{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T03:52:18Z","timestamp":1781927538169,"version":"3.54.5"},"reference-count":83,"publisher":"Japanese Society of Animal Reproduction","issue":"3","funder":[{"name":"Institute of Veterinary Anatomy, Vetsuisse Faculty, University of Zurich"},{"name":"JSPS KAKENHI","award":["22HP2009"],"award-info":[{"award-number":["22HP2009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Reprod. Dev.","Journal of Reproduction and Development"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1262\/jrd.2025-142","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T22:10:55Z","timestamp":1781734255000},"page":"380-389","source":"Crossref","is-referenced-by-count":0,"title":["Morpho-functional uterine and placental dynamics during establishment and maintenance of canine pregnancy, from early trophoblast invasion to parturition"],"prefix":"10.1262","volume":"72","author":[{"given":"Mariusz P.","family":"KOWALEWSKI","sequence":"first","affiliation":[{"name":"Institute of Veterinary Anatomy, Vetsuisse Faculty, University of                     Zurich (UZH), Zurich CH-8057, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"349","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1.  Hoffmann                     B,                        B\u00fcsges                     F,                        Engel                     E,                        Kowalewski                     MP,                        Papa                     P.                  Regulation of corpus luteum-function in the bitch.                     <i>Reprod Domest Anim<\/i>               2004; 39:                  232\u2013240.","DOI":"10.1111\/j.1439-0531.2004.00508.x"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2.  Kowalewski                     MP.                  Luteal regression vs. prepartum luteolysis: regulatory mechanisms                  governing canine corpus luteum function. <i>Reprod                     Biol<\/i>               2014; 14:               89\u2013102.","DOI":"10.1016\/j.repbio.2013.11.004"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3.  Kowalewski                     MP. Regulation of               Corpus Luteum Function in the Domestic Dog (Canis familiaris) and Comparative Aspects               of Luteal Function in the Domestic Cat (Felis catus). In:The life cycle of the Corpus               luteum. Ed.: Rina Meidan. Springer International Publishing Switzerland                  2017.","DOI":"10.1007\/978-3-319-43238-0_8"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4.  Duque Rodriguez                     M,                        Cittadini                     CO,                        Teplitz                     GM, De                        Stefano                     A,                        Lombardo                     DM,                        Salamone                     DF.                  Canine IVM with SOF medium, insulin-transferrin-selenium, and low                     O<sub>2<\/sub> tension improves oocyte meiotic competence and decreases reactive                  oxygen species levels. <i>Front Cell Dev                     Biol<\/i>               2021; 9: 694889.","DOI":"10.3389\/fcell.2021.694889"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5.  Lee                     SH,                        Lira-Albarr\u00e1n                     S,                        Saadeldin                     IM.                  Comprehensive proteomics analysis of in vitro canine oviductal                  cell-derived extracellular vesicles. <i>Animals                     (Basel)<\/i>               2021; 11: 573.","DOI":"10.3390\/ani11020573"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6.  Palomino                     J,                        Flores                     J,                        Ramirez                     G,                        Parraguez                     VH, De Los                        Reyes                     M.                  Expression profiles of the progesterone receptor, cyclooxygenase-2,                  growth differentiation factor 9, and bone morphogenetic protein 15 transcripts in                  the canine oviducts during the oestrous cycle.                     <i>Animals (Basel)<\/i>               2021; 11: 454.","DOI":"10.3390\/ani11020454"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7.  Chastant-Maillard                     S, Viaris de                        Lesegno                     C,                        Chebrout                     M,                        Thoumire                     S,                        Meylheuc                     T,                        Fontbonne                     A,                        Chodkiewicz                     M,                        Saint-Dizier                     M,                        Reynaud                     K. The                  canine oocyte: uncommon features of in vivo and in vitro                  maturation. <i>Reprod Fertil Dev<\/i>               2011; 23:                  391\u2013402.","DOI":"10.1071\/RD10064"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8.  Reynaud                     K,                        Saint-Dizier                     M,                        Tahir                     MZ,                        Havard                     T,                        Harichaux                     G,                        Labas                     V,                        Thoumire                     S,                        Fontbonne                     A,                        Grimard                     B,                        Chastant-Maillard                     S.                  Progesterone plays a critical role in canine oocyte maturation and                  fertilization. <i>Biol Reprod<\/i>               2015; 93: 87.","DOI":"10.1095\/biolreprod.115.130955"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9.  Kautz                     E, de Carvalho                        Papa                     P,                        Reichler                     IM,                        Gram                     A,                        Boos                     A,                        Kowalewski                     MP. In                  vitro decidualisation of canine uterine stromal cells.                     <i>Reprod Biol Endocrinol<\/i>               2015; 13: 85.","DOI":"10.1186\/s12958-015-0066-4"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10.  Graubner                     FR,                        Gram                     A,                        Kautz                     E,                        Bauersachs                     S,                        Aslan                     S,                        Agaoglu                     AR,                        Boos                     A,                        Kowalewski                     MP.                  Uterine responses to early pre-attachment embryos in the domestic                  dog and comparisons with other domestic animal species.                     <i>Biol Reprod<\/i>               2017; 97:                  197\u2013216.","DOI":"10.1093\/biolre\/iox063"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11.  Sch\u00e4fer-Somi                     S,                        Beceriklisoy                     HB,                        Budik                     S,                        Kanca                     H,                        Aksoy                     OA,                        Polat                     B,                        Cetin                     Y, Ay                     SS,                        Aslan                     S.                  Expression of genes in the canine pre-implantation uterus and                  embryo: implications for an active role of the embryo before and during                  invasion. <i>Reprod Domest Anim<\/i>               2008; 43:                  656\u2013663.","DOI":"10.1111\/j.1439-0531.2007.00966.x"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12.  Sch\u00e4fer-Somi                     S,                        Beceriklisoy                     HB,                        Walter                     I,                        Sabitzer                     S,                        Klein                     D,                        Kanca                     H,                        Kaya                     D,                        Agaoglu                     AR,                        Izg\u00fcr                     H,                        Aslan                     S.                  Expression of MHC-I and -II in uterine tissue from early pregnant                  bitches. <i>Reprod Domest Anim<\/i>               2009; 44(Suppl 2):                  103\u2013108.","DOI":"10.1111\/j.1439-0531.2009.01444.x"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13.  Kautz                     E,                        Gram                     A,                        Aslan                     S, Ay                     SS,                        Sel\u00e7uk                     M,                        Kanca                     H,                        Kolda\u015f                     E,                        Akal                     E,                        Karaka\u015f                     K,                        Findik                     M,                        Boos                     A,                        Kowalewski                     MP.                  Expression of genes involved in the embryo-maternal interaction in                  the early-pregnant canine uterus.                     <i>Reproduction<\/i>               2014; 147:                  703\u2013717.","DOI":"10.1530\/REP-13-0648"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14.  Mushati                     KA,                        Aslan                     S,                        Darbaz                     I,                        Zabitler                     F, Tavares                        Pereira                     M,                        Kowalewski                     MP.                  Modulation of uterine responses in dogs: The divergent effects of                  semen and embryonal signals on steroidogenic receptors and selected immune                  system-related factors. <i>Theriogenology<\/i>               2026; 250: 117644.","DOI":"10.1016\/j.theriogenology.2025.117644"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15.  Kowalewski                     MP.                  Advances in understanding canine pregnancy: Endocrine and                  morpho-functional regulation. <i>Reprod Domest                     Anim<\/i>               2023; 58(Suppl 2):                  163\u2013175.","DOI":"10.1111\/rda.14443"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16.  Corte                     GM,                        Griebel                     J,                        Klisch                     K,                        Wiesendanger                     M,                        Kowalewski                     MP.                  Morphological and functional aspects of the canine placental                  barrier: evidence supporting a deciduo-chorial model.                     <i>Reprod Fertil<\/i>               2025; 6: e250051.","DOI":"10.1530\/RAF-25-0051"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17.  Kowalewski                     MP,                        Gram                     A,                        Kautz                     E,                        Graubner                     FR. The                  dog: nonconformist, not only in maternal recognition signaling.                     <i>Adv Anat Embryol Cell Biol<\/i>               2015; 216:                  215\u2013237.","DOI":"10.1007\/978-3-319-15856-3_11"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18.  Hoffmann                     B,                        H\u00f6veler                     R,                        Hasan                     SH,                        Failing                     K.                  Ovarian and pituitary function in dogs after                  hysterectomy. <i>J Reprod Fertil<\/i>               1992; 96:                  837\u2013845.","DOI":"10.1530\/jrf.0.0960837"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19.  Stellflug                     JN,                        Han                     DK,                        Randel                     RD,                        Moody                     EL.                  Plasma estrogens in the periparturient cow.                     <i>Theriogenology<\/i>               1978; 10:                  269\u2013273.","DOI":"10.1016\/0093-691X(78)90104-8"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20.  Hoffmann                     B,                        H\u00f6veler                     R,                        Nohr                     B,                        Hasan                     SH.                  Investigations on hormonal changes around parturition in the dog                  and the occurrence of pregnancy-specific non conjugated               oestrogens. <i>Exp Clin Endocrinol<\/i>               1994; 102:                  185\u2013189.","DOI":"10.1055\/s-0029-1211280"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21.  Onclin                     K,                        Murphy                     B,                        Verstegen                     JP.                  Comparisons of estradiol, LH and FSH patterns in pregnant and                  nonpregnant beagle bitches.                     <i>Theriogenology<\/i>               2002; 57:                  1957\u20131972.","DOI":"10.1016\/S0093-691X(02)00644-1"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22.  Nowak                     M,                        Gram                     A,                        Boos                     A,                        Aslan                     S, Ay                     SS,                        \u00d6nyay                     F,                        Kowalewski                     MP.                  Functional implications of the utero-placental relaxin (RLN) system                  in the dog throughout pregnancy and at term.                     <i>Reproduction<\/i>               2017; 154:                  415\u2013431.","DOI":"10.1530\/REP-17-0135"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23.  Klonisch                     T,                        Hombach-Klonisch                     S,                        Froehlich                     C,                        Kauffold                     J,                        Steger                     K,                        Steinetz                     BG,                        Fischer                     B.                  Canine preprorelaxin: nucleic acid sequence and localization within                  the canine placenta. <i>Biol Reprod<\/i>               1999; 60:                  551\u2013557.","DOI":"10.1095\/biolreprod60.3.551"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24.  Nowak                     M,                        Boos                     A,                        Kowalewski                     MP.                  Luteal and hypophyseal expression of the canine relaxin (RLN)                  system during pregnancy: Implications for luteotropic function.                     <i>PLoS One<\/i>               2018; 13: e0191374.","DOI":"10.1371\/journal.pone.0191374"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25.  Kowalewski                     MP,                        Beceriklisoy                     HB,                        Pfarrer                     C,                        Aslan                     S,                        Kindahl                     H,                        K\u00fcc\u00fckaslan                     I,                        Hoffmann                     B.                  Canine placenta: a source of prepartal prostaglandins during normal                  and antiprogestin-induced parturition.                     <i>Reproduction<\/i>               2010; 139:                  655\u2013664.","DOI":"10.1530\/REP-09-0140"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26.  Gram                     A,                        Fox                     B,                        B\u00fcchler                     U,                        Boos                     A,                        Hoffmann                     B,                        Kowalewski                     MP.                  Canine placental prostaglandin E2 synthase: expression,                  localization, and biological functions in providing substrates for prepartum                  PGF2alpha synthesis. <i>Biol Reprod<\/i>               2014; 91: 154.","DOI":"10.1095\/biolreprod.114.122929"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27.  Gram                     A,                        B\u00fcchler                     U,                        Boos                     A,                        Hoffmann                     B,                        Kowalewski                     MP.                  Biosynthesis and degradation of canine placental prostaglandins:                  prepartum changes in expression and function of prostaglandin F2\u03b1-synthase (PGFS,                  AKR1C3) and 15-hydroxyprostaglandin dehydrogenase (HPGD).                     <i>Biol Reprod<\/i>               2013; 89: 2.","DOI":"10.1095\/biolreprod.113.109918"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28.  Jungmann                     C, Dyhrberg                        Haubuff                     S,                        Packeiser                     EM,                        K\u00f6rber                     H,                        Reichler                     IM,                        Balogh                     O,                        Mazzuoli-Weber                     G,                        Goericke-Pesch                     S.                  Insights into the role of PGF2\u03b1 in canine periparturient                  myometrium. <i>Front Physiol<\/i>               2024; 15: 1392080.","DOI":"10.3389\/fphys.2024.1392080"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29.  Kowalewski                     MP,                        Beceriklisoy                     HB,                        Aslan                     S,                        Agaoglu                     AR,                        Hoffmann                     B. Time                  related changes in luteal prostaglandin synthesis and steroidogenic capacity                  during pregnancy, normal and antiprogestin induced luteolysis in the                  bitch. <i>Anim Reprod Sci<\/i>               2009; 116:                  129\u2013138.","DOI":"10.1016\/j.anireprosci.2008.12.011"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30.  Luz                     MR,                        Bertan                     CM,                        Binelli                     M,                        Lopes                     MD. In                  vitro PGF2alpha production by endometrium and corpus luteum explants from pregnant                  and nonpregnant diestrus bitches and placental explants from pregnant                  bitches. <i>Theriogenology<\/i>               2006; 66:                  1442\u20131447.","DOI":"10.1016\/j.theriogenology.2006.01.037"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31.  Concannon                     PW,                        Butler                     WR,                        Hansel                     W,                        Knight                     PJ,                        Hamilton                     JM.                  Parturition and lactation in the bitch: serum progesterone,                  cortisol and prolactin. <i>Biol Reprod<\/i>               1978; 19:                  1113\u20131118.","DOI":"10.1095\/biolreprod19.5.1113"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32.  Fusi                     J,                        Veronesi                     MC.                  Canine parturition: what is known about the hormonal                  setting? <i>Domest Anim Endocrinol<\/i>               2022; 78: 106687.","DOI":"10.1016\/j.domaniend.2021.106687"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33.  Schnorr                     B,                        Kressin                     M. Embryologie der               Haustiere: ein Kurzlehrbuch. (Eng: Embryology of domestic animals: a short textbook).               Enke Verlag 2006.","DOI":"10.1055\/b-002-10329"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34.  Wildman                     DE,                        Chen                     C,                        Erez                     O,                        Grossman                     LI,                        Goodman                     M,                        Romero                     R.                  Evolution of the mammalian placenta revealed by phylogenetic                  analysis. <i>Proc Natl Acad Sci USA<\/i>               2006; 103:                  3203\u20133208.","DOI":"10.1073\/pnas.0511344103"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35.  Roberts                     RM,                        Green                     JA,                        Schulz                     LC. The                  evolution of the placenta. <i>Reproduction<\/i>               2016; 152:                  R179\u2013R189.","DOI":"10.1530\/REP-16-0325"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36.  Kowalewski                     MP,                        Kazemian                     A,                        Klisch                     K,                        Gysin                     T, Tavares                        Pereira                     M,                        Gram                     A.                  Canine endotheliochorial placenta: morpho-functional                  aspects. <i>Adv Anat Embryol Cell Biol<\/i>               2021; 234:                  155\u2013179.","DOI":"10.1007\/978-3-030-77360-1_8"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37.  Capellini                     I,                        Venditti                     C,                        Barton                     RA.                  Placentation and maternal investment in mammals.                     <i>Am Nat<\/i>               2011; 177:               86\u201398.","DOI":"10.1086\/657435"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38.  Haig                     D.                  Genetic conflicts in human pregnancy.                     <i>Q Rev Biol<\/i>               1993; 68:                  495\u2013532.","DOI":"10.1086\/418300"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39.  Favaro                     R,                        Abrahamsohn                     PA,                        Zorn                     MT. Decidualization               and Endometrial Extracellular Matrix Remodeling. In: p. 125\u201342.","DOI":"10.1016\/B978-0-12-394445-0.00011-4"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40.  Mori                     M,                        Bogdan                     A,                        Balassa                     T,                        Csabai                     T,                        Szekeres-Bartho                     J. The                  decidua-the maternal bed embracing the embryo-maintains the                  pregnancy. <i>Semin Immunopathol<\/i>               2016; 38:                  635\u2013649.","DOI":"10.1007\/s00281-016-0574-0"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41.  Muter                     J,                        Kong                     C-S,                        Brosens                     JJ. The                  Role of Decidual Subpopulations in Implantation, Menstruation and                  Miscarriage. <i>Front Reprod Health<\/i>               2021; 3: 804921.","DOI":"10.3389\/frph.2021.804921"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42.  Meng                     X,                        Chen                     C,                        Qian                     J,                        Cui                     L,                        Wang                     S.                  Energy metabolism and maternal-fetal tolerance working in                  decidualization. <i>Front Immunol<\/i>               2023; 14: 1203719.","DOI":"10.3389\/fimmu.2023.1203719"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43.  Jarzembowski                     JA. Normal Structure               and Function of the Placenta. In: p. 2308\u201321.","DOI":"10.1016\/B978-0-12-386456-7.05001-2"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44.  Gellersen                     B,                        Brosens                     IA,                        Brosens                     JJ.                  Decidualization of the human endometrium: mechanisms, functions,                  and clinical perspectives. <i>Semin Reprod                     Med<\/i>               2007; 25:                  445\u2013453.","DOI":"10.1055\/s-2007-991042"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45.  Stope                     MB,                        Mustea                     A,                        S\u00e4nger                     N,                        Einenkel                     R.                  Immune Cell Functionality during Decidualization and Potential                  Clinical Application. <i>Life (Basel)<\/i>               2023; 13: 1097.","DOI":"10.3390\/life13051097"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46.  Sharma                     S,                        Godbole                     G,                        Modi                     D.                  Decidual Control of Trophoblast Invasion.                     <i>Am J Reprod Immunol<\/i>               2016; 75:                  341\u2013350.","DOI":"10.1111\/aji.12466"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47.  Voorhorst                     MJ, van                        Brederode                     JC,                        Albers-Wolthers                     CHJ, de                        Gier                     J,                        Schaefers-Okkens                     AC.                  Successful treatment for subinvolution of placental sites in the                  bitch with low oral doses of progestagen. <i>Reprod                     Domest Anim<\/i>               2013; 48:                  840\u2013843.","DOI":"10.1111\/rda.12172"},{"key":"48","unstructured":"48.  Rosenberg                     LM,                        Marinoff                     J,                        Crouch                     EE,                        Valenzano                     DM,                        Peters-Kennedy                     J,                        Cheong                     SH, de                        Amorim                     MD.                  Uterine perforation secondary to metritis and placenta percreta in                  a postpartum bitch. <i>Can Vet J<\/i>               2020; 61:                  584\u2013588."},{"key":"49","doi-asserted-by":"crossref","unstructured":"49.  Diessler                     ME,                        Hern\u00e1ndez                     R, Gomez                        Castro                     G,                        Barbeito                     CG.                  Decidual cells and decidualization in the carnivoran                  endotheliochorial placenta. <i>Front Cell Dev                     Biol<\/i>               2023; 11: 1134874.","DOI":"10.3389\/fcell.2023.1134874"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50.  Cornelis                     G,                        Heidmann                     O,                        Bernard-Stoecklin                     S,                        Reynaud                     K,                        V\u00e9ron                     G,                        Mulot                     B,                        Dupressoir                     A,                        Heidmann                     T.                  Ancestral capture of syncytin-Car1, a fusogenic endogenous                  retroviral envelope gene involved in placentation and conserved in                  Carnivora. <i>Proc Natl Acad Sci USA<\/i>               2012; 109:                  E432\u2013E441.","DOI":"10.1073\/pnas.1115346109"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51.  Graubner                     FR,                        Reichler                     IM,                        Rahman                     NA,                        Payan-Carreira                     R,                        Boos                     A,                        Kowalewski                     MP.                  Decidualization of the canine uterus: From early until late                  gestational in vivo morphological observations, and functional characterization of                  immortalized canine uterine stromal cell lines.                     <i>Reprod Domest Anim<\/i>               2017; 52(Suppl 2):                  137\u2013147.","DOI":"10.1111\/rda.12849"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52.  Vermeirsch                     H,                        Simoens                     P,                        Hellemans                     A,                        Coryn                     M,                        Lauwers                     H.                  Immunohistochemical detection of progesterone receptors in the                  canine uterus and their relation to sex steroid hormone levels.                     <i>Theriogenology<\/i>               2000; 53:                  773\u2013788.","DOI":"10.1016\/S0093-691X(99)00273-3"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53.  Graubner                     FR, Tavares                        Pereira                     M,                        Boos                     A,                        Kowalewski                     MP.                  Canine decidualization in vitro: extracellular matrix modification,                  progesterone mediated effects and selective blocking of prostaglandin E2                  receptors. <i>J Reprod Dev<\/i>               2020; 66:                  319\u2013329.","DOI":"10.1262\/jrd.2019-157"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54.  Kazemian                     A, Tavares                        Pereira                     M,                        Hoffmann                     B,                        Kowalewski                     MP.                  Antigestagens mediate the expression of decidualization markers,                  extracellular matrix factors and connexin 43 in decidualized dog uterine stromal                  (DUS) cells. <i>Animals (Basel)<\/i>               2022; 12: 798.","DOI":"10.3390\/ani12070798"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55.  Tavares Pereira                     M,                        Kazemian                     A,                        Rehrauer                     H,                        Kowalewski                     MP.                  Transcriptomic profiling of canine decidualization and effects of                  antigestagens on decidualized dog uterine stromal cells.                     <i>Sci Rep<\/i>               2022; 12: 21890.","DOI":"10.1038\/s41598-022-24790-6"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56.  Kazemian                     A, Tavares                        Pereira                     M,                        Aslan                     S,                        Payan-Carreira                     R,                        Reichler                     IM,                        Agaoglu                     RA,                        Kowalewski                     MP.                  Membrane-bound progesterone receptors in the canine uterus and                  placenta; possible targets in the maintenance of pregnancy.                     <i>Theriogenology<\/i>               2023; 210:               68\u201383.","DOI":"10.1016\/j.theriogenology.2023.07.005"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57.  Kowalewski                     MP,                        Pereira                     MT,                        Papa                     P,                        Gram                     A.                  Progesterone receptor blockers: historical perspective, mode of                  function and insights into clinical and scientific applications.                     <i>Tierarztl Prax Ausg K Kleintiere Heimtiere<\/i>               2020; 48:                  433\u2013440.","DOI":"10.1055\/a-1274-9290"},{"key":"58","doi-asserted-by":"crossref","unstructured":"58.  De Geyter                     I,                        Kowalewski                     MP, Tavares                        Pereira                     M.                  Applying a novel kinomics approach to study decidualization and the                  effects of antigestagens using a canine model\u2020.                     <i>Biol Reprod<\/i>               2024; 110:                  583\u2013598.","DOI":"10.1093\/biolre\/ioad170"},{"key":"59","unstructured":"59.  Amoroso                     EC. Placentation. In:               Parkes AS (ed.) Marshall\u2019s physiology of reproduction. Longmans Green, London                  1952:127\u2013316."},{"key":"60","doi-asserted-by":"crossref","unstructured":"60.  Kehrer                     A. Zur                  Entwicklung und Ausbildung des Chorions der Placenta zonaria bei Katze, Hund und                  Fuchs. <i>Z Anat Entwicklungsgesch<\/i>               1973; 143:               24\u201342.","DOI":"10.1007\/BF00519908"},{"key":"61","doi-asserted-by":"crossref","unstructured":"61.  Enders                     AC.                  Electron microscopy of an early implantation stage, with a                  postulated mechanism of implantation. <i>Dev                     Biol<\/i>               1964; 10:                  395\u2013410.","DOI":"10.1016\/0012-1606(64)90052-1"},{"key":"62","doi-asserted-by":"crossref","unstructured":"62.  Rasweiler                     JJ                     4th, Oliveira                     SF,                        Badwaik                     NK. An                  ultrastructural study of interstitial implantation in captive-bred, short-tailed                  fruit bats, Carollia perspicillata: trophoblastic adhesion and penetration of the                  uterine epithelium. <i>Anat Embryol (Berl)<\/i>               2002; 205:                  371\u2013391.","DOI":"10.1007\/s00429-002-0267-4"},{"key":"63","doi-asserted-by":"crossref","unstructured":"63.  Nowak                     M,                        Rehrauer                     H, Ay                     SS,                        Findik                     M,                        Boos                     A,                        Kautz                     E,                        Kowalewski                     MP.                  Gene expression profiling of the canine placenta during normal and                  antigestagen-induced luteolysis. <i>Gen Comp                     Endocrinol<\/i>               2019; 282: 113194.","DOI":"10.1016\/j.ygcen.2019.05.019"},{"key":"64","doi-asserted-by":"crossref","unstructured":"64.  Jevti\u0107                     P,                        Edens                     LJ,                        Vukovi\u0107                     LD,                        Levy                     DL.                  Sizing and shaping the nucleus: mechanisms and                  significance. <i>Curr Opin Cell Biol<\/i>               2014; 28: 16\u201327.","DOI":"10.1016\/j.ceb.2014.01.003"},{"key":"65","doi-asserted-by":"crossref","unstructured":"65.  Tavares Pereira                     M,                        Schuler                     G,                        Aslan                     S,                        Payan-Carreira                     R,                        Reichler                     IM,                        Reynaud                     K,                        Kowalewski                     MP.                  Utero-placental expression and functional implications of HSD11B1                  and HSD11B2 in canine pregnancy. <i>Biol                     Reprod<\/i>               2023; 108:                  645\u2013658.","DOI":"10.1093\/biolre\/ioac214"},{"key":"66","doi-asserted-by":"crossref","unstructured":"66.  Steiner                     M,                        Schuler                     G,                        Frehner                     BL,                        Reichler                     IM,                        Goericke-Pesch                     S,                        Balogh                     O, Tavares                        Pereira                     M,                        Kowalewski                     MP.                  Primary Uterine inertia (PUI) in dogs is associated with impaired                  placental availability of factors involved in the parturition                  cascade. <i>Animals (Basel)<\/i>               2025; 15: 3043.","DOI":"10.3390\/ani15203043"},{"key":"67","doi-asserted-by":"crossref","unstructured":"67.  Baan                     M,                        Taverne                     MA,                        Kooistra                     HS, de                        Gier                     J,                        Dieleman                     SJ,                        Okkens                     AC.                  Induction of parturition in the bitch with the                  progesterone-receptor blocker agl\u00e9pristone.                     <i>Theriogenology<\/i>               2005; 63:                  1958\u20131972.","DOI":"10.1016\/j.theriogenology.2004.09.008"},{"key":"68","doi-asserted-by":"crossref","unstructured":"68.  Baan                     M,                        Taverne                     MA, de                        Gier                     J,                        Kooistra                     HS,                        Kindahl                     H,                        Dieleman                     SJ,                        Okkens                     AC.                  Hormonal changes in spontaneous and agl\u00e9pristone-induced                  parturition in dogs. <i>Theriogenology<\/i>               2008; 69:                  399\u2013407.","DOI":"10.1016\/j.theriogenology.2007.10.008"},{"key":"69","doi-asserted-by":"crossref","unstructured":"69.  Zatta                     S,                        Rehrauer                     H,                        Gram                     A,                        Boos                     A,                        Kowalewski                     MP.                  Transcriptome analysis reveals differences in mechanisms regulating                  cessation of luteal function in pregnant and non-pregnant dogs.                     <i>BMC Genomics<\/i>               2017; 18: 757.","DOI":"10.1186\/s12864-017-4084-9"},{"key":"70","doi-asserted-by":"crossref","unstructured":"70.  Lamond                     DR,                        Drost                     M. The                  counter-current transfer of prostaglandin in the ewe.                     <i>Prostaglandins<\/i>               1973; 3:               691\u2013702.","DOI":"10.1016\/0090-6980(73)90104-4"},{"key":"71","doi-asserted-by":"crossref","unstructured":"71.  Krzymowski                     T,                        Stefa\u0144czyk-Krzymowska                     S. The                  role of the endometrium in endocrine regulation of the animal oestrous                  cycle. <i>Reprod Domest Anim<\/i>               2008; 43: 80\u201391.","DOI":"10.1111\/j.1439-0531.2007.00859.x"},{"key":"72","doi-asserted-by":"crossref","unstructured":"72.  Cevik-Demirkan                     A,                        Ozdemir                     V,                        Demirkan                     I. The                  ovarian and uterine arteries in the chinchilla (Chinchilla                  lanigera). <i>J S Afr Vet Assoc<\/i>               2010; 81: 54\u201357.","DOI":"10.4102\/jsava.v81i1.97"},{"key":"73","doi-asserted-by":"crossref","unstructured":"73.  Greystoke                     AP,                        Kelly                     RW,                        Benediktsson                     R,                        Riley                     SC.                  Transfer and metabolism of prostaglandin E(2)in the dual perfused                  human placenta. <i>Placenta<\/i>               2000; 21:                  109\u2013114.","DOI":"10.1053\/plac.1999.0452"},{"key":"74","doi-asserted-by":"crossref","unstructured":"74.  Welsh                     T,                        Paul                     J,                        Palliser                     HK,                        Tabatabaee                     H,                        Hirst                     J,                        Mesiano                     S,                        Zakar                     T.                  15-Hydroxyprostaglandin dehydrogenase expression and localization                  in guinea pig gestational tissues during late pregnancy and                  parturition. <i>Reprod Sci<\/i>               2012; 19:                  1099\u20131109.","DOI":"10.1177\/1933719112442247"},{"key":"75","doi-asserted-by":"crossref","unstructured":"75.  Smith                     VG,                        Edgerton                     LA,                        Hafs                     HD,                        Convey                     EM.                  Bovine serum estrogens, progestins and glucocorticoids during late                  pregnancy parturition and early lactation. <i>J Anim                     Sci<\/i>               1973; 36:                  391\u2013396.","DOI":"10.2527\/jas1973.362391x"},{"key":"76","doi-asserted-by":"crossref","unstructured":"76.  Chida                     D,                        Miyoshi                     K,                        Sato                     T,                        Yoda                     T,                        Kikusui                     T,                        Iwakura                     Y. The                  role of glucocorticoids in pregnancy, parturition, lactation, and nurturing in                  melanocortin receptor 2-deficient mice.                     <i>Endocrinology<\/i>               2011; 152:                  1652\u20131660.","DOI":"10.1210\/en.2010-0935"},{"key":"77","doi-asserted-by":"crossref","unstructured":"77.  Magyar                     DM,                        Fridshal                     D,                        Elsner                     CW,                        Glatz                     T,                        Eliot                     J,                        Klein                     AH,                        Lowe                     KC,                        Buster                     JE,                        Nathanielsz                     PW.                  Time-trend analysis of plasma cortisol concentrations in the fetal                  sheep in relation to parturition.                     <i>Endocrinology<\/i>               1980; 107:                  155\u2013159.","DOI":"10.1210\/endo-107-1-155"},{"key":"78","doi-asserted-by":"crossref","unstructured":"78.  Gram                     A,                        Trachsel                     A,                        Boos                     A,                        Kowalewski                     MP.                  Elevated utero\/placental GR\/NR3C1 is not required for the induction                  of parturition in the dog. <i>Reproduction<\/i>               2016; 152:                  303\u2013311.","DOI":"10.1530\/REP-16-0213"},{"key":"79","doi-asserted-by":"crossref","unstructured":"79.  Karalis                     K,                        Goodwin                     G,                        Majzoub                     JA.                  Cortisol blockade of progesterone: a possible molecular mechanism                  involved in the initiation of human labor. <i>Nat                     Med<\/i>               1996; 2:               556\u2013560.","DOI":"10.1038\/nm0596-556"},{"key":"80","doi-asserted-by":"crossref","unstructured":"80.  Tavares Pereira                     M,                        Nowaczyk                     R,                        Aslan                     S, Ay                     SS,                        Kowalewski                     MP.                  Utero-Placental Immune Milieu during Normal and                  Aglepristone-Induced Parturition in the Dog.                     <i>Animals (Basel)<\/i>               2021; 11: 3598.","DOI":"10.3390\/ani11123598"},{"key":"81","doi-asserted-by":"crossref","unstructured":"81.  Tavares Pereira                     M,                        Aslan                     S,                        Payan-Carreira                     R,                        Reichler                     IM,                        Reynaud                     K,                        Kowalewski                     MP.                  Placental interleukin 1\u03b2 signaling in canine pregnancy:                  differential effects during and after decidualization in vitro.                     <i>Reproduction<\/i>               2025; 169: e240470.","DOI":"10.1530\/REP-24-0470"},{"key":"82","doi-asserted-by":"crossref","unstructured":"82.  Ma                     Q,                        Beal                     JR,                        Bhurke                     A,                        Kannan                     A, Yu                     J,                        Taylor                     RN,                        Bagchi                     IC,                        Bagchi                     MK.                  Extracellular vesicles secreted by human uterine stromal cells                  regulate decidualization, angiogenesis, and trophoblast                  differentiation. <i>Proc Natl Acad Sci USA<\/i>               2022; 119: e2200252119.","DOI":"10.1073\/pnas.2200252119"},{"key":"83","doi-asserted-by":"crossref","unstructured":"83.  Graham                     CH,                        Hawley                     TS,                        Hawley                     RG,                        MacDougall                     JR,                        Kerbel                     RS,                        Khoo                     N,                        Lala                     PK.                  Establishment and characterization of first trimester human                  trophoblast cells with extended lifespan. <i>Exp Cell                     Res<\/i>               1993; 206:                  204\u2013211.","DOI":"10.1006\/excr.1993.1139"}],"container-title":["Journal of Reproduction and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jrd\/72\/3\/72_2025-142\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T03:26:36Z","timestamp":1781925996000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jrd\/72\/3\/72_2025-142\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":83,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.1262\/jrd.2025-142","relation":{},"ISSN":["0916-8818","1348-4400"],"issn-type":[{"value":"0916-8818","type":"print"},{"value":"1348-4400","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"2025-142"}}