586,"version":"3.54.5"},"reference-count":155,"publisher":"Japanese Society of Animal Reproduction","issue":"3","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01ES032144"],"award-info":[{"award-number":["R01ES032144"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01ES035766"],"award-info":[{"award-number":["R01ES035766"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["P30ES005022"],"award-info":[{"award-number":["P30ES005022"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"JSPS KAKENHI","award":["22HP2009"],"award-info":[{"award-number":["22HP2009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Reprod. Dev.","Journal of Reproduction and Development"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1262\/jrd.2025-128","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T22:10:49Z","timestamp":1781734249000},"page":"553-564","source":"Crossref","is-referenced-by-count":0,"title":["Female reproductive impacts of emerging cyanobacterial harmful algal bloom toxins"],"prefix":"10.1262","volume":"72","author":[{"given":"Yingzheng","family":"WANG","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Ernest Mario School of                     Pharmacy, Environmental and Occupational Health Sciences Institute (EOHSI),                     Rutgers University, Piscataway, NJ 08854, USA"},{"name":"Department of Molecular Biology and Genetics, Weill Institute for                     Cell and Molecular Biology, Cornell University, Ithaca, NY 14850,                     USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"LU","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Ernest Mario School of                     Pharmacy, Environmental and Occupational Health Sciences Institute (EOHSI),                     Rutgers University, Piscataway, NJ 08854, USA"},{"name":"Division of Nutritional Sciences, College of Agriculture and Life                     Sciences, Cornell University, Ithaca, NY 14850, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuhelika","family":"MALI","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Ernest Mario School of                     Pharmacy, Environmental and Occupational Health Sciences Institute (EOHSI),                     Rutgers University, Piscataway, NJ 08854, USA"},{"name":"Department of Animal Sciences, Endocrinology and Animal Biosciences                     (EAB) Graduate Program, Rutgers University, New Brunswick, NJ 08901,                     USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"CHERON","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Ernest Mario School of                     Pharmacy, Environmental and Occupational Health Sciences Institute (EOHSI),                     Rutgers University, Piscataway, NJ 08854, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan","family":"COSTANZA","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Ernest Mario School of                     Pharmacy, Environmental and Occupational Health Sciences Institute (EOHSI),                     Rutgers University, Piscataway, NJ 08854, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie","family":"MITRA","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Ernest Mario School of                     Pharmacy, Environmental and Occupational Health Sciences Institute (EOHSI),                     Rutgers University, Piscataway, NJ 08854, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"XIAO","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Ernest Mario School of                     Pharmacy, Environmental and Occupational Health Sciences Institute (EOHSI),                     Rutgers University, Piscataway, NJ 08854, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"349","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1.  S\u00e1nchez-Baracaldo                     P,                        Cardona                     T. On                  the origin of oxygenic photosynthesis and Cyanobacteria.                     <i>New Phytol<\/i>               2020; 225:                  1440\u20131446.","DOI":"10.1111\/nph.16249"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2.  Lucius                     S,                        Hagemann                     M. The                  primary carbon metabolism in cyanobacteria and its regulation.                     <i>Front Plant Sci<\/i>               2024; 15: 1417680.","DOI":"10.3389\/fpls.2024.1417680"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3.  Landrigan                     PJ,                        Stegeman                     JJ,                        Fleming                     LE,                        Allemand                     D,                        Anderson                     DM,                        Backer                     LC,                        Brucker-Davis                     F,                        Chevalier                     N,                        Corra                     L,                        Czerucka                     D,                        Bottein                     MD,                        Demeneix                     B,                        Depledge                     M,                        Deheyn                     DD,                        Dorman                     CJ,                        F\u00e9nichel                     P,                        Fisher                     S,                        Gaill                     F,                        Galgani                     F,                        Gaze                     WH,                        Giuliano                     L,                        Grandjean                     P,                        Hahn                     ME,                        Hamdoun                     A,                        Hess                     P,                        Judson                     B,                        Laborde                     A,                        McGlade                     J, Mu                     J,                        Mustapha                     A,                        Neira                     M,                        Noble                     RT,                        Pedrotti                     ML,                        Reddy                     C,                        Rockl\u00f6v                     J,                        Scharler                     UM,                        Shanmugam                     H,                        Taghian                     G, van de                        Water                     JAJM,                        Vezzulli                     L,                        Weihe                     P,                        Zeka                     A,                        Raps                     H,                        Rampal                     P.                  Human health and ocean pollution.                     <i>Ann Glob Health<\/i>               2020; 86: 151.","DOI":"10.5334\/aogh.2831"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4.  Sellner                     KG,                        Doucette                     GJ,                        Kirkpatrick                     GJ.                  Harmful algal blooms: causes, impacts and               detection. <i>J Ind Microbiol Biotechnol<\/i>               2003; 30:                  383\u2013406.","DOI":"10.1007\/s10295-003-0074-9"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5.  Kimambo                     ON,                        Gumbo                     JR,                        Chikoore                     H. The                  occurrence of cyanobacteria blooms in\u00a0freshwater ecosystems and\u00a0their link with                  hydro-meteorological and environmental variations in\u00a0Tanzania.                     <i>Heliyon<\/i>               2019; 5: e01312.","DOI":"10.1016\/j.heliyon.2019.e01312"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6.  Pham                     TL,                        Utsumi                     M. An                  overview of the accumulation of microcystins in aquatic               ecosystems. <i>J Environ Manage<\/i>               2018; 213:                  520\u2013529.","DOI":"10.1016\/j.jenvman.2018.01.077"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7.  Ho                     JC,                        Michalak                     AM,                        Pahlevan                     N.                  Widespread global increase in intense lake phytoplankton blooms                  since the 1980s. <i>Nature<\/i>               2019; 574:                  667\u2013670.","DOI":"10.1038\/s41586-019-1648-7"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8.  Kaebernick                     M,                        Neilan                     BA.                  Ecological and molecular investigations of cyanotoxin                  production. <i>FEMS Microbiol Ecol<\/i>               2001; 35: 1\u20139.","DOI":"10.1111\/j.1574-6941.2001.tb00782.x"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9.  Du                     X,                        Liu                     H,                        Yuan                     L,                        Wang                     Y, Ma                     Y,                        Wang                     R,                        Chen                     X,                        Losiewicz                     MD,                        Guo                     H,                        Zhang                     H. The                  diversity of cyanobacterial toxins on structural characterization, distribution                  and identification: a systematic review. <i>Toxins                     (Basel)<\/i>               2019; 11: 11.","DOI":"10.3390\/toxins11090530"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10.  Buratti                     FM,                        Manganelli                     M,                        Vichi                     S,                        Stefanelli                     M,                        Scardala                     S,                        Testai                     E,                        Funari                     E.                  Cyanotoxins: producing organisms, occurrence, toxicity, mechanism                  of action and human health toxicological risk evaluation.                     <i>Arch Toxicol<\/i>               2017; 91:                  1049\u20131130.","DOI":"10.1007\/s00204-016-1913-6"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11.  Christiansen                     G,                        Fastner                     J,                        Erhard                     M,                        B\u00f6rner                     T,                        Dittmann                     E.                  Microcystin biosynthesis in planktothrix: genes, evolution, and                  manipulation. <i>J Bacteriol<\/i>               2003; 185:                  564\u2013572.","DOI":"10.1128\/JB.185.2.564-572.2003"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12.  Tillett                     D,                        Dittmann                     E,                        Erhard                     M, von                        D\u00f6hren                     H,                        B\u00f6rner                     T,                        Neilan                     BA.                  Structural organization of microcystin biosynthesis in Microcystis                  aeruginosa PCC7806: an integrated peptide-polyketide synthetase                  system. <i>Chem Biol<\/i>               2000; 7:               753\u2013764.","DOI":"10.1016\/S1074-5521(00)00021-1"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13.  Boua\u00efcha                     N,                        Miles                     CO,                        Beach                     DG,                        Labidi                     Z,                        Djabri                     A,                        Benayache                     NY,                        Nguyen-Quang                     T.                  Structural diversity, characterization and toxicology of                  microcystins. <i>Toxins (Basel)<\/i>               2019; 11: 11.","DOI":"10.20944\/preprints201910.0034.v1"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14.  Xie                     L,                        Rediske                     RR,                        Gillett                     ND,                        O\u2019Keefe                     JP,                        Scull                     B,                        Xue                     Q. The                  impact of environmental parameters on microcystin production in dialysis bag                  experiments. <i>Sci Rep<\/i>               2016; 6: 38722.","DOI":"10.1038\/srep38722"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15.  Rapala                     J,                        Sivonen                     K,                        Lyra                     C,                        Niemel\u00e4                     SI.                  Variation of microcystins, cyanobacterial hepatotoxins, in Anabaena                  spp. as a function of growth stimuli. <i>Appl Environ                     Microbiol<\/i>               1997; 63:                  2206\u20132212.","DOI":"10.1128\/aem.63.6.2206-2212.1997"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16.  Cui                     X,                        Yang                     N,                        Cui                     H,                        Yang                     Q, Wu                     Z,                        Shao                     B,                        Zhao                     Y,                        Tong                     Y.                  Interspecific competition enhances microcystin production by                  Microcystis aeruginosa under the interactive influences of temperature and                  nutrients. <i>Water Res<\/i>               2024; 265: 122308.","DOI":"10.1016\/j.watres.2024.122308"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17.  Xu                     S,                        Zhang                     L,                        Lin                     K,                        Bai                     M,                        Wang                     Y, Xu                     M,                        Zhang                     M,                        Zhang                     C,                        Shi                     Y,                        Zhou                     H.                  Effects of light and water disturbance on the growth of Microcystis                  aeruginosa and the release of algal toxins. <i>Water                     Environ Res<\/i>               2021; 93:                  2958\u20132970.","DOI":"10.1002\/wer.1644"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18.  Kulabhusan                     PK,                        Campbell                     K.                  Physico-chemical treatments for the removal of cyanotoxins from                  drinking water: Current challenges and future trends.                     <i>Sci Total Environ<\/i>               2024; 917: 170078.","DOI":"10.1016\/j.scitotenv.2024.170078"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19.  Ferr\u00e3o-Filho                     ADS,                        Kozlowsky-Suzuki                     B.                  Cyanotoxins: bioaccumulation and effects on aquatic                  animals. <i>Mar Drugs<\/i>               2011; 9:                  2729\u20132772.","DOI":"10.3390\/md9122729"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20.  Martins                     JC,                        Vasconcelos                     VM.                  Microcystin dynamics in aquatic organisms.                     <i>J Toxicol Environ Health B Crit Rev<\/i>               2009; 12: 65\u201382.","DOI":"10.1080\/10937400802545151"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21.  Wijewickrama                     MM,                        Manage                     PM.                  Accumulation of microcystin-LR in grains of two rice varieties                     (<i>Oryza sativa L.<\/i>) and a leafy vegetable, <i>Ipomoea                     aquatica<\/i>. <i>Toxins (Basel)<\/i>               2019; 11: 11.","DOI":"10.3390\/toxins11080432"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22.  Xiang                     L, Li                     YW,                        Wang                     ZR,                        Liu                     BL,                        Zhao                     HM,                        Li                     H,                        Cai                     QY,                        Mo                     CH,                        Li                     QX.                  Bioaccumulation and phytotoxicity and human health risk from                  microcystin-LR under various treatments: a pot study.                     <i>Toxins (Basel)<\/i>               2020; 12: 12.","DOI":"10.3390\/toxins12080523"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23.  Vidal                     F,                        Sedan                     D,                        D\u2019Agostino                     D,                        Cavalieri                     ML,                        Mullen                     E, Parot                        Varela                     MM,                        Flores                     C,                        Caixach                     J,                        Andrinolo                     D.                  Recreational exposure during algal bloom in Carrasco beach,                  Uruguay: a liver failure case report. <i>Toxins                     (Basel)<\/i>               2017; 9: 9.","DOI":"10.3390\/toxins9090267"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24.  Pouria                     S, de                        Andrade                     A,                        Barbosa                     J,                        Cavalcanti                     RL,                        Barreto                     VT,                        Ward                     CJ,                        Preiser                     W,                        Poon                     GK,                        Neild                     GH,                        Codd                     GA.                  Fatal microcystin intoxication in haemodialysis unit in Caruaru,                  Brazil. <i>Lancet<\/i>               1998; 352:               21\u201326.","DOI":"10.1016\/S0140-6736(97)12285-1"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25.  Scoglio                     S.                  Microcystins in water and in microalgae: Do microcystins as                  microalgae contaminants warrant the current public                     alarm? <i>Toxicol Rep<\/i>               2018; 5:               785\u2013792.","DOI":"10.1016\/j.toxrep.2018.07.002"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26.  Graham                     JL,                        Loftin                     KA,                        Meyer                     MT,                        Ziegler                     AC.                  Cyanotoxin mixtures and taste-and-odor compounds in cyanobacterial                  blooms from the Midwestern United States. <i>Environ                     Sci Technol<\/i>               2010; 44:                  7361\u20137368.","DOI":"10.1021\/es1008938"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27.  Tencalla                     F,                        Dietrich                     D.                  Biochemical characterization of microcystin toxicity in rainbow                  trout (Oncorhynchus mykiss). <i>Toxicon<\/i>               1997; 35:                  583\u2013595.","DOI":"10.1016\/S0041-0101(96)00153-5"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28.  Ito                     E,                        Kondo                     F,                        Harada                     K.                  First report on the distribution of orally administered                  microcystin-LR in mouse tissue using an immunostaining method.                     <i>Toxicon<\/i>               2000; 38: 37\u201348.","DOI":"10.1016\/S0041-0101(99)00084-7"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29.  Greer                     B,                        Meneely                     JP,                        Elliott                     CT.                  Uptake and accumulation of Microcystin-LR based on exposure through                  drinking water: An animal model assessing the human health risk.                     <i>Sci Rep<\/i>               2018; 8: 4913.","DOI":"10.1038\/s41598-018-23312-7"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30.  Rajpoot                     R,                        Rajput                     S,                        Koiri                     RK.                  Microcystin-LR and its health impacts: Chemistry, transmission                  routes, mechanisms of toxicity and target organs.                     <i>Toxicol Rep<\/i>               2025; 14: 101996.","DOI":"10.1016\/j.toxrep.2025.101996"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31.  Arman                     T,                        Clarke                     JD.                  Microcystin toxicokinetics, molecular toxicology, and                  pathophysiology in preclinical rodent models and humans.                     <i>Toxins (Basel)<\/i>               2021; 13: 13.","DOI":"10.3390\/toxins13080537"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32.  Xie                     L,                        Xie                     P,                        Guo                     L, Li                     L,                        Miyabara                     Y,                        Park                     HD.                  Organ distribution and bioaccumulation of microcystins in                  freshwater fish at different trophic levels from the eutrophic Lake Chaohu,                  China. <i>Environ Toxicol<\/i>               2005; 20:                  293\u2013300.","DOI":"10.1002\/tox.20120"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33.  Nishiwaki                     R,                        Ohta                     T,                        Sueoka                     E,                        Suganuma                     M,                        Harada                     K,                        Watanabe                     MF,                        Fujiki                     H. Two                  significant aspects of microcystin-LR: specific binding and liver                  specificity. <i>Cancer Lett<\/i>               1994; 83:                  283\u2013289.","DOI":"10.1016\/0304-3835(94)90331-X"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34.  Wang                     Q,                        Xie                     P,                        Chen                     J,                        Liang                     G.                  Distribution of microcystins in various organs (heart, liver,                  intestine, gonad, brain, kidney and lung) of Wistar rat via intravenous                  injection. <i>Toxicon<\/i>               2008; 52:                  721\u2013727.","DOI":"10.1016\/j.toxicon.2008.08.004"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35.  Zhang                     W,                        Liang                     G, Wu                     L,                        Tuo                     X,                        Wang                     W,                        Chen                     J,                        Xie                     P. Why                  mammals more susceptible to the hepatotoxic microcystins than fish: evidences from                  plasma and albumin protein binding through equilibrium dialysis.                     <i>Ecotoxicology<\/i>               2013; 22:                  1012\u20131019.","DOI":"10.1007\/s10646-013-1086-5"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36.  Setl\u00edkov\u00e1                     I,                        Wiegand                     C.                  Hepatic and branchial glutathione S-transferases of two fish                  species: substrate specificity and biotransformation of                  microcystin-LR. <i>Comp Biochem Physiol C Toxicol                     Pharmacol<\/i>               2009; 149:                  515\u2013523.","DOI":"10.1016\/j.cbpc.2008.11.008"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37.  Robinson                     NA,                        Pace                     JG,                        Matson                     CF,                        Miura                     GA,                        Lawrence                     WB.                  Tissue distribution, excretion and hepatic biotransformation of                  microcystin-LR in mice. <i>J Pharmacol Exp                     Ther<\/i>               1991; 256:                  176\u2013182.","DOI":"10.1016\/S0022-3565(25)23140-8"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38.  Kondo                     F,                        Matsumoto                     H,                        Yamada                     S,                        Ishikawa                     N,                        Ito                     E,                        Nagata                     S,                        Ueno                     Y,                        Suzuki                     M,                        Harada                     K.                  Detection and identification of metabolites of microcystins formed                  in vivo in mouse and rat livers. <i>Chem Res                     Toxicol<\/i>               1996; 9:                  1355\u20131359.","DOI":"10.1021\/tx960085a"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39.  Buratti                     FM,                        Scardala                     S,                        Funari                     E,                        Testai                     E.                  Human glutathione transferases catalyzing the conjugation of the                  hepatoxin microcystin-LR. <i>Chem Res                     Toxicol<\/i>               2011; 24:                  926\u2013933.","DOI":"10.1021\/tx2000976"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40.  Schmidt                     JR,                        Wilhelm                     SW,                        Boyer                     GL. The                  fate of microcystins in the environment and challenges for                  monitoring. <i>Toxins (Basel)<\/i>               2014; 6:                  3354\u20133387.","DOI":"10.3390\/toxins6123354"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41.  Kondo                     F,                        Ikai                     Y,                        Oka                     H,                        Okumura                     M,                        Ishikawa                     N,                        Harada                     K,                        Matsuura                     K,                        Murata                     H,                        Suzuki                     M.                  Formation, characterization, and toxicity of the glutathione and                  cysteine conjugates of toxic heptapeptide microcystins.                     <i>Chem Res Toxicol<\/i>               1992; 5:               591\u2013596.","DOI":"10.1021\/tx00029a002"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42.  Miles                     CO,                        Sandvik                     M,                        Nonga                     HE,                        Ballot                     A,                        Wilkins                     AL,                        Rise                     F,                        Jaabaek                     JA,                        Loader                     JI.                  Conjugation of microcystins with thiols is reversible:                  base-catalyzed deconjugation for chemical analysis.                     <i>Chem Res Toxicol<\/i>               2016; 29:                  860\u2013870.","DOI":"10.1021\/acs.chemrestox.6b00028"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43.  Li                     W,                        Chen                     J,                        Xie                     P, He                     J,                        Guo                     X,                        Tuo                     X,                        Zhang                     W, Wu                     L.                  Rapid conversion and reversible conjugation of glutathione                  detoxification of microcystins in bighead carp (Aristichthys                  nobilis). <i>Aquat Toxicol<\/i>               2014; 147:               18\u201325.","DOI":"10.1016\/j.aquatox.2013.12.001"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44.  Lu                     H,                        Choudhuri                     S,                        Ogura                     K,                        Csanaky                     IL,                        Lei                     X,                        Cheng                     X,                        Song                     PZ,                        Klaassen                     CD.                  Characterization of organic anion transporting polypeptide 1b2-null                  mice: essential role in hepatic uptake\/toxicity of phalloidin and                  microcystin-LR. <i>Toxicol Sci<\/i>               2008; 103:               35\u201345.","DOI":"10.1093\/toxsci\/kfn038"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45.  Komatsu                     M,                        Furukawa                     T,                        Ikeda                     R,                        Takumi                     S,                        Nong                     Q,                        Aoyama                     K,                        Akiyama                     S,                        Keppler                     D,                        Takeuchi                     T.                  Involvement of mitogen-activated protein kinase signaling pathways                  in microcystin-LR-induced apoptosis after its selective uptake mediated by OATP1B1                  and OATP1B3. <i>Toxicol Sci<\/i>               2007; 97:                  407\u2013416.","DOI":"10.1093\/toxsci\/kfm054"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46.  Kaur                     G,                        Fahrner                     R,                        Wittmann                     V,                        Stieger                     B,                        Dietrich                     DR.                  Human MRP2 exports MC-LR but not the glutathione                  conjugate. <i>Chem Biol Interact<\/i>               2019; 311: 108761.","DOI":"10.1016\/j.cbi.2019.108761"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47.  Chen                     X,                        Liu                     W,                        Liao                     Y,                        Xiang                     X,                        Yang                     Y,                        Tian                     L,                        Gao                     X,                        Cao                     Q,                        Guo                     H,                        Chao                     K,                        Song                     F,                        Liu                     R, Li                     Y, Ye                     S,                        Wang                     J,                        Yang                     F,                        Wang                     X.                  Serum microcystin-LR levels linked with risk of inflammatory bowel                  disease: a matched case-control study in China.                     <i>Environ Health (Wash)<\/i>               2024; 2:               453\u2013464.","DOI":"10.1021\/envhealth.3c00212"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48.  Li                     Y,                        Chen                     JA,                        Zhao                     Q, Pu                     C,                        Qiu                     Z,                        Zhang                     R,                        Shu                     W. A                  cross-sectional investigation of chronic exposure to microcystin in relationship                  to childhood liver damage in the Three Gorges Reservoir Region,                  China. <i>Environ Health Perspect<\/i>               2011; 119:                  1483\u20131488.","DOI":"10.1289\/ehp.1002412"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49.  Chen                     J,                        Xie                     P, Li                     L, Xu                     J.                  First identification of the hepatotoxic microcystins in the serum                  of a chronically exposed human population together with indication of                  hepatocellular damage. <i>Toxicol Sci<\/i>               2009; 108:               81\u201389.","DOI":"10.1093\/toxsci\/kfp009"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50.  Hilborn                     ED,                        Carmichael                     WW,                        Yuan                     M,                        Azevedo                     SM. A                  simple colorimetric method to detect biological evidence of human exposure to                  microcystins. <i>Toxicon<\/i>               2005; 46:                  218\u2013221.","DOI":"10.1016\/j.toxicon.2005.04.009"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51.  Fawell                     JK,                        Mitchell                     RE,                        Everett                     DJ,                        Hill                     RE. The                  toxicity of cyanobacterial toxins in the mouse: I microcystin-LR.                     <i>Hum Exp Toxicol<\/i>               1999; 18:                  162\u2013167.","DOI":"10.1177\/096032719901800305"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52.  Lad                     A, Su                     RC,                        Breidenbach                     JD,                        Stemmer                     PM,                        Carruthers                     NJ,                        Sanchez                     NK,                        Khalaf                     FK,                        Zhang                     S,                        Kleinhenz                     AL,                        Dube                     P,                        Mohammed                     CJ,                        Westrick                     JA,                        Crawford                     EL,                        Palagama                     D,                        Baliu-Rodriguez                     D,                        Isailovic                     D,                        Levison                     B,                        Modyanov                     N,                        Gohara                     AF,                        Malhotra                     D,                        Haller                     ST,                        Kennedy                     DJ.                  Chronic low dose oral exposure to microcystin-LR exacerbates                  hepatic injury in a murine model of non-alcoholic fatty liver                  disease. <i>Toxins (Basel)<\/i>               2019; 11: 11.","DOI":"10.3390\/toxins11090486"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53.  Song                     Y,                        Wang                     X, Lu                     X,                        Wang                     T.                  Exposure to microcystin-LR promotes colorectal cancer progression                  by altering gut microbiota and associated metabolites in APC<sup>min\/+<\/sup>                  mice. <i>Toxins (Basel)<\/i>               2024; 16: 16.","DOI":"10.3390\/toxins16050212"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54.  Lone                     Y,                        Bhide                     M,                        Koiri                     RK.                  Microcystin-LR induced immunotoxicity in mammals.                     <i>J Toxicol<\/i>               2016; 2016: 8048125.","DOI":"10.1155\/2016\/8048125"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55.  McLellan                     NL,                        Manderville                     RA.                  Toxic mechanisms of microcystins in mammals.                     <i>Toxicol Res (Camb)<\/i>               2017; 6:               391\u2013405.","DOI":"10.1039\/C7TX00043J"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56.  Zhang                     S, Du                     X,                        Liu                     H,                        Losiewic                     MD,                        Chen                     X, Ma                     Y,                        Wang                     R,                        Tian                     Z,                        Shi                     L,                        Guo                     H,                        Zhang                     H. The                  latest advances in the reproductive toxicity of microcystin-LR.                     <i>Environ Res<\/i>               2021; 192: 110254.","DOI":"10.1016\/j.envres.2020.110254"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57.  Yuan                     L,                        Liu                     H,                        Liu                     X,                        Zhang                     X, Wu                     J,                        Wang                     Y, Du                     X,                        Wang                     R, Ma                     Y,                        Chen                     X,                        Petlulu                     P,                        Cheng                     X,                        Zhuang                     D,                        Guo                     H,                        Zhang                     H.                  Epigenetic modification of H3K4 and oxidative stress are involved                  in MC-LR-induced apoptosis in testicular cells of SD rats.                     <i>Environ Toxicol<\/i>               2020; 35:                  277\u2013291.","DOI":"10.1002\/tox.22865"},{"key":"58","doi-asserted-by":"crossref","unstructured":"58.  Wang                     X,                        Ding                     J,                        Xiang                     Z,                        Jiang                     P, Du                     J,                        Han                     X.                  Microcystin-LR causes sexual hormone disturbance in male rat by                  targeting gonadotropin-releasing hormone neurons.                     <i>Toxicon<\/i>               2016; 123:               45\u201355.","DOI":"10.1016\/j.toxicon.2016.10.011"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59.  Zhou                     Y,                        Yuan                     J, Wu                     J,                        Han                     X. The                  toxic effects of microcystin-LR on rat spermatogonia in vitro.                     <i>Toxicol Lett<\/i>               2012; 212:               48\u201356.","DOI":"10.1016\/j.toxlet.2012.05.001"},{"key":"60","doi-asserted-by":"crossref","unstructured":"60.  Huang                     H,                        Liu                     C, Fu                     X,                        Zhang                     S,                        Xin                     Y, Li                     Y,                        Xue                     L,                        Cheng                     X,                        Zhang                     H.                  Microcystin-LR induced apoptosis in rat sertoli cells via the                  mitochondrial caspase-dependent pathway: role of reactive oxygen                  species. <i>Front Physiol<\/i>               2016; 7: 397.","DOI":"10.3389\/fphys.2016.00397"},{"key":"61","doi-asserted-by":"crossref","unstructured":"61.  Chen                     L,                        Xie                     P.                  Mechanisms of microcystin-induced cytotoxicity and                  apoptosis. <i>Mini Rev Med Chem<\/i>               2016; 16:                  1018\u20131031.","DOI":"10.2174\/1389557516666160219130407"},{"key":"62","doi-asserted-by":"crossref","unstructured":"62.  Campos                     A,                        Vasconcelos                     V.                  Molecular mechanisms of microcystin toxicity in animal                  cells. <i>Int J Mol Sci<\/i>               2010; 11:                  268\u2013287.","DOI":"10.3390\/ijms11010268"},{"key":"63","doi-asserted-by":"crossref","unstructured":"63.  Zhou                     M, Tu                     WW,                        Xu                     J.                  Mechanisms of microcystin-LR-induced cytoskeletal disruption in                  animal cells. <i>Toxicon<\/i>               2015; 101:                  92\u2013100.","DOI":"10.1016\/j.toxicon.2015.05.005"},{"key":"64","doi-asserted-by":"crossref","unstructured":"64.  Nasa                     I,                        Kettenbach                     AN.                  Coordination of protein kinase and phosphoprotein phosphatase                  activities in mitosis. <i>Front Cell Dev                     Biol<\/i>               2018; 6: 30.","DOI":"10.3389\/fcell.2018.00030"},{"key":"65","doi-asserted-by":"crossref","unstructured":"65.  Toivola                     DM,                        Eriksson                     JE,                        Brautigan                     DL.                  Identification of protein phosphatase 2A as the primary target for                  microcystin-LR in rat liver homogenates. <i>FEBS                     Lett<\/i>               1994; 344:                  175\u2013180.","DOI":"10.1016\/0014-5793(94)00382-3"},{"key":"66","doi-asserted-by":"crossref","unstructured":"66.  Goldberg                     J,                        Huang                     HB,                        Kwon                     YG,                        Greengard                     P,                        Nairn                     AC,                        Kuriyan                     J.                  Three-dimensional structure of the catalytic subunit of protein                  serine\/threonine phosphatase-1. <i>Nature<\/i>               1995; 376:                  745\u2013753.","DOI":"10.1038\/376745a0"},{"key":"67","doi-asserted-by":"crossref","unstructured":"67.  Xing                     Y, Xu                     Y,                        Chen                     Y,                        Jeffrey                     PD,                        Chao                     Y,                        Lin                     Z, Li                     Z,                        Strack                     S,                        Stock                     JB,                        Shi                     Y.                  Structure of protein phosphatase 2A core enzyme bound to                  tumor-inducing toxins. <i>Cell<\/i>               2006; 127:                  341\u2013353.","DOI":"10.1016\/j.cell.2006.09.025"},{"key":"68","doi-asserted-by":"crossref","unstructured":"68.  Meng                     G,                        Sun                     Y, Fu                     W,                        Guo                     Z, Xu                     L.                  Microcystin-LR induces cytoskeleton system reorganization through                  hyperphosphorylation of tau and HSP27 via PP2A inhibition and subsequent                  activation of the p38 MAPK signaling pathway in neuroendocrine (PC12)                  cells. <i>Toxicology<\/i>               2011; 290:                  218\u2013229.","DOI":"10.1016\/j.tox.2011.09.085"},{"key":"69","doi-asserted-by":"crossref","unstructured":"69.  Yang                     F,                        Wen                     C,                        Zheng                     S,                        Yang                     S,                        Chen                     J,                        Feng                     X.                  Involvement of MAPK\/ERK1\/2 pathway in microcystin-induced                  microfilament reorganization in HL7702 hepatocytes.                     <i>J Toxicol Environ Health A<\/i>               2018; 81:                  1135\u20131141.","DOI":"10.1080\/15287394.2018.1532715"},{"key":"70","doi-asserted-by":"crossref","unstructured":"70.  Christen                     V,                        Meili                     N,                        Fent                     K.                  Microcystin-LR induces endoplasmatic reticulum stress and leads to                  induction of NF\u03baB, interferon-alpha, and tumor necrosis                  factor-alpha. <i>Environ Sci Technol<\/i>               2013; 47:                  3378\u20133385.","DOI":"10.1021\/es304886y"},{"key":"71","doi-asserted-by":"crossref","unstructured":"71.  Kwon                     YG,                        Lee                     SY,                        Choi                     Y,                        Greengard                     P,                        Nairn                     AC.                  Cell cycle-dependent phosphorylation of mammalian protein                  phosphatase 1 by cdc2 kinase. <i>Proc Natl Acad Sci                     USA<\/i>               1997; 94:                  2168\u20132173.","DOI":"10.1073\/pnas.94.6.2168"},{"key":"72","doi-asserted-by":"crossref","unstructured":"72.  Vagnarelli                     P,                        Ribeiro                     S,                        Sennels                     L,                        Sanchez-Pulido                     L, de Lima                        Alves                     F,                        Verheyen                     T,                        Kelly                     DA,                        Ponting                     CP,                        Rappsilber                     J,                        Earnshaw                     WC.                  Repo-Man coordinates chromosomal reorganization with nuclear                  envelope reassembly during mitotic exit. <i>Dev                     Cell<\/i>               2011; 21:                  328\u2013342.","DOI":"10.1016\/j.devcel.2011.06.020"},{"key":"73","doi-asserted-by":"crossref","unstructured":"73.  Mochida                     S.                  Regulation of \u03b1-endosulfine, an inhibitor of protein phosphatase                  2A, by multisite phosphorylation. <i>FEBS J<\/i>               2014; 281:                  1159\u20131169.","DOI":"10.1111\/febs.12685"},{"key":"74","doi-asserted-by":"crossref","unstructured":"74.  Lorca                     T,                        Castro                     A. The                  Greatwall kinase: a new pathway in the control of the cell cycle.                     <i>Oncogene<\/i>               2013; 32:                  537\u2013543.","DOI":"10.1038\/onc.2012.79"},{"key":"75","doi-asserted-by":"crossref","unstructured":"75.  Li                     DW,                        Liu                     JP,                        Schmid                     PC,                        Schlosser                     R,                        Feng                     H,                        Liu                     WB,                        Yan                     Q,                        Gong                     L,                        Sun                     SM,                        Deng                     M,                        Liu                     Y.                  Protein serine\/threonine phosphatase-1 dephosphorylates p53 at                  Ser-15 and Ser-37 to modulate its transcriptional and apoptotic                  activities. <i>Oncogene<\/i>               2006; 25:                  3006\u20133022.","DOI":"10.1038\/sj.onc.1209334"},{"key":"76","doi-asserted-by":"crossref","unstructured":"76.  Chen                     BY,                        Huang                     CH,                        Lin                     YH,                        Huang                     CC,                        Deng                     CX,                        Hsu                     LC. The                  K898E germline variant in the PP1-binding motif of BRCA1 causes defects in DNA                  Repair. <i>Sci Rep<\/i>               2014; 4: 5812.","DOI":"10.1038\/srep05812"},{"key":"77","doi-asserted-by":"crossref","unstructured":"77.  Goodarzi                     AA,                        Jonnalagadda                     JC,                        Douglas                     P,                        Young                     D, Ye                     R,                        Moorhead                     GB,                        Lees-Miller                     SP,                        Khanna                     KK.                  Autophosphorylation of ataxia-telangiectasia mutated is regulated                  by protein phosphatase 2A. <i>EMBO J<\/i>               2004; 23:                  4451\u20134461.","DOI":"10.1038\/sj.emboj.7600455"},{"key":"78","doi-asserted-by":"crossref","unstructured":"78.  Pflugmacher                     S,                        Wiegand                     C,                        Oberemm                     A,                        Beattie                     KA,                        Krause                     E,                        Codd                     GA,                        Steinberg                     CE.                  Identification of an enzymatically formed glutathione conjugate of                  the cyanobacterial hepatotoxin microcystin-LR: the first step of                  detoxication. <i>Biochim Biophys Acta<\/i>               1998; 1425:                  527\u2013533.","DOI":"10.1016\/S0304-4165(98)00107-X"},{"key":"79","doi-asserted-by":"crossref","unstructured":"79.  Guo                     X,                        Chen                     L,                        Chen                     J,                        Xie                     P, Li                     S, He                     J, Li                     W,                        Fan                     H, Yu                     D,                        Zeng                     C.                  Quantitatively evaluating detoxification of the hepatotoxic                  microcystin-LR through the glutathione (GSH) pathway in SD rats.                     <i>Environ Sci Pollut Res Int<\/i>               2015; 22:                  19273\u201319284.","DOI":"10.1007\/s11356-015-5531-2"},{"key":"80","doi-asserted-by":"crossref","unstructured":"80.  Chen                     L, Li                     S,                        Guo                     X,                        Xie                     P,                        Chen                     J. The                  role of GSH in microcystin-induced apoptosis in rat liver: Involvement of                  oxidative stress and NF-\u03baB. <i>Environ                     Toxicol<\/i>               2016; 31:                  552\u2013560.","DOI":"10.1002\/tox.22068"},{"key":"81","doi-asserted-by":"crossref","unstructured":"81.  Venditti                     P, Di                        Stefano                     L, Di                        Meo                     S.                  Mitochondrial metabolism of reactive oxygen               species. <i>Mitochondrion<\/i>               2013; 13: 71\u201382.","DOI":"10.1016\/j.mito.2013.01.008"},{"key":"82","doi-asserted-by":"crossref","unstructured":"82.  Murphy                     MP. How                  mitochondria produce reactive oxygen species.                     <i>Biochem J<\/i>               2009; 417: 1\u201313.","DOI":"10.1042\/BJ20081386"},{"key":"83","unstructured":"83.  Guo                     C,                        Sun                     L,                        Chen                     X,                        Zhang                     D.                  Oxidative stress, mitochondrial damage and neurodegenerative                  diseases. <i>Neural Regen Res<\/i>               2013; 8:                  2003\u20132014."},{"key":"84","doi-asserted-by":"crossref","unstructured":"84.  Ding                     WX,                        Shen                     HM,                        Ong                     CN.                  Critical role of reactive oxygen species and mitochondrial                  permeability transition in microcystin-induced rapid apoptosis in rat                  hepatocytes. <i>Hepatology<\/i>               2000; 32:                  547\u2013555.","DOI":"10.1053\/jhep.2000.16183"},{"key":"85","doi-asserted-by":"crossref","unstructured":"85.  Weng                     D, Lu                     Y,                        Wei                     Y,                        Liu                     Y,                        Shen                     P. The                  role of ROS in microcystin-LR-induced hepatocyte apoptosis and liver injury in                  mice. <i>Toxicology<\/i>               2007; 232:               15\u201323.","DOI":"10.1016\/j.tox.2006.12.010"},{"key":"86","doi-asserted-by":"crossref","unstructured":"86.  Shi                     Y,                        Jiang                     J,                        Shan                     Z, Bu                     Y,                        Deng                     Z,                        Cheng                     Y.                  Oxidative stress and histopathological alterations in liver of                  Cyprinus carpio L. induced by intraperitoneal injection of                  microcystin-LR. <i>Ecotoxicology<\/i>               2015; 24:                  511\u2013519.","DOI":"10.1007\/s10646-014-1399-z"},{"key":"87","doi-asserted-by":"crossref","unstructured":"87.  Wickstrom                     ML,                        Khan                     SA,                        Haschek                     WM,                        Wyman                     JF,                        Eriksson                     JE,                        Schaeffer                     DJ,                        Beasley                     VR.                  Alterations in microtubules, intermediate filaments, and                  microfilaments induced by microcystin-LR in cultured cells.                     <i>Toxicol Pathol<\/i>               1995; 23:                  326\u2013337.","DOI":"10.1177\/019262339502300309"},{"key":"88","doi-asserted-by":"crossref","unstructured":"88.  Chen                     DN,                        Zeng                     J,                        Wang                     F,                        Zheng                     W, Tu                     WW,                        Zhao                     JS,                        Xu                     J.                  Hyperphosphorylation of intermediate filament proteins is involved                  in microcystin-LR-induced toxicity in HL7702 cells.                     <i>Toxicol Lett<\/i>               2012; 214:                  192\u2013199.","DOI":"10.1016\/j.toxlet.2012.08.024"},{"key":"89","doi-asserted-by":"crossref","unstructured":"89.  Huang                     X,                        Chen                     L,                        Liu                     W,                        Qiao                     Q, Wu                     K,                        Wen                     J,                        Huang                     C,                        Tang                     R,                        Zhang                     X.                  Involvement of oxidative stress and cytoskeletal disruption in                  microcystin-induced apoptosis in CIK cells. <i>Aquat                     Toxicol<\/i>               2015; 165:               41\u201350.","DOI":"10.1016\/j.aquatox.2015.05.009"},{"key":"90","doi-asserted-by":"crossref","unstructured":"90.  Wang                     Q,                        Chen                     G,                        Zhang                     Q,                        Wang                     M,                        Wang                     G, Hu                     T.                  Microcystin-leucine arginine blocks vasculogenesis and angiogenesis                  through impairing cytoskeleton and impeding endothelial cell migration by                  downregulating integrin-mediated Rho\/ROCK signaling pathway.                     <i>Environ Sci Pollut Res Int<\/i>               2021; 28:                  67108\u201367119.","DOI":"10.1007\/s11356-021-15337-9"},{"key":"91","doi-asserted-by":"crossref","unstructured":"91.  Chen                     L,                        Zhang                     X,                        Zhou                     W,                        Qiao                     Q,                        Liang                     H, Li                     G,                        Wang                     J,                        Cai                     F. The                  interactive effects of cytoskeleton disruption and mitochondria dysfunction lead                  to reproductive toxicity induced by microcystin-LR.                     <i>PLoS One<\/i>               2013; 8: e53949.","DOI":"10.1371\/journal.pone.0053949"},{"key":"92","doi-asserted-by":"crossref","unstructured":"92.  Zhang                     X,                        Zhou                     C, Li                     W, Li                     J, Wu                     W,                        Tao                     J,                        Liu                     H.                  Vitamin C protects porcine oocytes from microcystin-LR toxicity                  during maturation. <i>Front Cell Dev Biol<\/i>               2020; 8: 582715.","DOI":"10.3389\/fcell.2020.582715"},{"key":"93","doi-asserted-by":"crossref","unstructured":"93.  Jiang                     J,                        Shan                     Z, Xu                     W,                        Wang                     X,                        Zhou                     J,                        Kong                     D, Xu                     J.                  Microcystin-LR induced reactive oxygen species mediate cytoskeletal                  disruption and apoptosis of hepatocytes in Cyprinus carpio L.                     <i>PLoS One<\/i>               2013; 8: e84768.","DOI":"10.1371\/journal.pone.0084768"},{"key":"94","doi-asserted-by":"crossref","unstructured":"94.  Galluzzi                     L,                        Vitale                     I,                        Aaronson                           SA, et al. Molecular mechanisms of cell death: recommendations of the                  Nomenclature Committee on Cell Death 2018. <i>Cell                     Death Differ<\/i>               2018; 25:                  486\u2013541.","DOI":"10.1038\/s41418-018-0102-y"},{"key":"95","doi-asserted-by":"crossref","unstructured":"95.  Zegura                     B,                        Volcic                     M,                        Lah                     TT,                        Filipic                     M.                  Different sensitivities of human colon adenocarcinoma (CaCo-2),                  astrocytoma (IPDDC-A2) and lymphoblastoid (NCNC) cell lines to microcystin-LR                  induced reactive oxygen species and DNA damage.                     <i>Toxicon<\/i>               2008; 52:                  518\u2013525.","DOI":"10.1016\/j.toxicon.2008.06.026"},{"key":"96","doi-asserted-by":"crossref","unstructured":"96.  Dias                     E,                        Matos                     P,                        Pereira                     P,                        Bator\u00e9u                     MC,                        Silva                     MJ,                        Jordan                     P.                  Microcystin-LR activates the ERK1\/2 kinases and stimulates the                  proliferation of the monkey kidney-derived cell line Vero-E6.                     <i>Toxicol In Vitro<\/i>               2010; 24:                  1689\u20131695.","DOI":"10.1016\/j.tiv.2010.05.018"},{"key":"97","doi-asserted-by":"crossref","unstructured":"97.  Dias                     E,                        Andrade                     M,                        Alverca                     E,                        Pereira                     P,                        Bator\u00e9u                     MC,                        Jordan                     P,                        Silva                     MJ.                  Comparative study of the cytotoxic effect of microcistin-LR and                  purified extracts from Microcystis aeruginosa on a kidney cell                  line. <i>Toxicon<\/i>               2009; 53:                  487\u2013495.","DOI":"10.1016\/j.toxicon.2009.01.029"},{"key":"98","doi-asserted-by":"crossref","unstructured":"98.  Alverca                     E,                        Andrade                     M,                        Dias                     E, Sam                        Bento                     F,                        Bator\u00e9u                     MC,                        Jordan                     P,                        Silva                     MJ,                        Pereira                     P.                  Morphological and ultrastructural effects of microcystin-LR from                  Microcystis aeruginosa extract on a kidney cell line.                     <i>Toxicon<\/i>               2009; 54:                  283\u2013294.","DOI":"10.1016\/j.toxicon.2009.04.014"},{"key":"99","doi-asserted-by":"crossref","unstructured":"99.  Li                     Y, Li                     J,                        Huang                     H,                        Yang                     M,                        Zhuang                     D,                        Cheng                     X,                        Zhang                     H, Fu                     X.                  Microcystin-LR induces mitochondria-mediated apoptosis in human                  bronchial epithelial cells. <i>Exp Ther Med<\/i>               2016; 12:                  633\u2013640.","DOI":"10.3892\/etm.2016.3423"},{"key":"100","doi-asserted-by":"crossref","unstructured":"100.  Ji                     Y, Lu                     G,                        Chen                     G,                        Huang                     B,                        Zhang                     X,                        Shen                     K, Wu                     S.                  Microcystin-LR induces apoptosis via NF-\u03baB\/iNOS pathway in INS-1                  cells. <i>Int J Mol Sci<\/i>               2011; 12:                  4722\u20134734.","DOI":"10.3390\/ijms12074722"},{"key":"101","doi-asserted-by":"crossref","unstructured":"101.  Piyathilaka                     MA,                        Pathmalal                     MM,                        Tennekoon                     KH, De                        Silva                     BG,                        Samarakoon                     SR,                        Chanthirika                     S.                  Microcystin-LR-induced cytotoxicity and apoptosis in human                  embryonic kidney and human kidney adenocarcinoma cell lines.                     <i>Microbiology (Reading)<\/i>               2015; 161:                  819\u2013828.","DOI":"10.1099\/mic.0.000046"},{"key":"102","doi-asserted-by":"crossref","unstructured":"102.  Chen                     T,                        Wang                     Q,                        Cui                     J,                        Yang                     W,                        Shi                     Q,                        Hua                     Z, Ji                     J,                        Shen                     P.                  Induction of apoptosis in mouse liver by microcystin-LR: a combined                  transcriptomic, proteomic, and simulation strategy.                     <i>Mol Cell Proteomics<\/i>               2005; 4:               958\u2013974.","DOI":"10.1074\/mcp.M400185-MCP200"},{"key":"103","doi-asserted-by":"crossref","unstructured":"103.  Denton                     D,                        Kumar                     S.                  Autophagy-dependent cell death.                     <i>Cell Death Differ<\/i>               2019; 26:                  605\u2013616.","DOI":"10.1038\/s41418-018-0252-y"},{"key":"104","doi-asserted-by":"crossref","unstructured":"104.  Yang                     Y,                        Wen                     C,                        Zheng                     S,                        Liu                     W,                        Chen                     J,                        Feng                     X,                        Wang                     X,                        Yang                     F,                        Ding                     Z.                  Influence of microcystins-LR (MC-LR) on autophagy in human                  neuroblastoma SK-N-SH cells. <i>J Toxicol Environ                     Health A<\/i>               2019; 82:                  1129\u20131136.","DOI":"10.1080\/15287394.2019.1699732"},{"key":"105","doi-asserted-by":"crossref","unstructured":"105.  Liu                     H,                        Zhang                     X,                        Zhang                     S,                        Huang                     H, Wu                     J,                        Wang                     Y,                        Yuan                     L,                        Liu                     C,                        Zeng                     X,                        Cheng                     X,                        Zhuang                     D,                        Zhang                     H.                  Oxidative stress mediates microcystin-lr-induced endoplasmic                  reticulum stress and autophagy in KK-1 cells and C57BL\/6 mice                  ovaries. <i>Front Physiol<\/i>               2018; 9: 1058.","DOI":"10.3389\/fphys.2018.01058"},{"key":"106","doi-asserted-by":"crossref","unstructured":"106.  Chen                     Y,                        Zhou                     Y,                        Wang                     X,                        Qian                     W,                        Han                     X.                  Microcystin-LR induces autophagy and apoptosis in rat Sertoli cells                  in vitro. <i>Toxicon<\/i>               2013; 76: 84\u201393.","DOI":"10.1016\/j.toxicon.2013.09.005"},{"key":"107","doi-asserted-by":"crossref","unstructured":"107.  Zhang                     S,                        Liu                     C, Li                     Y,                        Imam                     MU,                        Huang                     H,                        Liu                     H,                        Xin                     Y,                        Zhang                     H.                  Novel role of ER stress and autophagy in microcystin-LR induced                  apoptosis in chinese hamster ovary cells. <i>Front                     Physiol<\/i>               2016; 7: 527.","DOI":"10.3389\/fphys.2016.00527"},{"key":"108","doi-asserted-by":"crossref","unstructured":"108.  Woolbright                     BL,                        Williams                     CD,                        Ni                     H,                        Kumer                     SC,                        Schmitt                     T,                        Kane                     B,                        Jaeschke                     H.                  Microcystin-LR induced liver injury in mice and in primary human                  hepatocytes is caused by oncotic necrosis.                     <i>Toxicon<\/i>               2017; 125:                  99\u2013109.","DOI":"10.1016\/j.toxicon.2016.11.254"},{"key":"109","doi-asserted-by":"crossref","unstructured":"109.  Du                     X,                        Liu                     H,                        Liu                     X,                        Chen                     X,                        Yuan                     L, Ma                     Y,                        Huang                     H,                        Wang                     Y,                        Wang                     R,                        Zhang                     S,                        Tian                     Z,                        Shi                     L,                        Zhang                     H.                  Microcystin-LR induces ovarian injury and apoptosis in mice via                  activating apoptosis signal-regulating kinase 1-mediated P38\/JNK                  pathway. <i>Ecotoxicol Environ Saf<\/i>               2021; 213: 112066.","DOI":"10.1016\/j.ecoenv.2021.112066"},{"key":"110","doi-asserted-by":"crossref","unstructured":"110.  Wang                     Y,                        Pattarawat                     P,                        Zhang                     J,                        Kim                     E,                        Zhang                     D,                        Fang                     M,                        Jannaman                     EA,                        Yuan                     Y,                        Chatterjee                     S,                        Kim                     JJ,                        Scott                     GI,                        Zhang                     Q,                        Xiao                     S.                  Effects of cyanobacterial harmful algal bloom toxin microcystin-LR                  on gonadotropin-dependent ovarian follicle maturation and ovulation in                  mice. <i>Environ Health Perspect<\/i>               2023; 131: 67010.","DOI":"10.1289\/EHP12034"},{"key":"111","doi-asserted-by":"crossref","unstructured":"111.  Wu                     J,                        Shao                     S,                        Zhou                     F,                        Wen                     S,                        Chen                     F,                        Han                     X.                  Reproductive toxicity on female mice induced by                  microcystin-LR. <i>Environ Toxicol Pharmacol<\/i>               2014; 37: 1\u20136.","DOI":"10.1016\/j.etap.2013.10.012"},{"key":"112","doi-asserted-by":"crossref","unstructured":"112.  Yuan                     J, Li                     X,                        Yan                     S,                        Luo                     C,                        Xian                     S, Li                     Y, Wu                     J.                  Microcystin-LR disrupts ovarian granulosa cell glycolysis via                  GSK3\u03b2-Mediated HK2 mitochondrial dissociation: Evidence from integrated In Vivo                  and In Vitro models. <i>Reprod Toxicol<\/i>               2025; 137: 109028.","DOI":"10.1016\/j.reprotox.2025.109028"},{"key":"113","doi-asserted-by":"crossref","unstructured":"113.  Dos Santos                     FCF,                        Lima                     GFC,                        Merlo                     E,                        Januario                     CF,                        Miranda-Alves                     L,                        Miranda                     RA,                        Lisboa                     PC,                        Graceli                     JB.                  Single microcystin exposure impairs the                  hypothalamic-pituitary-gonadal axis at different levels in female                  rats. <i>Mol Cell Endocrinol<\/i>               2024; 586: 112203.","DOI":"10.1016\/j.mce.2024.112203"},{"key":"114","doi-asserted-by":"crossref","unstructured":"114.  Du                     X,                        Liu                     J,                        Wang                     X,                        Chen                     X,                        Mao                     Z, Yu                     F,                        Wang                     P, Wu                     C,                        Guo                     H,                        Zhang                     H.                  Environmentally related microcystin-LR-induced ovarian dysfunction                  via the CCL2-CCR10 axis in mice ameliorated by dietary mulberry.                     <i>Environ Pollut<\/i>               2024; 349: 123929.","DOI":"10.1016\/j.envpol.2024.123929"},{"key":"115","doi-asserted-by":"crossref","unstructured":"115.  Wu                     J,                        Yuan                     M,                        Song                     Y,                        Sun                     F,                        Han                     X.                  MC-LR exposure leads to subfertility of female mice and induces                  oxidative stress in granulosa cells. <i>Toxins                     (Basel)<\/i>               2015; 7:                  5212\u20135223.","DOI":"10.3390\/toxins7124872"},{"key":"116","doi-asserted-by":"crossref","unstructured":"116.  Du                     X, Fu                     Y,                        Tian                     Z,                        Liu                     H,                        Xin                     H, Fu                     X,                        Wang                     F,                        Zhang                     H,                        Zeng                     X.                  Microcystin-LR accelerates follicular atresia in mice via                  JNK-mediated adherent junction damage of ovarian granulosa cells.                     <i>Ecotoxicol Environ Saf<\/i>               2023; 252: 114592.","DOI":"10.1016\/j.ecoenv.2023.114592"},{"key":"117","doi-asserted-by":"crossref","unstructured":"117.  Selman                     K,                        Wallace                     RA,                        Sarka                     A, Qi                     X.                  Stages of oocyte development in the zebrafish, Brachydanio                  rerio. <i>J Morphol<\/i>               1993; 218:                  203\u2013224.","DOI":"10.1002\/jmor.1052180209"},{"key":"118","doi-asserted-by":"crossref","unstructured":"118.  Liu                     H,                        Yang                     Q, Li                     G,                        Hung                     T-C,                        Zuo                     J,                        Luan                     N,                        Liu                     X, Wu                     Q.                  Probiotic Lactobacillus rhamnosus modulates MCLR-induced oogenesis                  disorders in zebrafish: Evidence from the transcriptome.                     <i>Sci Total Environ<\/i>               2024; 951: 175532.","DOI":"10.1016\/j.scitotenv.2024.175532"},{"key":"119","doi-asserted-by":"crossref","unstructured":"119.  Zhan                     C,                        Zhang                     F,                        Liu                     W,                        Zhang                     X.                  Microcystin-LR promotes zebrafish (Danio rerio) oocyte (in\u00a0vivo)                  maturation by activating ERK1\/2-MPF signaling pathways, and cAMP is involved in                  this process. <i>Environ Pollut<\/i>               2020; 259: 113843.","DOI":"10.1016\/j.envpol.2019.113843"},{"key":"120","doi-asserted-by":"crossref","unstructured":"120.  Trinchet                     I,                        Djediat                     C,                        Huet                     H,                        Dao                     SP,                        Edery                     M.                  Pathological modifications following sub-chronic exposure of medaka                  fish (Oryzias latipes) to microcystin-LR. <i>Reprod                     Toxicol<\/i>               2011; 32:                  329\u2013340.","DOI":"10.1016\/j.reprotox.2011.07.006"},{"key":"121","doi-asserted-by":"crossref","unstructured":"121.  Liu                     W,                        Zhan                     C,                        Zhang                     T,                        Zhang                     X.                  Microcystin-LR influences the in vitro oocyte maturation of                  zebrafish by activating the MAPK pathway. <i>Aquat                     Toxicol<\/i>               2019; 215: 105261.","DOI":"10.1016\/j.aquatox.2019.105261"},{"key":"122","doi-asserted-by":"crossref","unstructured":"122.  Li                     H,                        Kang                     S, Gu                     X,                        Yang                     H,                        Chen                     H,                        Mao                     Z,                        Zeng                     Q,                        Chen                     Y,                        Wang                     W,                        Gong                     C. The                  toxicological effects of life-cycle exposure to harmful benthic cyanobacteria                  Oscillatoria on zebrafish growth and reproduction: A comparative study with                  planktonic Microcystis. <i>Sci Total Environ<\/i>               2024; 912: 169302.","DOI":"10.1016\/j.scitotenv.2023.169302"},{"key":"123","doi-asserted-by":"crossref","unstructured":"123.  Zhang                     H,                        Ruan                     Y,                        Ding                     Z, Li                     Z, He                     J, Li                     J,                        Hong                     P, Wu                     H,                        Shu                     Y. The                  accumulation of Microcystin-LR in the gonads of Pelophylax nigromaculatus during                  the reproductive periods induces reproductive endocrine disorders in their                  offspring. <i>Ecotoxicol Environ Saf<\/i>               2025; 294: 118088.","DOI":"10.1016\/j.ecoenv.2025.118088"},{"key":"124","doi-asserted-by":"crossref","unstructured":"124.  Zhang                     H, Wu                     J,                        Fang                     N,                        Zhang                     S, Su                     X,                        Jiang                     H,                        Hong                     P, Wu                     H,                        Shu                     Y.                  Waterborne exposure to microcystin-leucine arginine induces                  endocrine disruption and gonadal dysplasia of Pelophylax nigromaculatus tadpoles                  via the hypothalamic-pituitary-gonadal-liver axis.                     <i>Sci Total Environ<\/i>               2024; 906: 167644.","DOI":"10.1016\/j.scitotenv.2023.167644"},{"key":"125","doi-asserted-by":"crossref","unstructured":"125.  Hou                     J, Li                     L,                        Xue                     T,                        Long                     M, Su                     Y, Wu                     N.                  Damage and recovery of the ovary in female zebrafish i.p.-injected                  with MC-LR. <i>Aquat Toxicol<\/i>               2014; 155:                  110\u2013118.","DOI":"10.1016\/j.aquatox.2014.06.010"},{"key":"126","doi-asserted-by":"crossref","unstructured":"126.  Shi                     F, Li                     W,                        Zhao                     H, He                     Y,                        Jiang                     Y, Ni                     J,                        Abbasi                     B,                        Rui                     R, Ju                     S.                  Microcystin-LR exposure results in aberrant spindles and induces                  apoptosis in porcine oocytes.                     <i>Theriogenology<\/i>               2020; 158:                  358\u2013367.","DOI":"10.1016\/j.theriogenology.2020.09.031"},{"key":"127","doi-asserted-by":"crossref","unstructured":"127.  Liu                     H,                        Tian                     Z,                        Guo                     Y,                        Liu                     X, Ma                     Y, Du                     X,                        Wang                     R,                        Zhang                     S,                        Shi                     L,                        Guo                     H,                        Zhang                     H.                  Microcystin-leucine arginine exposure contributes to apoptosis and                  follicular atresia in mice ovaries by endoplasmic reticulum stress-upregulated                  Ddit3. <i>Sci Total Environ<\/i>               2021; 756: 144070.","DOI":"10.1016\/j.scitotenv.2020.144070"},{"key":"128","doi-asserted-by":"crossref","unstructured":"128.  Wei                     L, Fu                     J, He                     L,                        Wang                     H,                        Ruan                     J, Li                     F, Wu                     H.                  Microcystin-LR-induced autophagy regulates oxidative stress,                  inflammation, and apoptosis in grass carp ovary cells in vitro.                     <i>Toxicol In Vitro<\/i>               2023; 87: 105520.","DOI":"10.1016\/j.tiv.2022.105520"},{"key":"129","doi-asserted-by":"crossref","unstructured":"129.  Ma                     Y,                        Liu                     H, Du                     X,                        Petlulu                     P,                        Chen                     X,                        Wang                     R,                        Zhang                     S,                        Tian                     Z,                        Shi                     L,                        Guo                     H,                        Zhang                     H. IRE1                  and CaMKK\u03b2 pathways to reveal the mechanism involved in microcystin-LR-induced                  autophagy in mouse ovarian cells. <i>Food Chem                     Toxicol<\/i>               2021; 147: 111911.","DOI":"10.1016\/j.fct.2020.111911"},{"key":"130","doi-asserted-by":"crossref","unstructured":"130.  G\u00e1csi                     M,                        Antal                     O,                        Vasas                     G,                        M\u00e1th\u00e9                     C,                        Borb\u00e9ly                     G,                        Saker                     ML,                        Gyori                     J,                        Farkas                     A,                        Vehovszky                     A,                        B\u00e1nfalvi                     G.                  Comparative study of cyanotoxins affecting cytoskeletal and                  chromatin structures in CHO-K1 cells. <i>Toxicol In                     Vitro<\/i>               2009; 23:                  710\u2013718.","DOI":"10.1016\/j.tiv.2009.02.006"},{"key":"131","doi-asserted-by":"crossref","unstructured":"131.  Kawan                     A,                        Zhang                     T,                        Liu                     W,                        Mukhtar                     H,                        Zhan                     C,                        Zhang                     X.                  Recovery of reproductive function of female zebrafish from the                  toxic effects of microcystin-LR exposure. <i>Aquat                     Toxicol<\/i>               2019; 214: 105240.","DOI":"10.1016\/j.aquatox.2019.105240"},{"key":"132","doi-asserted-by":"crossref","unstructured":"132.  Jacquet                     C,                        Thermes                     V, de                        Luze                     A,                        Puiseux-Dao                     S,                        Bernard                     C,                        Joly                     JS,                        Bourrat                     F,                        Edery                     M.                  Effects of microcystin-LR on development of medaka fish embryos                  (Oryzias latipes). <i>Toxicon<\/i>               2004; 43:                  141\u2013147.","DOI":"10.1016\/j.toxicon.2003.11.010"},{"key":"133","doi-asserted-by":"crossref","unstructured":"133.  Oberemm                     A,                        Fastner                     J,                        Steinberg                     CE.                  Effects of microcystin-LR and cyanobacterial crude extracts on                  embryo-larval development of zebrafish (Danio rerio).                     <i>Water Res<\/i>               1997; 31:                  2918\u20132921.","DOI":"10.1016\/S0043-1354(97)00120-6"},{"key":"134","doi-asserted-by":"crossref","unstructured":"134.  Yan                     P,                        Guo                     M,                        Gan                     Y,                        Zhu                     M,                        Han                     X, Wu                     J.                  Early pregnancy exposure to Microcystin-LR compromises endometrial                  decidualization in mice via the PI3K\/AKT\/FOXO1 signaling pathway.                     <i>Chemosphere<\/i>               2024; 366: 143466.","DOI":"10.1016\/j.chemosphere.2024.143466"},{"key":"135","doi-asserted-by":"crossref","unstructured":"135.  Zhao                     S,                        Zhong                     S,                        Wang                     F,                        Wang                     H, Xu                     D, Li                     G.                  Microcystin-LR exposure decreased the fetal weight of mice by                  disturbance of placental development and ROS-mediated endoplasmic reticulum stress                  in the placenta. <i>Environ Pollut<\/i>               2020; 256: 113362.","DOI":"10.1016\/j.envpol.2019.113362"},{"key":"136","doi-asserted-by":"crossref","unstructured":"136.  Gao                     L,                        Cui                     AQ,                        Wang                     J,                        Chen                     J,                        Zhang                     XY,                        Lin                     ZJ,                        Chen                     YH,                        Zhang                     C,                        Wang                     H, Xu                     DX.                  Paternal exposure to microcystin-LR induces fetal growth                  restriction partially through inhibiting cell proliferation and vascular                  development in placental labyrinth. <i>Environ Sci                     Pollut Res Int<\/i>               2021; 28:                  60032\u201360040.","DOI":"10.1007\/s11356-021-14725-5"},{"key":"137","doi-asserted-by":"crossref","unstructured":"137.  Douglas                     GC,                        Thirkill                     TL,                        Kumar                     P,                        Loi                     M,                        Hilborn                     ED.                  Effect of microcystin-LR on human placental villous trophoblast                  differentiation in vitro. <i>Environ Toxicol<\/i>               2016; 31:                  427\u2013439.","DOI":"10.1002\/tox.22056"},{"key":"138","doi-asserted-by":"crossref","unstructured":"138.  Lin                     Y, An                     R, Wu                     C,                        Liu                     H,                        Deng                     J,                        Tan                     H,                        Chen                     L,                        Chen                     M, Ma                     S.                  Serum microcystin-LR levels and risk of gestational diabetes                  mellitus: A Chinese nested case-control study.                     <i>Front Endocrinol (Lausanne)<\/i>               2023; 13: 1047866.","DOI":"10.3389\/fendo.2022.1047866"},{"key":"139","doi-asserted-by":"crossref","unstructured":"139.  Chan                     KA,                        Tsoulis                     MW,                        Sloboda                     DM.                  Early-life nutritional effects on the female reproductive                  system. <i>J Endocrinol<\/i>               2015; 224:                  R45\u2013R62.","DOI":"10.1530\/JOE-14-0469"},{"key":"140","doi-asserted-by":"crossref","unstructured":"140.  Lin                     W,                        Guo                     H,                        Wang                     L,                        Zhang                     D, Wu                     X, Li                     L,                        Qiu                     Y,                        Yang                     L, Li                     D,                        Tang                     R.                  Parental transfer of microcystin-LR-induced innate immune                  dysfunction of zebrafish: a cross-generational study.                     <i>Environ Sci Technol<\/i>               2020; 54:                  1014\u20131023.","DOI":"10.1021\/acs.est.9b04953"},{"key":"141","doi-asserted-by":"crossref","unstructured":"141.  Zhan                     C,                        Liu                     W,                        Zhang                     F,                        Zhang                     X.                  Microcystin-LR triggers different endoplasmic reticulum stress                  pathways in the liver, ovary, and offspring of zebrafish (Danio                  rerio). <i>J Hazard Mater<\/i>               2020; 386: 121939.","DOI":"10.1016\/j.jhazmat.2019.121939"},{"key":"142","doi-asserted-by":"crossref","unstructured":"142.  Zhang                     H,                        Ruan                     Y,                        Ding                     Z, Li                     Z, He                     J, Li                     J,                        Hong                     P, Wu                     H,                        Shu                     Y. The                  accumulation of Microcystin-LR in the gonads of Pelophylax nigromaculatus during                  the reproductive periods induces reproductive endocrine disorders in their                  offspring. <i>Ecotoxicol Environ Saf<\/i>               2025; 294: 118088.","DOI":"10.1016\/j.ecoenv.2025.118088"},{"key":"143","doi-asserted-by":"crossref","unstructured":"143.  Zhao                     S, Li                     G,                        Chen                     J. A                  proteomic analysis of prenatal transfer of microcystin-LR induced neurotoxicity in                  rat offspring. <i>J Proteomics<\/i>               2015; 114:                  197\u2013213.","DOI":"10.1016\/j.jprot.2014.11.015"},{"key":"144","doi-asserted-by":"crossref","unstructured":"144.  Chen                     Y,                        Chen                     G, Xu                     Y,                        Wei                     X, Li                     X,                        Zhou                     Y,                        Chen                     Z.                  Prenatal microcystin-LR exposure alters pancreatic proteome and                  impairs insulin secretion in offspring mice.                     <i>Toxicol Lett<\/i>               2025; 410:                  159\u2013168.","DOI":"10.1016\/j.toxlet.2025.06.009"},{"key":"145","doi-asserted-by":"crossref","unstructured":"145.  Foss                     AJ,                        Aubel                     MT.                  Using the MMPB technique to confirm microcystin concentrations in                  water measured by ELISA and HPLC (UV, MS, MS\/MS).                     <i>Toxicon<\/i>               2015; 104:                  91\u2013101.","DOI":"10.1016\/j.toxicon.2015.07.332"},{"key":"146","doi-asserted-by":"crossref","unstructured":"146.  Rosenblum                     L,                        Zaffiro                     A,                        Adams                     WA,                        Wendelken                     SC.                  Effect of chlorination by-products on the quantitation of                  microcystins in finished drinking water.                     <i>Toxicon<\/i>               2017; 138:                  138\u2013144.","DOI":"10.1016\/j.toxicon.2017.08.023"},{"key":"147","doi-asserted-by":"crossref","unstructured":"147.  Taranu                     ZE,                        Pick                     FR,                        Creed                     IF,                        Zastepa                     A,                        Watson                     SB.                  Meteorological and nutrient conditions influence microcystin                  congeners in freshwaters. <i>Toxins (Basel)<\/i>               2019; 11: 11.","DOI":"10.3390\/toxins11110620"},{"key":"148","doi-asserted-by":"crossref","unstructured":"148.  Wang                     Y, Xu                     J,                        Stanley                     JE,                        Xu                     M,                        Brooks                     BW,                        Scott                     GI,                        Chatterjee                     S,                        Zhang                     Q,                        Zelinski                     MB,                        Xiao                     S. A                  closed vitrification system enables a murine ovarian follicle bank for                  high-throughput ovotoxicity screening, which identifies endocrine disrupting                  activity of microcystins. <i>Reprod Toxicol<\/i>               2020; 93:                  118\u2013130.","DOI":"10.1016\/j.reprotox.2020.01.009"},{"key":"149","doi-asserted-by":"crossref","unstructured":"149.  Martin                     RM,                        Bereman                     MS,                        Marsden                     KC.                  BMAA and MCLR interact to modulate behavior and exacerbate                  molecular changes related to neurodegeneration in larval               zebrafish. <i>Toxicol Sci<\/i>               2021; 179:                  251\u2013261.","DOI":"10.1093\/toxsci\/kfaa178"},{"key":"150","doi-asserted-by":"crossref","unstructured":"150.  Freitas                     M,                        Azevedo                     J,                        Pinto                     E,                        Neves                     J,                        Campos                     A,                        Vasconcelos                     V.                  Effects of microcystin-LR, cylindrospermopsin and a                  microcystin-LR\/cylindrospermopsin mixture on growth, oxidative stress and mineral                  content in lettuce plants (Lactuca sativa L.).                     <i>Ecotoxicol Environ Saf<\/i>               2015; 116:               59\u201367.","DOI":"10.1016\/j.ecoenv.2015.02.002"},{"key":"151","doi-asserted-by":"crossref","unstructured":"151.  Pinheiro                     C,                        Azevedo                     J,                        Campos                     A,                        Vasconcelos                     V,                        Loureiro                     S. The                  interactive effects of microcystin-LR and cylindrospermopsin on the growth rate of                  the freshwater algae Chlorella vulgaris.                     <i>Ecotoxicology<\/i>               2016; 25:                  745\u2013758.","DOI":"10.1007\/s10646-016-1633-y"},{"key":"152","doi-asserted-by":"crossref","unstructured":"152.  Myhre                     O,                        Eide                     DM,                        Kleiven                     S,                        Utkilen                     HC,                        Hofer                     T.                  Repeated five-day administration of L-BMAA, microcystin-LR, or as                  mixture, in adult C57BL\/6 mice - lack of adverse cognitive               effects. <i>Sci Rep<\/i>               2018; 8: 2308.","DOI":"10.1038\/s41598-018-20327-y"},{"key":"153","doi-asserted-by":"crossref","unstructured":"153.  Cheng                     H,                        Yan                     W, Wu                     Q, Lu                     J,                        Liu                     C,                        Hung                     T-C,                        Li                     G.                  Adverse reproductive performance in zebrafish with increased                  bioconcentration of microcystin-LR in the presence of titanium dioxide                  nanoparticles. <i>Environ Sci Nano<\/i>               2018; 5:                  1208\u20131217.","DOI":"10.1039\/C8EN00174J"},{"key":"154","doi-asserted-by":"crossref","unstructured":"154.  Wang                     S,                        Tian                     D,                        Zheng                     W,                        Jiang                     S,                        Wang                     X,                        Andersen                     ME,                        Zheng                     Y, He                     G, Qu                     W.                  Combined exposure to                  3-chloro-4-dichloromethyl-5-hydroxy-2(5H)-furanone and microsytin-LR increases                  genotoxicity in Chinese hamster ovary cells through oxidative                  stress. <i>Environ Sci Technol<\/i>               2013; 47:                  1678\u20131687.","DOI":"10.1021\/es304541a"},{"key":"155","doi-asserted-by":"crossref","unstructured":"155.  Lin                     W,                        Luo                     H, Wu                     J,                        Liu                     X,                        Cao                     B,                        Liu                     Y,                        Yang                     P,                        Yang                     J.                  Polystyrene microplastics enhance the microcystin-LR-induced                  gonadal damage and reproductive endocrine disruption in zebrafish.                     <i>Sci Total Environ<\/i>               2023; 876: 162664.","DOI":"10.1016\/j.scitotenv.2023.162664"}],"container-title":["Journal of Reproduction and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jrd\/72\/3\/72_2025-128\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T03:25:17Z","timestamp":1781925917000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jrd\/72\/3\/72_2025-128\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":155,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.1262\/jrd.2025-128","relation":{},"ISSN":["0916-8818","1348-4400"],"issn-type":[{"value":"0916-8818","type":"print"},{"value":"1348-4400","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"2025-128"}}