{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T09:09:47Z","timestamp":1778317787881,"version":"3.51.4"},"reference-count":0,"publisher":"Pakistan Journal of Medical Sciences","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pak J Med Sci"],"abstract":"<jats:p>Objectives: To determine the clinical spectrum and underlying etiologies of children presented with precocious puberty at The Children\u2019s Hospital &amp;The Institute of Child health, Lahore.\r\nMethods: It is a retrospective review of all the children presented with precocious puberty over one year, from January 2015 to December 2015; at the department of Paediatric Endocrinology &amp; Diabetes, The Children\u2019s Hospital &amp; The Institute of Child Health, Lahore.\r\nResults: Total 43 cases of precocious puberty (PP), with 26 females were reported in one year. Central precocious puberty (CPP) constituted 55.8% (24\/43) and was found to be more prevalent in female (22\/24). In 20\/24 cases (83.3%) of central precocious puberty underlying etiology was idiopathic. Peripheral precocious puberty was found in 19\/43 cases (44.1%) with male predominance (15\/19). Congenital adrenal hyperplasia was the most frequent (12\/19) underlying cause of peripheral precocious puberty in our cohort.\r\nConclusion: Precocious puberty could be a manifestation of underlying serious medical condition. It should be thoroughly evaluated with the aim to diagnose the underlying pathology and to treat them promptly.\r\ndoi: https:\/\/doi.org\/10.12669\/pjms.38.4.4816\r\nHow to cite this:Aftab S, Manzoor J, Mahmood Q, Shaheen T. Precocious puberty: The clinical profile and the etiological classification of children presented at a tertiary care children\u2019s hospital. Pak J Med Sci. 2022;38(4):955-959.\u00a0 doi: https:\/\/doi.org\/10.12669\/pjms.38.4.4816\r\nThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (http:\/\/creativecommons.org\/licenses\/by\/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.<\/jats:p>","DOI":"10.12669\/pjms.38.4.4816","type":"journal-article","created":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T04:15:00Z","timestamp":1646626500000},"source":"Crossref","is-referenced-by-count":5,"title":["Precocious puberty: The clinical profile and the etiological classification of children presented at a tertiary care children\u2019s hospital"],"prefix":"10.12669","volume":"38","author":[{"given":"Sommayya","family":"Aftab","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaida","family":"Manzoor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qaiser","family":"Mahmood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tahir","family":"Shaheen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4935","published-online":{"date-parts":[[2022,3,7]]},"container-title":["Pakistan Journal of Medical Sciences"],"original-title":[],"link":[{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/download\/4816\/1307","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/download\/4816\/1307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T08:15:50Z","timestamp":1778314550000},"score":1,"resource":{"primary":{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/view\/4816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,7]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,3,4]]}},"URL":"https:\/\/doi.org\/10.12669\/pjms.38.4.4816","relation":{},"ISSN":["1681-715X","1682-024X"],"issn-type":[{"value":"1681-715X","type":"electronic"},{"value":"1682-024X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3,7]]}}}