{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T03:45:03Z","timestamp":1784605503621,"version":"3.55.0"},"reference-count":0,"publisher":"Pakistan Journal of Medical Sciences","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pak J Med Sci"],"abstract":"<jats:p>Objectives: To compare the success rates and safety of two-doses of methotrexate versus single dose of methotrexate in ectopic tubal pregnancy.\r\nMethods: This was an open-label, randomized controlled trial done at \u201cThe Department of Obstetrics &amp; Gynecology, Nishtar University Hospital, Multan\u201d from January 2020 to July 2021. A total of 100 women (50 in each group), aged 20 to 35 years with a tubal ectopic pregnancy were enrolled. All patients were randomly allocated to either single-dose or two-dose methotrexate protocol. Cases were evaluated for treatment success, side effects, beta-human chorionic gonadotrophin (\u03b2-hCG) resolution time and treatment satisfaction.\r\nResults: In a total of 100 cases, mean age was 29.6\u00b14.5 years. Mean serum \u03b2 -hCG levels at baseline was 1212\u00b178 mIU\/ml. Treatment success was noted among 43 (86.0%) cases of single-dose group versus 45 (90.0%) cases (p=0.5382). Duration of \u03b2 -hCG resolution time was significantly shorter in two-dose group (23.0\u00b112.1 days versus 28.2\u00b112.8 days, p=0.0394). No significant difference was noted in methotrexate associated side effects in both study groups (p=0.9996). Overall, mean satisfaction score was 4.0\u00b11.3 (out of 5).\r\nConclusion: Although, \u03b2 -hCG resolution time was significantly low in two-dose protocol but single-dose methotrexate offered comparable success rates versus two-dose protocol. Side effects were mild and comparable in both methotrexate treatment protocols. Methotrexate was found to be effective in the medical management of ectopic pregnancy.\r\nTrial Registry: NCT05208034 at: www.ClinicalTrials.gov\r\ndoi: https:\/\/doi.org\/10.12669\/pjms.38.6.5251\r\nHow to cite this:Riaz A, Sughra U, Jawaid SA, Masood J. Measurement of Service Quality Gaps in Dental Services using SERVQUAL in Public Hospitals of Rawalpindi. Pak J Med Sci. 2022;38(6):1436-1440. doi: https:\/\/doi.org\/10.12669\/pjms.38.6.5251\r\nThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (http:\/\/creativecommons.org\/licenses\/by\/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.<\/jats:p>","DOI":"10.12669\/pjms.38.6.5251","type":"journal-article","created":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T05:33:39Z","timestamp":1656135219000},"source":"Crossref","is-referenced-by-count":3,"title":["Treatment success with two doses of methotrexate vs single dose of methotrexate in Ectopic Tubal Pregnancy"],"prefix":"10.12669","volume":"38","author":[{"given":"Mehnaz","family":"Khakwani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashida","family":"Parveen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syeda","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4935","published-online":{"date-parts":[[2022,7,5]]},"container-title":["Pakistan Journal of Medical Sciences"],"original-title":[],"link":[{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/download\/5251\/1390","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/download\/5251\/1390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T08:43:14Z","timestamp":1778316194000},"score":1,"resource":{"primary":{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/view\/5251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,5]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,6,25]]}},"URL":"https:\/\/doi.org\/10.12669\/pjms.38.6.5251","relation":{},"ISSN":["1681-715X","1682-024X"],"issn-type":[{"value":"1681-715X","type":"electronic"},{"value":"1682-024X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7,5]]}}}