{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:52:25Z","timestamp":1787662345596,"version":"build-2736575974"},"reference-count":41,"publisher":"Japanese Society for Hygiene","issue":"0","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ. Health Prev. Med.","Environ Health Prev Med"],"published-print":{"date-parts":[[2025]]},"DOI":"10.1265\/ehpm.24-00321","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T22:08:09Z","timestamp":1746223689000},"page":"33-33","source":"Crossref","is-referenced-by-count":4,"title":["Single exposure to near-threshold 5G millimeter wave modifies restraint stress responses in rats"],"prefix":"10.1265","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8445-4071","authenticated-orcid":false,"given":"Akiko","family":"Matsumoto","sequence":"first","affiliation":[{"name":"Department of Social and Environmental Medicine, Saga University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikumi","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Social and Environmental Medicine, Saga University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etsuko","family":"Ijima","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine, Kurume University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akimasa","family":"Hirata","sequence":"additional","affiliation":[{"name":"Department of Electrical and Mechanical Engineering, Nagoya Institute of Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiko","family":"Kodera","sequence":"additional","affiliation":[{"name":"Department of Electrical and Mechanical Engineering, Nagoya Institute of Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayoshi","family":"Ichiba","sequence":"additional","affiliation":[{"name":"Department of Social and Environmental Medicine, Saga University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikiko","family":"Tokiya","sequence":"additional","affiliation":[{"name":"Department of Social and Environmental Medicine, Saga University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Hikage","sequence":"additional","affiliation":[{"name":"Faculty of Information Science and Technology, Hokkaido University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Masuda","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine, Kurume University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"335","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. ICNIRP. Guidelines for limiting exposure to electromagnetic fields (100 kHz to 300 GHz). Health Phys. 2020;118:483\u2013524. https:\/\/doi.org\/10.1097\/HP.0000000000001210.","DOI":"10.1097\/HP.0000000000001210"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Khan SA, Shayea I, Ergen M, Mohamad H. Handover management over dual connectivity in 5G technology with future ultra-dense mobile heterogeneous networks: A review. Engineering Science and Technology, an International Journal. 2022;35. https:\/\/doi.org\/10.1016\/j.jestch.2022.101172.","DOI":"10.1016\/j.jestch.2022.101172"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Saunders RD, Jefferys JG. A neurobiological basis for ELF guidelines. Health Phys. 2007;92:596\u2013603. https:\/\/doi.org\/10.1097\/01.HP.0000257856.83294.3e.","DOI":"10.1097\/01.HP.0000257856.83294.3e"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Zhadobov M, Alekseev SI, Le Drean Y, Sauleau R, Fesenko EE. Millimeter waves as a source of selective heating of skin. Bioelectromagnetics. 2015;36:464\u201375. https:\/\/doi.org\/10.1002\/bem.21929.","DOI":"10.1002\/bem.21929"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Alekseev SI, Ziskin MC. Human skin permittivity determined by millimeter wave reflection measurements. Bioelectromagnetics. 2007;28:331\u20139. https:\/\/doi.org\/10.1002\/bem.20308.","DOI":"10.1002\/bem.20308"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Nguyen TH, Shamis Y, Croft RJ, Wood A, McIntosh RL, Crawford RJ, et al. 18 GHz electromagnetic field induces permeability of Gram-positive cocci. Sci Rep. 2015;5:10980. https:\/\/doi.org\/10.1038\/srep10980.","DOI":"10.1038\/srep10980"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Brockow T, Wagner A, Franke A, Offenbacher M, Resch KL. A randomized controlled trial on the effectiveness of mild water-filtered near infrared whole-body hyperthermia as an adjunct to a standard multimodal rehabilitation in the treatment of fibromyalgia. Clin J Pain. 2007;23:67\u201375. https:\/\/doi.org\/10.1097\/AJP.0b013e31802b4f80.","DOI":"10.1097\/AJP.0b013e31802b4f80"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Hirata A, Laakso I, Oizumi T, Hanatani R, Chan KH, Wiart J. The relationship between specific absorption rate and temperature elevation in anatomically based human body models for plane wave exposure from 30 MHz to 6 GHz. Phys Med Biol. 2013;58:903\u201321. https:\/\/doi.org\/10.1088\/0031-9155\/58\/4\/903.","DOI":"10.1088\/0031-9155\/58\/4\/903"},{"key":"9","unstructured":"9. TLVs and BEIs: based on the documentation of the threshold limit values for chemical substances and physical agents and biological exposure indices. ACGIH (2017)."},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Adair ER, Blick DW, Allen SJ, Mylacraine KS, Ziriax JM, Scholl DM. Thermophysiological responses of human volunteers to whole body RF exposure at 220 MHz. Bioelectromagnetics. 2005;26:448\u201361. https:\/\/doi.org\/10.1002\/bem.20105.","DOI":"10.1002\/bem.20105"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Adair ER, Mylacraine KS, Allen SJ. Thermophysiological consequences of whole body resonant RF exposure (100 MHz) in human volunteers. Bioelectromagnetics. 2003;24:489\u2013501. https:\/\/doi.org\/10.1002\/bem.10128.","DOI":"10.1002\/bem.10128"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Adair ER, Mylacraine KS, Cobb BL. Partial-body exposure of human volunteers to 2450 MHz pulsed or CW fields provokes similar thermoregulatory responses. Bioelectromagnetics. 2001;22:246\u201359. https:\/\/doi.org\/10.1002\/bem.47.","DOI":"10.1002\/bem.47"},{"key":"13","unstructured":"13. ICNIRP. Gaps in Knowledge Relevant to the \u201cICNIRP Guidelines for Limiting Exposure to Time-Varying Electric, Magnetic and Electromagnetic Fields (100 kHz to 300 GHz)\u201d. Health Phys. 2024."},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Ijima E, Kodera S, Hirata A, Hikage T, Matsumoto A, Ishitake T, et al. Excessive whole-body exposure to 28 GHz quasi-millimeter wave induces thermoregulation accompanied by a change in skin blood flow proportion in rats. Front Public Health. 2023;11:1225896. https:\/\/doi.org\/10.3389\/fpubh.2023.1225896.","DOI":"10.3389\/fpubh.2023.1225896"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Hajat A, Diez Roux AV, Castro-Diehl C, Cosselman K, Golden SH, Hazlehurst MF, et al. The Association between Long-Term Air Pollution and Urinary Catecholamines: Evidence from the Multi-Ethnic Study of Atherosclerosis. Environ Health Perspect. 2019;127:57007. https:\/\/doi.org\/10.1289\/EHP3286.","DOI":"10.1289\/EHP3286"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Selander J, Bluhm G, Theorell T, Pershagen G, Babisch W, Seiffert I, et al. Saliva cortisol and exposure to aircraft noise in six European countries. Environ Health Perspect. 2009;117:1713\u20137. https:\/\/doi.org\/10.1289\/ehp.0900933.","DOI":"10.1289\/ehp.0900933"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Hajat A, Hazlehurst MF, Golden SH, Merkin SS, Seeman T, Szpiro AA, et al. The cross-sectional and longitudinal association between air pollution and salivary cortisol: Evidence from the Multi-Ethnic Study of Atherosclerosis. Environ Int. 2019;131:105062. https:\/\/doi.org\/10.1016\/j.envint.2019.105062.","DOI":"10.1016\/j.envint.2019.105062"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Ly JQM, Gaggioni G, Chellappa SL, Papachilleos S, Brzozowski A, Borsu C, et al. Circadian regulation of human cortical excitability. Nat Commun. 2016;7:11828. https:\/\/doi.org\/10.1038\/ncomms11828.","DOI":"10.1038\/ncomms11828"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Russell G, Lightman S. The human stress response. Nat Rev Endocrinol. 2019;15:525\u201334. https:\/\/doi.org\/10.1038\/s41574-019-0228-0.","DOI":"10.1038\/s41574-019-0228-0"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Gump BB, Stewart P, Reihman J, Lonky E, Darvill T, Parsons PJ, et al. Low-level prenatal and postnatal blood lead exposure and adrenocortical responses to acute stress in children. Environ Health Perspect. 2008;116:249\u201355. https:\/\/doi.org\/10.1289\/ehp.10391.","DOI":"10.1289\/ehp.10391"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Kvetnansky R, Sabban EL, Palkovits M. Catecholaminergic systems in stress: structural and molecular genetic approaches. Physiol Rev. 2009;89:535\u2013606. https:\/\/doi.org\/10.1152\/physrev.00042.2006.","DOI":"10.1152\/physrev.00042.2006"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Fukuda S, Nojima J, Motoki Y, Yamaguti K, Nakatomi Y, Okawa N, et al. A potential biomarker for fatigue: Oxidative stress and anti-oxidative activity. Biol Psychol. 2016;118:88\u201393. https:\/\/doi.org\/10.1016\/j.biopsycho.2016.05.005.","DOI":"10.1016\/j.biopsycho.2016.05.005"},{"key":"23","unstructured":"23. Hisamitsu N, Hlaing T, Guo S, Ishikawa S, Hisamistu T. The effect of small island stress on the blood fluidity and reactive oxygen metabolite level in rats. J Showa Univ Soc. 2017;77:156\u201361. https:\/\/doi.org\/10.14930\/jshowaunivsoc.77.156."},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Ngoula F, Lontio FA, Tchoffo H, Manfo Tsague FP, Djeunang RM, Vemo BN, et al. Heat Induces Oxidative Stress: Reproductive Organ Weights and Serum Metabolite Profile, Testes Structure, and Function Impairment in Male Cavy (Cavia porcellus). Front Vet Sci. 2020;7:37. https:\/\/doi.org\/10.3389\/fvets.2020.00037.","DOI":"10.3389\/fvets.2020.00037"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Ames BN, Shigenaga MK, Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA. 1993;90:7915\u201322. https:\/\/doi.org\/10.1073\/pnas.90.17.7915.","DOI":"10.1073\/pnas.90.17.7915"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Boveris A, Chance B. The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. Biochem J. 1973;134:707\u201316. https:\/\/doi.org\/10.1042\/bj1340707.","DOI":"10.1042\/bj1340707"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Negre-Salvayre A, Auge N, Ayala V, Basaga H, Boada J, Brenke R, et al. Pathological aspects of lipid peroxidation. Free Radic Res. 2010;44:1125\u201371. https:\/\/doi.org\/10.3109\/10715762.2010.498478.","DOI":"10.3109\/10715762.2010.498478"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol. 2007;39:44\u201384. https:\/\/doi.org\/10.1016\/j.biocel.2006.07.001.","DOI":"10.1016\/j.biocel.2006.07.001"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Matsumoto A, Shimanoe C, Tanaka K, Ichiba M, Hara M. Development of suitable method for large-scale urinary glucocorticoid analysis by liquid chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1057:62\u20139. https:\/\/doi.org\/10.1016\/j.jchromb.2017.04.031.","DOI":"10.1016\/j.jchromb.2017.04.031"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Morris SD. Heat shock proteins and the skin. Clin Exp Dermatol. 2002;27:220\u20134. https:\/\/doi.org\/10.1046\/j.1365-2230.2002.01012.x.","DOI":"10.1046\/j.1365-2230.2002.01012.x"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Ohtani S, Ushiyama A, Maeda M, Hattori K, Kunugita N, Wang J, et al. Exposure time-dependent thermal effects of radiofrequency electromagnetic field exposure on the whole body of rats. J Toxicol Sci. 2016;41:655\u201366. https:\/\/doi.org\/10.2131\/jts.41.655.","DOI":"10.2131\/jts.41.655"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Millenbaugh NJ, Roth C, Sypniewska R, Chan V, Eggers JS, Kiel JL, et al. Gene expression changes in the skin of rats induced by prolonged 35 GHz millimeter-wave exposure. Radiat Res. 2008;169:288\u2013300. https:\/\/doi.org\/10.1667\/RR1121.1.","DOI":"10.1667\/RR1121.1"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Uchimura T, Hara S, Yazawa T, Kamei Y, Kitano T. Involvement of heat shock proteins on the transcriptional regulation of corticotropin-releasing hormone in medaka. Front Endocrinol (Lausanne). 2019;10:529. https:\/\/doi.org\/10.3389\/fendo.2019.00529.","DOI":"10.3389\/fendo.2019.00529"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Hales JR, Iriki M, Tsuchiya K, Kozawa E. Thermally-induced cutaneous sympathetic activity related to blood flow through capillaries and arteriovenous anastomoses. Pflugers Arch. 1978;375:17\u201324. https:\/\/doi.org\/10.1007\/BF00584143.","DOI":"10.1007\/BF00584143"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Vanhoutte G, Verhoye M, Raman E, Roberts M, Van der Linden A. In-vivo non-invasive study of the thermoregulatory function of the blood vessels in the rat tail using magnetic resonance angiography. NMR Biomed. 2002;15:263\u20139. https:\/\/doi.org\/10.1002\/nbm.768.","DOI":"10.1002\/nbm.768"},{"key":"36","unstructured":"36. Hoffman BB, Lefkowitz RJ. Catecholamines, sympathomimetic drugs, and adrenergic receptor antagonists. In: Hardman JG, Limbird LE, Molinoff PB, Ruddon RW, editors. Goodman & Gilman\u2019s The Pharmacological basis of therapeutics: The McGraw-Hill Companies; 1996. p. 199\u2013248."},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Hainsworth FR. Saliva spreading, activity, and body temperature regulation in the rat. Am J Physiol. 1967;212:1288\u201392. https:\/\/doi.org\/10.1152\/ajplegacy.1967.212.6.1288.","DOI":"10.1152\/ajplegacy.1967.212.6.1288"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Furuyama F, Murakami M, Tanaka E, Hida H, Miyazawa D, Oiwa T, et al. Regulation mode of evaporative cooling underlying a strategy of the heat-tolerant FOK rat for enduring ambient heat. Am J Physiol Regul Integr Comp Physiol. 2003;285:R1439\u201345. https:\/\/doi.org\/10.1152\/ajpregu.00198.2003.","DOI":"10.1152\/ajpregu.00198.2003"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Yanase M, Kanosue K, Yasuda H, Tanaka H. Salivary secretion and grooming behaviour during heat exposure in freely moving rats. J Physiol. 1991;432:585\u201392. https:\/\/doi.org\/10.1113\/jphysiol.1991.sp018402.","DOI":"10.1113\/jphysiol.1991.sp018402"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Zhao Y, Vanhoutte PM, Leung SW. Vascular nitric oxide: Beyond eNOS. J Pharmacol Sci. 2015;129:83\u201394. https:\/\/doi.org\/10.1016\/j.jphs.2015.09.002.","DOI":"10.1016\/j.jphs.2015.09.002"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Wang ZY, Li A, Huang X, Bai GL, Jiang YX, Li RL, et al. HSP27 protects skin from ultraviolet B - Induced photodamage by regulating autophagy and reactive oxygen species production. Front Cell Dev Biol. 2022;10:852244. https:\/\/doi.org\/10.3389\/fcell.2022.852244.","DOI":"10.3389\/fcell.2022.852244"}],"container-title":["Environmental Health and Preventive Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ehpm\/30\/0\/30_24-00321\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T04:44:48Z","timestamp":1746247488000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ehpm\/30\/0\/30_24-00321\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":41,"journal-issue":{"issue":"0","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1265\/ehpm.24-00321","relation":{},"ISSN":["1342-078X","1347-4715"],"issn-type":[{"value":"1342-078X","type":"print"},{"value":"1347-4715","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"24-00321"}}