{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T15:09:36Z","timestamp":1778339376451,"version":"3.51.4"},"reference-count":0,"publisher":"Pakistan Journal of Medical Sciences","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pak J Med Sci"],"abstract":"<jats:p>Objective: To determine on-treatment changes in MELD-Na &amp; Fibroscan scores after a period of six months in patients with chronic Hepatitis-B who are treated with Entecavir (ETV).\nMethodology: This observational cohort was conducted at Department of Medicine\/Gastroenterology, Dow Medical College affiliated with Dow University of Health Sciences, Karachi, Pakistan during the period of August 2019 to December 2024. Patients of either gender aged between 18 - 80 years attending hepatitis clinic and who are on treatment for Hepatitis-B with Entecavir were inducted after informed consent. MELD-Na &amp; Fibroscan scores were recorded at induction and after six months of treatment with ETV.\nResults: A total of 288 patients were enrolled including 153 (53.1%) were males with mean age of 37.6 \u00b111.6 years and 135 (46.9%) were females with mean age of 43.5 \u00b19.6 years. The difference in age between genders was significant (p &lt; .001). Comparison of parameters at induction of study and after six months of treatment with Entecavir using Paired Sample T-Test, we found significant improvement in all parameters except serum albumin which showed significant reduction in levels after six months. MELD-Na Score improved from 9.38 to 8.94 (p &lt;.001). CTP Score &amp; Fibroscan improved from 5.7 to 5.66 (p &lt;.001) &amp; 8.95 to 8.61 (p &lt;.001) respectively. Albumen values reduced from 4.08 to 3.98 (p &lt;.001).\nConclusion: Significant improvement in MELD-Na &amp; Fibroscan scores were observed in patients on treatment with ETV.<\/jats:p>","DOI":"10.12669\/pjms.42.3.12534","type":"journal-article","created":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T06:05:07Z","timestamp":1773468307000},"page":"599-603","source":"Crossref","is-referenced-by-count":0,"title":["Changes in MELD-Na &amp; Fibroscan Scores in Patients with Chronic Hepatitis-B on Entecavir: A Cohort Analysis"],"prefix":"10.12669","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7695-3922","authenticated-orcid":false,"given":"Bader Faiyaz","family":"Zuberi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4286-8820","authenticated-orcid":false,"given":"Faiza Sadaqat","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0415-6649","authenticated-orcid":false,"given":"Tazeen","family":"Rasheed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7633-2632","authenticated-orcid":false,"given":"Nimrah","family":"Bader","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4935","published-online":{"date-parts":[[2026,3,5]]},"container-title":["Pakistan Journal of Medical Sciences"],"original-title":[],"link":[{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/download\/12534\/3258","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/download\/12534\/3258","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T14:19:12Z","timestamp":1778336352000},"score":1,"resource":{"primary":{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/view\/12534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,5]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,3,5]]}},"URL":"https:\/\/doi.org\/10.12669\/pjms.42.3.12534","relation":{},"ISSN":["1681-715X","1682-024X"],"issn-type":[{"value":"1681-715X","type":"electronic"},{"value":"1682-024X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3,5]]}}}