{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T15:06:21Z","timestamp":1784387181971,"version":"3.55.0"},"reference-count":0,"publisher":"Pakistan Journal of Medical Sciences","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pak J Med Sci"],"abstract":"<jats:p>Objective: To compare the clinical and biochemical profiles of adolescent and adult patients with Polycystic Ovary Syndrome (PCOS) and to evaluate the impact of insulin resistance on metabolic parameters.\nMethodology: A cross-sectional study was conducted at a tertiary care hospital from June to December 2024. A total of 150 PCOS patients, diagnosed using the Rotterdam criteria, were included. Clinical features (BMI, menstrual irregularities, hirsutism and family history) and biochemical parameters (fasting glucose, insulin, HOMA-IR, lipid profile and hormone levels) were analyzed. Patients were stratified into insulin-resistant and non-insulin-resistant groups for comparison. Insulin resistance was defined using HOMA-IR cut off value of more than 2.5.\nResults: Adolescents had lower BMI (25.5 \u00b1 3.8 vs. 29.1 \u00b1 4.9 kg\/m\u00b2, p &lt; 0.001) and more frequent menstrual irregularities (90.7% vs. 49.3%, p &lt; 0.001) than adults. Insulin resistance was observed in 85 (56.7%) patients and was associated with significantly higher fasting insulin (18.2 \u00b1 4.8 vs. 9.8 \u00b1 2.9 \u00b5U\/mL, p &lt; 0.001), HOMA-IR (4.8 \u00b1 1.2 vs. 2.3 \u00b1 0.6, p &lt; 0.001) and higher LDL with lower HDL levels.\nConclusions: Significant age-related differences in clinical and biochemical profiles exist among PCOS patients, along with insulin resistance status. Early identification of metabolic risks is crucial for timely intervention.<\/jats:p>","DOI":"10.12669\/pjms.41.9.12228","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T09:14:30Z","timestamp":1756977270000},"page":"2518-2522","source":"Crossref","is-referenced-by-count":1,"title":["Clinical and biochemical profile in adolescent and adult polycystic ovary syndrome patients"],"prefix":"10.12669","volume":"41","author":[{"given":"Bakht","family":"Babar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghulam","family":"Farooq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misbah","family":"Manzoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hashim","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4935","published-online":{"date-parts":[[2025,8,26]]},"container-title":["Pakistan Journal of Medical Sciences"],"original-title":[],"link":[{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/download\/12228\/2952","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/download\/12228\/2952","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T14:05:41Z","timestamp":1778335541000},"score":1,"resource":{"primary":{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/view\/12228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,26]]},"references-count":0,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,8,26]]}},"URL":"https:\/\/doi.org\/10.12669\/pjms.41.9.12228","relation":{},"ISSN":["1681-715X","1682-024X"],"issn-type":[{"value":"1681-715X","type":"electronic"},{"value":"1682-024X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8,26]]}}}