{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T05:19:44Z","timestamp":1787635184583,"version":"build-2736575974"},"reference-count":0,"publisher":"Pakistan Journal of Medical Sciences","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pak J Med Sci"],"abstract":"<jats:p>Objectives: To compare heart rate variability (HRV) parameters and cardiac biomarkers between patients with single-vessel and multivessel coronary artery disease (CAD) and assess their associations with multivessel involvement.\nMethodology: This retrospective study included 196 patients with angiographically confirmed CAD admitted between September 2022 and May 2025 at Ningguo People\u2019s Hospital. Patients were classified as having single-vessel (n=55) or multivessel (n=141) disease. Group differences were assessed, and logistic regression was used to examine associations of SDNN, deceleration capacity (DC), high-sensitivity cardiac troponin T (hs-TnT), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) with multivessel disease. Restricted cubic spline analysis explored potential nonlinear relationships.\nResults: The multivessel group had lower SDNN, SDANN, SDNN index, and DC and higher hs-TnT and NT-proBNP levels than the single-vessel group (all P&lt;0.05). After adjustment for age, sex, hypertension, and diabetes, higher SDNN was associated with lower odds of multivessel disease (OR=0.68, 95% CI: 0.49\u20130.94), whereas higher hs-TnT (OR=2.43, 95% CI: 1.35\u20134.37) and NT-proBNP (OR=3.51, 95% CI: 1.28\u20139.62) were associated with higher odds. DC was not significantly associated with multivessel disease. Spline analyses suggested possible nonlinear patterns for SDNN and DC, but these findings were exploratory.\nConclusion: Lower SDNN and higher hs-TnT and NT-proBNP were associated with multivessel CAD. The hs-TnT finding should be interpreted in the context of myocardial injury burden and limited control of confounding.<\/jats:p>","DOI":"10.12669\/pjms.42.9.20249","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T04:53:33Z","timestamp":1787633613000},"page":"2213-2220","source":"Crossref","is-referenced-by-count":0,"title":["Analysis of clinical and heart rate variability parameters associated with single-vessel and multivessel coronary artery disease: A retrospective study"],"prefix":"10.12669","volume":"42","author":[{"given":"Mingfang","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sixin","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4935","published-online":{"date-parts":[[2026,8,24]]},"container-title":["Pakistan Journal of Medical Sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.pjms.org.pk\/index.php\/pjms\/article\/download\/20249\/11608","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.pjms.org.pk\/index.php\/pjms\/article\/download\/20249\/11608","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T04:53:33Z","timestamp":1787633613000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.pjms.org.pk\/index.php\/pjms\/article\/view\/20249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,24]]},"references-count":0,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,8,24]]}},"URL":"https:\/\/doi.org\/10.12669\/pjms.42.9.20249","relation":{},"ISSN":["1681-715X","1682-024X"],"issn-type":[{"value":"1681-715X","type":"electronic"},{"value":"1682-024X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,24]]}}}