{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T06:12:42Z","timestamp":1778307162693,"version":"3.51.4"},"reference-count":0,"publisher":"Pakistan Journal of Medical Sciences","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pak J Med Sci"],"abstract":"<jats:p>Objective: To study the expressions of TIMP-1 and MMP-9 in patients with chronic obstructive pulmonary disease (COPD) complicated with spontaneous pneumothorax, and their correlations with treatment outcomes.\r\nMethods: A total of 80 COPD patients complicated with spontaneous pneumothorax treated in our hospital from December 2015 to December 2017. The serum expressions of TIMP-1 and MMP-9 in 80 COPD patients complicated with spontaneous pneumothorax (COPD group) and 52 healthy volunteers (control group) were detected by ELISA. The correlations of TIMP-1 and MMP-9 expressions with arterial blood gas parameters as well as scores of MRC breathlessness scale and St. George\u2019s Respiratory Questionnaire (SGRQ) were analyzed.\r\nResults: The serum expressions of TIMP-1 and MMP-9 of COPD group were significantly higher than those of control group (P&lt;0.05), but the two groups had similar MMP-9\/TIMP-1 ratios (P&gt;0.05). For COPD group, TIMP-1 expression, MMP-9 expression, MMP-9\/TIMP-1, Sa(O2) and p(O2) were not correlated (P&gt;0.05). TIMP-1 expression was significantly positively correlated with MRC scale and SGRQ scores (P&lt;0.05). Sa(O2), p(O2) and MRC scale score of low MMP-9 expression, low TIMP-1 expression and low MMP-9\/TIMP-1 group were significantly improved compared with those of high MMP-9 expression, high TIMP-1 expression and high MMP-9\/TIMP-1 group (P&lt;0.05). MMP-9 expression, TIMP-1 expression or MMP-9\/TIMP-1 was not correlated with improvement of SGRQ score. Pulmonary function improvement (Sa(O2) improvement rate \u22655% and\/or p(O2) improvement rate \u226510%) was correlated with serum MMP-9 expression, baseline Sa(O2) and p(O2).\r\nConclusion: Increase of serum TIMP-1 and MMP-9 expressions in COPD patients was correlated with symptoms and scores of quality of life, and the expressions were also correlated with short-term treatment reactivity.\r\ndoi: https:\/\/doi.org\/10.12669\/pjms.36.2.1244\r\nHow to cite this:Li H, Shi K, Zhao Y, Du J, Hu D, Liu Z. TIMP-1 and MMP-9 expressions in COPD patients complicated with spontaneous pneumothorax and their correlations with treatment outcomes. Pak J Med Sci. 2020;36(2):192-197. doi: https:\/\/doi.org\/10.12669\/pjms.36.2.1244\r\nThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (http:\/\/creativecommons.org\/licenses\/by\/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.<\/jats:p>","DOI":"10.12669\/pjms.36.2.1244","type":"journal-article","created":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T05:40:29Z","timestamp":1576474829000},"source":"Crossref","is-referenced-by-count":4,"title":["TIMP-1 and MMP-9 expressions in COPD patients complicated with spontaneous pneumothorax and their correlations with treatment outcomes"],"prefix":"10.12669","volume":"36","author":[{"given":"Hang","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaihu","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dinghui","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuntao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4935","published-online":{"date-parts":[[2019,12,16]]},"container-title":["Pakistan Journal of Medical Sciences"],"original-title":[],"link":[{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/download\/1244\/401","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/download\/1244\/401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T05:43:42Z","timestamp":1778305422000},"score":1,"resource":{"primary":{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/view\/1244"}},"subtitle":["TIMP-1, MMP-9 and COPD"],"short-title":[],"issued":{"date-parts":[[2019,12,16]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,12,13]]}},"URL":"https:\/\/doi.org\/10.12669\/pjms.36.2.1244","relation":{},"ISSN":["1681-715X","1682-024X"],"issn-type":[{"value":"1681-715X","type":"electronic"},{"value":"1682-024X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12,16]]}}}