{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T08:01:08Z","timestamp":1785312068752,"version":"3.55.0"},"reference-count":0,"publisher":"Pakistan Journal of Medical Sciences","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pak J Med Sci"],"abstract":"<jats:p>At present, there are no reported cases of CD56+ acute myeloid leukemia (AML) combined with hemophagocytic lymphohistiocytosis (HLH). Meanwhile, there is no standardized treatment plan for AML combined with HLH. This article reports a 27 years old female patient with CD56+ AML who received treatment with an HLH-94-based regimen combined with B cell lymphoma 2 (BCL-2) inhibitor venetoclax. After treatment, the patient\u2019s body temperature returned to normal and laboratory parameters related to HLH improved. Two weeks after chemotherapy, bone marrow reassessment showed 3% blast cells and undetectable MLL-AF9 fusion transcripts; complete remission was subsequently documented on May 23, 2024. To our knowledge, this represents a rarely reported case of CD56+AML with HLH. The result suggests that BCL-2 targeted therapy combined with HLH-94 regimen may be a safe and promising strategy for treating CD56+AML with HLH, and may provide a basis for the selection of treatment strategies for such patients in clinical practice.<\/jats:p>","DOI":"10.12669\/pjms.42.8.16163","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T07:12:34Z","timestamp":1785309154000},"page":"2189-2194","source":"Crossref","is-referenced-by-count":0,"title":["CD56-Positive Acute Myeloid Leukemia Complicated by Hemophagocytic Lymphohistiocytosis: A case report and narrative review"],"prefix":"10.12669","volume":"42","author":[{"given":"Xianjie","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuancai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaohui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junbin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4935","published-online":{"date-parts":[[2026,7,29]]},"container-title":["Pakistan Journal of Medical Sciences"],"original-title":[],"link":[{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/download\/16163\/11602","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/download\/16163\/11602","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T07:12:34Z","timestamp":1785309154000},"score":1,"resource":{"primary":{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/view\/16163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,29]]},"references-count":0,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,7,27]]}},"URL":"https:\/\/doi.org\/10.12669\/pjms.42.8.16163","relation":{},"ISSN":["1681-715X","1682-024X"],"issn-type":[{"value":"1681-715X","type":"electronic"},{"value":"1682-024X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7,29]]}}}