{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T03:53:02Z","timestamp":1781927582532,"version":"3.54.5"},"reference-count":46,"publisher":"Japanese Society of Animal Reproduction","issue":"3","funder":[{"name":"JSPS KAKENHI","award":["16H05014"],"award-info":[{"award-number":["16H05014"]}]},{"name":"JSPS KAKENHI","award":["21K19187"],"award-info":[{"award-number":["21K19187"]}]},{"name":"JSPS KAKENHI","award":["22H00397"],"award-info":[{"award-number":["22H00397"]}]},{"name":"JSPS KAKENHI","award":["23K14064"],"award-info":[{"award-number":["23K14064"]}]},{"name":"JSPS KAKENHI","award":["25K02154"],"award-info":[{"award-number":["25K02154"]}]},{"name":"JSPS KAKENHI","award":["22HP2009"],"award-info":[{"award-number":["22HP2009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Reprod. Dev.","Journal of Reproduction and Development"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1262\/jrd.2026-037","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T22:11:02Z","timestamp":1781734262000},"page":"398-402","source":"Crossref","is-referenced-by-count":0,"title":["Neuroendocrine mechanisms leading to novel control techniques of reproduction in livestock: Regulation of the GnRH pulse generator activity"],"prefix":"10.1262","volume":"72","author":[{"given":"Satoshi","family":"OHKURA","sequence":"first","affiliation":[{"name":"Laboratory of Animal Production Science, Graduate School of                     Bioagricultural Sciences, Nagoya University, Nagoya 464-8601,                     Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"NAKAMURA","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Production Science, Graduate School of                     Bioagricultural Sciences, Nagoya University, Nagoya 464-8601,                     Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"349","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1.  Belchetz                     PE,                        Plant                     TM,                        Nakai                     Y,                        Keogh                     EJ,                        Knobil                     E.                  Hypophysial responses to continuous and intermittent delivery of                  hypopthalamic gonadotropin-releasing hormone.                     <i>Science<\/i>               1978; 202:                  631\u2013633.","DOI":"10.1126\/science.100883"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2.  Knobil                     E. The                  neuroendocrine control of the menstrual cycle.                     <i>Recent Prog Horm Res<\/i>               1980; 36: 53\u201388.","DOI":"10.1016\/B978-0-12-571136-4.50008-5"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3.  Lincoln                     DW,                        Fraser                     HM,                        Lincoln                     GA,                        Martin                     GB,                        McNeilly                     AS.                  Hypothalamic pulse generators.                     <i>Recent Prog Horm Res<\/i>               1985; 41:                  369\u2013419.","DOI":"10.1016\/B978-0-12-571141-8.50013-5"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4.  Ohtaki                     T,                        Shintani                     Y,                        Honda                     S,                        Matsumoto                     H,                        Hori                     A,                        Kanehashi                     K,                        Terao                     Y,                        Kumano                     S,                        Takatsu                     Y,                        Masuda                     Y,                        Ishibashi                     Y,                        Watanabe                     T,                        Asada                     M,                        Yamada                     T,                        Suenaga                     M,                        Kitada                     C,                        Usuki                     S,                        Kurokawa                     T,                        Onda                     H,                        Nishimura                     O,                        Fujino                     M.                  Metastasis suppressor gene KiSS-1 encodes peptide ligand of a                  G-protein-coupled receptor. <i>Nature<\/i>               2001; 411:                  613\u2013617.","DOI":"10.1038\/35079135"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5.  Robinson                     JE,                        Radford                     HM,                        Karsch                     FJ.                  Seasonal changes in pulsatile luteinizing hormone (LH) secretion in                  the ewe: relationship of frequency of LH pulses to day length and response to                  estradiol negative feedback. <i>Biol Reprod<\/i>               1985; 33:                  324\u2013334.","DOI":"10.1095\/biolreprod33.2.324"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6.  Chemineau                     P,                        Martin                     GB,                        Saumande                     J,                        Normant                     E.                  Seasonal and hormonal control of pulsatile LH secretion in the                  dairy goat (<i>Capra hircus<\/i>). <i>J                     Reprod Fertil<\/i>               1988; 83: 91\u201398.","DOI":"10.1530\/jrf.0.0830091"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7.  Cagampang                     FR,                        Maeda                     K,                        Yokoyama                     A,                        Ota                     K.                  Effect of food deprivation on the pulsatile LH release in the                  cycling and ovariectomized female rat. <i>Horm Metab                     Res<\/i>               1990; 22:                  269\u2013272.","DOI":"10.1055\/s-2007-1004900"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8.  Foster                     DL,                        Olster                     DH.                  Effect of restricted nutrition on puberty in the lamb: patterns of                  tonic luteinizing hormone (LH) secretion and competency of the LH surge                  system. <i>Endocrinology<\/i>               1985; 116:                  375\u2013381.","DOI":"10.1210\/endo-116-1-375"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9.  Tanaka                     T,                        Akaboshi                     N,                        Inoue                     Y,                        Kamomae                     H,                        Kaneda                     Y.                  Fasting-induced suppression of pulsatile luteinizing hormone                  secretion is related to body energy status in ovariectomized               goats. <i>Anim Reprod Sci<\/i>               2002; 72:                  185\u2013196.","DOI":"10.1016\/S0378-4320(02)00091-X"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10.  O\u2019Byrne                     KT,                        Thalabard                     JC,                        Grosser                     PM,                        Wilson                     RC,                        Williams                     CL,                        Chen                     MD,                        Ladendorf                     D,                        Hotchkiss                     J,                        Knobil                     E.                  Radiotelemetric monitoring of hypothalamic gonadotropin-releasing                  hormone pulse generator activity throughout the menstrual cycle of the rhesus                  monkey. <i>Endocrinology<\/i>               1991; 129:                  1207\u20131214.","DOI":"10.1210\/endo-129-3-1207"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11.  Herbison                     AE,                        Pape                     JR. New                  evidence for estrogen receptors in gonadotropin-releasing hormone                  neurons. <i>Front Neuroendocrinol<\/i>               2001; 22:                  292\u2013308.","DOI":"10.1006\/frne.2001.0219"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12.  Mellon                     PL,                        Windle                     JJ,                        Goldsmith                     PC,                        Padula                     CA,                        Roberts                     JL,                        Weiner                     RI.                  Immortalization of hypothalamic GnRH neurons by genetically                  targeted tumorigenesis. <i>Neuron<\/i>               1990; 5: 1\u201310.","DOI":"10.1016\/0896-6273(90)90028-E"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13.  Stojilkovic                     SS,                        Krsmanovic                     LZ,                        Spergel                     DJ,                        Catt                     KJ.                  Gonadotropin-releasing hormone neurons: intrinsic pulsatility and                  receptor-mediated regulation. <i>Trends Endocrinol                     Metab<\/i>               1994; 5:               201\u2013209.","DOI":"10.1016\/1043-2760(94)90078-7"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14.  Kawano                     H,                        Daikoku                     S.                  Immunohistochemical demonstration of LHRH neurons and their                  pathways in the rat hypothalamus.                     <i>Neuroendocrinology<\/i>               1981; 32:                  179\u2013186.","DOI":"10.1159\/000123153"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15.  Blake                     CA,                        Sawyer                     CH.                  Effects of hypothalamic deafferentation on the pulsatile rhythm in                  plasma concentrations of luteinizing hormone in ovariectomized                  rats. <i>Endocrinology<\/i>               1974; 94:                  730\u2013736.","DOI":"10.1210\/endo-94-3-730"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16.  Ohkura                     S,                        Tsukamura                     H,                        Maeda                     K.                  Effects of various types of hypothalamic deafferentation on                  luteinizing hormone pulses in ovariectomized rats.                     <i>J Neuroendocrinol<\/i>               1991; 3:               503\u2013508.","DOI":"10.1111\/j.1365-2826.1991.tb00310.x"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17.  Ohkura                     S,                        Tsukamura                     H,                        Maeda                     K.                  Effects of transplants of fetal mediobasal hypothalamus on                  luteinizing hormone pulses impaired by hypothalamic deafferentation in adult                  ovariectomized rats. <i>Neuroendocrinology<\/i>               1992; 55:                  422\u2013426.","DOI":"10.1159\/000126153"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18.  Tanaka                     T,                        Ozawa                     T,                        Hoshino                     K,                        Mori                     Y.                  Changes in the gonadotropin-releasing hormone pulse generator                  activity during the estrous cycle in the goat.                     <i>Neuroendocrinology<\/i>               1995; 62:                  553\u2013561.","DOI":"10.1159\/000127051"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19.  Kinoshita                     M,                        Tsukamura                     H,                        Adachi                     S,                        Matsui                     H,                        Uenoyama                     Y,                        Iwata                     K,                        Yamada                     S,                        Inoue                     K,                        Ohtaki                     T,                        Matsumoto                     H,                        Maeda                     K.                  Involvement of central metastin in the regulation of preovulatory                  luteinizing hormone surge and estrous cyclicity in female rats.                     <i>Endocrinology<\/i>               2005; 146:                  4431\u20134436.","DOI":"10.1210\/en.2005-0195"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20.  Adachi                     S,                        Yamada                     S,                        Takatsu                     Y,                        Matsui                     H,                        Kinoshita                     M,                        Takase                     K,                        Sugiura                     H,                        Ohtaki                     T,                        Matsumoto                     H,                        Uenoyama                     Y,                        Tsukamura                     H,                        Inoue                     K,                        Maeda                     K.                  Involvement of anteroventral periventricular metastin\/kisspeptin                  neurons in estrogen positive feedback action on luteinizing hormone release in                  female rats. <i>J Reprod Dev<\/i>               2007; 53:                  367\u2013378.","DOI":"10.1262\/jrd.18146"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21.  Oakley                     AE,                        Clifton                     DK,                        Steiner                     RA.                  Kisspeptin signaling in the brain.                     <i>Endocr Rev<\/i>               2009; 30:                  713\u2013743.","DOI":"10.1210\/er.2009-0005"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22.  Hassaneen                     A,                        Naniwa                     Y,                        Suetomi                     Y,                        Matsuyama                     S,                        Kimura                     K,                        Ieda                     N,                        Inoue                     N,                        Uenoyama                     Y,                        Tsukamura                     H,                        Maeda                     KI,                        Matsuda                     F,                        Ohkura                     S.                  Immunohistochemical characterization of the arcuate                  kisspeptin\/neurokinin B\/dynorphin (KNDy) and preoptic kisspeptin neuronal                  populations in the hypothalamus during the estrous cycle in                  heifers. <i>J Reprod Dev<\/i>               2016; 62:                  471\u2013477.","DOI":"10.1262\/jrd.2016-075"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23.  Higo                     S,                        Honda                     S,                        Iijima                     N,                        Ozawa                     H.                  Mapping of kisspeptin receptor mRNA in the whole rat brain and its                  co-localisation with oxytocin in the paraventricular nucleus.                     <i>J Neuroendocrinol<\/i>               2016; 28: 12356.","DOI":"10.1111\/jne.12356"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24.  Zhang                     L,                        Hern\u00e1ndez                     VS,                        Zetter                     MA,                        Hern\u00e1ndez-P\u00e9rez                     OR,                        Hern\u00e1ndez-Gonz\u00e1lez                     R,                        Camacho-Arroyo                     I,                        Eiden                     LE,                        Millar                     RP.                  Kisspeptin fiber and receptor distribution analysis suggests its                  potential role in central sensorial processing and behavioral state                  control. <i>J Neuroendocrinol<\/i>               2025; 37: e70007.","DOI":"10.1111\/jne.70007"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25.  Li                     Q,                        Roa                     A,                        Clarke                     IJ,                        Smith                     JT.                  Seasonal variation in the gonadotropin-releasing hormone response                  to kisspeptin in sheep: possible kisspeptin regulation of the kisspeptin                  receptor. <i>Neuroendocrinology<\/i>               2012; 96:                  212\u2013221.","DOI":"10.1159\/000335998"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26.  Irwig                     MS,                        Fraley                     GS,                        Smith                     JT,                        Acohido                     BV,                        Popa                     SM,                        Cunningham                     MJ,                        Gottsch                     ML,                        Clifton                     DK,                        Steiner                     RA.                  Kisspeptin activation of gonadotropin releasing hormone neurons and                  regulation of KiSS-1 mRNA in the male rat.                     <i>Neuroendocrinology<\/i>               2004; 80:                  264\u2013272.","DOI":"10.1159\/000083140"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27.  Ohkura                     S,                        Takase                     K,                        Matsuyama                     S,                        Mogi                     K,                        Ichimaru                     T,                        Wakabayashi                     Y,                        Uenoyama                     Y,                        Mori                     Y,                        Steiner                     RA,                        Tsukamura                     H,                        Maeda                     KI,                        Okamura                     H.                  Gonadotrophin-releasing hormone pulse generator activity in the                  hypothalamus of the goat. <i>J                     Neuroendocrinol<\/i>               2009; 21:                  813\u2013821.","DOI":"10.1111\/j.1365-2826.2009.01909.x"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28.  Uenoyama                     Y,                        Nakamura                     S,                        Hayakawa                     Y,                        Ikegami                     K,                        Watanabe                     Y,                        Deura                     C,                        Minabe                     S,                        Tomikawa                     J,                        Goto                     T,                        Ieda                     N,                        Inoue                     N,                        Sanbo                     M,                        Tamura                     C,                        Hirabayashi                     M,                        Maeda                     KI,                        Tsukamura                     H. Lack                  of pulse and surge modes and glutamatergic stimulation of luteinising hormone                  release in <i>Kiss1<\/i> knockout rats. <i>J                     Neuroendocrinol<\/i>               2015; 27:                  187\u2013197.","DOI":"10.1111\/jne.12257"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29.  Nagae                     M,                        Uenoyama                     Y,                        Okamoto                     S,                        Tsuchida                     H,                        Ikegami                     K,                        Goto                     T,                        Majarune                     S,                        Nakamura                     S,                        Sanbo                     M,                        Hirabayashi                     M,                        Kobayashi                     K,                        Inoue                     N,                        Tsukamura                     H.                  Direct evidence that KNDy neurons maintain gonadotropin pulses and                  folliculogenesis as the GnRH pulse generator. <i>Proc                     Natl Acad Sci USA<\/i>               2021; 118: e2009156118.","DOI":"10.1073\/pnas.2009156118"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30.  Matsuyama                     S,                        Ohkura                     S,                        Ichimaru                     T,                        Sakurai                     K,                        Tsukamura                     H,                        Maeda                     K,                        Okamura                     H.                  Simultaneous observation of the GnRH pulse generator activity and                  plasma concentrations of metabolites and insulin during fasting and subsequent                  refeeding periods in Shiba goats. <i>J Reprod                     Dev<\/i>               2004; 50:                  697\u2013704.","DOI":"10.1262\/jrd.50.697"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31.  Nagatani                     S,                        Bucholtz                     DC,                        Murahashi                     K,                        Estacio                     MA,                        Tsukamura                     H,                        Foster                     DL,                        Maeda                     KI.                  Reduction of glucose availability suppresses pulsatile luteinizing                  hormone release in female and male rats.                     <i>Endocrinology<\/i>               1996; 137:                  1166\u20131170.","DOI":"10.1210\/endo.137.4.8625885"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32.  Ohkura                     S,                        Ichimaru                     T,                        Itoh                     F,                        Matsuyama                     S,                        Okamura                     H.                  Further evidence for the role of glucose as a metabolic regulator                  of hypothalamic gonadotropin-releasing hormone pulse generator activity in                  goats. <i>Endocrinology<\/i>               2004; 145:                  3239\u20133246.","DOI":"10.1210\/en.2003-1516"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33.  Takeuchi                     Y,                        Nagabukuro                     H,                        Kizumi                     O,                        Mori                     Y.                  Lipopolysaccharide-induced suppression of the hypothalamic                  gonadotropin-releasing hormone pulse generator in ovariectomized                  goats. <i>J Vet Med Sci<\/i>               1997; 59: 93\u201396.","DOI":"10.1292\/jvms.59.93"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34.  Martin                     GB,                        Oldham                     CM,                        Cogni\u00e9                     Y,                        Pearce                     DL. The                  physiological responses of anovulatory ewes to the introduction of rams \u2013 a                  review. <i>Livest Prod Sci<\/i>               1986; 15:                  219\u2013247.","DOI":"10.1016\/0301-6226(86)90031-X"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35.  Murata                     K,                        Tamogami                     S,                        Itou                     M,                        Ohkubo                     Y,                        Wakabayashi                     Y,                        Watanabe                     H,                        Okamura                     H,                        Takeuchi                     Y,                        Mori                     Y.                  Identification of an olfactory signal molecule that activates the                  central regulator of reproduction in goats. <i>Curr                     Biol<\/i>               2014; 24:                  681\u2013686.","DOI":"10.1016\/j.cub.2014.01.073"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36.  Okamura                     H,                        Murata                     K,                        Sakamoto                     K,                        Wakabayashi                     Y,                        Ohkura                     S,                        Takeuchi                     Y,                        Mori                     Y. Male                  effect pheromone tickles the gonadotrophin-releasing hormone pulse                  generator. <i>J Neuroendocrinol<\/i>               2010; 22:                  825\u2013832.","DOI":"10.1111\/j.1365-2826.2010.02037.x"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37.  Goodman                     RL,                        Lehman                     MN,                        Smith                     JT,                        Coolen                     LM, de                        Oliveira                     CV,                        Jafarzadehshirazi                     MR,                        Pereira                     A,                        Iqbal                     J,                        Caraty                     A,                        Ciofi                     P,                        Clarke                     IJ.                  Kisspeptin neurons in the arcuate nucleus of the ewe express both                  dynorphin A and neurokinin B.                     <i>Endocrinology<\/i>               2007; 148:                  5752\u20135760.","DOI":"10.1210\/en.2007-0961"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38.  Wakabayashi                     Y,                        Nakada                     T,                        Murata                     K,                        Ohkura                     S,                        Mogi                     K,                        Navarro                     VM,                        Clifton                     DK,                        Mori                     Y,                        Tsukamura                     H,                        Maeda                     K,                        Steiner                     RA,                        Okamura                     H.                  Neurokinin B and dynorphin A in kisspeptin neurons of the arcuate                  nucleus participate in generation of periodic oscillation of neural activity                  driving pulsatile gonadotropin-releasing hormone secretion in the                  goat. <i>J Neurosci<\/i>               2010; 30:                  3124\u20133132.","DOI":"10.1523\/JNEUROSCI.5848-09.2010"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39.  Lehman                     MN,                        Coolen                     LM,                        Goodman                     RL.                  Minireview: kisspeptin\/neurokinin B\/dynorphin (KNDy) cells of the                  arcuate nucleus: a central node in the control of gonadotropin-releasing hormone                  secretion. <i>Endocrinology<\/i>               2010; 151:                  3479\u20133489.","DOI":"10.1210\/en.2010-0022"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40.  Yamamura                     T,                        Wakabayashi                     Y,                        Ohkura                     S,                        Navarro                     VM,                        Okamura                     H.                  Effects of intravenous administration of neurokinin receptor                  subtype-selective agonists on gonadotropin-releasing hormone pulse generator                  activity and luteinizing hormone secretion in goats.                     <i>J Reprod Dev<\/i>               2015; 61: 20\u201329.","DOI":"10.1262\/jrd.2014-109"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41.  Sasaki                     T,                        Sonoda                     T,                        Tatebayashi                     R,                        Kitagawa                     Y,                        Oishi                     S,                        Yamamoto                     K,                        Fujii                     N,                        Inoue                     N,                        Uenoyama                     Y,                        Tsukamura                     H,                        Maeda                     KI,                        Matsuda                     F,                        Morita                     Y,                        Matsuyama                     S,                        Ohkura                     S.                  Peripheral administration of SB223412, a selective neurokinin-3                  receptor antagonist, suppresses pulsatile luteinizing hormone secretion by acting                  on the gonadotropin-releasing hormone pulse generator in estrogen-treated                  ovariectomized female goats. <i>J Reprod Dev<\/i>               2020; 66:                  351\u2013357.","DOI":"10.1262\/jrd.2019-145"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42.  Sasaki                     T,                        Ito                     D,                        Sonoda                     T,                        Morita                     Y,                        Wakabayashi                     Y,                        Yamamura                     T,                        Okamura                     H,                        Oishi                     S,                        Noguchi                     T,                        Fujii                     N,                        Uenoyama                     Y,                        Tsukamura                     H,                        Maeda                     KI,                        Matsuda                     F,                        Ohkura                     S.                  Peripheral administration of \u03ba-opioid receptor antagonist                  stimulates gonadotropin-releasing hormone pulse generator activity in                  ovariectomized, estrogen-treated female goats.                     <i>Domest Anim Endocrinol<\/i>               2019; 68: 83\u201391.","DOI":"10.1016\/j.domaniend.2018.12.011"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43.  Ichimaru                     T,                        Mori                     Y,                        Okamura                     H. A                  possible role of neuropeptide Y as a mediator of undernutrition to the                  hypothalamic gonadotropin-releasing hormone pulse generator in                  goats. <i>Endocrinology<\/i>               2001; 142:                  2489\u20132498.","DOI":"10.1210\/endo.142.6.8002"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44.  Ichimaru                     T,                        Matsuyama                     S,                        Ohkura                     S,                        Mori                     Y,                        Okamura                     H.                  Central cholecystokinin-octapeptide accelerates the activity of the                  hypothalamic gonadotropin-releasing hormone pulse generator in                  goats. <i>J Neuroendocrinol<\/i>               2003; 15: 80\u201386.","DOI":"10.1046\/j.1365-2826.2003.00965.x"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45.  Matsuyama                     S,                        Ohkura                     S,                        Sakurai                     K,                        Tsukamura                     H,                        Maeda                     K,                        Okamura                     H.                  Activation of melanocortin receptors accelerates the                  gonadotropin-releasing hormone pulse generator activity in goats.                     <i>Neurosci Lett<\/i>               2005; 383:                  289\u2013294.","DOI":"10.1016\/j.neulet.2005.04.026"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46.  Nakamura                     S,                        Sasaki                     T,                        Uenoyama                     Y,                        Inoue                     N,                        Nakanishi                     M,                        Yamada                     K,                        Morishima                     A,                        Suzumura                     R,                        Kitagawa                     Y,                        Morita                     Y,                        Ohkura                     S,                        Tsukamura                     H.                  Raphe glucose-sensing serotonergic neurons stimulate KNDy neurons                  to enhance LH pulses via 5HT2CR: rat and goat studies.                     <i>Sci Rep<\/i>               2024; 14: 10190.","DOI":"10.1038\/s41598-024-58470-4"}],"container-title":["Journal of Reproduction and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jrd\/72\/3\/72_2026-037\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T03:27:39Z","timestamp":1781926059000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jrd\/72\/3\/72_2026-037\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.1262\/jrd.2026-037","relation":{},"ISSN":["0916-8818","1348-4400"],"issn-type":[{"value":"0916-8818","type":"print"},{"value":"1348-4400","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"2026-037"}}