{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T15:08:59Z","timestamp":1778339339971,"version":"3.51.4"},"reference-count":0,"publisher":"Pakistan Journal of Medical Sciences","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pak J Med Sci"],"abstract":"<jats:p>Objective: To investigate the clinical efficacy of antibacterial drugs combined with proton pump inhibitors and bismuth in the treatment of Helicobacter pylori (Hp)-infected peptic ulcer.\nMethodology: This was a retrospective study. A total of 116 patients with Hp-infected peptic ulcer treated at Cangzhou People\u2019s Hospital from January 2023 to December 2024 were selected as study subjects and randomly divided into an observation group(n=58) treated with antibacterial drugs in addition to the treatment for the control group and a control group(n=58) received proton pump inhibitors and bismuth using the computer-based lottery method. The clinical efficacy, time to symptom subsidence treatment safety were assessed and compared between the two groups.\nResults: The overall response rate of the observation group was higher than that of the control group(P&lt;0.05). Specifically, the time to symptom subsidence in the observation group was shorter than that in the control group(P&lt;0.05), and the post-treatment levels of G-17, PGI and PGII in the observation group were lower than those in the control group(P&lt; 0.05). Meanwhile, the post-treatment serum levels of GAS, VIP, and MOT in the observation group were higher than those in the control group(P&lt;0.05). Additionally, the observation group reported lower post-treatment serum levels of TRX-1, TRAF1, and MMP-9 than the control group(P&lt;0.05), with no significant differences observed in the incidence of adverse reactions between the two groups(P&gt;0.05).\nConclusion: Antibacterial drugs combined with proton pump inhibitors and bismuth are remarkably effective in treating Hp-infected peptic ulcer, which promotes the subsidence of symptoms, improves gastric function, increases gastrointestinal hormone levels.<\/jats:p>","DOI":"10.12669\/pjms.41.11.12314","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T04:17:51Z","timestamp":1762316271000},"page":"3021-3026","source":"Crossref","is-referenced-by-count":0,"title":["Clinical efficacy of antibacterial drugs combined with Proton Pump Inhibitors and Bismuth in the treatment of Helicobacter Pylori-infected Peptic Ulcer"],"prefix":"10.12669","volume":"41","author":[{"given":"Xiaoying","family":"Fu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiyu","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4935","published-online":{"date-parts":[[2025,11,3]]},"container-title":["Pakistan Journal of Medical Sciences"],"original-title":[],"link":[{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/download\/12314\/3068","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/download\/12314\/3068","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T14:10:28Z","timestamp":1778335828000},"score":1,"resource":{"primary":{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/view\/12314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,3]]},"references-count":0,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,10,30]]}},"URL":"https:\/\/doi.org\/10.12669\/pjms.41.11.12314","relation":{},"ISSN":["1681-715X","1682-024X"],"issn-type":[{"value":"1681-715X","type":"electronic"},{"value":"1682-024X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11,3]]}}}