{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T15:09:33Z","timestamp":1778339373142,"version":"3.51.4"},"reference-count":0,"publisher":"Pakistan Journal of Medical Sciences","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pak J Med Sci"],"abstract":"<jats:p>Background &amp; objective:\u00a0Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) involving continuous colonic mucosal inflammation that leads to extraintestinal manifestations (EIMs) in many patients. Understanding the prevalence, patterns and factors associated with EIMs is vital for optimizing UC patient care, making this study essential for assessing EIM frequency, distribution and stratification.\r\nMethod:\u00a0This observational, cross-sectional study was conducted at Jinnah Postgraduate Medical Centre in Karachi from June 2022 to November 2024,\u00a0involving 147 UC patients. Prospective data collection was used to assess\u00a0disease severity using the standard criteria. EIMs were classified according to their type. Statistical analysis included descriptive and inferential methods using chi-square tests with p &lt;0.05.\r\nResults:\u00a0EIMs affected 53 (36.1%) patients, with musculoskeletal manifestations in 13(8.8%) and hepatobiliary issues in 12(8.2%). Ocular involvement was observed in 8(5.4%)\u00a0patients, dermatological manifestations in 09 (6.1%), renal issues (nephrolithiasis) in 5(3.4%) and systemic problems in 6(4.1%). Gender, age\u00a0and\u00a0disease duration did not significantly correlate\u00a0with the presence of EIM (p &gt;0.05), but severity showed a significant association\u00a0(p&lt;0.05).\r\nConclusion:\u00a0Extra-intestinal manifestations, especially musculoskeletal and hepatobiliary manifestations, are commonly found in ulcerative colitis. EIMs are correlated with disease severity and are not related to gender and age.<\/jats:p>","DOI":"10.12669\/pjms.42.1.12456","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:13:41Z","timestamp":1767676421000},"page":"168-172","source":"Crossref","is-referenced-by-count":0,"title":["Extraintestinal manifestations in ulcerative colitis patients with disease phenotype: Insights from a Pakistani population"],"prefix":"10.12669","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8345-5420","authenticated-orcid":false,"given":"Omar","family":"Idris","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Akbar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazish","family":"Butt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul Samad","family":"Bhatti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4935","published-online":{"date-parts":[[2026,1,5]]},"container-title":["Pakistan Journal of Medical Sciences"],"original-title":[],"link":[{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/download\/12456\/3175","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/download\/12456\/3175","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T14:15:35Z","timestamp":1778336135000},"score":1,"resource":{"primary":{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/view\/12456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,5]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,5]]}},"URL":"https:\/\/doi.org\/10.12669\/pjms.42.1.12456","relation":{},"ISSN":["1681-715X","1682-024X"],"issn-type":[{"value":"1681-715X","type":"electronic"},{"value":"1682-024X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1,5]]}}}