{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T08:12:40Z","timestamp":1778314360032,"version":"3.51.4"},"reference-count":0,"publisher":"Pakistan Journal of Medical Sciences","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pak J Med Sci"],"abstract":"<jats:p>Objectives: We designed this prospective observational study to clarify the associations between dialysate IL-6, a marker of ongoing peritoneal inflammation, Tie2, an important factor in angiogenesis in the peritoneum, and a high peritoneal solute transport rate (PSTR) in patients undergoing peritoneal dialysis (PD) and to investigate their outcome predictive roles.\r\nMethods: A total of 60 stable continuous ambulatory peritoneal dialysis (CAPD) patients from a single center in China were analyzed in this prospective study. We measured dialysate levels of IL-6 and Tie-2 using ELISAs. Our primary study endpoint was all-cause mortality with 10 years\u2019 follow-up.\r\nResults: For the evaluation of PSTR, we used the Dialysis\/Plasma creatinine (D\/Pcr) ratio. We subdivided the patients into two groups for statistical evaluation: low and low average D\/Pcr (&lt;0.64; L\/A), and high and high average D\/Pcr (\u22650.65; H\/A) transporters. The mean levels of dialysates IL-6 (21.71 \u00b1 8.88 pg\/mL) and Tie-2 (1.23 \u00b1 0.43 ng\/mL) were significantly higher in the H\/A (high and high average, group than those in the L\/A group (13.94 \u00b1 5.43 pg\/mL, p&lt;0.001 and 0.95 \u00b1 0.43 ng\/mL, p=0.019; respectively). Moreover, IL-6 and Tie-2 were positively correlated with D\/Pcr (r=0.366, p=0.004 and r=0.402, p=0.001; respectively). Both dialysates IL-6 and Tie-2 were independent determinants of a high peritoneal solute transport rate. After follow-up for 42.65\u00b118.08 months, 30 patients (50.0%) had died. An increased D\/Pcr increased the risk of all-cause mortality in patients with CAPD (p=0.018), but the dialysates IL-6 and Tie2 were not independent predictors of all-cause mortality (p&gt;0.05).\r\nConclusion: Our results suggest that patients undergoing CAPD have a high peritoneal solute transport status with local peritoneal inflammation and angiogenesis. Increased D\/Pcr is a relative risk factor for mortality and technique failure in patients undergoing CAPD.\r\ndoi: https:\/\/doi.org\/10.12669\/pjms.37.4.4328\r\nHow to cite this:Hang Y, Yan H, Zhang H, Li Z, Fang W. Associations between\u00a0dialysate interleukin-6 and Tie-2 and peritoneal solute transport rate and outcomes for patients undergoing\u00a0peritoneal dialysis: A prospective cohort study. Pak J Med Sci. 2021;37(4):1104-1110.\u00a0\u00a0doi: https:\/\/doi.org\/10.12669\/pjms.37.4.4328\r\nThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (http:\/\/creativecommons.org\/licenses\/by\/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.<\/jats:p>","DOI":"10.12669\/pjms.37.4.4328","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T04:50:58Z","timestamp":1619067058000},"source":"Crossref","is-referenced-by-count":2,"title":["Associations between\u00a0dialysate interleukin-6 and Tie-2 and peritoneal solute transport rate and outcomes for patients undergoing\u00a0peritoneal dialysis: A prospective cohort study"],"prefix":"10.12669","volume":"37","author":[{"given":"Ying","family":"Hang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"He","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4935","published-online":{"date-parts":[[2021,5,7]]},"container-title":["Pakistan Journal of Medical Sciences"],"original-title":[],"link":[{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/download\/4328\/929","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/download\/4328\/929","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T07:53:04Z","timestamp":1778313184000},"score":1,"resource":{"primary":{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/view\/4328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,7]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,4,21]]}},"URL":"https:\/\/doi.org\/10.12669\/pjms.37.4.4328","relation":{},"ISSN":["1681-715X","1682-024X"],"issn-type":[{"value":"1681-715X","type":"electronic"},{"value":"1682-024X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5,7]]}}}