{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T05:01:45Z","timestamp":1785214905865,"version":"3.55.0"},"reference-count":0,"publisher":"Pakistan Journal of Medical Sciences","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pak J Med Sci"],"abstract":"<jats:p>Objective: To evaluate the clinical efficiency and safety of bromhexine hydrochloride (BRH) combined with fiberoptic bronchoscopic alveolar lavage (BAL) in the treatment of patients with community-acquired pneumonia (CAP).\nMethodology: This retrospective cohort study included clinical data from 126 patients with mild-to-moderate CAP treated at Yongkang First People's Hospital from March 2023 to March 2025. Of them, 63 patients treated with BRH alone (BRH group) were matched 1:1 to a cohort treated with BRH combined with fiberoptic bronchoscopic BAL (BRH &amp; BAL group, n=63). The primary outcome was clinical efficacy. Secondary outcomes included clinical symptoms, levels of inflammatory factors, and incidence of adverse reactions.\nResults: After treatment, the efficacy of the BRH &amp; BAL group (95.2%) was significantly higher than that of the BRH group (84.1%) (P&lt;0.05). Post-treatment duration of fever, time to cough relief, time to resolution of pulmonary rales, and total hospital stay in the BRH &amp; BAL group were all shorter than those in the BRH group (P&lt;0.05). After treatment, the levels of IL-6, CRP, and PCT in both groups were considerably lower than pre-treatment and significantly lower in the BRH &amp; BAL group than in the BRH group (P&lt;0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P&gt;0.05).\nConclusion: BRH combined with BAL under FOB for the treatment of mild-to-moderate CAP is associated with improved therapeutic efficacy, alleviation of clinical symptoms, reduction of the inflammatory response, and good safety.<\/jats:p>","DOI":"10.12669\/pjms.42.8.19507","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T04:45:35Z","timestamp":1785213935000},"page":"2019-2025","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Bromhexine hydrochloride combined with bronchoalveolar lavage under fiberoptic bronchoscopy in the treatment of mild to moderate community-acquired pneumonia"],"prefix":"10.12669","volume":"42","author":[{"given":"Feiyan","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feijing","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4935","published-online":{"date-parts":[[2026,7,28]]},"container-title":["Pakistan Journal of Medical Sciences"],"original-title":[],"link":[{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/download\/19507\/11577","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/download\/19507\/11577","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T04:45:40Z","timestamp":1785213940000},"score":1,"resource":{"primary":{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/view\/19507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,28]]},"references-count":0,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,7,27]]}},"URL":"https:\/\/doi.org\/10.12669\/pjms.42.8.19507","relation":{},"ISSN":["1681-715X","1682-024X"],"issn-type":[{"value":"1681-715X","type":"electronic"},{"value":"1682-024X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7,28]]}}}