{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T14:14:50Z","timestamp":1778336090776,"version":"3.51.4"},"reference-count":0,"publisher":"Pakistan Journal of Medical Sciences","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pak J Med Sci"],"abstract":"<jats:p>Objective: To investigate the application of pharmacy practice based on the evidence\u2010based pharmacy (EBP) model in the anti\u2010infective treatment of patients with severe pneumonia.\nMethodology: This was a retrospective study. A total of 200 patients diagnosed with severe pneumonia caused by multidrug\u2010resistant Gram\u2010negative bacilli(MDR\u2010GNB) and admitted to Baoding No.1 Central Hospital from April 2023 to March 2024 were randomly assigned to a control group(received conventional anti\u2010infective treatment) and an experimental group(in addition to the conventional treatment, received pharmacy practice interventions based on the EBP model implemented by clinical pharmacists), with one hundred cases in each group..The two groups were compared in terms of antimicrobial drug use intensity, pre\u2010antibiotic microbiological testing rates, clinical efficacy, adverse reaction rates, and irrational drug use.\nResults: The antimicrobial drug use intensity in the experimental group was significantly lower than that in the control group (P&lt; 0.05), while the pre\u2010antibiotic microbiological testing rate was significantly higher (P&lt; 0.05). The antimicrobial drug costs and anti\u2010infective treatment duration in the experimental group were lower than those in the control group (P&lt; 0.05, respectively). The bacterial eradication and overall response in the experimental group were significantly higher than those in the control group (P&lt; 0.05, respectively). Furthermore, adverse reaction and irrational drug use rates were significantly lower in the experimental group compared to the control group (P&lt; 0.05, respectively).\nConclusion: EBP model\u2010based pharmacy practice may assist physicians in optimizing anti\u2010infective treatment regimens for patients with severe pneumonia caused by MDR\u2010GNB, improving treatment outcomes and medication safety while effectively enhancing patient prognosis.<\/jats:p>","DOI":"10.12669\/pjms.41.11.12232","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T04:17:54Z","timestamp":1762316274000},"page":"3076-3081","source":"Crossref","is-referenced-by-count":0,"title":["Feasibility analysis of pharmacy practice based on the evidence-based pharmacy model in the treatment of patients with severe pneumonia"],"prefix":"10.12669","volume":"41","author":[{"given":"Mingyue","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujia","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4935","published-online":{"date-parts":[[2025,11,3]]},"container-title":["Pakistan Journal of Medical Sciences"],"original-title":[],"link":[{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/download\/12232\/3060","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/download\/12232\/3060","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T14:06:08Z","timestamp":1778335568000},"score":1,"resource":{"primary":{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/view\/12232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,3]]},"references-count":0,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,10,30]]}},"URL":"https:\/\/doi.org\/10.12669\/pjms.41.11.12232","relation":{},"ISSN":["1681-715X","1682-024X"],"issn-type":[{"value":"1681-715X","type":"electronic"},{"value":"1682-024X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11,3]]}}}