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Environ Health Prev Med. 2010;15(1):9\u201317. https:\/\/doi.org\/10.1007\/s12199-008-0068-3.","DOI":"10.1007\/s12199-008-0068-3"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Han JW, Choi H, Jeon YH, Yoon CH, Woo JM, Kim W. The Effects of Forest Therapy on Coping with Chronic Widespread Pain: Physiological and Psychological Differences between Participants in a Forest Therapy Program and a Control Group. Int J Environ Res Public Health. 2016;13(3):1\u201313.","DOI":"10.3390\/ijerph13030255"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Tsao TM, Tsai MJ, Hwang JS, Cheng WF, Wu CF, Chou CK, et al. Health effects of a forest environment on natural killer cells in humans: an observational pilot study. Oncotarget. 2018;9(23):16501\u201311.","DOI":"10.18632\/oncotarget.24741"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Li Q, Otsuka T, Kobayashi M, Wakayama Y, Inagaki H, Katsumata M, et al. 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Effect of forest bathing on physiological and psychological responses in young Japanese male subjects. Public Health. 2011 Feb;125(2):93\u2013100. https:\/\/doi.org\/10.1016\/j.puhe.2010.09.005.","DOI":"10.1016\/j.puhe.2010.09.005"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Song C, Ikei H, Park BJ, Lee J, Kagawa T, Miyazaki Y. Psychological Benefits of Walking through Forest Areas. Int J Environ Res Public Health. 2018;15(12):2804. https:\/\/doi.org\/10.3390\/ijerph15122804.","DOI":"10.3390\/ijerph15122804"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Song C, Ikei H, Kagawa T, Miyazaki Y. Effects of Walking in a Forest on Young Women. Int J Environ Res Public Health. 2019;16(2):229. https:\/\/doi.org\/10.3390\/ijerph16020229.","DOI":"10.3390\/ijerph16020229"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Song C, Ikei H, Kobayashi M, Miura T, Taue M, Kagawa T, et al. Effect of Forest Walking on Autonomic Nervous System Activity in Middle-Aged Hypertensive Individuals: A Pilot Study. Int J Environ Res Public Health. 2015;12(3):2687\u201399. https:\/\/doi.org\/10.3390\/ijerph120302687.","DOI":"10.3390\/ijerph120302687"},{"key":"22","doi-asserted-by":"publisher","unstructured":"22. Tao R, Li H. High serum uric acid level in adolescent depressive patients. J Affect Disord. 2015;174:464\u20136. https:\/\/doi.org\/10.1016\/j.jad.2014.12.031.","DOI":"10.1016\/j.jad.2014.12.031"},{"key":"23","doi-asserted-by":"publisher","unstructured":"23. Baidina TV, Trushnikova TN, Danilova MA. Interferon-induced depression and peripheral blood serotonin in patients with multiple sclerosis. Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(8. Vyp. 2):77\u201381. [Article in Russian; Abstract in English]. https:\/\/doi.org\/10.17116\/jnevro201811808277.","DOI":"10.17116\/jnevro201811808277"},{"key":"24","doi-asserted-by":"publisher","unstructured":"24. Manoharan A, Rajkumar RP, Shewade DG, Sundaram R, Muthuramalingam A, Paul A. Evaluation of interleukin-6 and serotonin as biomarkers to predict response to fluoxetine. Hum Psychopharmacol. 2016;31(3):178\u201384. https:\/\/doi.org\/10.1002\/hup.2525.","DOI":"10.1002\/hup.2525"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Jaworek AK, Jaworek M, Makara-Studzi\u0144ska M, Szafraniec K, Doniec Z, Szepietowski J, et al. Depression and Serum Content of Serotonin in Adult Patients with Atopic Dermatitis. Adv Exp Med Biol. 2020 Jan 9. https:\/\/doi.org\/10.1007\/5584_2019_470.","DOI":"10.1007\/5584_2019_470"},{"key":"26","unstructured":"26. Almeida-Montes LG, Valles-Sanchez V, Moreno-Aguilar J, Chavez-Balderas RA, Garc\u00eda-Mar\u00edn JA, Cort\u00e9s Sotres JF, et al. Relation of serum cholesterol, lipid, serotonin and tryptophan levels to severity of depression and to suicide attempts. Psychiatry Neurosci. 2000;25(4):371\u20137."},{"key":"27","doi-asserted-by":"publisher","unstructured":"27. Moroianu LA, Cecilia C, Ardeleanu V, Pantea Stoian A, Cristescu V, et al. Clinical Study of Serum Serotonin as a Screening Marker for Anxiety and Depression in Patients with Type 2 Diabetes. Medicina (Kaunas). 2022;58(5):652. https:\/\/doi.org\/10.3390\/medicina58050652.","DOI":"10.3390\/medicina58050652"},{"key":"28","doi-asserted-by":"publisher","unstructured":"28. Li Q, Ochiai H, Ochiai T, Takayama N, Kumeda S, Miura T, et al. Effects of forest bathing (shinrin-yoku) on serotonin in serum, depressive symptoms and subjective sleep quality in middle-aged males. Environ Health Prev Med. 2022;27:44. https:\/\/doi.org\/10.1265\/ehpm.22-00136.","DOI":"10.1265\/ehpm.22-00136"},{"key":"29","doi-asserted-by":"publisher","unstructured":"29. Li Q, Takayama N, Katsumata M, Takayama H, Kimura Y, Kumeda S, Miura T, et al. Impacts of Forest Bathing (Shinrin-Yoku) in Female Participants with Depression\/Depressive Tendencies. Diseases. 2025;13(4):100. https:\/\/doi.org\/10.3390\/diseases13040100.","DOI":"10.3390\/diseases13040100"},{"key":"30","doi-asserted-by":"publisher","unstructured":"30. Yang B, Aoyagi Y, Li Q. The Effectiveness of Forest Bathing in Improving Mood: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Clin Quest. 2025. https:\/\/doi.org\/10.69854\/jcq.2025.0036.","DOI":"10.69854\/jcq.2025.0036"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Grilli G, Sacchelli S. Health Benefits Derived from Forest: A Review. Int J Environ Res Public Health. 2020;17(17):6125. https:\/\/doi.org\/10.3390\/ijerph17176125.","DOI":"10.3390\/ijerph17176125"},{"key":"32","doi-asserted-by":"publisher","unstructured":"32. Shang X, Lu J, Tao M, Fei C, Fei J. Benefits of forest therapy for adult mental health: a systematic review and meta-analysis based on the Profile of Mood States (POMS). Front Psychol. 2025 Nov 3;16:1670804. https:\/\/doi.org\/10.3389\/fpsyg.2025.1670804.","DOI":"10.3389\/fpsyg.2025.1670804"},{"key":"33","unstructured":"33. McNair DM, Lorr M, Droppleman LF. Manual: Profile of mood states. San Diego: Educational and Industrial Testing Service, 1971."},{"key":"34","unstructured":"34. Yokoyama K, Araki S, Kawakami N, Takeshita T. Production of the Japanese edition of Profile of Mood States (POMS): assessment of reliability and validity. Jpn J Publ Health. 1990;37:913\u20138."},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Bielinis E, Jaroszewska A, \u0141ukowski A, Takayama N. The Effects of a Forest Therapy Programme on Mental Hospital Patients with Affective and Psychotic Disorders. Int J Environ Res Public Health. 2019 Dec 23;17(1):118. https:\/\/doi.org\/10.3390\/ijerph17010118.","DOI":"10.3390\/ijerph17010118"},{"key":"36","doi-asserted-by":"publisher","unstructured":"36. Furuyashiki A, Tabuchi K, Norikoshi K, Kobayashi T, Oriyama S. A comparative study of the physiological and psychological effects of forest bathing (Shinrin-yoku) on working age people with and without depressive tendencies. Environ Health Prev Med. 2019;24(1):46. https:\/\/doi.org\/10.1186\/s12199-019-0800-1.","DOI":"10.1186\/s12199-019-0800-1"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Joung D, Lee B, Lee J, Lee C, Koo S, Park C, et al. Measures to Promote Rural Healthcare Tourism with a Scientific Evidence-Based Approach. Int J Environ Res Public Health. 2020;17(9):3266. https:\/\/doi.org\/10.3390\/ijerph17093266.","DOI":"10.3390\/ijerph17093266"},{"key":"38","doi-asserted-by":"publisher","unstructured":"38. Bielinis E, Janeczko E, Takayama N, Zawadzka A, S\u0142upska A, Pi\u0119tka S, et al. The effects of viewing a winter forest landscape with the ground and trees covered in snow on the psychological relaxation of young Finnish adults: A pilot study. PLoS One. 2021;16(1):e0244799. https:\/\/doi.org\/10.1371\/journal.pone.0244799.","DOI":"10.1371\/journal.pone.0244799"},{"key":"39","doi-asserted-by":"publisher","unstructured":"39. Ramanpong J, Yin J, Zhang CJ, Chen HT, Tsai MJ, Spengler JD, et al. The effects of viewing forests with different planting densities on physiological and psychological responses: A between-subject experiment. Trees For People. 2014;16. https:\/\/doi.org\/10.1016\/j.tfp.2024.100551.","DOI":"10.1016\/j.tfp.2024.100551"},{"key":"40","doi-asserted-by":"publisher","unstructured":"40. Sun X, Li Q, Zhang X, Sun M, Yin J, He J, et al. Physiological and psychological recovery in two pure forests: interaction between perception methods and perception durations. Front Public Health. 2024;12:1296714. https:\/\/doi.org\/10.3389\/fpubh.2024.1296714.","DOI":"10.3389\/fpubh.2024.1296714"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Takayama N, Korpela K, Lee J, Morikawa T, Tsunetsugu Y, Park BJ, et al. Emotional, restorative and vitalizing effects of forest and urban environments at four sites in Japan. Int J Environ Res Public Health. 2014;11(7):7207\u201330. https:\/\/doi.org\/10.3390\/ijerph110707207.","DOI":"10.3390\/ijerph110707207"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Takayama N, Morikawa T, Bielinis E. Relation between Psychological Restorativeness and Lifestyle, Quality of Life, Resilience, and Stress-Coping in Forest Settings. Int J Environ Res Public Health. 2019;16(8):1456. https:\/\/doi.org\/10.3390\/ijerph16081456.","DOI":"10.3390\/ijerph16081456"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Oomen-Welke K, Schlachter E, Hilbich T, Naumann J, M\u00fcller A, Hinterberger T, et al. Spending Time in the Forest or the Field: Investigations on Stress Perception and Psychological Well-Being-A Randomized Cross-Over Trial in Highly Sensitive Persons. Int J Environ Res Public Health. 2022;19(22):15322. https:\/\/doi.org\/10.3390\/ijerph192215322.","DOI":"10.3390\/ijerph192215322"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Bressane A, Medeiros LCC, Lima YCD. Five-Step Forest Bathing Protocol as a Nature-Based Solution for Student Wellbeing in Higher Education: A Research Brief on Insights and Lessons from a Pilot Study. Int J Environ Res Public Health. 2025;22(4):579. https:\/\/doi.org\/10.3390\/ijerph22040579.","DOI":"10.3390\/ijerph22040579"},{"key":"45","doi-asserted-by":"publisher","unstructured":"45. Ochiai H, Inoue S, Masuda G, Amagasa S, Sugishita T, Ochiai T, et al. Randomized controlled trial on the efficacy of forest walking compared to urban walking in enhancing mucosal immunity. Sci Rep. 2025;15(1):3272. https:\/\/doi.org\/10.1038\/s41598-025-87704-2.","DOI":"10.1038\/s41598-025-87704-2"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46. Ochiai H, Ikei H, Song C, Kobayashi M, Takamatsu A, Miura T, et al. Physiological and psychological effects of forest therapy on middle-age males with high-normal blood pressure. Int J Environ Res Public Health. 2015;12(3):2532\u201342. https:\/\/doi.org\/10.3390\/ijerph120302532.","DOI":"10.3390\/ijerph120302532"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47. Ochiai H, Ikei H, Song C, Kobayashi M, Miura T, Kagawa T, et al. Physiological and Psychological Effects of a Forest Therapy Program on Middle-Aged Females. Int J Environ Res Public Health. 2015;12(12):15222\u201332. https:\/\/doi.org\/10.3390\/ijerph121214984.","DOI":"10.3390\/ijerph121214984"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48. Fu D, Serra NI, Mansion H, Mansion ET, Blain-Moraes S. Assessing the Effects of Nature on Physiological States Using Wearable Technologies. Int J Environ Res Public Health. 2022 Jan 22;19(3):1231. https:\/\/doi.org\/10.3390\/ijerph19031231.","DOI":"10.3390\/ijerph19031231"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49. Yu CP, Lin CM, Tsai MJ, Tsai YC, Chen CY. Effects of Short Forest Bathing Program on Autonomic Nervous System Activity and Mood States in Middle-Aged and Elderly Individuals. Int J Environ Res Public Health. 2017;14(8):897. https:\/\/doi.org\/10.3390\/ijerph14080897.","DOI":"10.3390\/ijerph14080897"},{"key":"50","doi-asserted-by":"publisher","unstructured":"50. Wei RS, Chu YS, Hong MY, Li MY, Fan SW, Tung GS, et al. A comprehensive evaluation of the health benefits of forest therapy for cancer survivors. Environ Health Prev Med. 2026;31:7. https:\/\/doi.org\/10.1265\/ehpm.25-00333.","DOI":"10.1265\/ehpm.25-00333"},{"key":"51","doi-asserted-by":"publisher","unstructured":"51. Serrat M, Royuela-Colomer E, Alonso-Marsol S, Ferr\u00e9s S, Nieto R, Feliu-Soler A, et al. The Psychological Benefits of Forest Bathing in Individuals with Fibromyalgia and Chronic Fatigue Syndrome\/Myalgic Encephalomyelitis: A Pilot Study. Healthcare (Basel). 2025;13(14):1654. https:\/\/doi.org\/10.3390\/healthcare13141654.","DOI":"10.3390\/healthcare13141654"},{"key":"52","unstructured":"52. Mao GX, Lan XG, Cao YB, Chen ZM, He ZH, Lv YD, et al. Effects of short-term forest bathing on human health in a broad-leaved evergreen forest in Zhejiang Province, China. Biomed Environ Sci. 2012 Jun;25(3):317\u201324. https:\/\/doi.org\/10.3967\/0895-3988.2012.03.010."},{"key":"53","doi-asserted-by":"publisher","unstructured":"53. Chen HT, Yu CP, Lee HY. The Effects of Forest Bathing on Stress Recovery: Evidence from Middle-Aged Females of Taiwan. Forests. 2018;9(7):403. https:\/\/doi.org\/10.3390\/f9070403.","DOI":"10.3390\/f9070403"},{"key":"54","doi-asserted-by":"publisher","unstructured":"54. Li Q, Takayama N, Kimura Y, Takayama H, Kumeda S, Miura T, et al. Forest bathing improves inflammatory markers, SpO2, and subjective symptoms related to chronic obstructive pulmonary disease (COPD) in male subjects at risk of developing COPD. J Occup Health. 2025;67(1):uiaf041. https:\/\/doi.org\/10.1093\/joccuh\/uiaf041.","DOI":"10.1093\/joccuh\/uiaf041"},{"key":"55","doi-asserted-by":"publisher","unstructured":"55. Park BJ, Shin WS, Shin CS, Yeon PS, Chung CY, Lee SH, et al. Effects of Forest Therapy on Psychological Improvement in Middle-aged Women in Korea. J Prev Med Public Health. 2022;55(5):492\u20137. https:\/\/doi.org\/10.3961\/jpmph.22.086.","DOI":"10.3961\/jpmph.22.086"},{"key":"56","doi-asserted-by":"publisher","unstructured":"56. Li A, Liu Y, Qian H, Sun K, Zhao Z, Uehara I, et al. Therapeutic effects of forest bathing on older adult patients with essential hypertension: evidence from a subtropical evergreen broad-leaved forest. Front Public Health. 2025;13:1631613. https:\/\/doi.org\/10.3389\/fpubh.2025.1631613.","DOI":"10.3389\/fpubh.2025.1631613"},{"key":"57","doi-asserted-by":"publisher","unstructured":"57. Weng Y, Zhu Y, Huang Y, Chen Q, Dong J. Empirical Study on the Impact of Different Types of Forest Environments in Wuyishan National Park on Public Physiological and Psychological Health. Forests. 2024;15:393. https:\/\/doi.org\/10.3390\/f15020393.","DOI":"10.3390\/f15020393"},{"key":"58","doi-asserted-by":"publisher","unstructured":"58. Quan W, Yu S, Huang Q, Ying M. The effect of forest-based health and wellness on the stress-relieve of middle-aged people. Front Public Health. 2024;12:1366339. https:\/\/doi.org\/10.3389\/fpubh.2024.1366339.","DOI":"10.3389\/fpubh.2024.1366339"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59. Lyu B, Zeng C, Xie S, Li D, Lin W, Li N, et al. Benefits of A Three-Day Bamboo Forest Therapy Session on the Psychophysiology and Immune System Responses of Male College Students. Int J Environ Res Public Health. 2019;16(24):4991. https:\/\/doi.org\/10.3390\/ijerph16244991.","DOI":"10.3390\/ijerph16244991"},{"key":"60","doi-asserted-by":"publisher","unstructured":"60. Dai XH, Liao DT, Ouyang JH, Xiao HW, Tian ZJ, Qiu LJ, et al. Forest bathing enhances sleep, mood, and immunity: insights from low-latitude evergreen broad-leaved forests. Front For Glob Change. Sec. People and Forests. 2025;8. https:\/\/doi.org\/10.3389\/ffgc.2025.1619569.","DOI":"10.3389\/ffgc.2025.1619569"},{"key":"61","unstructured":"61. Jia BB, Yang ZX, Mao GX, Lyu YD, Wen XL, Xu WH, et al. Health effect of forest bathing trip on elderly patients with chronic obstructive pulmonary disease. Biomed Environ Sci. 2016;29(3):212\u20138. https:\/\/doi.org\/10.3967\/bes2016.026."},{"key":"62","doi-asserted-by":"crossref","unstructured":"62. Mao G, Cao Y, Wang B, Wang S, Chen Z, Wang J, et al. The Salutary Influence of Forest Bathing on Elderly Patients with Chronic Heart Failure. Int J Environ Res Public Health. 2017;14(4):368. https:\/\/doi.org\/10.3390\/ijerph14040368.","DOI":"10.3390\/ijerph14040368"},{"key":"63","doi-asserted-by":"publisher","unstructured":"63. Mao GX, Cao YB, Lan XG, He ZH, Chen ZM, Wang YZ, et al. Therapeutic effect of forest bathing on human hypertension in the elderly. J Cardiol. 2012;60(6):495\u2013502. https:\/\/doi.org\/10.1016\/j.jjcc.2012.08.003.","DOI":"10.1016\/j.jjcc.2012.08.003"},{"key":"64","doi-asserted-by":"publisher","unstructured":"64. Morita E, Fukuda S, Nagano J, Hamajima N, Yamamoto H, Iwai Y, et al. Psychological effects of forest environments on healthy adults: Shinrin-yoku (forest-air bathing, walking) as a possible method of stress reduction. Public Health. 2007;121(1):54\u201363. https:\/\/doi.org\/10.1016\/j.puhe.2006.05.024.","DOI":"10.1016\/j.puhe.2006.05.024"},{"key":"65","doi-asserted-by":"crossref","unstructured":"65. Kavanaugh J, Hardison ME, Rogers HH, White C, Gross J. Assessing the Impact of a Shinrin-Yoku (Forest Bathing) Intervention on Physician\/Healthcare Professional Burnout: A Randomized, Controlled Trial. Int J Environ Res Public Health. 2022;19(21):14505. https:\/\/doi.org\/10.3390\/ijerph192114505.","DOI":"10.3390\/ijerph192114505"},{"key":"66","doi-asserted-by":"crossref","unstructured":"66. Park BJ, Shin CS, Shin WS, Chung CY, Lee SH, Kim DJ, et al. Effects of Forest Therapy on Health Promotion among Middle-Aged Women: Focusing on Physiological Indicators. Int J Environ Res Public Health. 2020;17(12):4348. https:\/\/doi.org\/10.3390\/ijerph17124348.","DOI":"10.3390\/ijerph17124348"},{"key":"67","doi-asserted-by":"publisher","unstructured":"67. Kim JS, Lee MM, Kim DS, Shin CS. Effects of barefoot walking in urban forests on CRP, IFNgamma, and serotonin levels. Healthcare (Basel). 2024;12(23):2372. https:\/\/doi.org\/10.3390\/healthcare12232372.","DOI":"10.3390\/healthcare12232372"},{"key":"68","doi-asserted-by":"crossref","unstructured":"68. Zhu DM, Zhang C, Yang Y, Zhang Y, Zhao W, Zhang B, et al. The relationship between sleep efficiency and clinical symptoms is mediated by brain function in major depressive disorder. J Affect Disord. 2020;266:327\u201337.","DOI":"10.1016\/j.jad.2020.01.155"},{"key":"69","doi-asserted-by":"crossref","unstructured":"69. Eddie D, Bentley KH, Bernard R, Yeung A, Nyer M, Pedrelli P, et al. Major depressive disorder and insomnia: Exploring a hypothesis of a common neurological basis using waking and sleep-derived heart rate variability. J Psychiatr Res. 2020;123:89\u201394.","DOI":"10.1016\/j.jpsychires.2020.01.015"},{"key":"70","doi-asserted-by":"publisher","unstructured":"70. Kwok C. Depression, Stress, and Perceived Medical Errors in Singapore Psychiatry Residents. Acad Psychiatry. 2021;45(2):169\u201373. https:\/\/doi.org\/10.1007\/s40596-020-01376-w.","DOI":"10.1007\/s40596-020-01376-w"},{"key":"71","doi-asserted-by":"crossref","unstructured":"71. Geoffroy PA, Hoertel N, Etain B, Bellivier F, Delorme R, Limosin F, et al. Insomnia and Hypersomnia in Major Depressive Episode: Prevalence, Sociodemographic Characteristics and Psychiatric Comorbidity in a Population-Based Study. J Affect Disord. 2018;226:132\u201341.","DOI":"10.1016\/j.jad.2017.09.032"},{"key":"72","doi-asserted-by":"publisher","unstructured":"72. Morita E, Imai M, Okawa M, Miyaura T, Miyazaki S. A before and after comparison of the effects of forest walking on the sleep of a community-based sample of people with sleep complaints. Biopsychosoc Med. 2011;5:13. https:\/\/doi.org\/10.1186\/1751-0759-5-13.","DOI":"10.1186\/1751-0759-5-13"},{"key":"73","doi-asserted-by":"crossref","unstructured":"73. Morita E, Kadotani H, Yamada N, Sasakabe T, Kawai S, Naito M, et al. The Inverse Association between the Frequency of Forest Walking (Shinrin-yoku) and the Prevalence of Insomnia Symptoms in the General Japanese Population: A Japan Multi-Institutional Collaborative Cohort Daiko Study. Int J Environ Res Public Health. 2024;21:350. https:\/\/doi.org\/10.3390\/ijerph21030350.","DOI":"10.3390\/ijerph21030350"},{"key":"74","doi-asserted-by":"publisher","unstructured":"74. Quan W, Yu S, Xia L, Ying M. Effect of Forest-Based Health and Wellness on Sleep Quality of Middle-Aged People. J Sens. 2022;2022:1553716. https:\/\/doi.org\/10.1155\/2022\/1553716.","DOI":"10.1155\/2022\/1553716"},{"key":"75","doi-asserted-by":"publisher","unstructured":"75. Hassan A, Zhang D. Impact of sleeping in a forest on sleep quality and mental well-being. Explore. 2024;20:501\u20136. https:\/\/doi.org\/10.1016\/j.explore.2023.11.006.","DOI":"10.1016\/j.explore.2023.11.006"},{"key":"76","doi-asserted-by":"crossref","unstructured":"76. Kim H, Kim J, Ju HJ, Jang BJ, Wang TK, Kim YI. Effect of Forest Therapy for Menopausal Women with Insomnia. Int J Environ Res Public Health. 2020 S;17(18):6548. https:\/\/doi.org\/10.3390\/ijerph17186548.","DOI":"10.3390\/ijerph17186548"},{"key":"77","doi-asserted-by":"crossref","unstructured":"77. Slavich GM, Irwin MR. From stress to inflammation and major depressive disorder: a social signal transduction theory of depression. Psychol Bull. 2014;140:774\u2013815.","DOI":"10.1037\/a0035302"},{"key":"78","doi-asserted-by":"publisher","unstructured":"78. Ming Q, Zhong X, Zhang X, Pu W, Dong D, Jiang Y, et al. State-Independent and Dependent Neural Responses to Psychosocial Stress in Current and Remitted Depression. Am J Psychiatry. 2017;174(10):971\u20139. https:\/\/doi.org\/10.1176\/appi.ajp.2017.16080974.","DOI":"10.1176\/appi.ajp.2017.16080974"},{"key":"79","doi-asserted-by":"publisher","unstructured":"79. Schumann A, Andrack C, Baer KJ. Differences of sympathetic and parasympathetic modulation in major depression. Prog Neuropsychopharmacol Biol Psychiatry. 2017;79:324\u201331. https:\/\/doi.org\/10.1016\/j.pnpbp.2017.07.009.","DOI":"10.1016\/j.pnpbp.2017.07.009"},{"key":"80","unstructured":"80. Kiani AK, Maltese PE, Dautaj A, Paolacci S, Kurti D, Picotti PM, et al. Neurobiological basis of chiropractic manipulative treatment of the spine in the care of major depression. Acta Biomed. 2020;91(13-S):e2020006. https:\/\/doi.org\/10.23750\/abm.v91i13-S.10536."},{"key":"81","doi-asserted-by":"crossref","unstructured":"81. Elhwuegi AS. Central monoamines and their role in major depression. Prog Neuropsychopharmacol Biol Psychiatry. 2004;28(3):435\u201351.","DOI":"10.1016\/j.pnpbp.2003.11.018"},{"key":"82","doi-asserted-by":"crossref","unstructured":"82. Yoon S, Kim YK. The Role of the Oxytocin System in Anxiety Disorders. Adv Exp Med Biol. 2020;1191:103\u201320. https:\/\/doi.org\/10.1007\/978-981-32-9705-07.","DOI":"10.1007\/978-981-32-9705-0_7"},{"key":"83","doi-asserted-by":"publisher","unstructured":"83. Ozsoy S, Esel E, Kula M. Serum oxytocin levels in patients with depression and the effects of gender and antidepressant treatment. Psychiatry Res. 2009;169:249\u201352. https:\/\/doi.org\/10.1016\/j.psychres.2008.06.034.","DOI":"10.1016\/j.psychres.2008.06.034"},{"key":"84","doi-asserted-by":"publisher","unstructured":"84. Veiga L, Carolino E, Santos I, Ver\u00edssimo C, Almeida A, Grilo A, et al. Depressive symptomatology, temperament and oxytocin serum levels in a sample of healthy female university students. BMC Psychol. 2022;10:36. https:\/\/doi.org\/10.1186\/s40359-022-00744-5.","DOI":"10.1186\/s40359-022-00744-5"},{"key":"85","doi-asserted-by":"publisher","unstructured":"85. Yuen KW, Garner JP, Carson DS, Keller J, Lembke A, Hyde SA, et al. Plasma oxytocin concentrations are lower in depressed vs. healthy control women and are independent of cortisol. J Psychiatr Res. 2014;51:30\u20136. https:\/\/doi.org\/10.1016\/j.jpsychires.2013.12.012.","DOI":"10.1016\/j.jpsychires.2013.12.012"},{"key":"86","doi-asserted-by":"publisher","unstructured":"86. Turan T, Uysal C, Asdemir A, Kili\u00e7 E. May oxytocin be a trait marker for bipolar disorder? Psychoneuroendocrinology. 2013;38:2890\u20136. https:\/\/doi.org\/10.1016\/j.psyneuen.2013.07.017.","DOI":"10.1016\/j.psyneuen.2013.07.017"},{"key":"87","doi-asserted-by":"publisher","unstructured":"87. Trejo LJ, Carro E, Torres-Aleman I. Circulating insulin-like growth factor I mediates exercise-induced increases in the number of new neurons in the adult hippocampus. J Neurosci. 2001;21:1628\u201334. https:\/\/doi.org\/10.1523\/JNEUROSCI.21-05-01628.2001.","DOI":"10.1523\/JNEUROSCI.21-05-01628.2001"},{"key":"88","doi-asserted-by":"crossref","unstructured":"88. Aberg ND, Brywe KG, Isgaard J. Aspects of growth hormone and insulin-like growth factor-I related to neuroprotection, regeneration, and functional plasticity in the adult brain. ScientificWorldJournal. 2006;6:53\u201380. https:\/\/doi.org\/10.1100\/tsw.2006.22.","DOI":"10.1100\/tsw.2006.22"},{"key":"89","doi-asserted-by":"publisher","unstructured":"89. Klempin F, Beis D, Mosienko V, Kempermann G, Bader M, Alenina N. Serotonin is required for exercise-induced adult hippocampal neurogenesis. J Neurosci. 2013;33:8270\u20135. https:\/\/doi.org\/10.1523\/JNEUROSCI.5855-12.2013.","DOI":"10.1523\/JNEUROSCI.5855-12.2013"},{"key":"90","doi-asserted-by":"publisher","unstructured":"90. Kondo M. Molecular Mechanisms of Exercise-induced Hippocampal Neurogenesis and Antidepressant Effects. JMA J. 2023;6:114\u20139. https:\/\/doi.org\/10.31662\/jmaj.2023-0010.","DOI":"10.31662\/jmaj.2023-0010"},{"key":"91","doi-asserted-by":"publisher","unstructured":"91. Adachi S, Tokuda N, Kobayashi Y, Tanaka H, Sawai H, Shibahara H, Takeshima Y, Shima M. Association between the serum insulin-like growth factor-1 concentration in the first trimester of pregnancy and postpartum depression. Psychiatry Clin Neurosci. 2021;75:159\u201365. https:\/\/doi.org\/10.1111\/pcn.13200.","DOI":"10.1111\/pcn.13200"},{"key":"92","doi-asserted-by":"publisher","unstructured":"92. Ta\u015f D\u00fcrm\u00fc\u015f P, Vardar ME, Kaya O, Tayfur P, S\u00fct N, Vardar SA. Evaluation of the Effects of High Intensity Interval Training on Cytokine Levels and Clinical Course in Treatment of Opioid Use Disorder. Turk Psikiyatri Derg. 2020;31:151\u20138. https:\/\/doi.org\/10.5080\/u25070.","DOI":"10.5080\/u25070"},{"key":"93","doi-asserted-by":"publisher","unstructured":"93. Jung W, Irwin M. Reduction of natural killer cytotoxic activity in major depression: interaction between depression and cigarette smoking. Psychosom Med. 1999;61(3):263\u201370. https:\/\/doi.org\/10.1097\/00006842-199905000-00002.","DOI":"10.1097\/00006842-199905000-00002"},{"key":"94","doi-asserted-by":"publisher","unstructured":"94. Sza\u0142ach \u0141P, Lisowska KA, Cuba\u0142a WJ. The Influence of Antidepressants on the Immune System. Arch Immunol Ther Exp (Warsz). 2019;67(3):143\u201351. https:\/\/doi.org\/10.1007\/s00005-019-00543-8.","DOI":"10.1007\/s00005-019-00543-8"},{"key":"95","doi-asserted-by":"publisher","unstructured":"95. Patas K, Willing A, Demiralay C, et al. T cell phenotype and T cell receptor repertoire in patients with major depressive disorder. Front Immunol. 2018;9:291. https:\/\/doi.org\/10.3389\/fimmu.2018.00291.","DOI":"10.3389\/fimmu.2018.00291"},{"key":"96","doi-asserted-by":"publisher","unstructured":"96. Pinzi M, Fagiolini A, Koukouna D, Gualtieri G, Rescalli MB, Pierini C, et al. Inflammatory and Immune Biomarkers in Mood Disorders: From Mechanistic Pathways to Clinical Translation. Cells. 2025;14(19):1558. https:\/\/doi.org\/10.3390\/cells14191558.","DOI":"10.3390\/cells14191558"},{"key":"97","unstructured":"97. Mao GX, Cao YB, Yang Y, Chen ZM, Dong JH, Chen SS, et al. Additive benefits of twice forest bathing trips in elderly patients with chronic heart failure. Biomed Environ Sci. 2018;31(2):159\u201362. https:\/\/doi.org\/10.3967\/bes2018.020."},{"key":"98","doi-asserted-by":"publisher","unstructured":"98. Li Q, Kobayashi M, Wakayama Y, Inagaki H, Katsumata M, Hirata Y, et al. Effect of phytoncide from trees on human natural killer cell function. Int J Immunopathol Pharmacol. 2009 Oct\u2013Dec;22(4):951\u20139. https:\/\/doi.org\/10.1177\/039463200902200410.","DOI":"10.1177\/039463200902200410"},{"key":"99","doi-asserted-by":"publisher","unstructured":"99. Li Q, Nakadai A, Matsushima H, Miyazaki Y, Krensky AM, Kawada T, et al. Phytoncides (wood essential oils) induce human natural killer cell activity. Immunopharmacol Immunotoxicol. 2006;28(2):319\u201333. https:\/\/doi.org\/10.1080\/08923970600809439.","DOI":"10.1080\/08923970600809439"},{"key":"100","doi-asserted-by":"publisher","unstructured":"100. Kim J, Park S, Kim H, Roh D, Kim DH. Effects of Phytoncide Fragrance on Resting-State Brain Activity in Mild Cognitive Impairment: A Randomized Double-Blind Controlled Study. J Integr Complement Med. 2024 Sep;30(9):848\u201357. https:\/\/doi.org\/10.1089\/jicm.2023.0185.","DOI":"10.1089\/jicm.2023.0185"},{"key":"101","doi-asserted-by":"publisher","unstructured":"101. Cheong MJ, Kim S, Kim JS, Lee H, Lyu YS, Lee YR, et al. A systematic literature review and meta-analysis of the clinical effects of aroma inhalation therapy on sleep problems. Medicine (Baltimore). 2021 Mar 5;100(9):e24652. https:\/\/doi.org\/10.1097\/MD.0000000000024652.","DOI":"10.1097\/MD.0000000000024652"},{"key":"102","doi-asserted-by":"publisher","unstructured":"102. Xu K, Wang S, Ji Q, Ni Y, Liu T. Effects of aromatherapy on sleep quality in older adults: A meta-analysis. 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