{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T16:09:01Z","timestamp":1778342941824,"version":"3.51.4"},"reference-count":0,"publisher":"Pakistan Journal of Medical Sciences","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pak J Med Sci"],"abstract":"<jats:p>Objective:\u00a0To establish and validate a predictive model for postoperative hyperalgesia in patients with lower limb fractures undergoing nerve block surgery.\nMethodology:\u00a0This retrospective study analyzed 168 patients receiving postoperative nerve block analgesia at Huzhou Nanxun Hospital of Traditional Chinese Medicine (January 2022-October 2024). Patients were stratified into hyperalgesia and non-hyperalgesia groups. Logistic regression identified independent risk factors, followed by nomogram model development and validation using R software.\nResults:\u00a0Hyperalgesia incidence was 14.88% (25\/168). Significant differences existed in smoking history, diabetes history, operation time, distal compression at injection site, and ropivacaine dosage (P&lt;0.05). Multivariate analysis confirmed diabetes history (OR=4.12), operation time (OR=3.85), distal compression (OR=0.24), and ropivacaine dosage (OR=3.21) as independent predictors (P&lt;0.05). The nomogram achieved an AUC of 0.819 (95% CI: 0.732-0.906), with calibration curve slope=1 and intercept&lt;0.001. Decision curve analysis showed optimal net benefit at threshold probabilities of 0.05-0.55.\nConclusion:\u00a0Postoperative hyperalgesia is primarily associated with diabetes history, prolonged operation time, absence of distal compression, and higher ropivacaine dosage. The validated nomogram provides accurate individualized risk prediction.<\/jats:p>","DOI":"10.12669\/pjms.42.5.14933","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T14:47:08Z","timestamp":1778338028000},"page":"1234-1242","source":"Crossref","is-referenced-by-count":0,"title":["Predictive model for postoperative hyperalgesia in patients with lower limb fractures undergoing nerve block surgery"],"prefix":"10.12669","volume":"42","author":[{"given":"Pingping","family":"Pang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hengyi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengmei","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4935","published-online":{"date-parts":[[2026,5,8]]},"container-title":["Pakistan Journal of Medical Sciences"],"original-title":[],"link":[{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/download\/14933\/11452","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/download\/14933\/11452","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T15:11:02Z","timestamp":1778339462000},"score":1,"resource":{"primary":{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/view\/14933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,8]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,5,8]]}},"URL":"https:\/\/doi.org\/10.12669\/pjms.42.5.14933","relation":{},"ISSN":["1681-715X","1682-024X"],"issn-type":[{"value":"1681-715X","type":"electronic"},{"value":"1682-024X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,8]]}}}