{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T16:25:30Z","timestamp":1787934330274,"version":"build-2784847793"},"reference-count":109,"publisher":"Japanese Society of Animal Reproduction","issue":"3","funder":[{"name":"JSPS KAKENHI","award":["22HP2009"],"award-info":[{"award-number":["22HP2009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Reprod. Dev.","Journal of Reproduction and Development"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1262\/jrd.2026-006","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T22:10:57Z","timestamp":1781734257000},"page":"134-142","source":"Crossref","is-referenced-by-count":1,"title":["Placental adaptation to maternal environment in domestic animals"],"prefix":"10.1262","volume":"72","author":[{"given":"Pascale","family":"CHAVATTE-PALMER","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, UVSQ, INRAE, BREED, Jouy-en-Josas 78350, France"},{"name":"Ecole Nationale V\u00e9t\u00e9rinaire d\u2019Alfort, BREED, Maisons-Alfort, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey E.","family":"DAHL","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences, University of Florida, Gainesville, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"COUTURIER-TARRADE","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, UVSQ, INRAE, BREED, Jouy-en-Josas 78350, France"},{"name":"Ecole Nationale V\u00e9t\u00e9rinaire d\u2019Alfort, BREED, Maisons-Alfort, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"349","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Barker DJP, Winter PD, Osmond C, Margetts B, Simmonds SJ. Weight in infancy and death from ischaemic heart disease. Lancet<\/i> 1989; 2: 577\u2013580.","DOI":"10.1016\/S0140-6736(89)90710-1"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Hales CN, Barker DJP, Clark PMS, Cox LJ, Fall C, Osmond C, Winter PD. Fetal and infant growth and impaired glucose tolerance at age 64. BMJ<\/i> 1991; 303: 1019\u20131022.","DOI":"10.1136\/bmj.303.6809.1019"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Hales CN, Ozanne SE. The dangerous road of catch-up growth. J Physiol<\/i> 2003; 547: 5\u201310. .","DOI":"10.1111\/j..2002.00005.x"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Painter RC, Roseboom TJ, Bleker OP. Prenatal exposure to the Dutch famine and disease in later life: an overview. Reprod Toxicol<\/i> 2005; 20: 345\u2013352.","DOI":"10.1016\/j.reprotox.2005.04.005"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Barker DJ. The fetal and infant origins of adult disease. BMJ<\/i> 1990; 301: 1111.","DOI":"10.1136\/bmj.301.6761.1111"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Barker DJP, Gluckman PD, Godfrey KM, Harding JE, Owens JA, Robinson JS. Fetal nutrition and cardiovascular disease in adult life. Lancet<\/i> 1993; 341: 938\u2013941.","DOI":"10.1016\/0140-6736(93)91224-A"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Hales CN, Barker DJP. Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia<\/i> 1992; 35: 595\u2013601.","DOI":"10.1007\/BF00400248"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Bateson P, Barker D, Clutton-Brock T, Deb D, D\u2019Udine B, Foley RA, Gluckman P, Godfrey K, Kirkwood T, Lahr MM, McNamara J, Metcalfe NB, Monaghan P, Spencer HG, Sultan SE. Developmental plasticity and human health. Nature<\/i> 2004; 430: 419\u2013421.","DOI":"10.1038\/nature02725"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Burton GJ, Jauniaux E. What is the placenta? Am J Obstet Gynecol<\/i> 2015; 213: S6.e1\u2013S6.e4.","DOI":"10.1016\/j.ajog.2015.07.050"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Fowden AL, Forhead AJ, Coan PM, Burton GJ. The placenta and intrauterine programming. J Neuroendocrinol<\/i> 2008; 20: 439\u2013450.","DOI":"10.1111\/j.1365-2826.2008.01663.x"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Myatt L. Placental adaptive responses and fetal programming. J Physiol<\/i> 2006; 572: 25\u201330.","DOI":"10.1113\/jphysiol.2006.104968"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Tarrade A, Panchenko P, Junien C, Gabory A. Placental contribution to nutritional programming of health and diseases: epigenetics and sexual dimorphism. J Exp Biol<\/i> 2015; 218: 50\u201358.","DOI":"10.1242\/jeb.110320"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Wu G, Bazer FW, Wallace JM, Spencer TE. Board-invited review: intrauterine growth retardation: implications for the animal sciences. J Anim Sci<\/i> 2006; 84: 2316\u20132337.","DOI":"10.2527\/jas.2006-156"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Sirard M-A. How the environment affects early embryonic development. Reprod Fertil Dev<\/i> 2021; 34: 203\u2013213.","DOI":"10.1071\/RD21266"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Fowden AL, Vaughan OR, Forhead AJ. Early-life programming of livestock metabolism by glucocorticoids. J Dev Orig Health Dis<\/i> 2025; 16: e16.","DOI":"10.1017\/S2040174425000091"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Burton GJ, Fowden AL, Thornburg KL. Placental origins of chronic disease. Physiol Rev<\/i> 2016; 96: 1509\u20131565.","DOI":"10.1152\/physrev.00029.2015"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Godfrey KM, Lillycrop KA, Burdge GC, Gluckman PD, Hanson MA. Epigenetic mechanisms and the mismatch concept of the developmental origins of health and disease. Pediatr Res<\/i> 2007; 61: 5R\u201310R.","DOI":"10.1203\/pdr.0b013e318045bedb"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Godfrey KM. The role of the placenta in fetal programming-a review. Placenta<\/i> 2002; 23(Suppl A): S20\u2013S27.","DOI":"10.1053\/plac.2002.0773"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Jansson T, Myatt L, Powell TL. The role of trophoblast nutrient and ion transporters in the development of pregnancy complications and adult disease. Curr Vasc Pharmacol<\/i> 2009; 7: 521\u2013533.","DOI":"10.2174\/157016109789043982"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Kelly AC, Powell TL, Jansson T. Placental function in maternal obesity. Clin Sci (Lond)<\/i> 2020; 134: 961\u2013984.","DOI":"10.1042\/CS20190266"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Seckl JR, Holmes MC. Mechanisms of disease: glucocorticoids, their placental metabolism and fetal \u2018programming\u2019 of adult pathophysiology. Nat Clin Pract Endocrinol Metab<\/i> 2007; 3: 479\u2013488.","DOI":"10.1038\/ncpendmet0515"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Woods RM, Lorusso JM, Fletcher J, ElTaher H, McEwan F, Harris I, Kowash HM, D\u2019Souza SW, Harte M, Hager R, Glazier JD. Maternal immune activation and role of placenta in the prenatal programming of neurodevelopmental disorders. Neuronal Signal<\/i> 2023; 7: NS20220064.","DOI":"10.1042\/NS20220064"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Safi-Stibler S, Gabory A. Epigenetics and the developmental origins of health and disease: Parental environment signalling to the epigenome, critical time windows and sculpting the adult phenotype. Semin Cell Dev Biol<\/i> 2020; 97: 172\u2013180.","DOI":"10.1016\/j.semcdb.2019.09.008"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Bronson SL, Bale TL. The placenta as a mediator of stress effects on neurodevelopmental reprogramming. Neuropsychopharmacology<\/i> 2016; 41: 207\u2013218.","DOI":"10.1038\/npp.2015.231"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Togher KL, Togher KL, O\u2019Keeffe MM, O\u2019Keeffe MM, Khashan AS, Khashan AS, Gutierrez H, Gutierrez H, Kenny LC, Kenny LC, O\u2019Keeffe GW, O\u2019Keeffe GW. Epigenetic regulation of the placental HSD11B2 barrier and its role as a critical regulator of fetal development. Epigenetics<\/i> 2014; 9: 816\u2013822.","DOI":"10.4161\/epi.28703"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Lapehn S, Paquette AG. The placental epigenome as a molecular link between prenatal exposures and fetal health outcomes through the DOHaD hypothesis. Curr Environ Health Rep<\/i> 2022; 9: 490\u2013501.","DOI":"10.1007\/s40572-022-00354-8"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Rosenfeld CS. Sex-specific placental responses in fetal development. Endocrinology<\/i> 2015; 156: 3422\u20133434.","DOI":"10.1210\/en.2015-1227"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Mao J, Zhang X, Sieli PT, Falduto MT, Torres KE, Rosenfeld CS. Contrasting effects of different maternal diets on sexually dimorphic gene expression in the murine placenta. Proc Natl Acad Sci USA<\/i> 2010; 107: 5557\u20135562.","DOI":"10.1073\/pnas.1000440107"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Thornburg KL, O\u2019Tierney PF, Louey S. Review: The placenta is a programming agent for cardiovascular disease. Placenta<\/i> 2010; 31(Suppl): S54\u2013S59.","DOI":"10.1016\/j.placenta.2010.01.002"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Chavatte-Palmer P, Guillomot M. Comparative implantation and placentation. Gynecol Obstet Invest<\/i> 2007; 64: 166\u2013174.","DOI":"10.1159\/000101742"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Lewis RM, Cleal JK, Hanson MA. Review: Placenta, evolution and lifelong health. Placenta<\/i> 2012; 33(Suppl): S28\u2013S32.","DOI":"10.1016\/j.placenta.2011.12.003"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Laundon D, Gostling NJ, Sengers BG, Chavatte-Palmer P, Lewis RM. Placental evolution from a three-dimensional and multiscale structural perspective. Evolution<\/i> 2024; 78: 13\u201325. .","DOI":"10.1093\/evolut\/qpad209"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Laundon D, Sengers BG, Thompson J, Harris SE, Beasley O, Basford PJ, Katsamenis OL, Goggin P, Derisoud E, Fanelli D, Bocci C, Camillo F, Shotton J, Constable-Dakeyne G, Gostling NJ, Chavatte-Palmer P, Lewis RM. Convergently evolved placental villi show multiscale structural adaptations to differential placental invasiveness. Biol Lett<\/i> 2024; 20: 20240016.","DOI":"10.1098\/rsbl.2024.0016"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Reynolds LP, Redmer DA. Angiogenesis in the placenta. Biol Reprod<\/i> 2001; 64: 1033\u20131040.","DOI":"10.1095\/biolreprod64.4.1033"},{"key":"35","unstructured":"35. Vallet JL, Miles JR, Freking BA. Development of the pig placenta. Soc Reprod Fertil Suppl<\/i> 2009; 66: 265\u2013279."},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Wilson ME, Biensen NJ, Ford SP. Novel insight into the control of litter size in pigs, using placental efficiency as a selection tool. J Anim Sci<\/i> 1999; 77: 1654\u20131658.","DOI":"10.2527\/1999.7771654x"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Vallet JL, McNeel AK, Miles JR, Freking BA. Placental accommodations for transport and metabolism during intra-uterine crowding in pigs. J Anim Sci Biotechnol<\/i> 2014; 5: 55.","DOI":"10.1186\/2049-1891-5-55"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Allen WR, Wilsher S, Turnbull C, Stewart F, Ousey J, Rossdale PD, Fowden AL. Influence of maternal size on placental, fetal and postnatal growth in the horse. I. Development in utero. Reproduction<\/i> 2002; 123: 445\u2013453.","DOI":"10.1530\/rep.0.1230445"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Samuel CA, Allen WR, Steven DH. Studies on the equine placenta. I. Development of the microcotyledons. J Reprod Fertil<\/i> 1974; 41: 441\u2013445.","DOI":"10.1530\/jrf.0.0410441"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Robles M, Peugnet PM, Valentino SA, Dubois C, Dahirel M, Aubri\u00e8re M-C, Reigner F, Serteyn D, Wimel L, Couturier-Tarrade A, Chavatte-Palmer P. Placental alterations in structure and function in intra-uterine growth-retarded horses. Equine Vet J<\/i> 2018; 50: 405\u2013414.","DOI":"10.1111\/evj.12761"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Davenport KM, Ortega MS, Liu H, O\u2019Neil EV, Kelleher AM, Warren WC, Spencer TE. Single-nuclei RNA sequencing (snRNA-seq) uncovers trophoblast cell types and lineages in the mature bovine placenta. Proc Natl Acad Sci USA<\/i> 2023; 120: e2221526120.","DOI":"10.1073\/pnas.2221526120"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Davenport KM, Ortega MS, Johnson GA, Seo H, Spencer TE. Review: Implantation and placentation in ruminants. Animal<\/i> 2023; 17(Suppl 1): 100796.","DOI":"10.1016\/j.animal.2023.100796"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Haeger J-D, Hambruch N, Pfarrer C. The bovine placenta in\u00a0vivo and in\u00a0vitro. Theriogenology<\/i> 2016; 86: 306\u2013312.","DOI":"10.1016\/j.theriogenology.2016.04.043"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Heasman L, Clarke L, Stephenson TJ, Symonds ME. The influence of maternal nutrient restriction in early to mid-pregnancy on placental and fetal development in sheep. Proc Nutr Soc<\/i> 1999; 58: 283\u2013288.","DOI":"10.1017\/S0029665199000397"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45. Reynolds LP, Borowicz PP, Vonnahme KA, Johnson ML, Grazul-Bilska AT, Redmer DA, Caton JS. Placental angiogenesis in sheep models of compromised pregnancy. J Physiol<\/i> 2005; 565: 43\u201358.","DOI":"10.1113\/jphysiol.2004.081745"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46. Fowden AL, Ward JW, Wooding FPB, Forhead AJ, Constancia M. Programming placental nutrient transport capacity. J Physiol<\/i> 2006; 572: 5\u201315. .","DOI":"10.1113\/jphysiol.2005.104141"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47. Zhu MJ, Du M, Hess BW, Means WJ, Nathanielsz PW, Ford SP. Maternal nutrient restriction upregulates growth signaling pathways in the cotyledonary artery of cow placentomes. Placenta<\/i> 2007; 28: 361\u2013368.","DOI":"10.1016\/j.placenta.2006.04.005"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48. Fowden AL, Sferruzzi-Perri AN, Coan PM, Constancia M, Burton GJ. Placental efficiency and adaptation: endocrine regulation. J Physiol<\/i> 2009; 587: 3459\u20133472.","DOI":"10.1113\/jphysiol.2009.173013"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49. Clarke L, Heasman L, Juniper DT, Symonds ME. Maternal nutrition in early-mid gestation and placental size in sheep. Br J Nutr<\/i> 1998; 79: 359\u2013364.","DOI":"10.1079\/BJN19980060"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50. Vonnahme KA, Hess BW, Hansen TR, McCormick RJ, Rule DC, Moss GE, Murdoch WJ, Nijland MJ, Skinner DC, Nathanielsz PW, Ford SP. Maternal undernutrition from early- to mid-gestation leads to growth retardation, cardiac ventricular hypertrophy, and increased liver weight in the fetal sheep. Biol Reprod<\/i> 2003; 69: 133\u2013140.","DOI":"10.1095\/biolreprod.102.012120"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51. Vonnahme KA, Arndt WJ, Johnson ML, Borowicz PP, Reynolds LP. Effect of morphology on placentome size, vascularity, and vasoreactivity in late pregnant sheep. Biol Reprod<\/i> 2008; 79: 976\u2013982.","DOI":"10.1095\/biolreprod.108.070748"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52. Borowicz PP, Arnold DR, Johnson ML, Grazul-Bilska AT, Redmer DA, Reynolds LP. Placental growth throughout the last two thirds of pregnancy in sheep: vascular development and angiogenic factor expression. Biol Reprod<\/i> 2007; 76: 259\u2013267.","DOI":"10.1095\/biolreprod.106.054684"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53. Reynolds LP, Caton JS, Redmer DA, Grazul-Bilska AT, Vonnahme KA, Borowicz PP, Luther JS, Wallace JM, Wu G, Spencer TE. Evidence for altered placental blood flow and vascularity in compromised pregnancies. J Physiol<\/i> 2006; 572: 51\u201358.","DOI":"10.1113\/jphysiol.2005.104430"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54. Lassala A, Bazer FW, Cudd TA, Datta S, Keisler DH, Satterfield MC, Spencer TE, Wu G. Parenteral administration of L-arginine prevents fetal growth restriction in undernourished ewes. J Nutr<\/i> 2010; 140: 1242\u20131248.","DOI":"10.3945\/jn.110.125658"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55. Lassala A, Bazer FW, Cudd TA, Datta S, Keisler DH, Satterfield MC, Spencer TE, Wu G. Parenteral administration of L-arginine enhances fetal survival and growth in sheep carrying multiple fetuses. J Nutr<\/i> 2011; 141: 849\u2013855.","DOI":"10.3945\/jn.111.138172"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56. Satterfield MC, Edwards AK, Bazer FW, Dunlap KA, Steinhauser CB, Wu G. Placental adaptation to maternal malnutrition. Reproduction<\/i> 2021; 162: R73\u2013R83.","DOI":"10.1530\/REP-21-0179"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57. Wallace JM, Bourke DA, Aitken RP, Leitch N, Hay WW Jr. Blood flows and nutrient uptakes in growth-restricted pregnancies induced by overnourishing adolescent sheep. Am J Physiol Regul Integr Comp Physiol<\/i> 2002; 282: R1027\u2013R1036.","DOI":"10.1152\/ajpregu.00465.2001"},{"key":"58","doi-asserted-by":"crossref","unstructured":"58. Wallace JM, Milne JS, Aitken RP. Maternal growth hormone treatment from day 35 to 80 of gestation alters nutrient partitioning in favor of uteroplacental growth in the overnourished adolescent sheep. Biol Reprod<\/i> 2004; 70: 1277\u20131285.","DOI":"10.1095\/biolreprod.103.023853"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59. Wallace JM, Aitken RP, Milne JS, Hay WW Jr. Nutritionally mediated placental growth restriction in the growing adolescent: consequences for the fetus. Biol Reprod<\/i> 2004; 71: 1055\u20131062.","DOI":"10.1095\/biolreprod.104.030965"},{"key":"60","doi-asserted-by":"crossref","unstructured":"60. Tao S, Monteiro APA, Thompson IM, Hayen MJ, Dahl GE. Effect of late-gestation maternal heat stress on growth and immune function of dairy calves. J Dairy Sci<\/i> 2012; 95: 7128\u20137136.","DOI":"10.3168\/jds.2012-5697"},{"key":"61","doi-asserted-by":"crossref","unstructured":"61. Casarotto LT, Jones HN, Chavatte-Palmer P, Laporta J, Pe\u00f1agaricano F, Ouellet V, Ouellet V, Bromfield J, Dahl GE. Late gestation heat stress alters placental structure and function in multiparous dairy cows. J Dairy Sci<\/i> 2025; 108: 1125\u20131134.","DOI":"10.3168\/jds.2024-25529"},{"key":"62","doi-asserted-by":"crossref","unstructured":"62. Casarotto LT, Jones HN, Chavatte-Palmer P, Dahl GE. Late gestation heat stress alters O2<\/sub> regulation in placenta and neonatal heifers. Placenta<\/i> 2025; 159: 126\u2013130.","DOI":"10.1016\/j.placenta.2024.12.009"},{"key":"63","doi-asserted-by":"crossref","unstructured":"63. Casarotto LT, Jones HN, Chavatte-Palmer P, Dahl GE. Review: Placental physiology and fetal programming in ruminants under heat stress. Biol Reprod<\/i> 2025; ioaf047.","DOI":"10.1093\/biolre\/ioaf047"},{"key":"64","doi-asserted-by":"crossref","unstructured":"64. Tong W, Allison BJ, Brain KL, Patey OV, Niu Y, Botting KJ, Ford SG, Garrud TA, Wooding PFB, Lyu Q, Zhang L, Ma J, Sowton AP, O\u2019Brien KA, Cindrova-Davies T, Yung HW, Burton GJ, Murray AJ, Giussani DA. Placental mitochondrial metabolic adaptation maintains cellular energy balance in pregnancy complicated by gestational hypoxia. J Physiol<\/i> 2025; JP287897.","DOI":"10.1113\/JP287897"},{"key":"65","doi-asserted-by":"crossref","unstructured":"65. Casarotto LT, Jones HN, Chavatte-Palmer P, Lance JM, Olmo H, Dahl GE. Late gestation heat stress induces inflammation and impacts nutrient transfer signature in the placenta of dairy cows. Theriogenology<\/i> 2025; 245: 117506.","DOI":"10.1016\/j.theriogenology.2025.117506"},{"key":"66","doi-asserted-by":"crossref","unstructured":"66. Carvalho Neta AV, Stynen APR, Paix\u00e3o TA, Miranda KL, Silva FL, Roux CM, Tsolis RM, Everts RE, Lewin HA, Adams LG, Carvalho AF, Lage AP, Santos RL. Modulation of the bovine trophoblastic innate immune response by Brucella abortus<\/i>. Infect Immun<\/i> 2008; 76: 1897\u20131907.","DOI":"10.1128\/IAI.01554-07"},{"key":"67","doi-asserted-by":"crossref","unstructured":"67. Mol JPS, Costa EA, Carvalho AF, Sun Y-H, Tsolis RM, Paix\u00e3o TA, Santos RL. Early transcriptional responses of bovine chorioallantoic membrane explants to wild type, \u0394virB2 or \u0394btpB Brucella abortus infection. PLoS One<\/i> 2014; 9: e108606.","DOI":"10.1371\/journal.pone.0108606"},{"key":"68","doi-asserted-by":"crossref","unstructured":"68. Byndloss MX, Tsai AY, Walker GT, Miller CN, Young BM, English BC, Seyffert N, Kerrinnes T, de Jong MF, Atluri VL, Winter MG, Celli J, Tsolis RM. Brucella abortus Infection of Placental Trophoblasts Triggers Endoplasmic Reticulum Stress-Mediated Cell Death and Fetal Loss via Type IV Secretion System-Dependent Activation of CHOP. MBio<\/i> 2019; 10: e01538\u2013e19.","DOI":"10.1128\/mBio.01538-19"},{"key":"69","doi-asserted-by":"crossref","unstructured":"69. Abd-Elnaeim MMM, Leiser R, Wilsher S, Allen WR. Structural and haemovascular aspects of placental growth throughout gestation in young and aged mares. Placenta<\/i> 2006; 27: 1103\u20131113.","DOI":"10.1016\/j.placenta.2005.11.005"},{"key":"70","doi-asserted-by":"crossref","unstructured":"70. Peugnet P, Wimel L, Duchamp G, Sandersen C, Camous S, Guillaume D, et alEnhanced or reduced fetal growth induced by embryo transfer into smaller or larger breeds alters postnatal growth and metabolism in weaned horses. J Equine Vet Sci<\/i> 2017; 48: 143\u2013153.e2.","DOI":"10.1016\/j.jevs.2016.03.016"},{"key":"71","doi-asserted-by":"crossref","unstructured":"71. Peugnet P, Tarrade A, Sandersen C, Dahirel M, Guillaume D, Wimel L, et alEffect of embryo transfer in a larger breed on postnatal growth and glucose metabolism in horses. Reprod Fertil Dev<\/i> 2012; 25: 228. (abstract).","DOI":"10.1071\/RDv25n1Ab159"},{"key":"72","doi-asserted-by":"crossref","unstructured":"72. Wilsher S, Allen WR. The effects of maternal age and parity on placental and fetal development in the mare. Equine Vet J<\/i> 2003; 35: 476\u2013483.","DOI":"10.2746\/042516403775600550"},{"key":"73","doi-asserted-by":"crossref","unstructured":"73. Derisoud E, Auclair-Ronzaud J, Palmer E, Robles M, Chavatte-Palmer P. Female age and parity in horses: how and why does it matter? Reprod Fertil Dev<\/i> 2021; 34: 52\u2013116.","DOI":"10.1071\/RD21267"},{"key":"74","doi-asserted-by":"crossref","unstructured":"74. Robles M, Dubois C, Gautier C, Dahirel M, Guenon I, Bouraima-Lelong H, Vigui\u00e9 C, Wimel L, Couturier-Tarrade A, Chavatte-Palmer P. Maternal parity affects placental development, growth and metabolism of foals until 1 year and a half. Theriogenology<\/i> 2018; 108: 321\u2013330.","DOI":"10.1016\/j.theriogenology.2017.12.019"},{"key":"75","doi-asserted-by":"crossref","unstructured":"75. Derisoud E, Jouneau L, Dubois C, Archilla C, Jaszczyszyn Y, Legendre R, Daniel N, Peynot N, Dahirel M, Auclair-Ronzaud J, Wimel L, Duranthon V, Chavatte-Palmer P. Maternal age affects equine day 8 embryo gene expression both in trophoblast and inner cell mass. BMC Genomics<\/i> 2022; 23: 443.","DOI":"10.1186\/s12864-022-08593-7"},{"key":"76","doi-asserted-by":"crossref","unstructured":"76. Derisoud E, Valais O, Jouneau L, Durand A, Prezelin A, Dahirel M, et alPlacental gene expression reveals reduced angiogenesis in primiparous mares. J Equine Vet Sci<\/i> 2023; 125: 104763. .","DOI":"10.1016\/j.jevs.2023.104763"},{"key":"77","doi-asserted-by":"crossref","unstructured":"77. Robles M, Peugnet P, Dubois C, Piumi F, Jouneau L, Bouchez O, Aubri\u00e8re MC, Dahirel M, Aioun J, Wimel L, Couturier-Tarrade A, Chavatte-Palmer P. Placental function and structure at term is altered in broodmares fed with cereals from mid-gestation. Placenta<\/i> 2018; 64: 44\u201352. .","DOI":"10.1016\/j.placenta.2018.02.003"},{"key":"78","doi-asserted-by":"crossref","unstructured":"78. Frank N, Geor RJ, Bailey SR, Durham AE, Johnson PJ. American College of Veterinary Internal Medicine. Equine metabolic syndrome. J Vet Intern Med<\/i> 2010; 24: 467\u2013475.","DOI":"10.1111\/j.1939-1676.2010.0503.x"},{"key":"79","doi-asserted-by":"crossref","unstructured":"79. Giles SL, Rands SA, Nicol CJ, Harris PA. Obesity prevalence and associated risk factors in outdoor living domestic horses and ponies. PeerJ<\/i> 2014; 2: e299.","DOI":"10.7717\/peerj.299"},{"key":"80","doi-asserted-by":"crossref","unstructured":"80. Robin CA, Ireland JL, Wylie CE, Collins SN, Verheyen KLP, Newton JR. Prevalence of and risk factors for equine obesity in Great Britain based on owner-reported body condition scores. Equine Vet J<\/i> 2015; 47: 196\u2013201.","DOI":"10.1111\/evj.12275"},{"key":"81","doi-asserted-by":"crossref","unstructured":"81. Robles M, Nouveau E, Gautier C, Mendoza L, Dubois C, Dahirel M, Lagofun B, Aubri\u00e8re MC, Lejeune JP, Caudron I, Guenon I, Vigui\u00e9 C, Wimel L, Bouraima-Lelong H, Serteyn D, Couturier-Tarrade A, Chavatte-Palmer P. Maternal obesity increases insulin resistance, low-grade inflammation and osteochondrosis lesions in foals and yearlings until 18 months of age. PLoS One<\/i> 2018; 13: e0190309.","DOI":"10.1371\/journal.pone.0190309"},{"key":"82","doi-asserted-by":"crossref","unstructured":"82. Robles M, Rousseau-Ralliard D, Dubois C, Josse T, Nouveau \u00c9, Dahirel M, Wimel L, Couturier-Tarrade A, Chavatte-Palmer P. Obesity during pregnancy in the horse: effect on term placental structure and gene expression, as well as colostrum and milk fatty acid concentration. Vet Sci<\/i> 2023; 10: 691.","DOI":"10.3390\/vetsci10120691"},{"key":"83","doi-asserted-by":"crossref","unstructured":"83. Pazinato FM, Curcio BDR, Fernandes CG, Santos CA, Feij\u00f3 LS, Varela AS Jr, Nogueira CEW. Histomorphometry of the placental vasculature and microcotyledons in Thoroughbred mares with chronic laminitis. Theriogenology<\/i> 2017; 91: 77\u201381. .","DOI":"10.1016\/j.theriogenology.2016.12.009"},{"key":"84","doi-asserted-by":"crossref","unstructured":"84. Loux S, Robles M, Chavatte-Palmer P, de Mestre A. Markers of equine placental differentiation: insights from gene expression studies. Reproduction<\/i> 2022; 163: R39\u2013R54.","DOI":"10.1530\/REP-21-0115"},{"key":"85","doi-asserted-by":"crossref","unstructured":"85. Robles M, Loux S, de Mestre AM, Chavatte-Palmer P. Environmental constraints and pathologies that modulate equine placental genes and development. Reproduction<\/i> 2022; 163: R25\u2013R38.","DOI":"10.1530\/REP-21-0116"},{"key":"86","doi-asserted-by":"crossref","unstructured":"86. Chavatte-Palmer P, Derisoud E, Robles M. Pregnancy and placental development in horses: an update. Domest Anim Endocrinol<\/i> 2022; 79: 106692.","DOI":"10.1016\/j.domaniend.2021.106692"},{"key":"87","doi-asserted-by":"crossref","unstructured":"87. Vallet JL, Freking BA. Differences in placental structure during gestation associated with large and small pig fetuses. J Anim Sci<\/i> 2007; 85: 3267\u20133275.","DOI":"10.2527\/jas.2007-0368"},{"key":"88","doi-asserted-by":"crossref","unstructured":"88. Biensen NJ, Haussmann MF, Lay DC, Christian LL, Ford SP. The relationship between placental and piglet birth weights and growth traits. Anim Sci<\/i> 1999; 68: 709\u2013715.","DOI":"10.1017\/S1357729800050736"},{"key":"89","doi-asserted-by":"crossref","unstructured":"89. Christenson RK, Leymaster KA, Young LD. Justification of unilateral hysterectomy-ovariectomy as a model to evaluate uterine capacity in swine. J Anim Sci<\/i> 1987; 65: 738\u2013744.","DOI":"10.2527\/jas1987.653738x"},{"key":"90","doi-asserted-by":"crossref","unstructured":"90. Zhao W, Liu F, Bell AW, Le HH, Cottrell JJ, Leury BJ, Green MP, Dunshea FR. Controlled elevated temperatures during early-mid gestation cause placental insufficiency and implications for fetal growth in pregnant pigs. Sci Rep<\/i> 2020; 10: 20677.","DOI":"10.1038\/s41598-020-77647-1"},{"key":"91","doi-asserted-by":"crossref","unstructured":"91. Zhao W, Liu F, Marth CD, Green MP, Le HH, Leury BJ, Bell AW, Dunshea FR, Cottrell JJ. Maternal heat stress alters expression of genes associated with nutrient transport activity and metabolism in female placentae from mid-gestating pigs. Int J Mol Sci<\/i> 2021; 22: 4147.","DOI":"10.3390\/ijms22084147"},{"key":"92","doi-asserted-by":"crossref","unstructured":"92. Wang J, Zhou X, Han T, Zhang H. Epigenetic signatures of trophoblast lineage and their biological functions. Cells Dev<\/i> 2024; 179: 203934.","DOI":"10.1016\/j.cdev.2024.203934"},{"key":"93","doi-asserted-by":"crossref","unstructured":"93. Fowden AL, Coan PM, Angiolini E, Burton GJ, Constancia M. Imprinted genes and the epigenetic regulation of placental phenotype. Prog Biophys Mol Biol<\/i> 2011; 106: 281\u2013288.","DOI":"10.1016\/j.pbiomolbio.2010.11.005"},{"key":"94","doi-asserted-by":"crossref","unstructured":"94. Boucher A, Oudihat M, Martin H, Dufour P, Laporta J, Sirard M-A, et alEpigenetic signature of prenatal heat stress: DNA methylation changes in whole blood of dairy calves from birth to weaning. J Dairy Sci<\/i> 2026; 109: 1951\u20131967.","DOI":"10.3168\/jds.2025-27306"},{"key":"95","doi-asserted-by":"crossref","unstructured":"95. Orellana-Guerrero D, Uribe-Salazar JM, El-Sheikh Ali H, Scoggin KE, Ball B, Daels P, Finno CJ, Dini P. Dynamics of the equine placental DNA methylome and transcriptome from mid- to late gestation. Int J Mol Sci<\/i> 2023; 24: 7084.","DOI":"10.3390\/ijms24087084"},{"key":"96","doi-asserted-by":"crossref","unstructured":"96. Hwang JH, An SM, Kwon S, Park DH, Kim TW, Kang DG, Yu GE, Kim IS, Park HC, Ha J, Kim CW. DNA methylation patterns and gene expression associated with litter size in Berkshire pig placenta. PLoS One<\/i> 2017; 12: e0184539.","DOI":"10.1371\/journal.pone.0184539"},{"key":"97","doi-asserted-by":"crossref","unstructured":"97. Tan B, Xiao L, Wang Y, Zhou C, Huang H, Li Z, Hong L, Cai G, Wu Z, Gu T. Comprehensive analysis of placental DNA methylation changes and fetal birth weight in pigs. Int J Mol Sci<\/i> 2024; 25: 7702.","DOI":"10.3390\/ijms25147702"},{"key":"98","doi-asserted-by":"crossref","unstructured":"98. Zhang Z, Su J, Xue J, Xiao L, Hong L, Cai G, Gu T. The research progress of DNA methylation in the development and function of the porcine placenta. Int J Mol Sci<\/i> 2024; 25: 10687.","DOI":"10.3390\/ijms251910687"},{"key":"99","doi-asserted-by":"crossref","unstructured":"99. Th\u00e9ry C, Witwer KW, Aikawa E, et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles<\/i> 2018; 7: 1535750.","DOI":"10.1080\/20013078.2018.1535750"},{"key":"100","doi-asserted-by":"crossref","unstructured":"100. Tong M, Chamley LW. Placental extracellular vesicles and feto-maternal communication. Cold Spring Harb Perspect Med<\/i> 2015; 5: a023028.","DOI":"10.1101\/cshperspect.a023028"},{"key":"101","doi-asserted-by":"crossref","unstructured":"101. Martin C, Bergamelli M, Malnou CE, D\u2019Angelo G. Placental extracellular vesicles in maternal-fetal communication during pregnancy. Biochem Soc Trans<\/i> 2022; 50: 1785\u20131795.","DOI":"10.1042\/BST20220734"},{"key":"102","doi-asserted-by":"crossref","unstructured":"102. Farrelly R, Kennedy MG, Spencer R, Forbes K. Extracellular vesicles as markers and mediators of pregnancy complications: gestational diabetes, pre-eclampsia, preterm birth and fetal growth restriction. J Physiol<\/i> 2023; 601: 4973\u20134988.","DOI":"10.1113\/JP282849"},{"key":"103","doi-asserted-by":"crossref","unstructured":"103. Rosenfeld CS. Placenta Extracellular Vesicles: Messengers Connecting Maternal and Fetal Systems. Biomolecules<\/i> 2024; 14: 995.","DOI":"10.3390\/biom14080995"},{"key":"104","doi-asserted-by":"crossref","unstructured":"104. Pohler KG, Green JA, Moley LA, Gunewardena S, Hung WT, Payton RR, Hong X, Christenson LK, Geary TW, Smith MF. Circulating microRNA as candidates for early embryonic viability in cattle. Mol Reprod Dev<\/i> 2017; 84: 731\u2013743.","DOI":"10.1002\/mrd.22856"},{"key":"105","doi-asserted-by":"crossref","unstructured":"105. Ioannidis J, Donadeu FX. Circulating miRNA signatures of early pregnancy in cattle. BMC Genomics<\/i> 2016; 17: 184.","DOI":"10.1186\/s12864-016-2529-1"},{"key":"106","doi-asserted-by":"crossref","unstructured":"106. Ioannidis J, Donadeu FX. Changes in circulating microRNA levels can be identified as early as day 8 of pregnancy in cattle. PLoS One<\/i> 2017; 12: e0174892.","DOI":"10.1371\/journal.pone.0174892"},{"key":"107","doi-asserted-by":"crossref","unstructured":"107. Casarotto LT, Jones HN, Galio L, Henry C, Chavatte-Palmer P, Dahl GE. Characterization of extracellular vesicles at parturition in dairy cows with late-gestation heat stress. JDS Commun<\/i> 2025; 7: 101\u2013106.","DOI":"10.3168\/jdsc.2025-0821"},{"key":"108","doi-asserted-by":"crossref","unstructured":"108. Mourier E, Tarrade A, Duan J, Richard C, Bertholdt C, Beaumont M, Morel O, Chavatte-Palmer P. Non-invasive evaluation of placental blood flow: lessons from animal models. Reproduction<\/i> 2017; 153: R85\u2013R96.","DOI":"10.1530\/REP-16-0428"},{"key":"109","doi-asserted-by":"crossref","unstructured":"109. Reynolds LP, Dahlen CR, Ward AK, Crouse MS, Borowicz PP, Davila-Ruiz BJ, Kanjanaruch C, Bochantin KA, McLean KJ, McCarthy KL, Menezes ACB, Diniz WJS, Cushman RA, Caton JS. Role of the placenta in developmental programming: Observations from models using large animals. Anim Reprod Sci<\/i> 2023; 257: 107322.","DOI":"10.1016\/j.anireprosci.2023.107322"}],"container-title":["Journal of Reproduction and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jrd\/72\/3\/72_2026-006\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T03:26:43Z","timestamp":1781926003000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jrd\/72\/3\/72_2026-006\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":109,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.1262\/jrd.2026-006","relation":{},"ISSN":["0916-8818","1348-4400"],"issn-type":[{"value":"0916-8818","type":"print"},{"value":"1348-4400","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"2026-006"}}