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Inhal Toxicol 2007;19:419\u2013449.","DOI":"10.1080\/08958370601174941"},{"key":"11","doi-asserted-by":"crossref","unstructured":"(14) Xu ZH, Ottemess DM, Freimuth RR, Carlini EJ, Wood TC, Mitchell S, et al. Human 3\u2019-phosphoadenosine 5\u2019-phosphosulfate synthetase 1 (PAPSS 1) and PAPSS 2: gene cloning, characterization and chromosomal localization. Biochem Biophys Res Commun 2000;268:437\u2013444.","DOI":"10.1006\/bbrc.2000.2123"},{"key":"12","doi-asserted-by":"crossref","unstructured":"(15) Strott CA. Sulfonation and molecular action. Endcr Rev 2002;23:703\u2013732.","DOI":"10.1210\/er.2001-0040"},{"key":"13","doi-asserted-by":"crossref","unstructured":"(16) Mueller JW, Shafqat N. Adenosine-5\u2019-phosphosulfate, a multifaced modulator of bifunctional 3\u2019-phospho-adenosine-5\u2019-phosphosulfate synthases and related enzymes. FEBS J 2013;280:3050\u20133057.","DOI":"10.1111\/febs.12252"},{"key":"14","doi-asserted-by":"crossref","unstructured":"(19) Laggner H, Hermann M, Sturm B, Gmeiner BM, Kapiotis S. Sulfite facilitates LDL lipid oxidation by transition metal ions: a pro-oxidants in wine? FEBS Lett 2005;579:6486\u20136492.","DOI":"10.1016\/j.febslet.2005.10.045"},{"key":"15","unstructured":"(20) Amdur MO, Schulz RZ, Drinker P. Toxicity of sulfuric acid mist to guinea pigs. Arch Ind Hyg Occup Med 1952;5:318\u2013329."},{"key":"16","doi-asserted-by":"crossref","unstructured":"(21) Amdur MO, Bayles J, Ugro V, Underhill DW. Comparative irritant potency of sulfate salts. Environ Res 1978;16:1\u20138.","DOI":"10.1016\/0013-9351(78)90135-4"},{"key":"17","unstructured":"(22) Avol EL, Jones MP, Bailey RM, Chang NM, Kleinman MT, Linn WS, et al. Controlled exposures of human volunteers to sulfate aerosols. Health effects and aerosol characterization. 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