{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:04:38Z","timestamp":1790960678987,"version":"4.1.0"},"reference-count":88,"publisher":"International Scientific Information, Inc.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Sci Monit"],"DOI":"10.12659\/msm.937862","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T02:28:09Z","timestamp":1664504889000},"source":"Crossref","is-referenced-by-count":13,"title":["A Review of the Biological Mechanisms of Dexmedetomidine for Postoperative Neurocognitive Disorders"],"prefix":"10.12659","volume":"28","author":[{"given":"Shanshan","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China (mainland)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yashu","family":"Leng","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China (mainland)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China (mainland)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China (mainland)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4947","published-online":{"date-parts":[[2022,9,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0000000000000812"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000004053"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.4097\/kja.20294"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-018-0873-z"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.4097\/kja.d.18.00073.1"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"F1000 F","DOI":"10.12688\/f1000research.19590.2","volume":"8","author":"Wade","year":"2019","journal-title":"F1000Res"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aep291"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000003514"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000023977"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2014.02.002"},{"key":"ref11","first-page":"752","volume":"9","author":"Khedr","year":"2018","journal-title":"Psychiatry"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.5607\/en.2018.27.6.564"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv092"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0332-6"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22686"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-017-0507-7"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/anae.12636"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200003000-00035"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2017.1505"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-019-0783-x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097\/MJT.0000000000001271"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000015383"},{"key":"ref23","first-page":"4601","volume":"8","author":"Saur","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"ref24","first-page":"1091","volume":"31","author":"Szaflarski","year":"2018","journal-title":"Zhongguo Gu Shang"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2017.11.010"},{"key":"ref26","first-page":"600","volume":"41","author":"Karunanayaka","year":"2021","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.549516"},{"key":"ref28","first-page":"413","volume":"71","author":"Szaflarski","year":"2021","journal-title":"Braz J Anesthesiol"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e318215217e"},{"key":"ref30","first-page":"4685","volume":"16","author":"Mills","year":"2018","journal-title":"Exp Ther Med"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e31828a742c"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.4103\/0971-9784.97972"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.4103\/0971-9784.81566"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2253-11-9"},{"key":"ref35","first-page":"4014021","volume":"2018","author":"Naeser","year":"2018","journal-title":"Biomed Res Int"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0171498"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2015.2726"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-201590"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2021.110530"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1238"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-018-0873-z"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1582-5"},{"key":"ref43","first-page":"2119","volume":"20","author":"Homberg","year":"2019","journal-title":"Mol Med Rep"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.11.017"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000142"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12530"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-394309-5.00006-7"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S210511"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2007.08.014"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00496"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-012-9557-z"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2004.05.010"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2011.11.005"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0781-6"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1002\/kjm2.12234"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2016.00234"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2017.08.005"},{"key":"ref58","first-page":"5091","volume":"24","author":"Conti","year":"2020","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"ref59","first-page":"5442","volume":"9","author":"Baillie","year":"2017","journal-title":"Am J Transl Res"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.10.020"},{"key":"ref61","first-page":"63","volume":"17","author":"Adderley","year":"2019","journal-title":"Exp Ther Med"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S169099"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5321"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093639"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2017.03.017"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117359"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.01041"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-019-0808-5"},{"key":"ref69","first-page":"70","volume":"8","author":"Zhang","year":"2016","journal-title":"Am J Transl Res"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1992.tb19854.x"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1101\/lm.1438109"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13217"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12283"},{"key":"ref74","first-page":"302","volume":"17","author":"Kotera","year":"2018","journal-title":"EXCLI J"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12530"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-020-02069-z"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-021-02417-7"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2018.03.043"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1038\/nature13324"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050629"},{"key":"ref81","first-page":"4226","volume":"20","author":"Sun","year":"2019","journal-title":"Mol Med Rep"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-132792"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-016-0042-9"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu310"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.12659\/AOT.899340"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.4103\/2231-0770.160231"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2017.1505"},{"key":"ref88","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30631-0"}],"container-title":["Medical Science Monitor"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.medscimonit.com\/download\/index\/idArt\/937862","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T11:39:34Z","timestamp":1782560374000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.medscimonit.com\/abstract\/index\/idArt\/937862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,30]]},"references-count":88,"alternative-id":["937862"],"URL":"https:\/\/doi.org\/10.12659\/msm.937862","relation":{},"ISSN":["1643-3750"],"issn-type":[{"value":"1643-3750","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,30]]}}}