{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T05:19:45Z","timestamp":1787635185114,"version":"build-2736575974"},"reference-count":0,"publisher":"Pakistan Journal of Medical Sciences","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pak J Med Sci"],"abstract":"<jats:p>Objective: To determine the influence of recipients\u2019 pre-existing diabetes mellitus on the outcomes of living donor kidney transplantation.\nMethodology: This prospective observational cohort study included 202 patients who underwent kidney transplantation between September 2022 and December 2023 at Dow University Hospital, Pakistan, and were stratified into two equal groups: pre-existing diabetes and non-diabetes. Patients with new-onset diabetes after transplantation were excluded. Demographic and clinical data were collected. Outcomes, including one-year patient survival and post-transplant complications, were assessed and compared.\nResults: Complications were high in the pre-existing diabetes group (57.4% vs. 28.7%, p &lt;0.001). Infections occurred in 46.5% of patients with pre-existing diabetes versus 22.8% non-DM (p &lt;0.001). Post-transplant cardiovascular events were observed in 6.9% of patients in the pre-existing DM group, whereas none were observed in the non-DM group (p = 0.014). One-year patient survival was 88.1% in the pre-existing DM group versus 95% in the non-DM group (p = 0.075). Graft-related complications did not differ significantly between the groups. Multivariate analysis identified pre-transplant congestive heart failure (HR = 99.431, [95% CI 7.709\u2013128.441, p &lt;0.001]), pre-transplant peripheral vascular disease (HR =7.787, [95% CI 1.197\u201350.682, p = 0.032]), post-transplant cardiovascular events (HR = 7.839, [95% CI 1.423\u201343.198, p = 0.018]), and post-transplant FBS (HR = 1.023, [95% CI 1.001\u20131.046, p = 0.040]) as independent predictors of mortality.\nConclusion: Diabetes did not influence one-year patient survival and graft-specific outcomes but led to frequent post-transplant complications. Pre- and post-transplant cardiovascular disease and elevated post-transplant FBS levels were associated with mortality. Therefore, structured pre-transplant cardiovascular assessment and optimization, ongoing post-transplant cardiovascular surveillance, and strict glycemic control are required.<\/jats:p>","DOI":"10.12669\/pjms.42.9.13651","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T04:54:18Z","timestamp":1787633658000},"page":"2199-2205","source":"Crossref","is-referenced-by-count":0,"title":["The influence of recipient\u2019s pre-existing diabetes mellitus on outcomes of living donor kidney transplant"],"prefix":"10.12669","volume":"42","author":[{"family":"Hina Shahabuddin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Zareen Kiran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Muhammad Tassaduq Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Abdur Rasheed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4935","published-online":{"date-parts":[[2026,8,24]]},"container-title":["Pakistan Journal of Medical Sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.pjms.org.pk\/index.php\/pjms\/article\/download\/13651\/11606","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.pjms.org.pk\/index.php\/pjms\/article\/download\/13651\/11606","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T04:54:19Z","timestamp":1787633659000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.pjms.org.pk\/index.php\/pjms\/article\/view\/13651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,24]]},"references-count":0,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,8,24]]}},"URL":"https:\/\/doi.org\/10.12669\/pjms.42.9.13651","relation":{},"ISSN":["1681-715X","1682-024X"],"issn-type":[{"value":"1681-715X","type":"electronic"},{"value":"1682-024X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,24]]}}}