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Shakoor SK, Aldibbiat A, Ingoe LE, Campbell SC, Sibal L, Shaw J, Home PD, Razvi S, Weaver JU. Endothelial progenitor cells in subclinical hypothyroidism: the effect of thyroid hormone replacement therapy. J Clin Endocrinol Metab. 2010;95(1):319\u201322. https:\/\/doi.org\/10.1210\/jc.2009-1421.","DOI":"10.1210\/jc.2009-1421"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Liochev SI. Reflections on the theories of aging, of oxidative stress, and of science in general. Is it time to abandon the free radical (oxidative stress) theory of aging? Antioxid Redox Signal. 2015;23(3):187\u2013207. https:\/\/doi.org\/10.1089\/ars.2014.5928.","DOI":"10.1089\/ars.2014.5928"},{"key":"6","unstructured":"6. Satoh T, Yamakage M, Satoh J, Namiki A. [Effect of aging on preoperative oxidative stress]. Masui. 2007;56(12):1422\u20134. In Japanese."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Wu Q, Wu W, Kuca K. From hypoxia and hypoxia-inducible factors (HIF) to oxidative stress: A new understanding of the toxic mechanism of mycotoxins. Food Chem Toxicol. 2020;135:110968. https:\/\/doi.org\/10.1016\/j.fct.2019.110968.","DOI":"10.1016\/j.fct.2019.110968"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Juki\u0107 T, Vidranski V, Bla\u017eekovi\u0107 I, Prpi\u0107 M, Jak\u0161i\u0107 I, Pourmodjib K, Mihaljevi\u0107 I, Franceschi M, Fr\u00f6be A, Kusi\u0107 Z. The prevalence of subclinical hypothyroidism in the population of elderly nursing home residents in Zagreb. Acta Clin Croat. 2022;61(1):38\u201345. https:\/\/doi.org\/10.20471\/acc.2022.61.01.05.","DOI":"10.20471\/acc.2022.61.01.05"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Shimizu Y, Yamanashi H, Noguchi Y, Koyamatsu J, Nagayoshi M, Kiyoura K, Fukui S, Tamai M, Kawashiri SY, Kondo H, Maeda T. Association between chronic kidney disease and carotid intima-media thickness in relation to circulating CD34-positive cell count among community-dwelling elderly Japanese men. Atherosclerosis. 2019;283:85\u201391. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2019.02.004.","DOI":"10.1016\/j.atherosclerosis.2019.02.004"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Michishita R, Matsuda T, Kawakami S, Tanaka S, Kiyonaga A, Tanaka H, Morito N, Higaki Y. The association between changes in lifestyle behaviors and the incidence of chronic kidney disease (CKD) in middle-aged and older men. J Epidemiol. 2017;27(8):389\u201397. https:\/\/doi.org\/10.1016\/j.je.2016.08.013.","DOI":"10.1016\/j.je.2016.08.013"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Nakajima Y, Yamada M, Akuzawa M, Ishii S, Masamura Y, Satoh T, Hashimoto K, Negishi M, Shimomura Y, Kobayashi I, Andou Y, Mori M. 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Clin Chem Lab Med. 2006;44(7):824\u20139. https:\/\/doi.org\/10.1515\/CCLM.2006.149.","DOI":"10.1515\/CCLM.2006.149"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Yanase T, Nasu S, Mukuta Y, Shimizu Y, Nishihara T, Okabe T, Nomura M, Inoguchi T, Nawata H. Evaluation of a new carotid intima-media thickness measurement by B-mode ultrasonography using an innovative measurement software, intimascope. Am J Hypertens. 2006;19(12):1206\u201312. https:\/\/doi.org\/10.1016\/j.amjhyper.2006.05.010.","DOI":"10.1016\/j.amjhyper.2006.05.010"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Shimizu Y, Yamanashi H, Honda Y, Nonaka F, Miyata J, Kawashiri SY, Noguchi Y, Nakamichi S, Nagata Y, Maeda T. Low-density lipoprotein cholesterol, structural atherosclerosis, and functional atherosclerosis in older Japanese. Nutrients. 2022;15(1):183. https:\/\/doi.org\/10.3390\/nu15010183.","DOI":"10.3390\/nu15010183"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. 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