{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:07:37Z","timestamp":1792001257734,"version":"4.4.0"},"reference-count":0,"publisher":"Pakistan Journal of Medical Sciences","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pak J Med Sci"],"abstract":"<jats:p>Objectives: Emerging cases of vancomycin-resistant enterococci (VRE) are detrimental for the patients. The current study aimed to ascertain the occurrence of VRE, their antibiogram and the van genotype responsible for vancomycin resistance.\r\nMethods: A total number of 2,958 clinical specimens were processed at Microbiology Department of the Alrazi Health Care, Lahore during the one year (2016-2017) using microbiological culture media, biochemical and serology. Antibiogram of enterococcal strains was performed using disc diffusion and E-test. ATCC Enterococcus faecalis 29212 was used as a quality control strain. The detection of van genotypes was accomplished by multiplex PCR assay.\r\nResults: Out of the 147 enterococci, 139 (94.6%) were E. faecalis, and 8 (5.4%) were E. faecium. Statistically significant associations of urine (p &lt; 0.001), pus (p &lt; 0.001) and wound swabs (p = 0.001) were observed with E. faecalis. A significant correlation of enterococcal infections (p = 0.05) was seen with female patients. Four (2.9%) strains of E. faecalis found to be VRE with vanB (75%) and vanA (25%) genotypes.\r\nConclusion: The emerging strains of VRE (vanB and vanA genotype) in the current study are a potential menace for therapeutic failure, which left the physicians with only linezolid as a therapeutic option.\r\ndoi: https:\/\/doi.org\/10.12669\/pjms.35.6.1145\r\nHow to cite this:Ejaz H. Emerging resistance of van genotype in enterococci: A\u00a0potential menace for therapeutic failure. Pak J Med Sci. 2019;35(6):1659-1663. doi: https:\/\/doi.org\/10.12669\/pjms.35.6.1145\r\nThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (http:\/\/creativecommons.org\/licenses\/by\/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.<\/jats:p>","DOI":"10.12669\/pjms.35.6.1145","type":"journal-article","created":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T05:09:50Z","timestamp":1570684190000},"source":"Crossref","is-referenced-by-count":7,"title":["Emerging resistance of van genotype in enterococci: A\u00a0potential menace for therapeutic failure"],"prefix":"10.12669","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6185-2042","authenticated-orcid":false,"given":"Hasan","family":"Ejaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4935","published-online":{"date-parts":[[2019,10,9]]},"container-title":["Pakistan Journal of Medical Sciences"],"original-title":[],"link":[{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/download\/1145\/323","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/download\/1145\/323","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T05:40:53Z","timestamp":1778305253000},"score":1,"resource":{"primary":{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/view\/1145"}},"subtitle":["Emerging van genotype in enterococci"],"short-title":[],"issued":{"date-parts":[[2019,10,9]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,10,5]]}},"URL":"https:\/\/doi.org\/10.12669\/pjms.35.6.1145","relation":{},"ISSN":["1681-715X","1682-024X"],"issn-type":[{"value":"1681-715X","type":"electronic"},{"value":"1682-024X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10,9]]}}}