{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:59:50Z","timestamp":1777438790981,"version":"3.51.4"},"reference-count":59,"publisher":"Japan Society of Histochemistry & Cytochemistry","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Histochem. Cytochem.","Acta Histochemica et Cytochemica","Acta Histochem. Cytochem"],"published-print":{"date-parts":[[2011]]},"DOI":"10.1267\/ahc.11010","type":"journal-article","created":{"date-parts":[[2011,7,20]],"date-time":"2011-07-20T05:20:19Z","timestamp":1311139219000},"page":"165-173","source":"Crossref","is-referenced-by-count":24,"title":["Distribution of Dendritic Cells in Normal Human Salivary Glands"],"prefix":"10.1267","volume":"44","author":[{"given":"An","family":"Le","sequence":"first","affiliation":[{"name":"Division of Pediatric Dentistry, Department of Craniofacial Sciences, University of Connecticut School of Dental Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Saverin","sequence":"additional","affiliation":[{"name":"Division of Pediatric Dentistry, Department of Craniofacial Sciences, University of Connecticut School of Dental Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur R.","family":"Hand","sequence":"additional","affiliation":[{"name":"Division of Pediatric Dentistry, Department of Craniofacial Sciences, University of Connecticut School of Dental Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"334","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Arakaki, R., Nagaoka, A., Ishimaru, N., Yamada, A., Yoshida, S. and Hayashi, Y. (2009) Role of plasmacytoid dendritic cells for aberrant class II expression in exocrine glands from estrogen-deficient mice of healthy background. Am. J. Pathol. 174; 1715-1724.","DOI":"10.2353\/ajpath.2009.080695"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Aziz, K. E., McCluskey, P. J. and Wakefield, D. (1996) Expression of selectins (CD62 E, L, P) and cellular adhesion molecules in primary Sj&ouml;gren&rsquo;s syndrome: questions to immunoregulation. Clin. Immunol. Immunopathol. 80; 55-66.","DOI":"10.1006\/clin.1996.0094"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Banchereau, J. and Steinman, R. M. (1998) Dendritic cells and control of immunity. Nature 392; 245-252.","DOI":"10.1038\/32588"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.18.1.767"},{"key":"5","unstructured":"5. Birbeck, M. S., Breathnach, A. S. and Everall, J. D. (1961) An electron microscope study of basal melanocytes and high-level clear cells (Langerhans cells) in vitiligo. J. Invest. Dermatol. 37; 51-64."},{"key":"6","unstructured":"6. Brandtzaeg, P. (2007) Do salivary antibodies reliably reflect both mucosal and systemic immunity? Ann. N.Y. Acad. Sci. 1098; 288-311."},{"key":"7","unstructured":"7. Chaudhry, A. P., Cutler, L. S., Yamane, G. M., Labay, G. R., Sunderrai, M., Manak, J. R. Jr. (1987) Ultrastructure of normal human parotid gland with special emphasis on myoepithelial cell distribution. J. Anat. 152; 1-11."},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Cohen, R. E., Noble, B., Neiders, M. E., Bedi, G. S. and Comeau, R. L. (1992) Phenotypic characterization of resident macrophages in submandibular salivary glands of normal and isoproterenol-treated rats. Arch. Oral Biol. 37; 503-509.","DOI":"10.1016\/0003-9969(92)90107-J"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1038\/ni1141"},{"key":"10","unstructured":"10. Coquerelle, C. and Moser, M. (2010) DC subsets in positive and negative regulation of immunity. Immunol. Rev. 234; 317-334."},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(87)90173-3"},{"key":"12","unstructured":"12. Dardick, I., Stratis, M., Parks, W. R., DeNardi, F. G. and Kahn, H. J. (1991) S-100 protein antibodies do not label normal salivary gland myoepithelium. Histogenetic implications for salivary gland tumors. Am. J. Pathol. 138; 619-628."},{"key":"13","unstructured":"13. Davalanga, Y. A., Drosos, A. A. and Moutsopoulos, H. M. (1986) Labial salivary gland immunopathology in Sj&ouml;gren&rsquo;s syndrome. Scand. J. Rheumatol. Suppl. 61; 67-70."},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.189"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Fox, R. I., Bumol, T., Fantozzi, R., Bone, R. and Schreiber, R. (1986) Expression of histocompatibility antigen HLA-DR by salivary gland epithelial cells in Sj&ouml;gren&rsquo;s syndrome. Arthritis Rheum. 29; 1105-1111.","DOI":"10.1002\/art.1780290908"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510837103"},{"key":"17","unstructured":"17. Haimoto, H., Hosoda, S. and Kato, K. (1987) Differential distribution of immunoreactive S100-&alpha; and S100-&beta; proteins in normal nonnervous human tissues. Lab. Invest. 57; 489-498."},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Jonsson, R., Klareskog, L., B&auml;ckman, K. and Tarkowski, A. (1987) Expression of HLA-D-locus (DP, DQ, DR)-coded antigens, &beta;<sub>2<\/sub>-microglobulin, and the interleukin 2 receptor in Sj&ouml;gren&rsquo;s syndrome. Clin. Immunol. Immunopathol. 45; 235-243.","DOI":"10.1016\/0090-1229(87)90038-9"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Kaissling, B., Hegyi, I., Loffing, J. and Le Hir, M. (1996) Morphology of interstitial cells in the healthy kidney. Anat. Embryol. 193; 303-318.","DOI":"10.1007\/BF00186688"},{"issue":"5\/6","key":"20","first-page":"292","volume":"62","year":"1994","ISSN":"https:\/\/id.crossref.org\/issn\/1015-2008","issn-type":"print"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Kutta, H., May, J., Jaehne, M., M&uuml;nscher, A. and Paulsen, F. P. (2006) Antimicrobial defence mechanisms of the human parotid duct. J. Anat. 208; 609-619.","DOI":"10.1111\/j.1469-7580.2006.00567.x"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05152.x"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Latchney, L. R., Fallon, M. A., Culp, D. J., Gelbard, H. A. and Dewhurst, S. (2004) Immunohistochemical assessment of fractalkine, inflammatory cells, and human herpesvirus 7 in human salivary glands. J. Histochem. Cytochem. 52; 671-681.","DOI":"10.1177\/002215540405200511"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Linehan, S. A. (2005) The mannose receptor is expressed by subsets of APC in non-lymphoid organs. BMC Immunol. 6; 4-14.","DOI":"10.1186\/1471-2172-6-4"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Manoussakis, M. N., Boiu, S., Korkolopoulou, P., Kpasogeorgou, E. K., Kavantzas, N., Ziakas, P., Patsouris, E. and Moutsopoulos, H. M. (2007) Rates of infiltration by macrophages and dendritic cells and expression of interleukin-18 and interleuin-12 in the chronic inflammatory lesions of Sj&ouml;gren&rsquo;s syndrome. Arthritis Rheum. 56; 3977-3988.","DOI":"10.1002\/art.23073"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1679\/aohc.60.493"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Matthews, J. B., Potts, A. J., Hamburger, J. and Scott, D. G. (1985) T6 antigen-positive cells in human labial salivary glands. Arch. Oral Biol. 30; 325-329.","DOI":"10.1016\/0003-9969(85)90005-6"},{"key":"28","unstructured":"28. Matthews, J. B., Potts, A. J. C., Hamburger, J., Scott, D. G. I. and Struthers, G. (1986) An immunohistochemical study of lymphocyte subsets and expression of glandular HLA-DR in labial salivary glands from patients with symptomatic xerostomia, rheumatoid arthritis and systemic lupus erythematosus. Scand. J. Rhematol. Suppl. 61; 56-60."},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Matthews, J. B., Mason, G. I. and Lawrence, G. M. (1992) Epithelial expression of major histocompatibility complex (MHC) antigens in normal rat salivary and lacrimal glands. Arch. Oral Biol. 37; 93-97.","DOI":"10.1016\/0003-9969(92)90003-Q"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.1.17-27.2005"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1993.tb18352.x"},{"issue":"1","key":"32","first-page":"223","volume":"240","year":"1985","ISSN":"https:\/\/id.crossref.org\/issn\/0302-766X","issn-type":"print"},{"key":"33","unstructured":"33. Nakazato, Y., Ishida, Y., Takahashi, K. and Suzuki, K. (1985) Immunohistochemical distribution of S-100 protein and glial fibrillary acidic protein in normal and neoplastic salivary glands. Virchows Arch. A Pathol. Anat. Histopathol. 405; 299-310."},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1126\/science.1102901"},{"key":"35","unstructured":"35. Oxholm, P., Manthorpe, R., Oxholm, A. and Schi&oslash;dt, M. (1985) Langerhans cells in labial minor salivary glands in primary Sj&ouml;gren&rsquo;s syndrome. Acta Pathol. Microbio. Immunol. Scand. [A] 93; 105-107."},{"key":"36","unstructured":"36. Ozaki, Y., Ito, T., Son, Y., Amuro, H., Shimamoto, K., Sugimoto, H., Katashiba, Y., Ogata, M., Miyamoto, R., Murakami, N., Amakawa, R. and Fukuhara, S. (2009) Decrease of blood dendritic cells and increase of tissue-infiltrating dendritic cells are involved in the induction of Sj&ouml;gren&rsquo;s syndrome but not in the maintenance. Clin. Exp. Immunol. 159; 315-326."},{"issue":"1","key":"37","first-page":"99","volume":"63","year":"1988","ISSN":"https:\/\/id.crossref.org\/issn\/0019-2805","issn-type":"print"},{"issue":"2","key":"38","first-page":"295","volume":"64","year":"1988","ISSN":"https:\/\/id.crossref.org\/issn\/0019-2805","issn-type":"print"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Pober, J. S., Collins, T., Gimbrone, M. A. Jr., Libby, P. and Reiss, C. S. (1986) Inducible expression of class II major histocompatibility complex antigens and the immunogenicity of vascular endothelium. Transplantation 41; 141-146.","DOI":"10.1097\/00007890-198602000-00001"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1038\/86373"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199909)29:09<2769::AID-IMMU2769>3.0.CO;2-2"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Rogers, A. V., Adelroth, E., Hattotuwa, K., Dewar, A. and Jeffery, P. K. (2008) Bronchial mucosal dendritic cells in smokers and ex-smokers with COPD: an electron microscopic study. Thorax 63; 108-114.","DOI":"10.1136\/thx.2007.078253"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.59.897"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Stasulis, C. A. and Hand, A. R. (2003) Immunohistochemical identification of antigen presenting cells in rat salivary glands. Arch. Oral Biol. 48; 691-699.","DOI":"10.1016\/S0003-9969(03)00133-X"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45. Steinbrink, K., Mahnke, K., Grabbe, S., Enk, A. H. and Jonuleit, H. (2009) Myeloid dendritic cell: From sentinel of immunity to key player of peripheral tolerance? Hum. Immunol. 70; 289-293.","DOI":"10.1016\/j.humimm.2009.02.003"},{"key":"46","unstructured":"46. Steiniger, B., Falk, M., Lohm&uuml;ller, M. and van der Meide, P. H. (1989) Class II MHC antigens in the rat digestive system. Normal distribution and induced expression after interferon-gamma treatment in vivo. Immunology 68; 507-513."},{"key":"47","unstructured":"47. Steinman, R. M. and Hemmi, H. (2006) Dendritic cells: translating innate to adaptive immunity. Curr. Top. Microbiol. Immunol. 311; 17-58."},{"key":"48","doi-asserted-by":"crossref","unstructured":"48. Takano, Y., Kawahara, I., Hoshino, M., Takeuchi, K., Maeda, T., Ohshima, H., Hanaizumi, Y. and Kawano, Y. (1996) Dendritic cells: a novel cellular component of the rat incisor enamel organ appearing in the late stages of enamel maturation. Adv. Dent. Res. 10; 94-104.","DOI":"10.1177\/08959374960100022701"},{"issue":"1","key":"49","first-page":"27","volume":"15","author":"TAKAYA M","year":"1990","ISSN":"https:\/\/id.crossref.org\/issn\/0385-0005","issn-type":"print"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50. Thrane, P. S. and Brandtzaeg, P. (1988) Differential expression of epithelial MHC class II determinants (HLA-DR, -DP, and -DQ) and increased class I expression in inflamed salivary glands. Adv. Exp. Med. Biol. 237; 681-688.","DOI":"10.1007\/978-1-4684-5535-9_102"},{"key":"51","unstructured":"51. Thrane, P. S., Halstensen, T. S., Rognum, T. O. and Brandtzaeg, P. (1991) Expression of HLA class I and II (DR, DP and DQ) determinants in fetal and postnatal salivary glands. Scand. J. Immunol. 34; 539-548."},{"key":"52","unstructured":"52. Thrane, P. S., Halstensen, T. S., Haanaes, H. R. and Brandtzaeg, P. (1993) Increased epithelial expression of HLA-DQ and HLA-DP molecules in salivary glands from patients with Sj&ouml;gren&rsquo;s syndrome compared with obstructive sialadenitis. Clin. Exp. Immunol. 92; 256-262."},{"key":"53","unstructured":"53. Turesson, C. (2004) Endothelial expression of MHC class II molecules in autoimmune disease. Curr. Pharm. Des. 10; 129-143."},{"key":"54","doi-asserted-by":"crossref","unstructured":"54. Valladeau, J., Ravel, O., Dezutter-Dambuyant, C., Moore, K., Kleijmeer, M., Liu, Y., Duvert-Frances, V., Vincent, C., Schmitt, D., Davoust, J., Caux, C., Lebecque, S. and Saeland, S. (2000) Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity 12; 71-81.","DOI":"10.1016\/S1074-7613(00)80160-0"},{"key":"55","unstructured":"55. van Blokland, S. C. A., van Helden-Meeuwsen, C. G., Wierenga-Wolf, A. F., Drexhage, H. A., Hooijkaas, H., Van De Merwe, J. P. and Versnel, M. A. (2000) Two different types of sialoadenitis in the NOD- and MRL\/lpr mouse models for Sj&ouml;gren&rsquo;s syndrome: a differential role for dendritic cells in the initiation of sialoadenitis? Lab. Invest. 80; 575-585."},{"key":"56","unstructured":"56. van Blokland, S. C. A., Wierenga-Wolf, A. F., van Helden-Meeuwesen, C. G., Drexhage, H. A., Hooijkaas, H., van de Merwe, J. P. and Versnel, M. A. (2000) Professional antigen presenting cells in minor salivary glands in Sj&ouml;gren&rsquo;s syndrome: potential contribution to the histopathological diagnosis? Lab. Invest. 80; 1935-1941."},{"key":"57","unstructured":"57. Vogelsang, P., Jonsson, M. V., Dalvin, S. T. and Appel, S. (2006) Role of dendritic cells in Sj&ouml;gren&rsquo;s syndrome. Scand. J. Immunol. 64; 219-226."},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.118158"},{"key":"59","unstructured":"59. Wildenberg, M. E., Welzen-Coppens, J. M., van Helden-Meeuwsen, C. G., Bootsma, H., Vissink, A., van Rooijen, N., van de Merwe, J. P., Drexhage, H. A. and Versnel, M. A. (2009) Increased frequency of CD16+ monocytes and the presence of activated dendritic cells in salivary glands in primary Sj&ouml;gren syndrome. Ann. Rheum. Dis. 68; 420-426."}],"container-title":["ACTA HISTOCHEMICA ET CYTOCHEMICA"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/ahc\/44\/4\/44_11010\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T06:34:19Z","timestamp":1616999659000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/ahc\/44\/4\/44_11010\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":59,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1267\/ahc.11010","relation":{},"ISSN":["0044-5991","1347-5800"],"issn-type":[{"value":"0044-5991","type":"print"},{"value":"1347-5800","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}