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Organization WH. Mental health action plan: 2013\u20132020. 2013."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Alexopoulos GS. Depression in the elderly. Lancet. 2005;365(9475):1961\u201370.","DOI":"10.1016\/S0140-6736(05)66665-2"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Buoli M, Grassi S, Caldiroli A, Carnevali GS, Mucci F, Iodice S, et al. Is there a link between air pollution and mental disorders? Environ Int. 2018;118:154\u201368.","DOI":"10.1016\/j.envint.2018.05.044"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Braithwaite I, Zhang S, Kirkbride JB, Osborn DPJ, Hayes JF. Air Pollution (Particulate Matter) Exposure and Associations with Depression, Anxiety, Bipolar, Psychosis and Suicide Risk: A Systematic Review and Meta-Analysis. Environ Health Perspect. 2019;127(12):126002.","DOI":"10.1289\/EHP4595"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Gu X, Liu Q, Deng F, Wang X, Lin H, Guo X, et al. 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Ambient air pollution exposure and risk of depression: A systematic review and meta-analysis of observational studies. Psychiatry Res. 2019;276:69\u201378.","DOI":"10.1016\/j.psychres.2019.04.019"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Fan SJ, Heinrich J, Bloom MS, Zhao TY, Shi TX, Feng WR, et al. Ambient air pollution and depression: A systematic review with meta-analysis up to 2019. Sci Total Environ. 2020;701:134721.","DOI":"10.1016\/j.scitotenv.2019.134721"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Pun VC, Manjourides J, Suh H. Association of Ambient Air Pollution with Depressive and Anxiety Symptoms in Older Adults: Results from the NSHAP Study. Environ Health Perspect. 2017;125(3):342\u20138.","DOI":"10.1289\/EHP494"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Wang Y, Eliot MN, Koutrakis P, Gryparis A, Schwartz JD, Coull BA, et al. Ambient air pollution and depressive symptoms in older adults: results from the MOBILIZE Boston study. Environ Health Perspect. 2014;122(6):553\u20138.","DOI":"10.1289\/ehp.1205909"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Hahad O, Lelieveld J, Birklein F, Lieb K, Daiber A, Munzel T. Ambient Air Pollution Increases the Risk of Cerebrovascular and Neuropsychiatric Disorders through Induction of Inflammation and Oxidative Stress. Int J Mol Sci. 2020;21(12).","DOI":"10.3390\/ijms21124306"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Li H, Cai J, Chen R, Zhao Z, Ying Z, Wang L, et al. Particulate Matter Exposure and Stress Hormone Levels: A Randomized, Double-Blind, Crossover Trial of Air Purification. Circulation. 2017;136(7):618\u201327.","DOI":"10.1161\/CIRCULATIONAHA.116.026796"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Gonzalez-Guevara E, Martinez-Lazcano JC, Custodio V, Hernandez-Ceron M, Rubio C, Paz C. Exposure to ozone induces a systemic inflammatory response: possible source of the neurological alterations induced by this gas. Inhal Toxicol. 2014;26(8):485\u201391.","DOI":"10.3109\/08958378.2014.922648"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Yao G, Yue H, Yun Y, Sang N. Chronic SO2 inhalation above environmental standard impairs neuronal behavior and represses glutamate receptor gene expression and memory-related kinase activation via neuroinflammation in rats. Environ Res. 2015;137:85\u201393.","DOI":"10.1016\/j.envres.2014.11.012"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Power MC, Adar SD, Yanosky JD, Weuve J. Exposure to air pollution as a potential contributor to cognitive function, cognitive decline, brain imaging, and dementia: A systematic review of epidemiologic research. Neurotoxicology. 2016;56:235\u201353.","DOI":"10.1016\/j.neuro.2016.06.004"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Fonken LK, Xu X, Weil ZM, Chen G, Sun Q, Rajagopalan S, et al. Air pollution impairs cognition, provokes depressive-like behaviors and alters hippocampal cytokine expression and morphology. Mol Psychiatry. 2011;16(10):987\u201395, 73.","DOI":"10.1038\/mp.2011.76"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Zhang S, Li G, Tian L, Guo Q, Pan X. Short-term exposure to air pollution and morbidity of COPD and asthma in East Asian area: A systematic review and meta-analysis. Environ Res. 2016;148:15\u201323.","DOI":"10.1016\/j.envres.2016.03.008"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Franklin BA, Brook R, Arden Pope C 3rd. Air pollution and cardiovascular disease. Curr Probl Cardiol. 2015;40(5):207\u201338.","DOI":"10.1016\/j.cpcardiol.2015.01.003"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Hamra GB, Guha N, Cohen A, Laden F, Raaschou-Nielsen O, Samet JM, et al. Outdoor particulate matter exposure and lung cancer: a systematic review and meta-analysis. Environ Health Perspect. 2014;122(9):906\u201311.","DOI":"10.1289\/ehp\/1408092"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Roe J, Mondschein A, Neale C, Barnes L, Boukhechba M, Lopez S. The Urban Built Environment, Walking and Mental Health Outcomes Among Older Adults: A Pilot Study. Front Public Health. 2020;8:575946.","DOI":"10.3389\/fpubh.2020.575946"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Hegewald J, Schubert M, Freiberg A, Romero Starke K, Augustin F, Riedel-Heller SG, et al. Traffic Noise and Mental Health: A Systematic Review and Meta-Analysis. Int J Environ Res Public Health. 2020;17(17).","DOI":"10.3390\/ijerph17176175"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Dzhambov AM, Lercher P. Road Traffic Noise Exposure and Depression\/Anxiety: An Updated Systematic Review and Meta-Analysis. Int J Environ Res Public Health. 2019;16(21).","DOI":"10.3390\/ijerph16214134"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Beutel ME, Brahler E, Ernst M, Klein E, Reiner I, Wiltink J, et al. Noise annoyance predicts symptoms of depression, anxiety and sleep disturbance 5 years later. Findings from the Gutenberg Health Study. Eur J Public Health. 2020;30(3):516\u201321.","DOI":"10.1093\/eurpub\/ckaa015"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Eze IC, Foraster M, Schaffner E, Vienneau D, Pieren R, Imboden M, et al. Incidence of depression in relation to transportation noise exposure and noise annoyance in the SAPALDIA study. Environ Int. 2020;144:106014.","DOI":"10.1016\/j.envint.2020.106014"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Lin JY, Cheng WJ, Wu CF, Chang TY. Associations of road traffic noise and its frequency spectrum with prevalent depression in Taichung, Taiwan. Front Public Health. 2023;11:1116345.","DOI":"10.3389\/fpubh.2023.1116345"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Cheng Y, Wang X, Yu Y, Gu J, Zhao M, Fu Q, et al. Noise Induced Depression-Like Behavior, Neuroinflammation and Synaptic Plasticity Impairments: The Protective Effects of Luteolin. Neurochem Res. 2022;47(11):3318\u201330.","DOI":"10.1007\/s11064-022-03683-0"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Hsu CC, Chang HY, Wu IC, Chen CC, Tsai HJ, Chiu YF, et al. Cohort Profile: The Healthy Aging Longitudinal Study in Taiwan (HALST). Int J Epidemiol. 2017;46(4):1106-j.","DOI":"10.1093\/ije\/dyw331"},{"key":"29","unstructured":"29. Chang TY, Wang YC, Cheng WJ. Road Traffic Noise, Air Pollutants and Temperature on Mental Disorders: the Taiwan Biobank-Based Study. Project mid-term report in the first year (MOST 109-2314-B-039-037-MY3). Ministry of Science and Technology, Taipei, Taiwan; 2021."},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Chang TY, Liang CH, Wu CF, Chang LT. Application of land-use regression models to estimate sound pressure levels and frequency components of road traffic noise in Taichung, Taiwan. Environ Int. 2019;131:104959.","DOI":"10.1016\/j.envint.2019.104959"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Chang TY, Tsai CC, Wu CF, Chang LT, Chuang KJ, Chuang HC, et al. Development of land-use regression models to estimate particle mass and number concentrations in Taichung, Taiwan. Atmos Environ. 2021;252(118303):1\u201310.","DOI":"10.1016\/j.atmosenv.2021.118303"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Cho CI, Chen JJ, Chuang KJ, Chuang HC, Wang IJ, Chang TY. Associations of particulate matter, gaseous pollutants, and road traffic noise with the prevalence of asthma in children. Chemosphere. 2023;338:139523.","DOI":"10.1016\/j.chemosphere.2023.139523"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Lin LY, Warren-Gash C, Smeeth L, Chen PC. Data resource profile: the National Health Insurance Research Database (NHIRD). Epidemiol Health. 2018;40:e2018062.","DOI":"10.4178\/epih.e2018062"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Wu CS, Hsu LY, Pan YJ, Wang SH. Associations Between Antidepressant Use and Advanced Diabetes Outcomes in Patients with Depression and Diabetes Mellitus. J Clin Endocrinol Metab. 2021;106(12):e5136\u201346.","DOI":"10.1210\/clinem\/dgab443"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Wu CS, Kuo CJ, Su CH, Wang SH, Dai HJ. Using text mining to extract depressive symptoms and to validate the diagnosis of major depressive disorder from electronic health records. J Affect Disord. 2020;260:617\u201323.","DOI":"10.1016\/j.jad.2019.09.044"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373\u201383.","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Chuang SC, Chang YH, Wu IC, Fang YH, Chan HT, Wu RC, et al. Impact of physical activity on disability-free and disabled life expectancies in middle-aged and older adults: Data from the healthy aging longitudinal study in Taiwan. Geriatr Gerontol Int. 2024;24 Suppl 1:229\u201339.","DOI":"10.1111\/ggi.14796"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Desquilbet L, Mariotti F. Dose-response analyses using restricted cubic spline functions in public health research. Stat Med. 2010;29(9):1037\u201357.","DOI":"10.1002\/sim.3841"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Radua J, De Prisco M, Oliva V, Fico G, Vieta E, Fusar-Poli P. Impact of air pollution and climate change on mental health outcomes: an umbrella review of global evidence. World Psychiatry. 2024;23(2):244\u201356.","DOI":"10.1002\/wps.21219"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Kim KN, Lim YH, Bae HJ, Kim M, Jung K, Hong YC. Long-Term Fine Particulate Matter Exposure and Major Depressive Disorder in a Community-Based Urban Cohort. Environ Health Perspect. 2016;124(10):1547\u201353.","DOI":"10.1289\/EHP192"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Kioumourtzoglou MA, Power MC, Hart JE, Okereke OI, Coull BA, Laden F, et al. The Association Between Air Pollution and Onset of Depression Among Middle-Aged and Older Women. Am J Epidemiol. 2017;185(9):801\u20139.","DOI":"10.1093\/aje\/kww163"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Zijlema WL, Wolf K, Emeny R, Ladwig KH, Peters A, Kongsgard H, et al. The association of air pollution and depressed mood in 70,928 individuals from four European cohorts. Int J Hyg Environ Health. 2016;219(2):212\u20139.","DOI":"10.1016\/j.ijheh.2015.11.006"},{"key":"43","unstructured":"43. World Health Organization. WHO global air quality guidelines. Geneva: World Health Organization; 2021."},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Villeneuve PJ, Weichenthal SA, Crouse D, Miller AB, To T, Martin RV, et al. Long-term Exposure to Fine Particulate Matter Air Pollution and Mortality Among Canadian Women. Epidemiology. 2015;26(4):536\u201345.","DOI":"10.1097\/EDE.0000000000000294"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45. Purtle J, Nelson KL, Yang Y, Langellier B, Stankov I, Diez Roux AV. Urban-Rural Differences in Older Adult Depression: A Systematic Review and Meta-analysis of Comparative Studies. Am J Prev Med. 2019;56(4):603\u201313.","DOI":"10.1016\/j.amepre.2018.11.008"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46. Orban E, McDonald K, Sutcliffe R, Hoffmann B, Fuks KB, Dragano N, et al. Residential Road Traffic Noise and High Depressive Symptoms after Five Years of Follow-up: Results from the Heinz Nixdorf Recall Study. Environ Health Perspect. 2016;124(5):578\u201385.","DOI":"10.1289\/ehp.1409400"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47. Calderon-Garciduenas L, Calderon-Garciduenas A, Torres-Jardon R, Avila-Ramirez J, Kulesza RJ, Angiulli AD. Air pollution and your brain: what do you need to know right now. Prim Health Care Res Dev. 2015;16(4):329\u201345.","DOI":"10.1017\/S146342361400036X"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48. Hantrakool S, Kumfu S, Chattipakorn SC, Chattipakorn N. Effects of Particulate Matter on Inflammation and Thrombosis: Past Evidence for Future Prevention. Int J Environ Res Public Health. 2022;19(14).","DOI":"10.3390\/ijerph19148771"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49. Fu W, Hettinghouse A, Chen Y, Hu W, Ding X, Chen M, et al. 14-3-3 epsilon is an intracellular component of TNFR2 receptor complex and its activation protects against osteoarthritis. Ann Rheum Dis. 2021;80(12):1615\u201327.","DOI":"10.1136\/annrheumdis-2021-220000"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50. Zhang N, Wang Z, Zhao Y. Selective inhibition of Tumor necrosis factor receptor-1 (TNFR1) for the treatment of autoimmune diseases. Cytokine Growth Factor Rev. 2020;55:80\u20135.","DOI":"10.1016\/j.cytogfr.2020.03.002"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51. Beurel E, Toups M, Nemeroff CB. The Bidirectional Relationship of Depression and Inflammation: Double Trouble. Neuron. 2020;107(2):234\u201356.","DOI":"10.1016\/j.neuron.2020.06.002"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52. Gao M, Song Y, Liu Y, Miao Y, Guo Y, Chai H. TNF-alpha\/TNFR1 activated astrocytes exacerbate depression-like behavior in CUMS mice. Cell Death Discov. 2024;10(1):220.","DOI":"10.1038\/s41420-024-01987-4"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53. Kim KH, Jahan SA, Kabir E. A review on human health perspective of air pollution with respect to allergies and asthma. Environ Int. 2013;59:41\u201352.","DOI":"10.1016\/j.envint.2013.05.007"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54. Bhatnagar A. Cardiovascular Effects of Particulate Air Pollution. Annu Rev Med. 2022;73:393\u2013406.","DOI":"10.1146\/annurev-med-042220-011549"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55. Louis S, Carlson AK, Suresh A, Rim J, Mays M, Ontaneda D, et al. Impacts of Climate Change and Air Pollution on Neurologic Health, Disease, and Practice: A Scoping Review. Neurology. 2023;100(10):474\u201383.","DOI":"10.1212\/WNL.0000000000201630"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56. Chang TY, Liao SC, Chang CM, Wu CS, Huang WL, Hwang JJ, et al. Barriers to depression care among middle-aged and older adults in Taiwan\u2019s universal healthcare system. Lancet Reg Health West Pac. 2022;26:100501.","DOI":"10.1016\/j.lanwpc.2022.100501"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57. Zwicker A, Fabbri C, Rietschel M, Hauser J, Mors O, Maier W, et al. Genetic disposition to inflammation and response to antidepressants in major depressive disorder. J Psychiatr Res. 2018;105:17\u201322.","DOI":"10.1016\/j.jpsychires.2018.08.011"},{"key":"58","doi-asserted-by":"crossref","unstructured":"58. Lin CF, Wang CY, Bai CH. Polypharmacy, aging and potential drug-drug interactions in outpatients in Taiwan: a retrospective computerized screening study. Drugs Aging. 2011;28(3):219\u201325.","DOI":"10.2165\/11586870-000000000-00000"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59. Lozupone M, Castellana F, Sardone R, Berardino G, Mollica A, Zupo R, et al. Late-Onset Depression but not Early-Onset Depression may Increase the Risk of All-Cause Mortality in Older Age: 8-Year Follow-Up of the Salus in Apulia Study. 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