{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:58:57Z","timestamp":1785308337217,"version":"3.55.0"},"reference-count":0,"publisher":"Pakistan Journal of Medical Sciences","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pak J Med Sci"],"abstract":"<jats:p>Objective: To evaluate the effect of intravenous esketamine administration during anesthesia induction on postoperative sleep quality in female patients undergoing laparoscopic surgery.\nMethodology: This study was designed as a prospective, double-blind, single-center randomized controlled trial and was conducted at Huzhou Maternity &amp; Child Health Care Hospital between December 5, 2025, and January 31, 2026. One hundred ASA I-II female patients (25-50 years) undergoing elective laparoscopic surgery (Dec 2025-Jan 2026) were randomized to control (Group C, n=50) or esketamine (Group S, n=50). Both groups received propofol 2 mg\/kg, cisatracurium 0.15 mg\/kg, and sufentanil 0.3 \u03bcg\/kg for induction; Group-S additionally received esketamine 0.3 mg\/kg, while Group-C received normal saline. Anesthesia was maintained with propofol (4\u20136 mg\/kg\/h) and remifentanil (0.1\u20130.2 \u03bcg\/kg\/min) via infusion pumps to maintain the Bispectral Index (BIS) between 40 and 60 and end-tidal carbon dioxide (PETCO\u2082) between 35 and 45 mmHg. Outcomes included Pittsburgh Sleep Quality Index (PSQI) on postoperative days (POD) one, three, seven; intraoperative sufentanil use; 6\/24 h VAS pain scores; 24 hours rescue analgesia rate; adverse events; emergence time; and PACU stay.\nResults: Ninety eight patients (Group C: 49; Group S: 49) completed the study. Group-S had lower PSQI scores on POD one and three (P&lt;0.05), reduced intraoperative sufentanil consumption (P&lt;0.05), lower 6\/24 hours VAS scores (P&lt;0.05), and lower 24 hours rescue analgesia rate (P&lt;0.05). No significant differences in emergence time, PACU duration, or adverse event rates were observed (P&gt;0.05), with no severe adverse events.\nConclusion: Administration of 0.3 mg\/kg esketamine during anesthesia induction reduces opioid consumption, improves early postoperative sleep quality, and decreases sleep disturbance incidence in female laparoscopic patients without increasing adverse event risks.<\/jats:p>","DOI":"10.12669\/pjms.42.8.16352","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T05:59:26Z","timestamp":1785304766000},"page":"2088-2093","source":"Crossref","is-referenced-by-count":0,"title":["Esketamine during anesthesia induction improves early postoperative sleep quality in female patients undergoing laparoscopic surgery: A randomized trial"],"prefix":"10.12669","volume":"42","author":[{"given":"Rui","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guofang","family":"Fei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4935","published-online":{"date-parts":[[2026,7,29]]},"container-title":["Pakistan Journal of Medical Sciences"],"original-title":[],"link":[{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/download\/16352\/11589","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/download\/16352\/11589","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T05:59:26Z","timestamp":1785304766000},"score":1,"resource":{"primary":{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/view\/16352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,29]]},"references-count":0,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,7,27]]}},"URL":"https:\/\/doi.org\/10.12669\/pjms.42.8.16352","relation":{},"ISSN":["1681-715X","1682-024X"],"issn-type":[{"value":"1681-715X","type":"electronic"},{"value":"1682-024X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7,29]]}}}