{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T05:08:13Z","timestamp":1779512893369,"version":"3.53.1"},"reference-count":28,"publisher":"Japanese Society for Hygiene","issue":"0","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ. Health Prev. Med.","Environ Health Prev Med"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1265\/ehpm.26-00008","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T22:12:46Z","timestamp":1779142366000},"page":"33-33","source":"Crossref","is-referenced-by-count":0,"title":["Association of estimated glomerular filtration rate with stroke risk in middle-aged and older Chinese adults: an integrated analysis of national and hospital cohorts"],"prefix":"10.1265","volume":"31","author":[{"given":"Jun","family":"Mao","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, The Fifth Affiliated Hospital, Southern Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Fifth Affiliated Hospital, Southern Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Fifth Affiliated Hospital, Southern Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyao","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Fifth Affiliated Hospital, Southern Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuowen","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Fifth Affiliated Hospital, Southern Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuping","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Fifth Affiliated Hospital, Southern Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"335","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Campbell BCV, Khatri P. Stroke. Lancet. 2020;396(10244):129\u201342.","DOI":"10.1016\/S0140-6736(20)31179-X"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Campbell BCV, De Silva DA, Macleod MR, Coutts SB, Schwamm LH, Davis SM, Donnan GA. Ischaemic stroke. Nat Rev Dis Primers. 2019;5(1):70.","DOI":"10.1038\/s41572-019-0118-8"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Feigin VL, Brainin M, Norrving B, Martins SO, Pandian J, Lindsay P, F Grupper M, Rautalin I. World Stroke Organization: Global Stroke Fact Sheet 2025. Int J Stroke. 2025;20(2):132\u201344.","DOI":"10.1177\/17474930241308142"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Global, regional, and national burden of stroke and its risk factors, 1990\u20132021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet Neurol. 2024;23(10):973\u20131003.","DOI":"10.1016\/S1474-4422(24)00369-7"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Ma J, Tian Z, Chai P, Wan Q, Zhai T, Guo F, Li Y. Estimating the economic burden of stroke in China: a cost-of-illness study. BMJ Open. 2024;14(3):e080634.","DOI":"10.1136\/bmjopen-2023-080634"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Flach C, Muruet W, Wolfe CDA, Bhalla A, Douiri A. Risk and Secondary Prevention of Stroke Recurrence: A Population-Base Cohort Study. Stroke. 2020;51(8):2435\u201344.","DOI":"10.1161\/STROKEAHA.120.028992"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Stahmeyer JT, Stubenrauch S, Geyer S, Weissenborn K, Eberhard S. The Frequency and Timing of Recurrent Stroke: An Analysis of Routine Health Insurance Data. Dtsch Arztebl Int. 2019;116(42):711\u20137.","DOI":"10.3238\/arztebl.2019.0711"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Kelly DM, Ademi Z, Doehner W, Lip GYH, Mark P, Toyoda K, Wong CX, Sarnak M, Cheung M, Herzog CA, Johansen KL, Reinecke H, Sood MM. Chronic Kidney Disease and Cerebrovascular Disease: Consensus and Guidance From a KDIGO Controversies Conference. Stroke. 2021;52(7):e328\u201346.","DOI":"10.1161\/STROKEAHA.120.029680"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Karbowska M, Kaminski TW, Marcinczyk N, Misztal T, Rusak T, Smyk L, Pawlak D. The Uremic Toxin Indoxyl Sulfate Accelerates Thrombotic Response after Vascular Injury in Animal Models. Toxins (Basel). 2017;9(7):null.","DOI":"10.3390\/toxins9070229"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Wakamatsu T, Yamamoto S, Yoshida S, Narita I. Indoxyl Sulfate-Induced Macrophage Toxicity and Therapeutic Strategies in Uremic Atherosclerosis. Toxins (Basel). 2024;16(6):null.","DOI":"10.3390\/toxins16060254"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Yang K, Du C, Wang X, Li F, Xu Y, Wang S, Chen S, Chen F, Shen M, Chen M, Hu M, He T, Su Y, Wang J, Zhao J. Indoxyl sulfate induces platelet hyperactivity and contributes to chronic kidney disease-associated thrombosis in mice. Blood. 2017;129(19):2667\u201379.","DOI":"10.1182\/blood-2016-10-744060"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Lee M, Saver JL, Chang KH, Liao HW, Chang SC, Ovbiagele B. Low glomerular filtration rate and risk of stroke: meta-analysis. BMJ. 2010;341(-):c4249.","DOI":"10.1136\/bmj.c4249"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. K\u00fchn A, van der Giet M, Kuhlmann MK, Martus P, Mielke N, Ebert N, Schaeffner ES. Kidney Function as Risk Factor and Predictor of Cardiovascular Outcomes and Mortality Among Older Adults. Am J Kidney Dis. 2021;77(3):386\u201396.e381.","DOI":"10.1053\/j.ajkd.2020.09.015"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Sarfo FS, Mobula LM, Sarfo-Kantanka O, Adamu S, Plange-Rhule J, Ansong D, Gyamfi RA, Duah J, Abraham B, Ofori-Adjei D. Estimated glomerular filtration rate predicts incident stroke among Ghanaians with diabetes and hypertension. J Neurol Sci. 2019;396(-):140\u20137.","DOI":"10.1016\/j.jns.2018.11.017"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Liu C, Qiu L, Zhang Y, Chen L, Wang H, Lin H, Tao Y, Ye H. The interaction between estimated glomerular filtration rate and dietary magnesium intake and its effect on stroke prevalence: a cross-sectional study spanning 2003\u20132018. Front Nutr. 2024;11(-):1395685.","DOI":"10.3389\/fnut.2024.1395685"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Oh CM, Park SK, Jung JY, Choi JM, Ha E, Lee EY, Kim JW, Kang HY, Yang HJ, Ryoo JH. Reduced Glomerular Filtration Rate and Risk of Stroke: A Nationwide Cohort Study in South Korea. J Atheroscler Thromb. 2021;28(9):928\u201341.","DOI":"10.5551\/jat.56143"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Zhao Y, Hu Y, Smith JP, Strauss J, Yang G. Cohort profile: the China health and retirement longitudinal study (CHARLS). 2014;43(1):61\u20138.","DOI":"10.1093\/ije\/dys203"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Horio M, Imai E, Yasuda Y, Watanabe T, Matsuo S. Modification of the CKD epidemiology collaboration (CKD-EPI) equation for Japanese: accuracy and use for population estimates. Am J Kidney Dis. 2010;56(1):32\u20138.","DOI":"10.1053\/j.ajkd.2010.02.344"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Levin A, Ahmed SB, Carrero JJ, Foster B, Francis A, Hall RK, Herrington WG, Hill G, Inker LA, Kazanc\u0131o\u011flu R, Lamb E, Lin P, Madero M, McIntyre N, Morrow K, Roberts G, Sabanayagam D, Schaeffner E, Shlipak M, Shroff R, Tangri N, Thanachayanont T, Ulasi I, Wong G, Yang CW, Zhang L, Robinson KA, Wilson L, Wilson RF, Kasiske BL, Cheung M, Earley A, Stevens PE. Executive summary of the KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease: known knowns and known unknowns. Kidney Int. 2024;105(4):684\u2013701.","DOI":"10.1016\/j.kint.2023.10.016"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Kim JH. Multicollinearity and misleading statistical results. Korean J Anesthesiol. 2019;72(6):558\u201369.","DOI":"10.4097\/kja.19087"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Masson P, Webster AC, Hong M, Turner R, Lindley RI, Craig JC. Chronic kidney disease and the risk of stroke: a systematic review and meta-analysis. Nephrol Dial Transpl. 2015;30(7):1162\u20139.","DOI":"10.1093\/ndt\/gfv009"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Xiang J, Tong M, Yu D, Chen Y. Association between estimated glomerular filtration rate, urinary albuminuria-creatinine ratio, and stroke prevalence in patients with chronic kidney disease. Ren Fail. 2025;47(1):2452219.","DOI":"10.1080\/0886022X.2025.2452219"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Bays HE, Kulkarni A, German C, Satish P, Iluyomade A, Dudum R, Thakkar A, Rifai MA, Mehta A, Thobani A, Al-Saiegh Y, Nelson AJ, Sheth S, Toth PP. Ten things to know about ten cardiovascular disease risk factors - 2022. Am J Prev Cardiol. 2022;10(null):100342.","DOI":"10.1016\/j.ajpc.2022.100342"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Kelly DM, Rothwell PM. Does Chronic Kidney Disease Predict Stroke Risk Independent of Blood Pressure?: A Systematic Review and Meta-Regression. Stroke. 2019;50(11):3085\u201392.","DOI":"10.1161\/STROKEAHA.119.025442"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Filipska I, Winiarska A, Knysak M, Stomp\u00f3r T. Contribution of Gut Microbiota-Derived Uremic Toxins to the Cardiovascular System Mineralization. Toxins (Basel). 2021;13(4):null.","DOI":"10.3390\/toxins13040274"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Kelly DM, Kelleher EM, Rothwell PM. The Kidney-Immune-Brain Axis: The Role of Inflammation in the Pathogenesis and Treatment of Stroke in Chronic Kidney Disease. Stroke. 2025;56(4):1069\u201381.","DOI":"10.1161\/STROKEAHA.124.047070"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Fujii H. Is Oxidative Stress a Key Player for Progression of Cardiovascular Disease in Dialysis Patients?. J Atheroscler Thromb. 2021;28(3):227\u20139.","DOI":"10.5551\/jat.ED145"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Harlacher E, Wollenhaupt J, Baaten C, Noels H. Impact of Uremic Toxins on Endothelial Dysfunction in Chronic Kidney Disease: A Systematic Review. Int J Mol Sci. 2022;23(1):null.","DOI":"10.3390\/ijms23010531"}],"container-title":["Environmental Health and Preventive Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ehpm\/31\/0\/31_26-00008\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T04:50:01Z","timestamp":1779511801000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ehpm\/31\/0\/31_26-00008\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":28,"journal-issue":{"issue":"0","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.1265\/ehpm.26-00008","relation":{},"ISSN":["1342-078X","1347-4715"],"issn-type":[{"value":"1342-078X","type":"print"},{"value":"1347-4715","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"26-00008"}}