{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T23:02:56Z","timestamp":1782946976323,"version":"3.54.5"},"reference-count":0,"publisher":"Pakistan Journal of Medical Sciences","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pak J Med Sci"],"abstract":"<jats:p>Objective: To compare the effects of simple saline dressings versus topical vancomycin dressings on Methicillin-resistant Staphylococcus Aureus positive chronic diabetic foot ulcers.\r\nMethods: It was quasi experimental study conducted in Combined Military Hospital Kohat and PNS-Shifa Hospital Karachi from 01 January 2017 to 31 December 2017. A total of 23 patients were included based on non-probability convenient sampling who had diabetes and presented with foot ulcers for more than two weeks showing positive growth of Methicillin-Resistant Staphylococcus Aureus. The patients were treated with simple saline soaked dressings and debridement at first for three weeks followed by three weeks of topical vancomycin dressings with debridement. Thus\u00a0patients served as their own controls\r\nResults: The average change in surface area with saline dressing was +1.73 \u00b11.53cm2 per week whereas with vancomycin soaked dressing it was --0.06\u00b11.60 cm2 per week (p &lt;0.05). The\u00a0average exudate also decreased from 1.78\u00b11.23 to 0.99\u00b10.72 (p&lt;0.05) and same trend was observed in percentage of slough covering the ulcer from 45% \u00b1 22.3% to 24.3% \u00b112.90% (p&lt;0.05) with vancomycin dressing. Moreover, fifteen patients had negative culture for MRSA within 2 weeks.\r\nConclusion: Vancomycin impregnated dressing in MRSA positive Diabetic foot may help achieve early healing as compared to simple conventional dressings with no systemic toxicity.\r\ndoi: https:\/\/doi.org\/10.12669\/pjms.35.4.368\r\nHow to cite this:Saif AB, Jabbar S, Akhtar MS, Mushtaq A, Tariq M. Effects of topical Vancomycin Dressing on Methicillin-Resistant Staphylococcus Aureus (MRSA) positive diabetic foot ulcers. Pak J Med Sci. 2019;35(4):1099-1103. doi: https:\/\/doi.org\/10.12669\/pjms.35.4.368\r\nThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (http:\/\/creativecommons.org\/licenses\/by\/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.<\/jats:p>","DOI":"10.12669\/pjms.35.4.368","type":"journal-article","created":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T03:47:02Z","timestamp":1561693622000},"source":"Crossref","is-referenced-by-count":6,"title":["Effects of topical Vancomycin Dressing on Methicillin-Resistant Staphylococcus Aureus (MRSA) positive diabetic foot ulcers"],"prefix":"10.12669","volume":"35","author":[{"given":"Anas bin","family":"Saif","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohail","family":"Jabbar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Saeed","family":"Akhtar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Mushtaq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansoor","family":"Tariq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4935","published-online":{"date-parts":[[2019,7,9]]},"container-title":["Pakistan Journal of Medical Sciences"],"original-title":[],"link":[{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/download\/368\/193","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/download\/368\/193","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T05:09:26Z","timestamp":1778303366000},"score":1,"resource":{"primary":{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/view\/368"}},"subtitle":["Vancomycin Dressing on diabetic foot ulcers"],"short-title":[],"issued":{"date-parts":[[2019,7,9]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,6,26]]}},"URL":"https:\/\/doi.org\/10.12669\/pjms.35.4.368","relation":{},"ISSN":["1681-715X","1682-024X"],"issn-type":[{"value":"1681-715X","type":"electronic"},{"value":"1682-024X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7,9]]}}}