{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T06:12:34Z","timestamp":1778307154654,"version":"3.51.4"},"reference-count":0,"publisher":"Pakistan Journal of Medical Sciences","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pak J Med Sci"],"abstract":"<jats:p>Objective: To determine effect of pre-endoscopy intake of simethicone solution on endoscopic mucosal visibility.\r\nMethods: A randomized, single blinded placebo control trial was done in patients undergoing oesophago-gastro-duodenoscopy for any indication at DOTs Endoscopy Suite, CHK during the period of April to June 2019. Informed consent was taken. Patients were randomly allocated in two groups. Group-A received placebo while Group-B received Simethicone. Evaluation of mucosal visibility was assessed at 4 sites (oesophagus, fundus, antrum &amp; duodenum) by previously validated scoring. Mean of visibility scores were compared in two groups.\r\nResults: Two hundred and forty-eight patients were inducted and randomly allocate to two groups of 124 each. Mean of total sum of scores in Group-A was 8.14 \u00b12.44 and that of Group-B was 5.80 \u00b11.75 (p&lt;0.001). Adequate visibility in Group-A was seen in 41.1% and that in Group-B was 78.2% (p&lt;0.001).Conclusion: Use of Simethicone significantly improves mucosal visibility during OGD.\r\ndoi: https:\/\/doi.org\/10.12669\/pjms.36.2.1241\r\nHow to cite this:Zuberi BF, Shaikh MA, Ali FS, Rasheed T, Nawaz Z. Effect of pre-endoscopy intake of simethicone solution\u00a0on endoscopic mucosal visibility: A single blinded, placebo control, randomized trial. Pak J Med Sci. 2020;36(2):172-176.\u00a0\u00a0doi: https:\/\/doi.org\/10.12669\/pjms.36.2.1241\r\nThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (http:\/\/creativecommons.org\/licenses\/by\/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.<\/jats:p>","DOI":"10.12669\/pjms.36.2.1241","type":"journal-article","created":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T05:40:29Z","timestamp":1576474829000},"source":"Crossref","is-referenced-by-count":1,"title":["Effect of pre-endoscopy intake of simethicone solution\u00a0on endoscopic mucosal visibility: A single blinded,  placebo control, randomized trial"],"prefix":"10.12669","volume":"36","author":[{"given":"Bader Faiyaz","family":"Zuberi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majid Ahmed","family":"Shaikh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faiza Sadaqat","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tazeen","family":"Rasheed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zunaira","family":"Nawaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4935","published-online":{"date-parts":[[2019,12,15]]},"container-title":["Pakistan Journal of Medical Sciences"],"original-title":[],"link":[{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/download\/1241\/397","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/download\/1241\/397","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T05:43:34Z","timestamp":1778305414000},"score":1,"resource":{"primary":{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/view\/1241"}},"subtitle":["Simethicone solution\u00a0&amp; endoscopic mucosal visibility"],"short-title":[],"issued":{"date-parts":[[2019,12,15]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,12,13]]}},"URL":"https:\/\/doi.org\/10.12669\/pjms.36.2.1241","relation":{},"ISSN":["1681-715X","1682-024X"],"issn-type":[{"value":"1681-715X","type":"electronic"},{"value":"1682-024X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12,15]]}}}