{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:24:27Z","timestamp":1787653467716,"version":"build-2736575974"},"reference-count":0,"publisher":"Pakistan Journal of Medical Sciences","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pak J Med Sci"],"abstract":"<jats:p>Objective: To explore the diagnostic value of antinuclear antibody(ANA) titer, anti-double-stranded DNA(anti-ds-DNA) antibody, anti-nuclear ribonucleoprotein\/Smith(anti-nRNPSm) antibody, and Smith (Sm) antibody for early atypical systemic lupus erythematosus(SLE).\nMethodology: This was a retrospective study. Forty-nine patients diagnosed with early atypical SLE admitted to Affiliated Hospital of Hebei University between January 2023 to June 2025 were assigned to Group-A, and 66 patients with other autoimmune diseases admitted during the same period were enrolled in Group-B. Compared the results of ANA, anti-ds-DNA, anti-nRNPSm and Sm antibody tests between the two groups, and analyzed the diagnostic value of the individual indicators and their combined detection for early atypical SLE.\nResults: There were statistically significant differences in the results of ANA, anti-ds-DNA, anti-nRNPSm and Sm antibodies between the two groups(P&lt;0.05). Multivariate Logistic regression analysis confirmed that ANA, anti-ds-DNA, anti-nRNPSm and Sm were independent influencing factors for early atypical SLE (P&lt;0.05). ROC curve analysis showed that the AUC of combined diagnosis was 0.856, with a predictive sensitivity of 87.8%, a specificity of 71.2%, and a predictive probability of 0.79. Significant differences in AUC were observed between ANA and anti-ds-DNA antibody, Sm antibody, or the four-antibody combination(P&lt;0.05); between anti-ds-DNA antibody and the four-antibody combination(P&lt;0.05); and between anti-nRNPSm antibody, Sm antibody and the four-antibody combination(P&lt;0.05).\nConclusion: ANA, anti-ds-DNA, anti-nRNPSm and Sm antibodies are major independent influencing factors for early atypical SLE. Combined detection of these indicators can effectively improve the diagnostic value for this disease.<\/jats:p>","DOI":"10.12669\/pjms.42.9.14966","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:04:22Z","timestamp":1787652262000},"page":"2318-2323","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Value of ANA Titer, Anti-ds-DNA, Anti-nRNPSm, and Sm Antibodies in Early Atypical Systemic Lupus Erythematosus"],"prefix":"10.12669","volume":"42","author":[{"given":"Jianqiao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meichen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4935","published-online":{"date-parts":[[2026,8,25]]},"container-title":["Pakistan Journal of Medical Sciences"],"original-title":[],"link":[{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/download\/14966\/11623","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/download\/14966\/11623","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:04:22Z","timestamp":1787652262000},"score":1,"resource":{"primary":{"URL":"https:\/\/pjms.org.pk\/index.php\/pjms\/article\/view\/14966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,25]]},"references-count":0,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,8,24]]}},"URL":"https:\/\/doi.org\/10.12669\/pjms.42.9.14966","relation":{},"ISSN":["1681-715X","1682-024X"],"issn-type":[{"value":"1681-715X","type":"electronic"},{"value":"1682-024X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,25]]}}}