{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T03:10:21Z","timestamp":1778382621372,"version":"3.51.4"},"reference-count":0,"publisher":"Pakistan Journal of Medical Sciences","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pak J Med Sci"],"abstract":"<jats:p>Objective: Ankylosing Spondylitis (AS) is an inflammatory rheumatic disease that mainly affects the axial spine. Osteopenia and osteoporosis are the main complications of AS. Vitamin D has functions on the immune system. In this study, we aimed to compare vitamin D levels and Bone Mineral Density (BMD) values between AS patients and controls.Methods: A total of 68 patients with axial AS and 34 healthy controls were enrolled in this study conducted between March 2018 and May 2018. Vitamin D concentrations, BMD values, disease activity, back mobility, functionality and radiologic damage were evaluated.Results: Vitamin D concentrations, the total BMD-femur and BMD-femur neck values were significantly lower in AS patients (p = 0.001, p = 0.011 and p = 0.003). No significant correlations were detected between vitamin D levels and BMD-femur total, BMD-femur neck values, disease activity, back mobility, functionality and radiologic damage scores (p &gt; 0.05). Disease activity parameters were significantly and negatively correlated with total BMD-femur and BMD-femur neck values (p &lt; 0.05).Conclusion: Our study demonstrates that AS patients have lower vitamin D levels, total BMD-femur and BMD-femur neck values. Higher disease activity increases bone loss in AS. Regular measurement of BMD and vitamin D should be kept in mind when planning a treatment in AS.doi: https:\/\/doi.org\/10.12669\/pjms.345.15739How to cite this:Kocyigit BF, Akyol A. Vitamin D levels in patients with ankylosing spondylitis: Is it related to disease activity? Pak J Med Sci. 2018;34(5):1209-1214.<\/jats:p>","DOI":"10.12669\/pjms.345.15739","type":"journal-article","created":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T05:51:45Z","timestamp":1537595505000},"source":"Crossref","is-referenced-by-count":9,"title":["Vitamin D levels in patients with ankylosing spondylitis: Is it related to disease activity?"],"prefix":"10.12669","volume":"34","author":[{"given":"Burhan Fatih","family":"Ko\u00e7yi\u011fit","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"Akyol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4935","published-online":{"date-parts":[[2018,10,2]]},"container-title":["Pakistan Journal of Medical Sciences"],"original-title":[],"link":[{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/download\/19350\/11022","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/download\/19350\/11022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T02:28:15Z","timestamp":1778380095000},"score":1,"resource":{"primary":{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/view\/19350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,2]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2018,10,1]]}},"URL":"https:\/\/doi.org\/10.12669\/pjms.345.15739","relation":{},"ISSN":["1681-715X","1682-024X"],"issn-type":[{"value":"1681-715X","type":"electronic"},{"value":"1682-024X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10,2]]}}}