{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T16:09:05Z","timestamp":1778342945874,"version":"3.51.4"},"reference-count":0,"publisher":"Pakistan Journal of Medical Sciences","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pak J Med Sci"],"abstract":"<jats:p>Background and Objective: Radical cystectomy (RC) is standard treatment for muscle-invasive bladder cancer (MIBC); however, disease recurrence remains a major challenge. This study aimed to describe recurrence patterns and explore clinical and pathological factors associated with early recurrence post-RC.\nMethodology: This retrospective cohort study included adult patients with histologically confirmed bladder cancer who underwent RC at the Pakistan Kidney and Liver Institute &amp; Research Center, Lahore, between February 2023 and August 2025. Demographic, pathological, treatment, and follow-up data were extracted. Recurrence status was available for 40 patients and was analyzed using descriptive statistics and univariate analyses.\nResults: Among 70 patients, follow-up sufficient to evaluate recurrence was available for 40 (57.1%). Recurrence occurred in nine patients (9\/40, 22.5%) during the available follow-up period. Mean time to recurrence among affected patients was 5.0 \u00b1 2.7 months. Histological subtype showed a possible signal with recurrence, with squamous cell carcinoma appearing more frequently among recurrence cases (p = 0.019); however, this observation was based on a very small number of patients and should be interpreted with caution. Other demographic, tumor-related, and treatment variables were not significantly associated with recurrence. Follow-up duration was varied and shorter among recurrence cases compared with non-recurrence cases, which may establish detection bias.\nConclusion: In this single-center cohort, early recurrence after radical cystectomy was observed in a subset of patients; however, the small sample size, short follow-up duration, and substantial loss to follow-up limit reliable identification of predictors. Larger prospective studies are needed to characterize recurrence patterns post-RC.<\/jats:p>","DOI":"10.12669\/pjms.42.4.14997","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T04:26:18Z","timestamp":1776140778000},"page":"932-937","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and pathological factors associated with recurrence after radical cystectomy for bladder cancer: A single-center retrospective study"],"prefix":"10.12669","volume":"42","author":[{"given":"Nadeem Bin","family":"Nusrat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarmad","family":"Imtiaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asadullah","family":"Aslam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Assad ur","family":"Rehman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shujah","family":"Muhammad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nauman","family":"Zafar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah Muhammad","family":"Ashfaq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan","family":"Arshad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4935","published-online":{"date-parts":[[2026,4,11]]},"container-title":["Pakistan Journal of Medical Sciences"],"original-title":[],"link":[{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/download\/14997\/3377","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/download\/14997\/3377","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T15:12:24Z","timestamp":1778339544000},"score":1,"resource":{"primary":{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/view\/14997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,11]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,4,11]]}},"URL":"https:\/\/doi.org\/10.12669\/pjms.42.4.14997","relation":{},"ISSN":["1681-715X","1682-024X"],"issn-type":[{"value":"1681-715X","type":"electronic"},{"value":"1682-024X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4,11]]}}}